Viral Pathogenesis

About our Research

Research themes covered by the Viral Pathogenesis Group include:

  • The Molecular Virology Research Group.  Most of the group's current research programme is centred on the use of influenza A virus, respiratory syncytial virus and murine γ-herpesvirus-68 (MHV-68) to study pathogenesis, immunology and virus-host interactions in the respiratory tract.  These studies use virus reverse genetics combined with transgenic mouse technology, molecular pathology, transcriptomics and proteomics to dissect pathogenic mechanisms.  The group is led by Professor James Stewart
  • The Respiratory and Emerging Viruses Group.  Respiratory and emerging hemorrhagic fever viruses represent some of the greatest threats to global health and food security.  Many are characterized as zoonotic infections with life cycles occurring in multiple species.  Vaccines and anti-viral therapy are difficult to develop due to high mutation rates and efficient immune avoidance mechanisms.  Our laboratory has used quantitative proteomics extensively to study the interaction of examples of these viruses (from Biosafety Level 2 to Biosafety Level 4 pathogens).  The group is led by Professor Julian Hiscox