Prof Bill Paxton PhD DIC
Professor Clinical Infection, Microbiology & Immunology
- +44 (0)151 795 9605
- Work email W.A.Paxton@liverpool.ac.uk
Publications
Selected Publications
- Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro (Journal article - 2019)
- DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users (Journal article - 2018)
- Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes (Journal article - 2005)
- Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection (Journal article - 1996)
- Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures (Journal article - 1996)
2020
Human leucocyte antigen-G (HLA-G) 3’UTR genetic polymorphisms associate with HIV-1 high risk seronegative status in the Amsterdam Cohorts Studies (Journal article)
Paxton, W., Alyami, A., McKay, L., Bonnett, L., Flanagan, B., Pollakis, G., . . . Christmas, S. (2020). Human leucocyte antigen-G (HLA-G) 3’UTR genetic polymorphisms associate with HIV-1 high risk seronegative status in the Amsterdam Cohorts Studies. Journal of HIV/AIDS and Infectious Diseases.
Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease (Journal article)
Dong, X., Munoz-Basagoiti, J., Rickett, N. Y., Pollakis, G., Paxton, W. A., Guenther, S., . . . Hiscox, J. A. (2020). Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease. GENOME BIOLOGY, 21(1). doi:10.1186/s13059-020-02148-3
Measuring the Success of HIV-1 Cure Strategies (Journal article)
Thomas, J., Ruggiero, A., Paxton, W. A., & Pollakis, G. (2020). Measuring the Success of HIV-1 Cure Strategies. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10. doi:10.3389/fcimb.2020.00134
2019
Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility (Journal article)
Steba, G. S., Koekkoek, S. M., Prins, M., Brinkman, K., Kwa, D., van der Meer, J. T. M., . . . Acu, M. O. S. A. I. C. M. S. M. O. S. (2019). Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility. VIRUS RESEARCH, 274. doi:10.1016/j.virusres.2019.197715
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro (Journal article)
Mouser, E., Pollakis, G., Smits, H., Thomas, J., Yazdanbakhsh, M., De Jong, E., & Paxton, W. (2019). Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro. PLoS Pathogens, 15(9). doi:10.1371/journal.ppat.1007924
SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility (Journal article)
Steba, G. S., Koekkoek, S. M., Tanck, M. W. T., Vanhommerig, J. W., van der Meer, J. T. M., Kwa, D., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) Study Group and the ACS (Amsterdam Cohort Studies). (2019). SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility. Liver International, 39(3), 463-469. doi:10.1111/liv.13978
Comparative analysis and generation of a robust HIV-1 DNA quantification assay (Journal article)
Thomas, J., Ruggiero, A., Procopio, F., Pantaleo, G., Paxton, A. W., & Pollakis, G. (2019). Comparative analysis and generation of a robust HIV-1 DNA quantificationassay. Journal of Virological Methods, 263, 24-31. doi:10.1016/j.jviromet.2018.10.010
2018
Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells (Journal article)
Ruggiero, A., Malatinkova, E., De Spiegelaere, W., Thomas, J., Rutsaert, S., Geretti, A. M., . . . Paxton, W. A. (n.d.). Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells. Journal of Virological Methods.
Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals (Journal article)
Banga, R., Procopio, F. A., Ruggiero, A., Noto, A., Ohmiti, K., Cavassini, M., . . . Perreau, M. (2018). Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals. Frontiers in Immunology, 9. doi:10.3389/fimmu.2018.00144
DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users (Journal article)
Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van Der Meer, J. T. M., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) study group and the ACS (Amsterdam Cohort Studies). (2018). DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users. The Journal of Infectious Diseases, 217(3), 353-357. doi:10.1093/infdis/jix587
Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Investigators, E. C. P. C. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580
2017
Utility of integrated HIV-1 DNA quantification in cure studies (Journal article)
Ruggiero, A., Malatinkova, E., Rutsaert, S., Paxton, W. A., Vandekerckhove, L., & De Spiegelaere, W. (2017). Utility of integrated HIV-1 DNA quantification in cure studies. FUTURE VIROLOGY, 12(4), 215-225. doi:10.2217/fvl-2016-0130
DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels (Conference Paper)
Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., van der Meer, J. T. M., Prins, M., . . . Schinkel, J. (2017). DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels. In JOURNAL OF HEPATOLOGY Vol. 66 (pp. S318-S319). doi:10.1016/S0168-8278(17)30958-3
2016
Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease? (Journal article)
Paxton, W. A. (2016). Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease?. EBIOMEDICINE, 13, 27-28. doi:10.1016/j.ebiom.2016.10.023
Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells (Journal article)
Mouser, E. E. I. M., Pollakis, G., Yazdanbakhsh, M., Harnett, W., de Jong, E. C., & Paxton, W. A. (2016). Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146527
2015
Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody (Journal article)
van Montfort, T., Thomas, A. A. M., Krawczyk, P. M., Berkhout, B., Sanders, R. W., & Paxton, W. A. (2015). Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody. Journal of Immunology, 195(8), 3759-3768. doi:10.4049/jimmunol.1402344
Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster (Journal article)
Pollakis, G., Baan, E., van Werkhoven, M. B., Berkhout, B., Bakker, M., Jurriaans, S., & Paxton, W. A. (2015). Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster. AIDS, 29(10), 1161-1171. doi:10.1097/QAD.0000000000000692
Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4(+) T-Lymphocytes (Journal article)
Stax, M. J., Mouser, E. E. I. M., van Montfort, T., Sanders, R. W., de Vries, H. J. C., Dekker, H. L., . . . Paxton, W. A. (2015). Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4(+) T-Lymphocytes. PLOS ONE, 10(3). doi:10.1371/journal.pone.0122020
Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations (Journal article)
Span, P. N., Pollakis, G., Paxton, W. A., Sweep, F. C. G. J., Foekens, J. A., Martens, J. W. M., . . . van Laarhoven, H. W. M. (2015). Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations. INTERNATIONAL JOURNAL OF CANCER, 136(1), 91-97. doi:10.1002/ijc.28962
2014
The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin (Journal article)
Herrera-Carrillo, E., Paxton, W. A., & Berkhout, B. (2014). The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin. JOURNAL OF VIROLOGICAL METHODS, 203, 88-96. doi:10.1016/j.jviromet.2014.03.021
Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men (Journal article)
Pollakis, G., Richel, O., Vis, J. D., Prins, J. M., Paxton, W. A., & de Vries, H. J. C. (2014). Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men. CLINICAL INFECTIOUS DISEASES, 58(11), 1634-1637. doi:10.1093/cid/ciu133
2013
HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission (Journal article)
Baan, E., de Ronde, A., Stax, M., Sanders, R. W., Luchters, S., Vyankandondera, J., . . . Paxton, W. A. (2013). HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission. PLOS ONE, 8(7). doi:10.1371/journal.pone.0069274
Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses (Journal article)
Baan, E., van der Sluis, R. M., Bakker, M. E., Bekker, V., Pajkrt, D., Jurriaans, S., . . . Pollakis, G. (2013). Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses. JOURNAL OF GENERAL VIROLOGY, 94, 20-29. doi:10.1099/vir.0.046185-0
Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity (Journal article)
van der Sluis, R. M., van Montfort, T., Centlivre, M., Schopman, N. C. T., Cornelissen, M., Sanders, R. W., . . . Pollakis, G. (2013). Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity. JOURNAL OF VIROLOGICAL METHODS, 187(1), 94-102. doi:10.1016/j.jviromet.2012.09.019
2012
