Dr Daniel Neill MA (Hons) PhD

Senior Lecturer/Wellcome Trust and Royal Society Sir Henry Dale Fellow Clinical Infection, Microbiology and Immunology

Publications

2020

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. (Journal article)

Badgujar, D. C., Anil, A., Green, A. E., Surve, M. V., Madhavan, S., Beckett, A., . . . Banerjee, A. (2020). Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle.. PLoS pathogens, 16(11), e1009016. doi:10.1371/journal.ppat.1009016

DOI: 10.1371/journal.ppat.1009016

Influenza-like illness is associated with high pneumococcal carriage density in Malawian children (Journal article)

Nyazika, T. K., Law, A., Swarthout, T. D., Sibale, L., ter Braake, D., French, N., . . . Neill, D. R. (2020). Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. JOURNAL OF INFECTION, 81(4), 549-556. doi:10.1016/j.jinf.2020.06.079

DOI: 10.1016/j.jinf.2020.06.079

Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models (Journal article)

Green, A., Howarth, D., Chaguza, C., Echlin, H., Langendonk, F., Munro, C., . . . Neill, D. (2020). Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models. doi:10.1101/2020.09.08.287698

DOI: 10.1101/2020.09.08.287698

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle (Journal article)

Badgujar, D. C., Anil, A., Green, A. E., Surve, M. V., Madhavan, S., Beckett, A., . . . Banerjee, A. (n.d.). Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. doi:10.1101/2020.05.13.093682

DOI: 10.1101/2020.05.13.093682

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin (Journal article)

Jacques, L. C., Panagiotou, S., Baltazar, M., Senghore, M., Khandaker, S., Xu, R., . . . Kadioglu, A. (2020). Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-15751-6

DOI: 10.1038/s41467-020-15751-6

Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease (Journal article)

Shears, R. K., Jacques, L. C., Naylor, G., Miyashita, L., Khandaker, S., Lebre, F., . . . Kadioglu, A. (2020). Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1272-+. doi:10.1016/j.jaci.2019.11.039

DOI: 10.1016/j.jaci.2019.11.039

2019

Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses (Conference Paper)

Subramanian, K., Neill, D. R., Malak, H. A., Spelmink, L., Khandaker, S., Marchiori, G. D. L., . . . Henriques-Normark, B. (2019). Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses. In SCANDINAVIAN JOURNAL OF IMMUNOLOGY Vol. 90. Retrieved from http://gateway.webofknowledge.com/

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria (Journal article)

Mullins, A., Murray, J. A. H., Bull, M. J., Jenner, M., Jones, C., Webster, G., . . . Mahenthiralingam, E. (2019). Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nature Microbiology, 4(09), 996-1005. doi:10.1038/s41564-019-0383-z

DOI: 10.1038/s41564-019-0383-z

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival (Journal article)

Subramanian, K., Neill, D. R., Malak, H., Spelmink, L., Khandaker, S., Marchiori, G., . . . Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature Microbiology, 4(1), 62-70. doi:10.1038/s41564-018-0280-x

DOI: 10.1038/s41564-018-0280-x

2018

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa (Journal article)

Bricio-Moreno, L., Sheridan, V. H., Goodhead, I., Armstrong, S., Wong, J. K. L., Waters, E. M., . . . Neill, D. R. (2018). Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa. Nature Communications, 9. doi:10.1038/s41467-018-04996-x

DOI: 10.1038/s41467-018-04996-x

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells (Journal article)

Miyashita, L., Suri, R., Dearing, E., Mudway, I., Dove, R. E., Neill, D. R., . . . Grigg, J. (2018). E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. EUROPEAN RESPIRATORY JOURNAL, 51(02), 10 pages. doi:10.1183/13993003.01592-2017

DOI: 10.1183/13993003.01592-2017

Innate lymphoid cells and parasites: Ancient foes with shared history (Journal article)

Neill, D. R., & Fallon, P. G. (2018). Innate lymphoid cells and parasites: Ancient foes with shared history. PARASITE IMMUNOLOGY, 40(2). doi:10.1111/pim.12513

DOI: 10.1111/pim.12513

Origins and evolution of innate lymphoid cells: Wardens of barrier immunity (Journal article)

