Dr Michael Griffiths BMedSci, BM.BS., MRCP Paeds., MSc Paediatrics and Child Health, DTMH, DPhil.

Reader Clinical Infection, Microbiology and Immunology

    Publications

    2020

    Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study (Journal article)

    Brito Ferreira, M. L., Militao de Albuquerque, M. D. F. P., Antunes de Brito, C. A., de Oliveira Franca, R. F., Porto Moreira, A. J., de Morais Machado, M. I., . . . Solomon, T. (2020). Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study. LANCET NEUROLOGY, 19(10), 826-839. Retrieved from http://gateway.webofknowledge.com/

    Methods of inactivation of SARS-CoV-2 for downstream biological assays. (Journal article)

    Patterson, E. I., Prince, T., Anderson, E. R., Casas-Sanchez, A., Smith, S. L., Cansado-Utrilla, C., . . . Hughes, G. L. (2020). Methods of inactivation of SARS-CoV-2 for downstream biological assays.. The Journal of infectious diseases. doi:10.1093/infdis/jiaa507

    DOI: 10.1093/infdis/jiaa507

    Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study. (Journal article)

    Harris, L., Griem, J., Gummery, A., Marsh, L., Defres, S., Bhojak, M., . . . ENCEPH UK study group. (2020). Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.. PloS one, 15(3), e0230436. doi:10.1371/journal.pone.0230436

    DOI: 10.1371/journal.pone.0230436

    TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection (Journal article)

    Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (2020). TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-60761-5

    DOI: 10.1038/s41598-020-60761-5

    58. Acute Bacterial Meningitis (Chapter)

    Griffiths, M. J., Carrol, E., & Ghadasan, R. (2020). 58. Acute Bacterial Meningitis. In Hunter's Tropical Medicine and Emerging Infectious Disease. Elsevier.

    Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT (Journal article)

    Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., . . . Collaborators, B. A. S. I. C. S. S. (2020). Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(17), 1-+. doi:10.3310/hta24170

    DOI: 10.3310/hta24170

    2019

    BACTERIAL MENINGITIS IN MALAWIAN CHILDREN, 2000-2018 (Conference Paper)

    Nielsen, M., Ray, S. T. J., Kawaza, K., Denis, B., Gordon, S. B., Griffiths, M. J., . . . Tam, P. -Y. I. (2019). BACTERIAL MENINGITIS IN MALAWIAN CHILDREN, 2000-2018. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 146). Retrieved from http://gateway.webofknowledge.com/

    Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation (Journal article)

    Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., . . . Gamble, C. (2019). Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation. Lancet, 394(10208), 1530-1539. doi:10.1016/S0140-6736(19)31603-4

    DOI: 10.1016/S0140-6736(19)31603-4

    Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study (Journal article)

    Solomon, T. (2019). Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study. PLoS One.

    The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS (Journal article)

    Lima, M. C., de Mendonca, L. R., Rezende, A. M., Carrera, R. M., Anibal-Silva, C. E., Demers, M., . . . Franca, R. F. O. (2019). The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.01928

    DOI: 10.3389/fimmu.2019.01928

    Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection (Internet publication)

    Goh, C., Golubchik, T., Ansari, M. A., de Cesare, M., Trebes, A., Elliott, I., . . . Bowden, R. (n.d.). Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection. Cold Spring Harbor Laboratory. doi:10.1101/716902

    DOI: 10.1101/716902

    TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection (Internet publication)

    Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (n.d.). TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection. Cold Spring Harbor Laboratory. doi:10.1101/682914

    DOI: 10.1101/682914

    Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns? (Journal article)

    Turtle, L. C. W. (n.d.). Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns?. PLoS Neglected Tropical Diseases, 13. doi:10.1371/journal.pntd.0007269

    DOI: 10.1371/journal.pntd.0007269

    HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting (Journal article)

    Kamtchum-Tatuene, J., Mwandumba, H., Al-Bayati, Z., Flatley, J., Griffiths, M., Solomon, T., & Benjamin, L. (2019). HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting. NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 6(2). doi:10.1212/NXI.0000000000000531

    DOI: 10.1212/NXI.0000000000000531

    SCREENING FOR CEREBROVASCULAR PATHOLOGY ON THE BASIS OF POSITIVE FAMILY HISTORY IN THE PAEDIATRIC POPULATION (Conference Paper)

