Photo of Prof Bill Paxton

Prof Bill Paxton PhD DIC

Professor Clinical Infection, Microbiology and Immunology

    Publications

    Selected Publications

    1. Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4(+) T-lymphocyte responses and HIV-1 infection in vitro (Journal article - 2019)
    2. DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users (Journal article - 2017)
    3. Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes (Journal article - 2005)
    4. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection (Journal article - 1996)
    5. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures (Journal article - 1996)

    2019

    Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility (Journal article)

    Steba, G. S., Koekkoek, S. M., Prins, M., Brinkman, K., Kwa, D., van der Meer, J. T. M., . . . Acu, M. O. S. A. I. C. M. S. M. O. S. (2019). Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility. VIRUS RESEARCH, 274. doi:10.1016/j.virusres.2019.197715

    DOI: 10.1016/j.virusres.2019.197715

    Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4(+) T-lymphocyte responses and HIV-1 infection in vitro (Journal article)

    Mouser, E. E. I. M., Pollakis, G., Smits, H. H., Thomas, J., Yazdanbakhsh, M., de Jong, E. C., & Paxton, W. A. (2019). Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4(+) T-lymphocyte responses and HIV-1 infection in vitro. PLOS PATHOGENS, 15(9). doi:10.1371/journal.ppat.1007924

    DOI: 10.1371/journal.ppat.1007924

    2018

    Comparative analysis and generation of a robust HIV-1 DNA quantification assay (Journal article)

    Thomas, J., Ruggiero, A., Procopio, F. A., Pantaleo, G., Paxton, W. A., & Pollakis, G. (2019). Comparative analysis and generation of a robust HIV-1 DNA quantification assay. JOURNAL OF VIROLOGICAL METHODS, 263, 24-31. doi:10.1016/j.jviromet.2018.10.010

    DOI: 10.1016/j.jviromet.2018.10.010

    Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells (Journal article)

    Ruggiero, A., Malatinkova, E., De Spiegelaere, W., Thomas, J., Rutsaert, S., Geretti, A. M., . . . Paxton, W. A. (n.d.). Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells. Journal of Virological Methods.

    SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility. (Journal article)

    Steba, G. S., Koekkoek, S. M., Tanck, M. W. T., Vanhommerig, J. W., van der Meer, J. T. M., Kwa, D., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) Study Group and the ACS (Amsterdam Cohort Studies). (2018). SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility.. Liver international : official journal of the International Association for the Study of the Liver. doi:10.1111/liv.13978

    DOI: 10.1111/liv.13978

    Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals (Journal article)

    Banga, R., Procopio, F. A., Ruggiero, A., Noto, A., Ohmiti, K., Cavassini, M., . . . Perreau, M. (2018). Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals. FRONTIERS IN IMMUNOLOGY, 9. doi:10.3389/fimmu.2018.00144

    DOI: 10.3389/fimmu.2018.00144

    Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)

    Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Investigators, E. C. P. C. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580

    DOI: 10.1111/trf.14580

    2017

    DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users (Journal article)

    Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van der Meer, J. T. M., . . . Studies, A. C. (2018). DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users. JOURNAL OF INFECTIOUS DISEASES, 217(3), 353-357. doi:10.1093/infdis/jix587

    DOI: 10.1093/infdis/jix587

    Utility of integrated HIV-1 DNA quantification in cure studies (Journal article)

    Ruggiero, A., Malatinkova, E., Rutsaert, S., Paxton, W. A., Vandekerckhove, L., & De Spiegelaere, W. (2017). Utility of integrated HIV-1 DNA quantification in cure studies. FUTURE VIROLOGY, 12(4), 215-225. doi:10.2217/fvl-2016-0130

    DOI: 10.2217/fvl-2016-0130

    DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels (Conference Paper)

    Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., van der Meer, J. T. M., Prins, M., . . . Schinkel, J. (2017). DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels. In JOURNAL OF HEPATOLOGY Vol. 66 (pp. S318-S319). doi:10.1016/S0168-8278(17)30958-3

    DOI: 10.1016/S0168-8278(17)30958-3

    2016

    Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells (Journal article)

    Mouser, E. E. I. M., Pollakis, G., Yazdanbakhsh, M., Harnett, W., de Jong, E. C., & Paxton, W. A. (2016). Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146527

