Dr Janine Coombes DPhil

Lecturer Infection Biology

    Publications

    Selected Publications

    1. Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo (Journal article - 2015)
    2. Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread (Journal article - 2013)
    3. Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus (Journal article - 2012)
    4. Dynamic imaging of host-pathogen interactions in vivo (Journal article - 2010)

    2019

    Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract (Journal article)

    Carvalho, A. L., Fonseca, S., Miquel-Clopés, A., Cross, K., Kok, K. S., Wegmann, U., . . . Carding, S. R. (2019). Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract. Journal of Extracellular Vesicles, 8(1). doi:10.1080/20013078.2019.1632100

    DOI: 10.1080/20013078.2019.1632100

    An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium (Journal article)

    Luu, L., Johnston, L. J., Derricott, H., Armstrong, S. D., Randle, N., Hartley, C. S., . . . Coombes, J. L. (2019). An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00300

    DOI: 10.3389/fcimb.2019.00300

    Developing a 3D intestinal epithelium model for livestock species (Journal article)

    Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. CELL AND TISSUE RESEARCH, 375(2), 409-424. doi:10.1007/s00441-018-2924-9

    DOI: 10.1007/s00441-018-2924-9

    2018

    Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages (Journal article)

    Luu, L., Matthews, Z. J., Armstrong, S. D., Powell, P. P., Wileman, T., Wastling, J. M., & Coombes, J. L. (2018). Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages. PROTEOMICS, 18(16). doi:10.1002/pmic.201800132

    DOI: 10.1002/pmic.201800132

    Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain (Journal article)

    Petit-Jentreau, L., Glover, C., & Coombes, J. L. (2018). Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain. PARASITE IMMUNOLOGY, 40(4). doi:10.1111/pim.12522

    DOI: 10.1111/pim.12522

    2017

    Purinergic Signaling: A Common Path in the Macrophage Response against Mycobacterium tuberculosis and Toxoplasma gondii (Journal article)

    Petit-Jentreau, L., Tailleux, L., & Coombes, J. L. (2017). Purinergic Signaling: A Common Path in the Macrophage Response against Mycobacterium tuberculosis and Toxoplasma gondii. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 7, 1-7. doi:10.3389/fcimb.2017.00347

    DOI: 10.3389/fcimb.2017.00347

    2015

    Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo (Journal article)

    Ueno, N., Lodoen, M. B., Hickey, G. L., Robey, E. A., & Coombes, J. L. (2015). Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo. IMMUNOLOGY AND CELL BIOLOGY, 93(5), 508-513. doi:10.1038/icb.2014.106

    DOI: 10.1038/icb.2014.106

    Dynamic two-photon imaging of the immune response to Toxoplasma gondii infection (Journal article)

    Luu, L., & Coombes, J. L. (2015). Dynamic two-photon imaging of the immune response to Toxoplasma gondii infection. PARASITE IMMUNOLOGY, 37(3), 118-126. doi:10.1111/pim.12161

    DOI: 10.1111/pim.12161

    Immunity to Toxoplasma gondii - into the 21st century (Journal article)

    Coombes, J. L., & Hunter, C. A. (2015). Immunity to Toxoplasma gondii - into the 21st century. PARASITE IMMUNOLOGY, 37(3), 105-107. doi:10.1111/pim.12177

    DOI: 10.1111/pim.12177

    2014

    Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo (Journal article)

    Ueno, N., Lodoen, M. B., Robey, E. A., & Coombes, J. L. (2014). Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo. IMMUNOLOGY, 143, 153-154. Retrieved from http://gateway.webofknowledge.com/

    Monophasic expression of FliC by Salmonella 4,[5],12:i:- DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells (Journal article)

    Crayford, G., Coombes, J. L., Humphrey, T. J., & Wigley, P. (2014). Monophasic expression of FliC by Salmonella 4,[5],12:i:- DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells. Microbiology, 160(Pt_11), 2507-2516. doi:10.1099/mic.0.081349-0

    DOI: 10.1099/mic.0.081349-0

    Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii (Journal article)

    Han, S. -J., Melichar, H. J., Coombes, J. L., Chan, S. W., Koshy, A. A., Boothroyd, J. C., . . . Robey, E. A. (2014). Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii. IMMUNOLOGY AND CELL BIOLOGY, 92(10), 872-881. doi:10.1038/icb.2014.70

    DOI: 10.1038/icb.2014.70

    Monophasic expression of FliC by Salmonella 4,[5], 12:i:-DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells (Journal article)

    Crayford, G., Coombes, J. L., Humphrey, T. J., & Wigley, P. (2014). Monophasic expression of FliC by Salmonella 4,[5], 12:i:-DT193 does not alter its pathogenicity during infection of porcine intestinal epithelial cells. MICROBIOLOGY-SGM, 160, 2507-2516. doi:10.1099/mic.0.081349-0

    DOI: 10.1099/mic.0.081349-0

    2013

    Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread (Journal article)

    Coombes, J. L., Charsar, B. A., Han, S. -J., Halkias, J., Chan, S. W., Koshy, A. A., . . . Robey, E. A. (2013). Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(21), E1913-E1922. doi:10.1073/pnas.1220272110