Use of (alternative) coreceptors for HIV entry (Journal article)
Pollakis, G., & Paxton, W. A. (2012). Use of (alternative) coreceptors for HIV entry. CURRENT OPINION IN HIV AND AIDS, 7(5), 440-449. doi:10.1097/COH.0b013e328356e9f3
HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein (Journal article)
Baan, E., de Ronde, A., Luchters, S., Vyankandondera, J., Lange, J. M., Pollakis, G., & Paxton, W. A. (2012). HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(7), 715-724. doi:10.1089/aid.2011.0023
Effects of helminths and Mycobacterium tuberculosis infection on HIV-1: a cellular immunological perspective (Journal article)
Mouser, E. E. I. M., Pollakis, G., & Paxton, W. A. (2012). Effects of helminths and Mycobacterium tuberculosis infection on HIV-1: a cellular immunological perspective. CURRENT OPINION IN HIV AND AIDS, 7(3), 260-267. doi:10.1097/COH.0b013e3283521144
HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (BSSL) Gene Polymorphism (Journal article)
Stax, M. J., Kootstra, N. A., van 't Wout, A. B., Tanck, M. W. T., Bakker, M., Pollakis, G., & Paxton, W. A. (2012). HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 7(3). doi:10.1371/journal.pone.0032534
Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another (Journal article)
van Werkhoven, M. B., Baan, E., Bakker, M., Jurriaans, S., Paxton, W. A., & Pollakis, G. (2012). Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(2), 225-227. doi:10.1089/aid.2011.0178
2011
Innate immune factors associated with HIV-1 transmission (Journal article)
Pollakis, G., Stax, M. J., & Paxton, W. A. (2011). Innate immune factors associated with HIV-1 transmission. CURRENT OPINION IN HIV AND AIDS, 6(5), 341-347. doi:10.1097/COH.0b013e3283499e11
Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection (Journal article)
Centlivre, M., Legrand, N., Steingrover, R., van der Sluis, R., Grijsen, M. L., Bakker, M., . . . Pollakis, G. (2011). Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. JOURNAL OF LEUKOCYTE BIOLOGY, 89(5), 785-795. doi:10.1189/jlb.0410231
Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism (Journal article)
Stax, M. J., Naarding, M. A., Tanck, M. W. T., Lindquist, S., Hernell, O., Lyle, R., . . . Paxton, W. A. (2011). Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 6(2). doi:10.1371/journal.pone.0017316
Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports (Journal article)
van de Laar, T. J. W., Paxton, W. A., Zorgdrager, F., Cornelissen, M., & de Vries, H. J. C. (2011). Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports. SEXUALLY TRANSMITTED DISEASES, 38(2), 102-104. doi:10.1097/OLQ.0b013e3181ec9de5
2010
Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection (Journal article)
Geldmacher, C., Ngwenyama, N., Schuetz, A., Petrovas, C., Reither, K., Heeregrave, E. J., . . . Koup, R. A. (2010). Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection. JOURNAL OF EXPERIMENTAL MEDICINE, 207(13), 2869-2881. doi:10.1084/jem.20100090
Varied sensitivity to therapy of HIV-1 strains in CD4(+) lymphocyte sub-populations upon ART initiation (Journal article)
Heeregrave, E. J., Geels, M. J., Baan, E., van der Sluis, R. M., Paxton, W. A., & Pollakis, G. (2010). Varied sensitivity to therapy of HIV-1 strains in CD4(+) lymphocyte sub-populations upon ART initiation. AIDS RESEARCH AND THERAPY, 7. doi:10.1186/1742-6405-7-42
Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads (Journal article)
Cornelissen, M., Heeregrave, E. J., Zorgdrager, F., Pollakis, G., Paxton, W. A., & van der Kuyl, A. C. (2010). Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads. ARCHIVES OF VIROLOGY, 155(12), 2017-2022. doi:10.1007/s00705-010-0806-x
BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION (Conference Paper)
Affram, Y., Martijn, M., Pollakis, G., Sagoe, K. W., Mingle, J. A., Ampofo, W. K., . . . Jacob, B. (2010). BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 83 (pp. 199). Retrieved from http://gateway.webofknowledge.com/
Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line (Journal article)
Heeregrave, E. J., Ampofo, W. K., Tetteh, J. K. A., Ofori, M., Ofori, S. B., Shah, A. S., . . . Paxton, W. A. (2010). Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line. JOURNAL OF VIROLOGICAL METHODS, 169(2), 341-350. doi:10.1016/j.jviromet.2010.08.001
HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design (Journal article)
Pollakis, G., & Paxton, W. A. (2010). HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design. CURRENT PHARMACEUTICAL DESIGN, 16(33), 3701-3715. doi:10.2174/138161210794079146
Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C ' (Journal article)
Ayele, W., Mekonnen, Y., Messele, T., Mengistu, Y., Tsegaye, A., Bakker, M., . . . Pollakis, G. (2010). Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C '. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(7), 805-813. doi:10.1089/aid.2009.0152