Neill, D. R., & Flynn, R. J. (2018). Origins and evolution of innate lymphoid cells: Wardens of barrier immunity. PARASITE IMMUNOLOGY, 40(2). doi:10.1111/pim.12436

DOI: 10.1111/pim.12436

2017

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa (Journal article)

Waters, E. M., Neill, D. R., Kaman, B., Sahota, J. S., Clokie, M. R. J., Winstanley, C., & Kadioglu, A. (2017). Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa. THORAX, 72(7), 666-667. doi:10.1136/thoraxjnl-2016-209265

DOI: 10.1136/thoraxjnl-2016-209265

Airborne dust and high temperatures are risk factors for invasive bacterial disease (Journal article)

Jusot, J. -F., Neill, D. R., Waters, E., Bangert, M., Collins, M., Bricio Moreno, L., . . . Kadioglu, A. (2017). Airborne dust and high temperatures are risk factors for invasive bacterial disease. Journal of Allergy and Clinical Immunology, 139(3), 977-986.E2. doi:10.1016/j.jaci.2016.04.062

DOI: 10.1016/j.jaci.2016.04.062

2016

Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection (Chapter)

Neill, D. R., Yang, M., & Kadioglu, A. (2016). Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection. In Encyclopedia of Immunobiology (pp. 60-65). Elsevier. doi:10.1016/b978-0-12-374279-7.13019-x

DOI: 10.1016/b978-0-12-374279-7.13019-x

2015

Ca²?-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. (Journal article)

Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca²?-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.. Biochimica et biophysica acta, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005

DOI: 10.1016/j.bbamcr.2014.09.005

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection (Journal article)

Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836

DOI: 10.1371/journal.ppat.1004836

Pneumolysin (Chapter)

Neill, D. R., Mitchell, T. J., & Kadioglu, A. (2015). Pneumolysin. In Streptococcus Pneumoniae (pp. 257-275). Elsevier. doi:10.1016/b978-0-12-410530-0.00014-4

DOI: 10.1016/b978-0-12-410530-0.00014-4

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice (Journal article)

Henry, B. D., Neill, D., Becker, K. A., Gore, S., Bricio Moreno, L., Ziobro, R., . . . Babiychuk, E. B. (2015). Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature Biotechnology, 33(1), 81-88. doi:10.1038/nbt.3037

DOI: 10.1038/nbt.3037

2014

Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. (Journal article)

Fothergill, J. L., Neill, D. R., Loman, N., Winstanley, C., & Kadioglu, A. (2014). Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.. Nature Communications, 5, 9 pages. doi:10.1038/ncomms5780

DOI: 10.1038/ncomms5780

Ca2+-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins (Journal article)

Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca2+-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005

DOI: 10.1016/j.bbamcr.2014.09.005

THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA (Journal article)

Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.

DOI: 10.1371/journal.pone.0095892.

Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor ß1 and T Regulatory Cells (Journal article)

Neill, D. R., Coward, W. R., Gritzfeld, J. F., Richards, L., Garcia-Garcia, F. J., Dotor, J., . . . Kadioglu, A. (2014). Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor ß1 and T Regulatory Cells. American Journal of Respiratory and Critical Care Medicine, 189(10), 1250-1259. doi:10.1164/rccm.201401-0128OC

DOI: 10.1164/rccm.201401-0128OC

The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract (Journal article)

Kueng, E., Coward, W. R., Neill, D. R., Malak, H. A., Muehlemann, K., Kadioglu, A., . . . Hathaway, L. J. (2014). The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract. PLOS ONE, 9(3). doi:10.1371/journal.pone.0092355

DOI: 10.1371/journal.pone.0092355

A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia (Journal article)

De Filippo, K., Neill, D. R., Mathies, M., Bangert, M., McNeill, E., Kadioglu, A., & Hogg, N. (2014). A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia. FASEB JOURNAL, 28(8), 3600-3608. doi:10.1096/fj.13-247460

DOI: 10.1096/fj.13-247460

2013

IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction (Journal article)

Barlow, J. L., Peel, S., Fox, J., Panova, V., Hardman, C. S., Camelo, A., . . . McKenzie, A. N. J. (2013). IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(4), 933-941. doi:10.1016/j.jaci.2013.05.012