    DOI: 10.1371/journal.pone.0146527

    Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease? (Journal article)

    Paxton, W. A. (2016). Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease?. EBIOMEDICINE, 13, 27-28. doi:10.1016/j.ebiom.2016.10.023

    DOI: 10.1016/j.ebiom.2016.10.023

    2015

    Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody (Journal article)

    van Montfort, T., Thomas, A. A. M., Krawczyk, P. M., Berkhout, B., Sanders, R. W., & Paxton, W. A. (2015). Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody. JOURNAL OF IMMUNOLOGY, 195(8), 3759-3768. doi:10.4049/jimmunol.1402344

    DOI: 10.4049/jimmunol.1402344

    Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster (Journal article)

    Pollakis, G., Baan, E., van Werkhoven, M. B., Berkhout, B., Bakker, M., Jurriaans, S., & Paxton, W. A. (2015). Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster. AIDS, 29(10), 1161-1171. doi:10.1097/QAD.0000000000000692

    DOI: 10.1097/QAD.0000000000000692

    Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4(+) T-Lymphocytes (Journal article)

    Stax, M. J., Mouser, E. E. I. M., van Montfort, T., Sanders, R. W., de Vries, H. J. C., Dekker, H. L., . . . Paxton, W. A. (2015). Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4(+) T-Lymphocytes. PLOS ONE, 10(3). doi:10.1371/journal.pone.0122020

    DOI: 10.1371/journal.pone.0122020

    Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations (Journal article)

    Span, P. N., Pollakis, G., Paxton, W. A., Sweep, F. C. G. J., Foekens, J. A., Martens, J. W. M., . . . van Laarhoven, H. W. M. (2015). Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations. INTERNATIONAL JOURNAL OF CANCER, 136(1), 91-97. doi:10.1002/ijc.28962

    DOI: 10.1002/ijc.28962

    2014

    The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin (Journal article)

    Herrera-Carrillo, E., Paxton, W. A., & Berkhout, B. (2014). The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin. JOURNAL OF VIROLOGICAL METHODS, 203, 88-96. doi:10.1016/j.jviromet.2014.03.021

    DOI: 10.1016/j.jviromet.2014.03.021

    Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men (Journal article)

    Pollakis, G., Richel, O., Vis, J. D., Prins, J. M., Paxton, W. A., & de Vries, H. J. C. (2014). Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men. CLINICAL INFECTIOUS DISEASES, 58(11), 1634-1637. doi:10.1093/cid/ciu133

    DOI: 10.1093/cid/ciu133

    2013

    HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission (Journal article)

    Baan, E., de Ronde, A., Stax, M., Sanders, R. W., Luchters, S., Vyankandondera, J., . . . Paxton, W. A. (2013). HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission. PLOS ONE, 8(7). doi:10.1371/journal.pone.0069274

    DOI: 10.1371/journal.pone.0069274

    Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses (Journal article)

    Baan, E., van der Sluis, R. M., Bakker, M. E., Bekker, V., Pajkrt, D., Jurriaans, S., . . . Pollakis, G. (2013). Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses. JOURNAL OF GENERAL VIROLOGY, 94, 20-29. doi:10.1099/vir.0.046185-0

    DOI: 10.1099/vir.0.046185-0

    Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity (Journal article)

    van der Sluis, R. M., van Montfort, T., Centlivre, M., Schopman, N. C. T., Cornelissen, M., Sanders, R. W., . . . Pollakis, G. (2013). Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity. JOURNAL OF VIROLOGICAL METHODS, 187(1), 94-102. doi:10.1016/j.jviromet.2012.09.019

    DOI: 10.1016/j.jviromet.2012.09.019

    2012

    Use of (alternative) coreceptors for HIV entry (Journal article)

    Pollakis, G., & Paxton, W. A. (2012). Use of (alternative) coreceptors for HIV entry. CURRENT OPINION IN HIV AND AIDS, 7(5), 440-449. doi:10.1097/COH.0b013e328356e9f3

    DOI: 10.1097/COH.0b013e328356e9f3

    HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein (Journal article)

    Baan, E., de Ronde, A., Luchters, S., Vyankandondera, J., Lange, J. M., Pollakis, G., & Paxton, W. A. (2012). HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(7), 715-724. doi:10.1089/aid.2011.0023

