Dr Benedict Michael MBChB (Hons), MRCP (Neurol), PhD

Senior Clinician Scientist Fellow and Honorary Consultant Neurologist Clinical Infection, Microbiology and Immunology

About

Personal Statement

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KEY AREAS
Zoonotic Infection; Pandemic Infection; Neurology; Encephalitis; Para-Infectious CNS pathology; Innate networks


SUMMARY
Dr Benedict D Michael is a Senior Clinician Scientist Fellow at The NIHR Health Protection Research Unit for Emerging and Zoonotic Infection and an Honorary Consultant Neurologist at The Walton Centre.

He completed Post-Doctoral Training at the Center for Immunology and Inflammatory Disease, Massachusettes General Hospital and Harvard Medical School where he was developed an intravital microscopy model of viral encephalitis to image leucocyte migration into the brain in real-time.

He has received The Liversage Award for Neurology and The British Medical Association Vera Down Award for Neuroscience, and for his neurological education work in Africa, he is Honorary Faculty for the Royal College of Physicians and his team were The 2020 Finalists for the Royal College Awards for Excellence in Education.

He has an h-index of 21, an i10-index of 30, with >70 publications, and >1,900 citations, primarily on neurological infection and inflammation. He has grant income from Wellcome, the MRC, NIHR, and Academy of Medical Sciences, of approximately £5M as PI/Co-I.

He is Vice Chair of the Encephalitis Society's Scientific Advisory Panel and a Scientific Advisor to the Meningitis Research Foundation. He has worked as a Royal College of Physicians Faculty Tutor in West Africa and with the NIHR to promote Patient and Public Engagement in research.


COVID-19
He is currently co-Chairing the World Health Organisation (WHO) - Commissioned Task Force on Acute Clinical Care for Neurological complications of COVID-19.

He is currently leading the National Surveillance Programme for Neurological Complications of COVID-19, CoroNerve, for the University as part of the Study Management Group (with the universities of Newcastle, Southampton, and UCL), in collaboration with the Association of British Neurologists, British Paediatric Neurology Association, British Association of Stroke Physicians, Royal College of Psychiatry, The NeuroAnaesthesia and Critical Care Society, and other key stakeholders:


INTERVEIWS

.NATURE NEWS- COVID-19 affecting the brain

.BBC NEWS World Service Lancet Psych Paper

.BBC NEWS London COVID-19 Neurology in Hospitals and the Community

.ROYAL COLLEGE OF PHYSICIANS and ASSOCIATION OF BRITISH NEUROLOGISTS: COVID-19 for Neurologists

.ROYAL COLLEGE OF PSYCHIATRISTS: COVID-19 and the Brain

.ENCEPHALITIS SOCIETY: COVID-19 Interview

.BRITISH ASSOCIATION OF STROKE PHYSICIANS: Stroke in the era of COVID-19 Password: 5K@8M12U

.CoroNerve.com



MEDIA HIGHLIGHTS
.THE GUARDIAN
.NEW YORK TIMES
.CNN
.ITV News
.NeuroRehab Times
.RADIO CANADA
.THE EXPRESS
.SUNDAY TIMES: COVID-19 and Neuroscience
.DER SPIEGEL: Chronic impacts of COVID-19 on the brain
.THE TELEGRAPH
.THE LANCET NEUROLOGY: Neurological Education in Africa; Breaking the cycle
.THE LANCET INFECTIOUS DISEASES: Surveillance of Neurological Infection
.DAILY MAIL: COVID-19's effects on the brain
.THE TIMES: UK Experts Back Meningitis B Vaccine
.GUARDIAN: App That Maps Disease Outbreaks
.ENCEPHALITIS SOCIETY/HOLLYOAKS: What is Encephalitis?