    DOI: 10.1073/pnas.1220272110

    2012

    Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus (Journal article)

    Coombes, J. L., Han, S. -J., van Rooijen, N., Raulet, D. H., & Robey, E. A. (2012). Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus. CELL REPORTS, 2(1), 124-135. doi:10.1016/j.celrep.2012.06.001

    DOI: 10.1016/j.celrep.2012.06.001

    2011

    Faculty of 1000 evaluation for T lymphocytes negatively regulate lymph node lymphatic vessel formation. (Dataset)

    Robey, E., & Coombes, J. (2011). Faculty of 1000 evaluation for T lymphocytes negatively regulate lymph node lymphatic vessel formation.. doi:10.3410/f.8095960.8746054

    DOI: 10.3410/f.8095960.8746054

    2010

    Dynamic imaging of host-pathogen interactions in vivo (Journal article)

    Coombes, J. L., & Robey, E. A. (2010). Dynamic imaging of host-pathogen interactions in vivo. NATURE REVIEWS IMMUNOLOGY, 10(5), 353-364. doi:10.1038/nri2746

    DOI: 10.1038/nri2746

    2009

    Regulatory Lymphocytes and Intestinal Inflammation (Journal article)

    Izcue, A., Coombes, J. L., & Powrie, F. (2009). Regulatory Lymphocytes and Intestinal Inflammation. ANNUAL REVIEW OF IMMUNOLOGY, 27, 313-338. doi:10.1146/annurev.immunol.021908.132657

    DOI: 10.1146/annurev.immunol.021908.132657

    2008

    Dendritic cells in intestinal immune regulation (Journal article)

    Coombes, J. L., & Powrie, F. (2008). Dendritic cells in intestinal immune regulation. NATURE REVIEWS IMMUNOLOGY, 8(6), 435-446. doi:10.1038/nri2335

    DOI: 10.1038/nri2335

    Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans (Journal article)

    Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., . . . Agace, W. W. (2008). Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans. JOURNAL OF EXPERIMENTAL MEDICINE, 205(9), 2139-2149. doi:10.1084/jem.20080414

    DOI: 10.1084/jem.20080414

    2007

    A functionally specialized population of mucosal CD103(+) DCs induces Foxp3(+) regulatory T cells via a TGF-beta- and retinoic acid-dependent mechanism (Journal article)

    Coombes, J. L., Siddiqui, K. R. R., Arancibia-Carcamo, C. V., Hall, J., Sun, C. -M., Belkaid, Y., & Powrie, F. (2007). A functionally specialized population of mucosal CD103(+) DCs induces Foxp3(+) regulatory T cells via a TGF-beta- and retinoic acid-dependent mechanism. JOURNAL OF EXPERIMENTAL MEDICINE, 204(8), 1757-1764. doi:10.1084/jem.20070590

    DOI: 10.1084/jem.20070590

    Control of intestinal homeostasis by regulatory T cells and dendritic cells (Journal article)

    Coombes, J. L., & Maloy, K. J. (2007). Control of intestinal homeostasis by regulatory T cells and dendritic cells. SEMINARS IN IMMUNOLOGY, 19(2), 116-126. doi:10.1016/j.smim.2007.01.001

    DOI: 10.1016/j.smim.2007.01.001

    2006

    Characterization of Foxp3(+)CD4(+)CD25(+) and IL-10-secreting CD4(+)CD25(+) T cells during cure of colitis (Journal article)

    Uhlig, H. H., Coombes, J., Mottet, C., Izcue, A., Thompson, C., Fanger, A., . . . Powrie, F. (2006). Characterization of Foxp3(+)CD4(+)CD25(+) and IL-10-secreting CD4(+)CD25(+) T cells during cure of colitis. JOURNAL OF IMMUNOLOGY, 177(9), 5852-5860. doi:10.4049/jimmunol.177.9.5852

    DOI: 10.4049/jimmunol.177.9.5852

    Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation (Journal article)

    Izcue, A., Coombes, J. L., & Powrie, F. (2006). Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. IMMUNOLOGICAL REVIEWS, 212, 256-271. doi:10.1111/j.0105-2896.2006.00423.x

    DOI: 10.1111/j.0105-2896.2006.00423.x

    2005

    Essential role for CD103 in the T cell-mediated regulation of experimental colitis (Journal article)

    Annacker, O., Coombes, J. L., Malmstrom, V., Uhlig, H. H., Bourne, T., Johansson-Lindbom, B., . . . Powrie, F. (2005). Essential role for CD103 in the T cell-mediated regulation of experimental colitis. JOURNAL OF EXPERIMENTAL MEDICINE, 202(8), 1051-1061. doi:10.1084/jem.20040662

    DOI: 10.1084/jem.20040662

    Regulatory T cells and intestinal homeostasis (Journal article)

    Coombes, J. L., Robinson, N. J., Maloy, K. J., Uhlig, H. H., & Powrie, F. (2005). Regulatory T cells and intestinal homeostasis. IMMUNOLOGICAL REVIEWS, 204, 184-194. doi:10.1111/j.0105-2896.2005.00250.x

    DOI: 10.1111/j.0105-2896.2005.00250.x