    DOI: 10.1089/aid.2011.0023

    Effects of helminths and Mycobacterium tuberculosis infection on HIV-1: a cellular immunological perspective (Journal article)

    Mouser, E. E. I. M., Pollakis, G., & Paxton, W. A. (2012). Effects of helminths and Mycobacterium tuberculosis infection on HIV-1: a cellular immunological perspective. CURRENT OPINION IN HIV AND AIDS, 7(3), 260-267. doi:10.1097/COH.0b013e3283521144

    DOI: 10.1097/COH.0b013e3283521144

    HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (BSSL) Gene Polymorphism (Journal article)

    Stax, M. J., Kootstra, N. A., van 't Wout, A. B., Tanck, M. W. T., Bakker, M., Pollakis, G., & Paxton, W. A. (2012). HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 7(3). doi:10.1371/journal.pone.0032534

    DOI: 10.1371/journal.pone.0032534

    Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another (Journal article)

    van Werkhoven, M. B., Baan, E., Bakker, M., Jurriaans, S., Paxton, W. A., & Pollakis, G. (2012). Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(2), 225-227. doi:10.1089/aid.2011.0178

    DOI: 10.1089/aid.2011.0178

    2011

    Innate immune factors associated with HIV-1 transmission (Journal article)

    Pollakis, G., Stax, M. J., & Paxton, W. A. (2011). Innate immune factors associated with HIV-1 transmission. CURRENT OPINION IN HIV AND AIDS, 6(5), 341-347. doi:10.1097/COH.0b013e3283499e11

    DOI: 10.1097/COH.0b013e3283499e11

    Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection (Journal article)

    Centlivre, M., Legrand, N., Steingrover, R., van der Sluis, R., Grijsen, M. L., Bakker, M., . . . Pollakis, G. (2011). Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. JOURNAL OF LEUKOCYTE BIOLOGY, 89(5), 785-795. doi:10.1189/jlb.0410231

    DOI: 10.1189/jlb.0410231

    Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism (Journal article)

    Stax, M. J., Naarding, M. A., Tanck, M. W. T., Lindquist, S., Hernell, O., Lyle, R., . . . Paxton, W. A. (2011). Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 6(2). doi:10.1371/journal.pone.0017316

    DOI: 10.1371/journal.pone.0017316

    Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports (Journal article)

    van de Laar, T. J. W., Paxton, W. A., Zorgdrager, F., Cornelissen, M., & de Vries, H. J. C. (2011). Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports. SEXUALLY TRANSMITTED DISEASES, 38(2), 102-104. doi:10.1097/OLQ.0b013e3181ec9de5

    DOI: 10.1097/OLQ.0b013e3181ec9de5

    2010

    Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection (Journal article)

    Geldmacher, C., Ngwenyama, N., Schuetz, A., Petrovas, C., Reither, K., Heeregrave, E. J., . . . Koup, R. A. (2010). Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection. JOURNAL OF EXPERIMENTAL MEDICINE, 207(13), 2869-2881. doi:10.1084/jem.20100090

    DOI: 10.1084/jem.20100090

    Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads (Journal article)

    Cornelissen, M., Heeregrave, E. J., Zorgdrager, F., Pollakis, G., Paxton, W. A., & van der Kuyl, A. C. (2010). Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads. ARCHIVES OF VIROLOGY, 155(12), 2017-2022. doi:10.1007/s00705-010-0806-x

    DOI: 10.1007/s00705-010-0806-x

    BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION (Conference Paper)

    Affram, Y., Martijn, M., Pollakis, G., Sagoe, K. W., Mingle, J. A., Ampofo, W. K., . . . Jacob, B. (2010). BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 83 (pp. 199). Retrieved from http://gateway.webofknowledge.com/

    Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line (Journal article)

    Heeregrave, E. J., Ampofo, W. K., Tetteh, J. K. A., Ofori, M., Ofori, S. B., Shah, A. S., . . . Paxton, W. A. (2010). Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line. JOURNAL OF VIROLOGICAL METHODS, 169(2), 341-350. doi:10.1016/j.jviromet.2010.08.001

    DOI: 10.1016/j.jviromet.2010.08.001

    Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C ' (Journal article)

