Dr Andrew Jackson BSc MSc DPhil

Senior Lecturer in Parasite Biology Infection Biology

    Research

    Research Interest 1

    My research plans in the immediate and long-term are based on recent research into cell surface gene families of parasite genomes. Genes expressed on the surfaces of parasites are instrumental to the host-pathogen interaction, frequently employed in antigenic variation and therefore are usually the most dynamic features of parasite genomes. Making sense of the enormous diversity and atypical evolution of these important features has formed the core of my recent work in Trypanosoma, Leishmania, Plasmodium, Candida and other parasites. In particular, I have discovered a recent contraction in genetic variation in the Human parasite Trypanosoma brucei that has resulted in increased recombination among its variant surface glycoprotein (VSG) genes. The task now is to apply my knowledge of reference genomes to molecular variation in the field, studying VSG evolution across populations and timescales to understand the importance of antigenic diversity to the severity and epidemiology of disease.

    Research Grants

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    New approaches to a livestock trypanosomiasis vaccine: targeting the bite-site by immunization with novel metacyclic-stage parasite antigens

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    November 2018 - April 2020

    Rethinking ‘impossible’: creating a platform for developing novel vaccines against animal trypanosomiasis in Brazil

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    December 2018 - April 2020

    Genomic analysis of antigenic diversity in Brazilian Trypanosoma vivax strains

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    August 2018 - February 2019

    Variant antigen profiling: a novel genomic tool for diagnosis and surveillance of animal African trypanosomiasis

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2016 - February 2019

    A Collaborative Initiative to Develop Animal Trypanosomiasis Vaccines in Brazil

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2018 - June 2020

    Molecular genetics of farm animal protozoa

    ROYAL THAI EMBASSY

    September 2012 - August 2015

    Bench fees for Alessandra Romero Ramirez

    PRESIDENCIA DEL CONSEJO DE MINISTROS (PERU)

    September 2016 - September 2020

    Challenging trypanosome antigenic variation paradigms using natural systems

    WELLCOME TRUST (UK)

    April 2018 - April 2022

    An Analytical Tool to Transform Genomic Approaches to Nagana

    BILL & MELINDA GATES FOUNDATION (USA)

    November 2013 - April 2015

    Inside the Trojan horse: systematics of Acanthamoeba spp. and their endosymbionts

    LINNEAN SOCIETY OF LONDON (UK)

    June 2012 - June 2014

    Evolutionary genomics of free-living and parasitic amoebae

    LEVERHULME TRUST (UK)

    August 2014 - July 2017