What is RoVI: Rotavirus Vacccine Immunogenicity study?
- RoVI is a study that will investigate why rotavirus vaccines are less effective in babies living in the poorest countries.
- Rotavirus is the most common cause of diarrhoea in children worldwide, and an important cause of child mortality in the poorest countries.
- Rotavirus vaccination is currently offered routinely to all children born in the UK, and since the vaccine was introduced in 2013, the numbers of babies with severe diarrhoea in the UK has been reduced enormously.
- However, not all children are protected by the vaccine, and this is particularly true for children living in the poorest countries, where the vaccine protection is about half of that seen in richer countries such as the UK.
What is the purpose of the study?
This study aims to investigate the different factors that can affect how effective rotavirus vaccine is in different children. Research will take place in three locations; Liverpool, UK; Vellore, India and Blantyre in Malawi.
In this study we will compare the protection passed on from mothers to babies during pregnancy and after birth in the three places. We will also study the bacteria in the baby’s stool from birth to the time of rotavirus vaccination and investigate how the gut bacteria may be linked to better or worse responses to the rotavirus vaccine.
The information we obtain should help us design better vaccines or strategies to improve the performance of current vaccines, so that all babies, regardless of where they are born, can be protected equally well.
What would I have to do?
We are asking women in or near the third trimester of their pregnancy (~20 weeks), who are planning to give birth at Liverpool Women's Hospital, to register their interest in participating in the project.
When doing so, please include details of your name, postcode and due date.
The study has been designed to be as unobtrusive as possible, and you or your baby’s normal health care will not be altered.
The study team which include research midwifes and nurses will facilitate the collection of samples and data in a time and place that is most convenient to you.
How long will I be involved?
The study will take place from birth until your baby is 16 weeks old.
You can however stop taking part at any time and you do not need to tell us why.
How can I sign up?
That's easy! Click the link on the top right of the page and register your interest.
A study midwife will provide you more detailed information.
You will have an opportunity to ask any question about the study directly to a study team member.
If, after having read and understood all the information, you decide to participate in the study; you will be asked to sign a consent form just before you deliver your baby at the Liverpool Women’s Hospital.