2009
Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4(+) T cell subsets (Journal article)
Heeregrave, E. J., Geels, M. J., Brenchley, J. M., Laan, E., Ambrozak, D. R., van der Sluis, R. M., . . . Paxton, W. A. (2009). Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4(+) T cell subsets. VIROLOGY, 393(1), 24-32. doi:10.1016/j.virol.2009.07.011
HIV vaccine: it may take two to tango, but no party time yet (Journal article)
Berkhout, B., & Paxton, W. A. (2009). HIV vaccine: it may take two to tango, but no party time yet. RETROVIROLOGY, 6. doi:10.1186/1742-4690-6-88
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes (Journal article)
Stax, M. J., van Montfort, T., Sprenger, R. R., Melchers, M., Sanders, R. W., van Leeuwen, E., . . . Paxton, W. A. (2009). Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes. VIROLOGY, 391(2), 203-211. doi:10.1016/j.virol.2009.06.011
Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells (Conference Paper)
Stax, M. J., Pollakis, G., Sprenger, R. R., Melchers, M., van Montfort, T., Sanders, R. W., . . . Paxton, W. A. (2009). Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells. In RETROVIROLOGY Vol. 6. doi:10.1186/1742-4690-6-S3-P108
Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution (Journal article)
Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2009). Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution. JOURNAL OF VIROLOGY, 83(1), 368-383. doi:10.1128/JVI.01404-08
2008
Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein (Journal article)
van Anken, E., Sanders, R. W., Liscaljet, I. M., Land, A., Bontjer, I., Tillemans, S., . . . Braakman, I. (2008). Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein. MOLECULAR BIOLOGY OF THE CELL, 19(10), 4298-4309. doi:10.1091/mbc.E07-12-1282
Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution (Conference Paper)
Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2008). Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 24 (pp. 56). Retrieved from http://gateway.webofknowledge.com/
Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4(+) T lymphocytes in trans (Journal article)
van Montfort, T., Thomas, A. A. M., Pollakis, G., & Paxton, W. A. (2008). Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4(+) T lymphocytes in trans. JOURNAL OF VIROLOGY, 82(16), 7886-7896. doi:10.1128/JVI.00245-08
Increased virus replication in mammalian cells by blocking intracellular innate defense responses (Journal article)
de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., . . . Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. GENE THERAPY, 15(7), 545-552. doi:10.1038/gt.2008.12
The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion (Journal article)
Sanders, R. W., van Anken, E., Nabatov, A. A., Liscaljet, M., Bontjer, I., Eggink, D., . . . Paxton, W. A. (2008). The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion. RETROVIROLOGY, 5. doi:10.1186/1742-4690-5-10
2007
Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1 (Journal article)
Nabatov, A. A., Pollakis, G., Linnemann, T., Paxton, W. A., & de Baar, M. P. (2007). Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1. PLOS ONE, 2(5). doi:10.1371/journal.pone.0000470
Characterization of an HIV-1 group m variant that is distinct from the known subtypes (Journal article)
Van der Hoek, L., Pollakis, G., Lukashov, V. V., Jebbink, M. F., Jeeninga, R. E., Bakker, M., . . . Berkhout, B. (2007). Characterization of an HIV-1 group m variant that is distinct from the known subtypes. AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(3), 466-470. doi:10.1089/aid.2006.0184
Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4(+) T lymphocytes (Journal article)
van Montfort, T., Nabatov, A. A., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2007). Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4(+) T lymphocytes. JOURNAL OF IMMUNOLOGY, 178(5), 3177-3185. doi:10.4049/jimmunol.178.5.3177
Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden (Journal article)
Ayele, W., Schuurman, R., Messele, T., Dorigo-Zetsma, W., Mengistu, Y., Goudsmit, J., . . . Pollakis, G. (2007). Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden. JOURNAL OF CLINICAL MICROBIOLOGY, 45(3), 891-896. doi:10.1128/JCM.01919-06
Effect of chloroquine on reducing HIV-I replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes (Journal article)
Naarding, M. A., Baan, E., Pollakis, G., & Paxton, W. A. (2007). Effect of chloroquine on reducing HIV-I replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes. RETROVIROLOGY, 4. doi:10.1186/1742-4690-4-6
2006
Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression (Journal article)