    Millward, C. P., Tonder, L. V., Foster, M., Williams, D., Griffiths, M., Kneen, R., . . . Mallucci, C. (2019). SCREENING FOR CEREBROVASCULAR PATHOLOGY ON THE BASIS OF POSITIVE FAMILY HISTORY IN THE PAEDIATRIC POPULATION. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 90 (pp. E47). doi:10.1136/jnnp-2019-ABN.153

    DOI: 10.1136/jnnp-2019-ABN.153

    141 Systematic cerebrospinal fluid testing improves pathogen detection among childhood central nervous system infections in Yogyakarta, Indonesia (Conference Paper)

    Griffiths, M. J., Aifa, B., Prince, T., & Solomon, T. (2019, January 23). 141 Systematic cerebrospinal fluid testing improves pathogen detection among childhood central nervous system infections in Yogyakarta, Indonesia. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). LIverpool: Wiley-Blackwell.

    150 Diverse intra-cranial imaging abnormalities identified in Malawian children with febrile coma (Conference Paper)

    Griffiths, M. J., Ray, S., & Fuller, C. (2019, January 23). 150 Diverse intra-cranial imaging abnormalities identified in Malawian children with febrile coma. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). Liverpool: Wiley-Blackwell.

    159 The benefit of workshops for families with children with congenital Zika syndrome in Brazil (Conference Paper)

    Griffiths, M. J., Medialdea-Carrera, R., & Beets, K. (2019, January 23). 159 The benefit of workshops for families with children with congenital Zika syndrome in Brazil. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). Liverpool: Wiley-Blackwell.

    Oral Session 3 Thursday 24th January 2019 - Improving the diagnosis of neurosurgical CSF infections (Conference Paper)

    Griffiths, M. J., Van Tonder, L., Prince, T., Solomon, T., & Mallucci, C. (2019, January 23). Oral Session 3 Thursday 24th January 2019 - Improving the diagnosis of neurosurgical CSF infections. In Developmental Medicine and Child Neurology Vol. 61 (pp. 4-15). Liverpool: Wiley-Blackwell.

    THE ETIOLOGY, NEUROIMAGING AND NEURODEVELOPMENTAL OUTCOME OF SEVERE FEBRILE ENCEPHALOPATHY IN MALAWIAN CHILDREN (Conference Paper)

    Ray, S. T. J., Fuller, C., Stockdale, E., Dwivedi, R., Chetcuti, K., Moxon, C., . . . Seydel, K. B. (2019). THE ETIOLOGY, NEUROIMAGING AND NEURODEVELOPMENTAL OUTCOME OF SEVERE FEBRILE ENCEPHALOPATHY IN MALAWIAN CHILDREN. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 342). Retrieved from http://gateway.webofknowledge.com/

    2018

    A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis (Journal article)

    Backman, R., Foy, R., Diggle, P. J., Kneen, R., Easton, A., Defres, S., . . . Comm, E. N. C. E. P. H. U. K. P. S. (2018). A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis. PLoS One, 13(12). doi:10.1371/journal.pone.0202257

    DOI: 10.1371/journal.pone.0202257

    The role of SIGLEC-1 in flavivirus infections (Conference Paper)

    Prince, T. A. C., Medialdea Carrera, R., Rainbow, L., Solomon, T., Blake, N., & Griffiths, M. J. (2018). The role of SIGLEC-1 in flavivirus infections. In Encephalitis Society Conference. London.

    Importance of CSF lactate concentration in the diagnosis of acute bacterial meningitis Response (Journal article)

    Griffiths, M. J., Mcgill, F., & Solomon, T. (2018). Importance of CSF lactate concentration in the diagnosis of acute bacterial meningitis Response. CLINICAL MEDICINE, 18(4), 352. doi:10.7861/clinmedicine.18-4-352

    DOI: 10.7861/clinmedicine.18-4-352

    Response. (Journal article)

    Griffiths, M. J., McGill, F., & Solomon, T. (2018). Response.. Clinical medicine (London, England), 18(4), 352. doi:10.7861/clinmedicine.18-4-352

    DOI: 10.7861/clinmedicine.18-4-352

    Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study (Journal article)