    Ayele, W., Mekonnen, Y., Messele, T., Mengistu, Y., Tsegaye, A., Bakker, M., . . . Pollakis, G. (2010). Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C '. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(7), 805-813. doi:10.1089/aid.2009.0152

    DOI: 10.1089/aid.2009.0152

    HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design (Journal article)

    Pollakis, G., & Paxton, W. A. (2010). HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design. CURRENT PHARMACEUTICAL DESIGN, 16(33), 3701-3715. doi:10.2174/138161210794079146

    DOI: 10.2174/138161210794079146

    Varied sensitivity to therapy of HIV-1 strains in CD4(+) lymphocyte sub-populations upon ART initiation (Journal article)

    Heeregrave, E. J., Geels, M. J., Baan, E., van der Sluis, R. M., Paxton, W. A., & Pollakis, G. (2010). Varied sensitivity to therapy of HIV-1 strains in CD4(+) lymphocyte sub-populations upon ART initiation. AIDS RESEARCH AND THERAPY, 7. doi:10.1186/1742-6405-7-42

    DOI: 10.1186/1742-6405-7-42

    2009

    Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4(+) T cell subsets (Journal article)

    Heeregrave, E. J., Geels, M. J., Brenchley, J. M., Laan, E., Ambrozak, D. R., van der Sluis, R. M., . . . Paxton, W. A. (2009). Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4(+) T cell subsets. VIROLOGY, 393(1), 24-32. doi:10.1016/j.virol.2009.07.011

    DOI: 10.1016/j.virol.2009.07.011

    HIV vaccine: it may take two to tango, but no party time yet (Journal article)

    Berkhout, B., & Paxton, W. A. (2009). HIV vaccine: it may take two to tango, but no party time yet. RETROVIROLOGY, 6. doi:10.1186/1742-4690-6-88

    DOI: 10.1186/1742-4690-6-88

    Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes (Journal article)

    Stax, M. J., van Montfort, T., Sprenger, R. R., Melchers, M., Sanders, R. W., van Leeuwen, E., . . . Paxton, W. A. (2009). Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes. VIROLOGY, 391(2), 203-211. doi:10.1016/j.virol.2009.06.011

    DOI: 10.1016/j.virol.2009.06.011

    Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells (Conference Paper)

    Stax, M. J., Pollakis, G., Sprenger, R. R., Melchers, M., van Montfort, T., Sanders, R. W., . . . Paxton, W. A. (2009). Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells. In RETROVIROLOGY Vol. 6. doi:10.1186/1742-4690-6-S3-P108

    DOI: 10.1186/1742-4690-6-S3-P108

    Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution (Journal article)

    Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2009). Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution. JOURNAL OF VIROLOGY, 83(1), 368-383. doi:10.1128/JVI.01404-08

    DOI: 10.1128/JVI.01404-08

    2008

    Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein (Journal article)

    van Anken, E., Sanders, R. W., Liscaljet, I. M., Land, A., Bontjer, I., Tillemans, S., . . . Braakman, I. (2008). Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein. MOLECULAR BIOLOGY OF THE CELL, 19(10), 4298-4309. doi:10.1091/mbc.E07-12-1282

    DOI: 10.1091/mbc.E07-12-1282

    Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution (Conference Paper)

    Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2008). Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 24 (pp. 56). Retrieved from http://gateway.webofknowledge.com/

    Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4(+) T lymphocytes in trans (Journal article)

    van Montfort, T., Thomas, A. A. M., Pollakis, G., & Paxton, W. A. (2008). Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4(+) T lymphocytes in trans. JOURNAL OF VIROLOGY, 82(16), 7886-7896. doi:10.1128/JVI.00245-08

    DOI: 10.1128/JVI.00245-08

    Increased virus replication in mammalian cells by blocking intracellular innate defense responses (Journal article)

    de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., . . . Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. GENE THERAPY, 15(7), 545-552. doi:10.1038/gt.2008.12

    DOI: 10.1038/gt.2008.12

    The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion (Journal article)

    Sanders, R. W., van Anken, E., Nabatov, A. A., Liscaljet, M., Bontjer, I., Eggink, D., . . . Paxton, W. A. (2008). The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion. RETROVIROLOGY, 5. doi:10.1186/1742-4690-5-10

    DOI: 10.1186/1742-4690-5-10

    2007

    Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1 (Journal article)