Nabatov, A. A., van Montfort, T., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2006). Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression. FEBS JOURNAL, 273(21), 4944-4958. doi:10.1111/j.1742-4658.2006.05491.x
Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4(+) T cells (Journal article)
Naarding, M. A., Dirac, A. M., Ludwig, I. S., Speijer, D., Lindquist, S., Vestman, E. -L., . . . Paxton, W. A. (2006). Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4(+) T cells. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(10), 3367-3374. doi:10.1128/AAC.00593-06
CTL escape and increased viremia irrespective of HIV-specific CD4(+) T-helper responses in two HIV-infected individuals (Journal article)
Geels, M. J., Jansen, C. A., Baan, E., De Cuyper, I. M., van Schijndel, G. J. M., Schuitemaker, H., . . . van Baarle, D. (2006). CTL escape and increased viremia irrespective of HIV-specific CD4(+) T-helper responses in two HIV-infected individuals. VIROLOGY, 345(1), 209-219. doi:10.1016/j.virol.2005.09.023
2005
Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes (Journal article)
Naarding, M. A., Ludwig, I. S., Groot, F., Berkhout, B., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2005). Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes. JOURNAL OF CLINICAL INVESTIGATION, 115(11), 3256-3264. doi:10.1172/JCI25105
Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation (Journal article)
Geels, M. J., Dubey, S. A., Anderson, K., Baan, E., Bakker, M., Pollakis, G., . . . Goudsmit, J. (2005). Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation. JOURNAL OF VIROLOGY, 79(17), 11247-11258. doi:10.1128/JVI.79.17.11247-11258.2005
2004
Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals (Journal article)
Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., . . . Paxton, W. A. (2004). Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals. JOURNAL OF VIROLOGY, 78(6), 2841-2852. doi:10.1128/JVI.78.6.2841-2852.2004
Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies (Journal article)
Nabatov, A. A., Pollakis, G., Linnemann, T., Kliphius, A., Chalaby, M. I. M., & Paxton, W. A. (2004). Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies. JOURNAL OF VIROLOGY, 78(1), 524-530. doi:10.1128/JVI.78.1.524-530.2004
2003
Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual (Journal article)
Geels, M. J., Cornelissen, M., Schuitemaker, H., Anderson, K., Kwa, D., Maas, J., . . . Goudsmit, J. (2003). Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual. JOURNAL OF VIROLOGY, 77(23), 12430-12440. doi:10.1128/JVI.77.23.12430-12440.2003
2001
RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression (Conference Paper)
Paxton, W. A., Neumann, A. U., Kang, S., Deutch, L., Brown, R. C., Koup, R. A., & Wolinsky, S. M. (2001). RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression. In JOURNAL OF INFECTIOUS DISEASES Vol. 183 (pp. 1678-1681). doi:10.1086/320701
N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization (Journal article)
Pollakis, G., Kang, S., Kliphuis, A., Chalaby, M. I. M., Goudsmit, J., & Paxton, W. A. (2001). N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(16), 13433-13441. doi:10.1074/jbc.M009779200
2000
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines (Journal article)
Juffermans, N. P., Paxton, W. A., Dekkers, P. E. P., Verbon, A., de Jonge, E., Speelman, P., . . . van der Poll, T. (2000). Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines. BLOOD, 96(8), 2649-2654. Retrieved from http://gateway.webofknowledge.com/
1999
HIV-1 infectability of CD4(+) lymphocytes with relation to beta-chemokines and the CCR5 coreceptor (Conference Paper)
Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L. J., . . . Koup, R. A. (1999). HIV-1 infectability of CD4(+) lymphocytes with relation to beta-chemokines and the CCR5 coreceptor. In IMMUNOLOGY LETTERS Vol. 66 (pp. 71-75). doi:10.1016/S0165-2478(98)00154-0
1998
Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression (Journal article)
Paxton, W. A., & Kang, S. (1998). Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression. SEMINARS IN IMMUNOLOGY, 10(3), 187-194. doi:10.1006/smim.1998.0132
Reduced HIV-1 infectability of CD4(+) lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of beta-chemokines (Journal article)
Paxton, W. A., Liu, R., Kang, S., Wu, L. J., Gingeras, T. R., Landau, N. R., . . . Koup, R. A. (1998). Reduced HIV-1 infectability of CD4(+) lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of beta-chemokines. VIROLOGY, 244(1), 66-73. doi:10.1006/viro.1998.9082
Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells (Journal article)
Granelli-Piperno, A., Delgado, E., Finkel, V., Paxton, W., & Steinman, R. M. (1998). Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells. JOURNAL OF VIROLOGY, 72(4), 2733-2737. doi:10.1128/JVI.72.4.2733-2737.1998
The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression (Conference Paper)