    McGill, F. J., Griffiths, M., Bonnett, L., Geretti, A., Michael, B., Beeching, N., . . . Solomon, T. (2018). Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infectious Diseases, 18(9), 992-1003. doi:10.1016/S1473-3099(18)30245-7

    DOI: 10.1016/S1473-3099(18)30245-7

    Comment on CME Infectious diseases Response (Journal article)

    Ellul, M., Griffiths, M., McGill, F., & Solomon, T. (2018). Comment on CME Infectious diseases Response. CLINICAL MEDICINE, 18(3), 269-270. doi:10.7861/clinmedicine.18-3-269a

    DOI: 10.7861/clinmedicine.18-3-269a

    DETECTION OF BACTERIAL INFECTIONS (Patent)

    Griffiths, M. J. (2018, April 12). PCT/GB2019/051048, DETECTION OF BACTERIAL INFECTIONS. International.

    Management of acute meningitis (Journal article)

    Griffiths, M. J., McGill, F., & Solomon, T. (2018). Management of acute meningitis. CLINICAL MEDICINE, 18(2), 164-169. doi:10.7861/clinmedicine.18-2-164

    DOI: 10.7861/clinmedicine.18-2-164

    Recommendations for enterovirus diagnostics and characterisation within and beyond Europe (Journal article)

    Harvala, H., Broberg, E., Benschop, K., Berginc, N., Ladhani, S., Susi, P., . . . Fischer, T. K. (2018). Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. JOURNAL OF CLINICAL VIROLOGY, 101, 11-17. doi:10.1016/j.jcv.2018.01.008

    DOI: 10.1016/j.jcv.2018.01.008

    Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool (Journal article)

    Goenka, A., Jeena, P. M., Mlisana, K., Solomon, T., Spicer, K., Stephenson, R., . . . Griffiths, M. J. (2018). Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool. The Pediatric Infectious Disease Journal, 37(3), 229-234. doi:10.1097/INF.0000000000001726

    DOI: 10.1097/INF.0000000000001726

    The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series (Journal article)

    Mehta, R., Soares, C. N., Medialdea-Carrera, R., Ellul, M., Texeira da Silva, M. T., Rosala-Hallas, A., . . . Solomon, T. (2018). The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. PLoS Neglected Tropical Diseases, 12(2). doi:10.1371/journal.pntd.0006212

    DOI: 10.1371/journal.pntd.0006212

    The inter-rater reliability and prognostic value of coma scales in Nepali children with acute encephalitis syndrome (Journal article)

    Ray, S., Rayamajhi, A., Bonnett, L. J., Solomon, T., Kneen, R., & Griffiths, M. J. (2018). The inter-rater reliability and prognostic value of coma scales in Nepali children with acute encephalitis syndrome. PAEDIATRICS AND INTERNATIONAL CHILD HEALTH, 38(1), 60-65. doi:10.1080/20469047.2017.1398503

    DOI: 10.1080/20469047.2017.1398503

    2017

    IMPROVING THE DIAGNOSIS OF ENCEPHALITIS THROUGH EXAMINING HOST PROTEOME AND GENE EXPRESSION (Conference Paper)

    Ellul, M., Griffiths, M., Hiscox, J., & Solomon, T. (2017). IMPROVING THE DIAGNOSIS OF ENCEPHALITIS THROUGH EXAMINING HOST PROTEOME AND GENE EXPRESSION. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A55-A56). doi:10.1136/jnnp-2017-ABN.191

    DOI: 10.1136/jnnp-2017-ABN.191

    INCIDENCE AND HEALTHCARE COSTS OF VIRAL MENINGITIS IN ADULTS - A MULTICENTRE PROSPECTIVE OBSERVATIONAL STUDY IN ENGLAND (Conference Paper)

    McGill, F., Griffiths, M. J., Bonnett, L., Martin, A., Geretti, A. M., Michael, B. D., . . . Investigators, U. K. M. S. (2017). INCIDENCE AND HEALTHCARE COSTS OF VIRAL MENINGITIS IN ADULTS - A MULTICENTRE PROSPECTIVE OBSERVATIONAL STUDY IN ENGLAND. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A73). doi:10.1136/jnnp-2017-ABN.253

    DOI: 10.1136/jnnp-2017-ABN.253

    NEUROPSYCHOLOGICAL SEQUELAE OF VIRAL MENINGITIS (Conference Paper)

