Dr Andrew Jackson BSc MSc DPhil

Senior Lecturer in Parasite Biology Infection Biology

    Research

    Research Interest 1

    My research plans in the immediate and long-term are based on recent research into cell surface gene families of parasite genomes. Genes expressed on the surfaces of parasites are instrumental to the host-pathogen interaction, frequently employed in antigenic variation and therefore are usually the most dynamic features of parasite genomes. Making sense of the enormous diversity and atypical evolution of these important features has formed the core of my recent work in Trypanosoma, Leishmania, Plasmodium, Candida and other parasites. In particular, I have discovered a recent contraction in genetic variation in the Human parasite Trypanosoma brucei that has resulted in increased recombination among its variant surface glycoprotein (VSG) genes. The task now is to apply my knowledge of reference genomes to molecular variation in the field, studying VSG evolution across populations and timescales to understand the importance of antigenic diversity to the severity and epidemiology of disease.

    Research Grants
    • 2014 allocation - Wellcome ISSF non clinical fellowships
    • New approaches to a livestock trypanosomiasis vaccine: targeting the bite-site by immunization with novel metacyclic-stage parasite antigens
    • Rethinking ‘impossible’: creating a platform for developing novel vaccines against animal trypanosomiasis in Brazil
    • Genomic analysis of antigenic diversity in Brazilian Trypanosoma vivax strains
    • Variant antigen profiling: a novel genomic tool for diagnosis and surveillance of animal African trypanosomiasis
    • A Collaborative Initiative to Develop Animal Trypanosomiasis Vaccines in Brazil
    • Molecular genetics of farm animal protozoa
    • Bench fees for Alessandra Romero Ramirez
    • Challenging trypanosome antigenic variation paradigms using natural systems
    • An Analytical Tool to Transform Genomic Approaches to Nagana
    • Inside the Trojan horse: systematics of Acanthamoeba spp. and their endosymbionts
    • Evolutionary genomics of free-living and parasitic amoebae

    Untitled Document