Paxton, W. A., Kang, S., & Koup, R. A. (1998). The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 14 (pp. S89-S92). Retrieved from http://gateway.webofknowledge.com/
1997
CCR-5: A hot target for drug discovery (Conference Paper)
Landau, N. R., Liu, R., DiMarzio, P., Choe, S., Ceradini, D., Yang, J., . . . Koup, R. A. (1997). CCR-5: A hot target for drug discovery. In FASEB JOURNAL Vol. 11 (pp. A855). Retrieved from http://gateway.webofknowledge.com/
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro (Journal article)
Wu, L. J., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., . . . Mackay, C. R. (1997). CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. JOURNAL OF EXPERIMENTAL MEDICINE, 185(9), 1681-1691. doi:10.1084/jem.185.9.1681
Mechanisms of resistance to HIV infection (Journal article)
Paxton, W. A., & Koup, R. A. (1997). Mechanisms of resistance to HIV infection. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 18(3), 323-340. doi:10.1007/BF00813501
1996
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors (Journal article)
GranelliPiperno, A., Moser, B., Pope, M., Chen, D. L., Wei, Y., Isdell, F., . . . Steinman, R. M. (1996). Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. JOURNAL OF EXPERIMENTAL MEDICINE, 184(6), 2433-2438. doi:10.1084/jem.184.6.2433
Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1 (Journal article)
Connor, R. I., Paxton, W. A., Sheridan, K. E., & Koup, R. A. (1996). Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1. JOURNAL OF VIROLOGY, 70(12), 8758-8764. doi:10.1128/JVI.70.12.8758-8764.1996
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression (Journal article)
Huang, Y. X., Paxton, W. A., Wolinsky, S. M., Neumann, A. U., Zhang, L. Q., He, T., . . . Koup, R. A. (1996). The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. NATURE MEDICINE, 2(11), 1240-1243. doi:10.1038/nm1196-1240
Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons (Journal article)
Paxton, W. A., Dragic, T., Koup, R. A., & Moore, J. P. (1996). Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons. AIDS RESEARCH AND HUMAN RETROVIRUSES, 12(13), 1203-1207. doi:10.1089/aid.1996.12.1203
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection (Journal article)
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., . . . Landau, N. R. (1996). Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. CELL, 86(3), 367-377. doi:10.1016/S0092-8674(00)80110-5
HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 (Journal article)
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y. X., Nagashima, K. A., . . . Paxton, W. A. (1996). HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5. NATURE, 381(6584), 667-673. doi:10.1038/381667a0
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures (Journal article)
Paxton, W. A., Martin, S. R., Tse, D., OBrien, T. R., Skurnick, J., VanDevanter, N. L., . . . Koup, R. A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. NATURE MEDICINE, 2(4), 412-417. doi:10.1038/nm0496-412
1995
DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2 (Journal article)
YAZDANBAKHSH, M., PAXTON, W. A., BRANDENBURG, A., VANREE, R., LENS, M., PARTONO, F., . . . SELKIRK, M. E. (1995). DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2. INFECTION AND IMMUNITY, 63(10), 3772-3779. doi:10.1128/IAI.63.10.3772-3779.1995
1993
INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS (Journal article)
PAXTON, W., CONNOR, R. I., & LANDAU, N. R. (1993). INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS. JOURNAL OF VIROLOGY, 67(12), 7229-7237. doi:10.1128/JVI.67.12.7229-7237.1993
PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES (Journal article)
PAXTON, W. A., YAZDANBAKHSH, M., KURNIAWAN, A., PARTONO, F., MAIZELS, R. M., & SELKIRK, M. E. (1993). PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES. INFECTION AND IMMUNITY, 61(7), 2827-2833. doi:10.1128/IAI.61.7.2827-2833.1993
T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS (Journal article)
YAZDANBAKHSH, M., PAXTON, W. A., KRUIZE, Y. C. M., SARTONO, E., KURNIAWAN, A., WOUT, A. V., . . . MAIZELS, R. M. (1993). T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS. JOURNAL OF INFECTIOUS DISEASES, 167(4), 925-931. doi:10.1093/infdis/167.4.925
VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4 (Conference Paper)
LANDAU, N. R., LENBURG, M. E., & PAXTON, W. (1993). VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 50). Retrieved from http://gateway.webofknowledge.com/
BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR (Journal article)
TWEEDIE, S., PAXTON, W. A., INGRAM, L., MAIZELS, R. M., MCREYNOLDS, L. A., & SELKIRK, M. E. (1993). BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR. EXPERIMENTAL PARASITOLOGY, 76(2), 156-164. doi:10.1006/expr.1993.1018