    Adan, G., Griffiths, M., Bonnett, L., Miller, A., Geretti, A. M., Michael, B., . . . Solomon, T. (2017). NEUROPSYCHOLOGICAL SEQUELAE OF VIRAL MENINGITIS. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A68). doi:10.1136/jnnp-2017-ABN.235

    DOI: 10.1136/jnnp-2017-ABN.235

    STUDY OF THE FEASIBILITY AND ACCURACY OF NEXT GENERATION SEQUENCING, PROTEOMICS, TRANSCRIPTOMICS AND CYTOKINE MEASUREMENT FOR IMPROVING THE DIAGNOSIS OF NEUROSURGICAL CEREBROSPINAL FLUID INFECTION (Conference Paper)

    van Tonder, L., Griffiths, M., Mallucci, C., Jenkinson, M., Kamali, I., Griffiths, M., & Solomon, T. (2017). STUDY OF THE FEASIBILITY AND ACCURACY OF NEXT GENERATION SEQUENCING, PROTEOMICS, TRANSCRIPTOMICS AND CYTOKINE MEASUREMENT FOR IMPROVING THE DIAGNOSIS OF NEUROSURGICAL CEREBROSPINAL FLUID INFECTION. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A78). doi:10.1136/jnnp-2017-ABN.271

    DOI: 10.1136/jnnp-2017-ABN.271

    Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function (Journal article)

    Hemingway, C., Berk, M., Anderson, S. T., Wright, V. J., Hamilton, S., Eleftherohorinou, H., . . . Levin, M. (2017). Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function. PLOS ONE, 12(11). doi:10.1371/journal.pone.0185973

    DOI: 10.1371/journal.pone.0185973

    Decoding the association between herpes simplex virus and antibody-mediated encephalitis (Journal article)

    Ellul, M. A., & Griffiths, M. J. (2017). Decoding the association between herpes simplex virus and antibody-mediated encephalitis. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 59(8), 776-777. doi:10.1111/dmcn.13471

    DOI: 10.1111/dmcn.13471

    A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology (Journal article)

    Defres, S., Keller, S. S., Das, K., Vidyasagar, R., Parkes, L. M., Burnside, G., . . . Solomon, T. (2017). A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology. PLOS ONE, 12(01), 15 pages. doi:10.1371/journal.pone.0170215

    DOI: 10.1371/journal.pone.0170215

    Viral meningitis: current issues in diagnosis and treatment (Journal article)

    McGill, F., Griffiths, M. J., & Solomon, T. (2017). Viral meningitis: current issues in diagnosis and treatment. CURRENT OPINION IN INFECTIOUS DISEASES, 30(2), 248-256. doi:10.1097/QCO.0000000000000355

    DOI: 10.1097/QCO.0000000000000355

    2016

    The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections (Conference Paper)

    Griffiths, M. J. (2016). The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections.

    A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease (Journal article)

    Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

    DOI: 10.1080/1354750X.2016.1265003

    ENCEPHALITIS: PARENCHYMAL LEUCOCYTES IN INFECTIOUS, IMMUNE AND UNKNOWN CAUSE (Conference Paper)

    Daramola, O., Rathi, N., Michael, B. D., Griffiths, M. J., Moxham, N., Benjamin, L., . . . Solomon, T. (2016). ENCEPHALITIS: PARENCHYMAL LEUCOCYTES IN INFECTIOUS, IMMUNE AND UNKNOWN CAUSE. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 87. doi:10.1136/jnnp-2016-315106.126

    DOI: 10.1136/jnnp-2016-315106.126

    Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study (Journal article)

    Malgorzata Wnek., Lorenzo Ressel., Ricci, E., Rodriguez-Martinez, C., Villalvazo Geurrero, J. C., Ismail, Z., . . . Michael J. Griffiths. (2016). Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study. Acta Neuropathologica, 132(3), 433-451. doi:10.1007/s00401-016-1597-2

    DOI: 10.1007/s00401-016-1597-2

    The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome (Journal article)

    Michael, B. D., Griffiths, M. J., Granerod, J., Brown, D., Keir, G., Wnek, G., . . . Solomon, T. (2016). The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome. JOURNAL OF INFECTIOUS DISEASES, 213(10), 1651-1660. doi:10.1093/infdis/jiv771

    DOI: 10.1093/infdis/jiv771

    Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection (Journal article)