    Nabatov, A. A., Pollakis, G., Linnemann, T., Paxton, W. A., & de Baar, M. P. (2007). Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1. PLOS ONE, 2(5). doi:10.1371/journal.pone.0000470

    DOI: 10.1371/journal.pone.0000470

    Characterization of an HIV-1 group m variant that is distinct from the known subtypes (Journal article)

    Van der Hoek, L., Pollakis, G., Lukashov, V. V., Jebbink, M. F., Jeeninga, R. E., Bakker, M., . . . Berkhout, B. (2007). Characterization of an HIV-1 group m variant that is distinct from the known subtypes. AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(3), 466-470. doi:10.1089/aid.2006.0184

    DOI: 10.1089/aid.2006.0184

    Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4(+) T lymphocytes (Journal article)

    van Montfort, T., Nabatov, A. A., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2007). Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4(+) T lymphocytes. JOURNAL OF IMMUNOLOGY, 178(5), 3177-3185. doi:10.4049/jimmunol.178.5.3177

    DOI: 10.4049/jimmunol.178.5.3177

    Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden (Journal article)

    Ayele, W., Schuurman, R., Messele, T., Dorigo-Zetsma, W., Mengistu, Y., Goudsmit, J., . . . Pollakis, G. (2007). Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden. JOURNAL OF CLINICAL MICROBIOLOGY, 45(3), 891-896. doi:10.1128/JCM.01919-06

    DOI: 10.1128/JCM.01919-06

    Effect of chloroquine on reducing HIV-I replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes (Journal article)

    Naarding, M. A., Baan, E., Pollakis, G., & Paxton, W. A. (2007). Effect of chloroquine on reducing HIV-I replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes. RETROVIROLOGY, 4. doi:10.1186/1742-4690-4-6

    DOI: 10.1186/1742-4690-4-6

    2006

    Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression (Journal article)

    Nabatov, A. A., van Montfort, T., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2006). Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression. FEBS JOURNAL, 273(21), 4944-4958. doi:10.1111/j.1742-4658.2006.05491.x

    DOI: 10.1111/j.1742-4658.2006.05491.x

    Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4(+) T cells (Journal article)

    Naarding, M. A., Dirac, A. M., Ludwig, I. S., Speijer, D., Lindquist, S., Vestman, E. -L., . . . Paxton, W. A. (2006). Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4(+) T cells. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(10), 3367-3374. doi:10.1128/AAC.00593-06

    DOI: 10.1128/AAC.00593-06

    CTL escape and increased viremia irrespective of HIV-specific CD4(+) T-helper responses in two HIV-infected individuals (Journal article)

    Geels, M. J., Jansen, C. A., Baan, E., De Cuyper, I. M., van Schijndel, G. J. M., Schuitemaker, H., . . . van Baarle, D. (2006). CTL escape and increased viremia irrespective of HIV-specific CD4(+) T-helper responses in two HIV-infected individuals. VIROLOGY, 345(1), 209-219. doi:10.1016/j.virol.2005.09.023

    DOI: 10.1016/j.virol.2005.09.023

    2005

    Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes (Journal article)

    Naarding, M. A., Ludwig, I. S., Groot, F., Berkhout, B., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2005). Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4(+) T lymphocytes. JOURNAL OF CLINICAL INVESTIGATION, 115(11), 3256-3264. doi:10.1172/JCI25105

    DOI: 10.1172/JCI25105

    Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation (Journal article)

    Geels, M. J., Dubey, S. A., Anderson, K., Baan, E., Bakker, M., Pollakis, G., . . . Goudsmit, J. (2005). Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation. JOURNAL OF VIROLOGY, 79(17), 11247-11258. doi:10.1128/JVI.79.17.11247-11258.2005

    DOI: 10.1128/JVI.79.17.11247-11258.2005

    2004

    Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals (Journal article)

    Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., . . . Paxton, W. A. (2004). Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals. JOURNAL OF VIROLOGY, 78(6), 2841-2852. doi:10.1128/JVI.78.6.2841-2852.2004

    DOI: 10.1128/JVI.78.6.2841-2852.2004

    Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies (Journal article)

    Nabatov, A. A., Pollakis, G., Linnemann, T., Kliphius, A., Chalaby, M. I. M., & Paxton, W. A. (2004). Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies. JOURNAL OF VIROLOGY, 78(1), 524-530. doi:10.1128/JVI.78.1.524-530.2004