DOI: 10.1016/j.jaci.2013.05.012

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B (Journal article)

Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. Journal of Allergy and Clinical Immunology, 131(5), 1433-1435.e1. doi:10.1016/j.jaci.2012.11.004

DOI: 10.1016/j.jaci.2012.11.004

Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults (Journal article)

Ferreira, D. M., Neill, D. R., Bangert, M., Gritzfeld, J. F., Green, N., Wright, A. K. A., . . . Gordon, S. B. (2013). Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(8), 855-864. doi:10.1164/rccm.201212-2277OC

DOI: 10.1164/rccm.201212-2277OC

Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice (Journal article)

Wisby, L., Fernandes, V. E., Neill, D. R., Kadioglu, A., Andrew, P. W., & Denny, P. (2013). Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice. BMC GENOMICS, 14. doi:10.1186/1471-2164-14-242

DOI: 10.1186/1471-2164-14-242

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B (Journal article)

Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(5), 1433-+. doi:10.1016/j.jaci.2012.11.004

DOI: 10.1016/j.jaci.2012.11.004

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B (Journal article)

Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. Journal of Allergy and Clinical Immunology, 131(5), 1433-1435. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23260752

2012

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13 (Journal article)

Camelo, A., Barlow, J. L., Drynan, L. F., Neill, D. R., Ballantyne, S. J., Wong, S. H., . . . McKenzie, A. N. J. (2012). Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. JOURNAL OF GASTROENTEROLOGY, 47(11), 1198-1211. doi:10.1007/s00535-012-0591-2

DOI: 10.1007/s00535-012-0591-2

T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice (Journal article)

Neill, D. R., Fernandes, V. E., Wisby, L., Haynes, A. R., Ferreira, D. M., Laher, A., . . . Andrew, P. W. (2012). T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice. PLOS PATHOGENS, 8(4). doi:10.1371/journal.ppat.1002660

DOI: 10.1371/journal.ppat.1002660

Transcription factor ROR alpha is critical for nuocyte development (Journal article)

Wong, S. H., Walker, J. A., Jolin, H. E., Drynan, L. F., Hams, E., Camelo, A., . . . McKenzie, A. N. J. (2012). Transcription factor ROR alpha is critical for nuocyte development. NATURE IMMUNOLOGY, 13(3), 229-U43. doi:10.1038/ni.2208

DOI: 10.1038/ni.2208

2011

Novel Immunogenic Peptides Elicit Systemic Anaphylaxis in Mice: Implications for Peptide Vaccines (Journal article)

Smith, C. M., Bradding, P., Neill, D. R., Baxendale, H., Felici, F., & Andrew, P. W. (2011). Novel Immunogenic Peptides Elicit Systemic Anaphylaxis in Mice: Implications for Peptide Vaccines. JOURNAL OF IMMUNOLOGY, 187(3), 1201-1206. doi:10.4049/jimmunol.1002152

DOI: 10.4049/jimmunol.1002152

Nuocytes and beyond: new insights into helminth expulsion (Journal article)

Neill, D. R., & McKenzie, A. N. J. (2011). Nuocytes and beyond: new insights into helminth expulsion. TRENDS IN PARASITOLOGY, 27(5), 214-221. doi:10.1016/j.pt.2011.01.001

DOI: 10.1016/j.pt.2011.01.001

2010

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4 (Journal article)

McNeela, E. A., Burke, A., Neill, D. R., Baxter, C., Fernandes, V. E., Ferreira, D., . . . Lavelle, E. C. (2010). Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4. PLOS PATHOGENS, 6(11). doi:10.1371/journal.ppat.1001191

DOI: 10.1371/journal.ppat.1001191

T(H)9: the latest addition to the expanding repertoire of IL-25 targets (Journal article)

Neill, D. R., & McKenzie, A. N. J. (2010). T(H)9: the latest addition to the expanding repertoire of IL-25 targets. IMMUNOLOGY AND CELL BIOLOGY, 88(5), 502-504. doi:10.1038/icb.2010.43

DOI: 10.1038/icb.2010.43

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity (Journal article)

Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K. A., . . . McKenzie, A. N. J. (2010). Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. NATURE, 464(7293), 1367-13U9. doi:10.1038/nature08900

DOI: 10.1038/nature08900