    Ellul, M. A., Griffiths, M. J., Iyer, A., Avula, S., Defres, S., Baborie, A., . . . Kneen, R. (2016). Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 35(3), 347-349. doi:10.1097/INF.0000000000001011

    DOI: 10.1097/INF.0000000000001011

    Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology (Journal article)

    Michael, B. D., Griffiths, M. J., Granerod, J., Brown, D., Davies, N. W. S., Borrow, R., & Solomon, T. (2016). Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146288

    DOI: 10.1371/journal.pone.0146288

    2015

    DETECTION OF BACTERIAL INFECTION (Patent)

    Griffiths, M. J. (2015, October 20). PCT/GB2016/053269 (Publication No. WO/2017/068347), DETECTION OF BACTERIAL INFECTION. International.

    A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal (vol 10, e0122608, 2015) (Journal article)

    Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal (vol 10, e0122608, 2015). PLOS ONE, 10(8). doi:10.1371/journal.pone.0136008

    DOI: 10.1371/journal.pone.0136008

    A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal (Journal article)

    Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal. PLOS ONE, 10(4). doi:10.1371/journal.pone.0122608

    DOI: 10.1371/journal.pone.0122608

    2014

    The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol (Journal article)

    Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. TRIALS, 15. doi:10.1186/1745-6215-15-4

    DOI: 10.1186/1745-6215-15-4

    Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children (Journal article)

    Harvala, H., Griffiths, M., Solomon, T., & Simmonds, P. (2014). Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. JOURNAL OF INFECTION, 69(1), 69-74. doi:10.1016/j.jinf.2014.02.017

    DOI: 10.1016/j.jinf.2014.02.017

    Japanese encephalitis virus infection. (Chapter)

    Griffiths, M. J., Turtle, L., & Solomon, T. (2014). Japanese encephalitis virus infection.. In Unknown Book (Vol. 123, pp. 561-576). doi:10.1016/b978-0-444-53488-0.00026-2

    DOI: 10.1016/b978-0-444-53488-0.00026-2

    NMDAR encephalitis with evidence of coexistant HSV infection proven on brain biopsy; Poster 049 (Conference Paper)

    Griffiths, M. J., Iyer, A., Solomon, T., Kneen, R., & Barborie, A. (n.d.). NMDAR encephalitis with evidence of coexistant HSV infection proven on brain biopsy; Poster 049. In Developmental Medicine and Child Neurology Vol. 56. Wiley-Blackwell.

    2013

    Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms - A pilot study (Journal article)

    Michael, B. D., Elsone, L., Griffiths, M. J., Faragher, B., Borrow, R., Solomon, T., & Jacob, A. (2013). Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms - A pilot study. CYTOKINE, 64(1), 90-96. doi:10.1016/j.cyto.2013.07.019

    DOI: 10.1016/j.cyto.2013.07.019

    Improving the diagnosis of central nervous system infections in adults through introduction of a simple lumbar puncture pack (Journal article)

    Michael, B. D., Powell, G., Curtis, S., Bailey, L., Almond, S., McGill, F., . . . Solomon, T. (2013). Improving the diagnosis of central nervous system infections in adults through introduction of a simple lumbar puncture pack. EMERGENCY MEDICINE JOURNAL, 30(5), 402-405. doi:10.1136/emermed-2012-201248

    DOI: 10.1136/emermed-2012-201248

    A Panel of Serum Cytokines/Chemokines Can Distinguish between Patients with Neuromyelitis Optica and Multiple Sclerosis and Identifies Potential Pathophysiological Mechanisms and Therapeutic Targets (Conference Paper)

    Michael, B., Elsone, L., Griffiths, M., Borrow, R., Faragher, B., Solomon, T., & Jacob, A. (2013). A Panel of Serum Cytokines/Chemokines Can Distinguish between Patients with Neuromyelitis Optica and Multiple Sclerosis and Identifies Potential Pathophysiological Mechanisms and Therapeutic Targets. In NEUROLOGY Vol. 80. Retrieved from http://gateway.webofknowledge.com/

    The Functional, Social and Economic Impact of Acute Encephalitis Syndrome in Nepal - a Longitudinal Follow-Up Study (Journal article)