MEDICAL EDUCATION LEADERSHIP
.NeuroACCESS- Neurological education in sub-Saharan Africa
.NeuroPACES Course- Neurology for MRCP
.NeuroPASS- Neurology for Finals
.Royal College of Physicians- Finalist Excellence in Patient Care Awards 2020



SELECTED PUBLICATIONS

MICHAEL BD, Bricio-Moreno L, Sorensen E, Lian J, Knipe DM, Solomon T, Kurt-Jones EA, Luster AD. Astrocyte-derived CXCL1 drives neutrophil transmigration and blood-brain barrier permeability in HSV encephalitis. CELL REP 2020; 32: 108150

Varatharaj A, Thomas N, Ellul MA,... MICHAEL BD. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. LANCET PSYCH 2020: 25; online ahead of print

Ellul MA, Benjamin L, Singh B, Lant S, MICHAEL BD.. Solomon T. Neurological associations of COVID-19. LANCET NEUROL 2020: 2; online ahead of print

Winkler AS, Knauss S, Schmutzhard E, Leonardi M, Padovani A, Abd-Allah F, Charway-Felli A, Emmrich JV, Umapathi T, Satishchandra P, Hoo FK, Dalmau J, Oreja-Guevara C, Ferreira MLB, Pfausler B, MICHAEL BD, ...Solomon T. A call for a global COVID-19 Neuro Research Coalition. LANCET NEUROL 2020; 19:482-484

Venketesan A, MICHAEL BD, Probasco JC, Geocadin RG, Solomon T. Acute encephalitis in immunocompetent adults. LANCET 2019; 393:702-716

Ellul MA, Varatharaj A, , ... MICHAEL BD. Defining causality in COVID-19 and neurological disorders. J NEUROL NEUROSURG PSYCH 2020; 91: 811-822

Patabendgie A, MICHAEL BD, Craig A, Solomon T. Japanese encephalitis virus infection increases blood-brain barrier permeability in a human model by inducing a strong pro-inflammatory endothelial response. MOL CELL NEUROSCI 2017: 89;60-70

MICHAEL BD, Griffiths MJ, Granerod J, .. Solomon T. The Interleukin-1 balance during encephalitis is associated with clinical severity, blood-brain barrier permeability, neuroimaging changes and disease outcome. J INFECT DIS 2016; 213:1651-60

MICHAEL BD, Griffiths MJ, Granerod J, .. Solomon T. Cytokine profiles differ between infectious and immune-mediated encephalitis, and those of unknown cause have an infectious pattern. PLOS ONE 2016; 11: e0146288

Pandey S, Rathore C, MICHAEL BD. Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis. COCHRANE DATABASE SYST REV 2014; 10; CD010247

Goenka A, MICHAEL BD, Ledger E, .. Solomon T, Kneen R. Neurological manifestations of influenza in adults and children: Results of a national British surveillance study. CLIN INFECT DIS 2014; 58(6): 775-84

Solomon T, MICHAEL BD (JOINT FIRST), Smith PE, .. Beeching NJ. On behalf of the National Encephalitis Guidelines Development Group. Management of suspected viral encephalitis in adults: Association of British Neurologists and British Infection Association National Guideline. J INFECT 2012; 64(4):347-73


ADDITIONAL PROFILES
.Faculty of One Thousand Profile
.Encephalitis Society Profile
.Meningitis Research Foundation Profile
.ORCID Profile
.Harvard University and MGH Center for Immune and Inflammatory Disease
.The Walton Centre NHS Foundation Trust

Prizes or Honours

  • Excellence in Patient Care (Royal College of Physicians, 2020)
  • Faculty Award- Teaching and Learning Award (University of Liverpool, 2020)
  • MRC-AMED Collaborative Grant (MRC, 2020)
  • Annual Liversage Award (NENA, 2018)
  • Wellcome Trust Competitive Seed Grant (Wellcome Trust, 2018)
  • Vera Down Award for Neuroscience (British Medical Association, 2016)
  • Grant for Clinical Lecturers (Academy of Medical Science, 2016)
  • Doctors as volunteers (NeuroAccess)- Highly commended (British Medical Association, 2016)
  • Medical Education (Association of British Neurologists, 2015)
  • Medical Education (Association of British Neurologists, 2014)
  • Excellence in Innovation- Celebrating Success Awards (University of Liverpool, 2013)
  • Guarantors of Brain International Travel Award (Guarantors of Brain, 2011)
  • ACP Annual Junior Investigators Award (Association of Clinical Pathologists, 2009)

Funded Fellowships

  • NIHR Doctoral Research Fellowship (National Institute for Health Research, 2011)
  • NIHR Academic Clinical Fellowship (National Institute for Health Research , 2008)