    DOI: 10.1128/JVI.78.1.524-530.2004

    2003

    Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual (Journal article)

    Geels, M. J., Cornelissen, M., Schuitemaker, H., Anderson, K., Kwa, D., Maas, J., . . . Goudsmit, J. (2003). Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual. JOURNAL OF VIROLOGY, 77(23), 12430-12440. doi:10.1128/JVI.77.23.12430-12440.2003

    DOI: 10.1128/JVI.77.23.12430-12440.2003

    2001

    RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression (Conference Paper)

    Paxton, W. A., Neumann, A. U., Kang, S., Deutch, L., Brown, R. C., Koup, R. A., & Wolinsky, S. M. (2001). RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression. In JOURNAL OF INFECTIOUS DISEASES Vol. 183 (pp. 1678-1681). doi:10.1086/320701

    DOI: 10.1086/320701

    N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization (Journal article)

    Pollakis, G., Kang, S., Kliphuis, A., Chalaby, M. I. M., Goudsmit, J., & Paxton, W. A. (2001). N-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(16), 13433-13441. doi:10.1074/jbc.M009779200

    DOI: 10.1074/jbc.M009779200

    2000

    Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines (Journal article)

    Juffermans, N. P., Paxton, W. A., Dekkers, P. E. P., Verbon, A., de Jonge, E., Speelman, P., . . . van der Poll, T. (2000). Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines. BLOOD, 96(8), 2649-2654. Retrieved from http://gateway.webofknowledge.com/

    1999

    HIV-1 infectability of CD4(+) lymphocytes with relation to beta-chemokines and the CCR5 coreceptor (Conference Paper)

    Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L. J., . . . Koup, R. A. (1999). HIV-1 infectability of CD4(+) lymphocytes with relation to beta-chemokines and the CCR5 coreceptor. In IMMUNOLOGY LETTERS Vol. 66 (pp. 71-75). doi:10.1016/S0165-2478(98)00154-0

    DOI: 10.1016/S0165-2478(98)00154-0

    1998

    Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression (Journal article)

    Paxton, W. A., & Kang, S. (1998). Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression. SEMINARS IN IMMUNOLOGY, 10(3), 187-194. doi:10.1006/smim.1998.0132

    DOI: 10.1006/smim.1998.0132

    Reduced HIV-1 infectability of CD4(+) lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of beta-chemokines (Journal article)

    Paxton, W. A., Liu, R., Kang, S., Wu, L. J., Gingeras, T. R., Landau, N. R., . . . Koup, R. A. (1998). Reduced HIV-1 infectability of CD4(+) lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of beta-chemokines. VIROLOGY, 244(1), 66-73. doi:10.1006/viro.1998.9082

    DOI: 10.1006/viro.1998.9082

    Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells (Journal article)

    Granelli-Piperno, A., Delgado, E., Finkel, V., Paxton, W., & Steinman, R. M. (1998). Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells. JOURNAL OF VIROLOGY, 72(4), 2733-2737. doi:10.1128/JVI.72.4.2733-2737.1998

    DOI: 10.1128/JVI.72.4.2733-2737.1998

    The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression (Conference Paper)

    Paxton, W. A., Kang, S., & Koup, R. A. (1998). The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 14 (pp. S89-S92). Retrieved from http://gateway.webofknowledge.com/

    1997

    CCR-5: A hot target for drug discovery (Conference Paper)

    Landau, N. R., Liu, R., DiMarzio, P., Choe, S., Ceradini, D., Yang, J., . . . Koup, R. A. (1997). CCR-5: A hot target for drug discovery. In FASEB JOURNAL Vol. 11 (pp. A855). Retrieved from http://gateway.webofknowledge.com/

    CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro (Journal article)

    Wu, L. J., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., . . . Mackay, C. R. (1997). CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. JOURNAL OF EXPERIMENTAL MEDICINE, 185(9), 1681-1691. doi:10.1084/jem.185.9.1681

    DOI: 10.1084/jem.185.9.1681

    Mechanisms of resistance to HIV infection (Journal article)

    Paxton, W. A., & Koup, R. A. (1997). Mechanisms of resistance to HIV infection. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 18(3), 323-340. doi:10.1007/BF00813501