    Griffiths, M. J., Lemon, J. V., Rayamajhi, A., Poudel, P., Shrestha, P., Srivastav, V., . . . Solomon, T. (2013). The Functional, Social and Economic Impact of Acute Encephalitis Syndrome in Nepal - a Longitudinal Follow-Up Study. PLOS NEGLECTED TROPICAL DISEASES, 7(9). doi:10.1371/journal.pntd.0002383

    DOI: 10.1371/journal.pntd.0002383

    2012

    In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1 beta, Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis (Journal article)

    Griffiths, M. J., Ooi, M. H., Wong, S. C., Mohan, A., Podin, Y., Perera, D., . . . Solomon, T. (2012). In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1 beta, Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis. JOURNAL OF INFECTIOUS DISEASES, 206(6), 881-892. doi:10.1093/infdis/jis446

    DOI: 10.1093/infdis/jis446

    1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children (Conference Paper)

    Griffiths, M. J. (n.d.). 1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children.

    1648 Raised levels of interleukin 1ß, interleukin 1 receptor antagonist and G-CSF predict fatality among encephalitis patients infected with enterovirus 71 (Conference Paper)

    Griffiths, M. (n.d.). 1648 Raised levels of interleukin 1ß, interleukin 1 receptor antagonist and G-CSF predict fatality among encephalitis patients infected with enterovirus 71.

    Encephalitis caused by flaviviruses (Journal article)

    Turtle, L., Griffiths, M. J., & Solomon, T. (2012). Encephalitis caused by flaviviruses. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 105(3), 219-223. doi:10.1093/qjmed/hcs013

    DOI: 10.1093/qjmed/hcs013

    INTRODUCTION OF A SIMPLE LUMBAR PUNCTURE PACK TO A BUSY MEDICAL ADMISSIONS UNIT IMPROVES DIAGNOSIS OF CENTRAL NERVOUS SYSTEM INFECTIONS (Conference Paper)

    Michael, B., Powell, G., Hatch, S., Bailey, L., Almond, S., Nightingale, S., . . . Solomon, T. (2012). INTRODUCTION OF A SIMPLE LUMBAR PUNCTURE PACK TO A BUSY MEDICAL ADMISSIONS UNIT IMPROVES DIAGNOSIS OF CENTRAL NERVOUS SYSTEM INFECTIONS. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 83. doi:10.1136/jnnp-2011-301993.111

    DOI: 10.1136/jnnp-2011-301993.111

    2011

    Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study (Journal article)

    Rayamajhi, A., Ansari, I., Ledger, E., Bista, K. P., Impoinvil, D. E., Nightingale, S., . . . Griffiths, M. J. (2011). Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study. BMC INFECTIOUS DISEASES, 11. doi:10.1186/1471-2334-11-294

    DOI: 10.1186/1471-2334-11-294

    ACUTE VARICELLA ZOSTER VIRUS ENCEPHALITIS IN ADULTS - RELATIONSHIP BETWEEN VIRAL LOAD, TIME, CLINICAL FEATURES AND OUTCOME (Journal article)

    Michael, B. D., Griffiths, M., Stewart, A., Buckley, C., Hopkins, M., Hart, I. J., . . . Solomon, T. (2011). ACUTE VARICELLA ZOSTER VIRUS ENCEPHALITIS IN ADULTS - RELATIONSHIP BETWEEN VIRAL LOAD, TIME, CLINICAL FEATURES AND OUTCOME. EUROPEAN JOURNAL OF NEUROLOGY, 18, 474. Retrieved from http://gateway.webofknowledge.com/

    PO.06 Acute varicella zoster virus encephalitis in adults: relationship between viral load, time, clinical features and outcome (Conference Paper)

    Griffiths, M. J. (n.d.). PO.06 Acute varicella zoster virus encephalitis in adults: relationship between viral load, time, clinical features and outcome.

    Whole genome expression pathway signatures after antigen stimulation: identifying diagnostic and prognostic disease markers (Conference Paper)

    Griffiths, M. J., Harrison, G. L. A., & Klenermann, P. (n.d.). Whole genome expression pathway signatures after antigen stimulation: identifying diagnostic and prognostic disease markers.

    Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. (Journal article)

    Pathan, N., Franklin, J. L., Eleftherohorinou, H., Wright, V. J., Hemingway, C. A., Waddell, S. J., . . . Levin, M. (2011). Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.. Critical Care Medicine, 39(7), 1692-1711.