    DOI: 10.1007/BF00813501

    1996

    Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors (Journal article)

    GranelliPiperno, A., Moser, B., Pope, M., Chen, D. L., Wei, Y., Isdell, F., . . . Steinman, R. M. (1996). Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. JOURNAL OF EXPERIMENTAL MEDICINE, 184(6), 2433-2438. doi:10.1084/jem.184.6.2433

    DOI: 10.1084/jem.184.6.2433

    Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1 (Journal article)

    Connor, R. I., Paxton, W. A., Sheridan, K. E., & Koup, R. A. (1996). Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1. JOURNAL OF VIROLOGY, 70(12), 8758-8764. Retrieved from http://gateway.webofknowledge.com/

    The role of a mutant CCR5 allele in HIV-1 transmission and disease progression (Journal article)

    Huang, Y. X., Paxton, W. A., Wolinsky, S. M., Neumann, A. U., Zhang, L. Q., He, T., . . . Koup, R. A. (1996). The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. NATURE MEDICINE, 2(11), 1240-1243. doi:10.1038/nm1196-1240

    DOI: 10.1038/nm1196-1240

    Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons (Journal article)

    Paxton, W. A., Dragic, T., Koup, R. A., & Moore, J. P. (1996). Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons. AIDS RESEARCH AND HUMAN RETROVIRUSES, 12(13), 1203-1207. doi:10.1089/aid.1996.12.1203

    DOI: 10.1089/aid.1996.12.1203

    Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection (Journal article)

    Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., . . . Landau, N. R. (1996). Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. CELL, 86(3), 367-377. doi:10.1016/S0092-8674(00)80110-5

    DOI: 10.1016/S0092-8674(00)80110-5

    HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 (Journal article)

    Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y. X., Nagashima, K. A., . . . Paxton, W. A. (1996). HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5. NATURE, 381(6584), 667-673. doi:10.1038/381667a0

    DOI: 10.1038/381667a0

    Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures (Journal article)

    Paxton, W. A., Martin, S. R., Tse, D., OBrien, T. R., Skurnick, J., VanDevanter, N. L., . . . Koup, R. A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. NATURE MEDICINE, 2(4), 412-417. doi:10.1038/nm0496-412

    DOI: 10.1038/nm0496-412

    1995

    DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2 (Journal article)

    YAZDANBAKHSH, M., PAXTON, W. A., BRANDENBURG, A., VANREE, R., LENS, M., PARTONO, F., . . . SELKIRK, M. E. (1995). DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2. INFECTION AND IMMUNITY, 63(10), 3772-3779. Retrieved from http://gateway.webofknowledge.com/

    1993

    INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS (Journal article)

    PAXTON, W., CONNOR, R. I., & LANDAU, N. R. (1993). INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS. JOURNAL OF VIROLOGY, 67(12), 7229-7237. Retrieved from http://gateway.webofknowledge.com/

    PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES (Journal article)

    PAXTON, W. A., YAZDANBAKHSH, M., KURNIAWAN, A., PARTONO, F., MAIZELS, R. M., & SELKIRK, M. E. (1993). PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES. INFECTION AND IMMUNITY, 61(7), 2827-2833. doi:10.1128/IAI.61.7.2827-2833.1993

    DOI: 10.1128/IAI.61.7.2827-2833.1993

    T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS (Journal article)

    YAZDANBAKHSH, M., PAXTON, W. A., KRUIZE, Y. C. M., SARTONO, E., KURNIAWAN, A., WOUT, A. V., . . . MAIZELS, R. M. (1993). T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS. JOURNAL OF INFECTIOUS DISEASES, 167(4), 925-931. doi:10.1093/infdis/167.4.925

    DOI: 10.1093/infdis/167.4.925

    VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4 (Conference Paper)

    LANDAU, N. R., LENBURG, M. E., & PAXTON, W. (1993). VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 50). Retrieved from http://gateway.webofknowledge.com/

    BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR (Journal article)

    TWEEDIE, S., PAXTON, W. A., INGRAM, L., MAIZELS, R. M., MCREYNOLDS, L. A., & SELKIRK, M. E. (1993). BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR. EXPERIMENTAL PARASITOLOGY, 76(2), 156-164. doi:10.1006/expr.1993.1018

    DOI: 10.1006/expr.1993.1018