    2010

    Dissecting interferon-induced transcriptional programs in human peripheral blood cells. (Journal article)

    Waddell, S. J., Popper, S. J., Rubins, K. H., Griffiths, M. J., Brown, P. O., Levin, M., & Relman, D. A. (2010). Dissecting interferon-induced transcriptional programs in human peripheral blood cells.. Plos One, 5(3), e9753.

    2009

    Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. (Journal article)

    Fry, A. E., Ghansa, A., Small, K. S., Palma, A., Auburn, S., Diakite, M., . . . Kwiatkowski, D. P. (2009). Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.. Human molecular genetics, 18(14), 2683-2692. doi:10.1093/hmg/ddp192

    DOI: 10.1093/hmg/ddp192

    Lack of Association of Interferon Regulatory Factor 1 with Severe Malaria in Affected Child-Parental Trio Studies across Three African Populations (Journal article)

    Mangano, V. D., Clark, T. G., Auburn, S., Campino, S., Diakite, M., Fry, A. E., . . . Rockett, K. A. (2009). Lack of Association of Interferon Regulatory Factor 1 with Severe Malaria in Affected Child-Parental Trio Studies across Three African Populations. PLOS ONE, 4(1). doi:10.1371/journal.pone.0004206

    DOI: 10.1371/journal.pone.0004206

    Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. (Journal article)

    Clark, T. G., Diakite, M., Auburn, S., Campino, S., Fry, A. E., Green, A., . . . Kwiatkowski, D. P. (2009). Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.. Journal of Infectious Diseases, 199(4), 569-575.

    2008

    Association of the GNAS locus with severe malaria (Journal article)

    Auburn, S., Diakite, M., Fry, A. E., Ghansah, A., Campino, S., Richardson, A., . . . Kwiatkowski, D. P. (2008). Association of the GNAS locus with severe malaria. Human Genetics, 124(5), 499-506. doi:10.1007/s00439-008-0575-8

    DOI: 10.1007/s00439-008-0575-8

    Variation in the ICAM1 gene is not associated with severe malaria phenotypes (Journal article)

    Fry, A. E., Auburn, S., Diakite, M., Green, A., Richardson, A., Wilson, J., . . . Kwiatkowski, D. P. (2008). Variation in the ICAM1 gene is not associated with severe malaria phenotypes. Genes & Immunity, 9(5), 462-469. doi:10.1038/gene.2008.38

    DOI: 10.1038/gene.2008.38

    Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria (Journal article)

    Fry, A. E., Griffiths, M. J., Auburn, S., Diakite, M., Forton, J. T., Green, A., . . . Kwiatkowski, D. P. (2008). Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Human Molecular Genetics, 17(4), 567-576. doi:10.1093/hmg/ddm331

    DOI: 10.1093/hmg/ddm331

    2007

    The molecular basis of paediatric malarial disease (Chapter)

    Griffiths, M. J., & Clarke, I. A. (2007). The molecular basis of paediatric malarial disease. In Pediatric Infectious Diseases Revisited. Springer Science & Business Media.

    Patterns of Host Genome–Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever (Journal article)

    Simmons, C. P., Popper, S., Dolocek, C., Chau, T. N. B., Griffiths, M., Dung, N. T. P., . . . Farrar, J. (2007). Patterns of Host Genome–Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever. The Journal of Infectious Diseases, 195(8), 1097-1107. doi:10.1086/512162

    DOI: 10.1086/512162

    2005

    Genomewide Analysis of the Host Response to Malaria in Kenyan Children (Journal article)

    Griffiths, M. J., Shafi, M. J., Popper, S. J., Hemingway, C. A., Kortok, M. M., Wathen, A., . . . Kwiatkowski, D. P. (2005). Genomewide Analysis of the Host Response to Malaria in Kenyan Children. The Journal of Infectious Diseases, 191(10), 1599-1611. doi:10.1086/429297

    DOI: 10.1086/429297

    2001

    Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria (Journal article)

    Griffiths, M. J., Ndungu, F., Baird, K. L., Muller, D. P. R., Marsh, K., & Newton, C. R. J. C. (2001). Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria. British Journal of Haematology, 113(2), 486-491. doi:10.1046/j.1365-2141.2001.02758.x

    DOI: 10.1046/j.1365-2141.2001.02758.x