Studentships

The Institute of Ageing and Chronic Disease is fully committed to promoting gender equality in all activities. We offer a supportive working environment with flexible family support for all our staff and students and applications for part-time study are encouraged. The Institute holds a silver Athena SWAN award in recognition of on-going commitment to ensuring that the Athena SWAN principles are embedded in its activities and strategic initiatives. 

PhD studentships with funding

The design and manufacture of 3D peptide gels for tissue engineering applications

Analysing cardiac ion channels with deep learning: human supervised analysis versus A.I. (Artificial Intelligence)

Musculoskeletal tissue ageing: the role of microRNAs and joints homeostasis

Tissue engineering of functional cardiac tissue using a newly characterised cardiac stem cell population

Bone Remodelling Around the Clock: Developing Chrono-Therapeutic Strategies for Treatment of Osteoporosis

Determination of the microstructural extracellular and cellular response of young and aged anterior cruciate ligaments in the mammalian knee joint to mechanical load

Determining how post-transcriptional control of mRNA turnover and translation contributes towards age-associated joint diseases

Regulating Shedding of Syndecan-3: A Novel Approach to Combat Bone Ageing

Role of abnormal collagen (I) homotrimer in cardiovascular ageing and disease

Studying energy metabolism in tissue engineered cartilage – are mitochondria crucial regulators of joint rejuvenation?

 

PhD studentships for students with their own funding

 

Eye and Vision Science

Investigating Early Worsening of Diabetic Retinopathy with Rapid Improvement in Glycaemic Control

Controlling the switches; determining the regulation of laminin gene expression

Determination of laminin matrix contribution to blood retina barrier function in a novel 3D flow model with application to diabetic retinopathy

Development of new computer vision techniques for automated reconstruction of curvilinear structures from images

Development of Novel Imaging Technologies for Eye Disease

Molecular Mechanisms of Glaucoma; dissecting the roles of cross-linked actin networks.

Oculomotor approaches to inhibitory control

MicroRNA regulation of MMP14 in Corneal Neovascularisation: Development of ‘AngioMirs’ as a Novel Therapy

Mitochondrial Dysfunction and Fuchs Endothelial Corneal Dystrophy

MicroRNA regulation of FOXC1 and glaucoma development

Characterisation of cell death mechanisms in cancer: protein interactions in p53/PERP-mediated apoptosis

Advanced Microscopy Image Analysis for Life Science Applications

Development of Advanced Methods for Biological Signal Analysis

Development of nanomedicines for the treatment of eye diseases 

 

 

Musculoskeletal Biology

Characterization and functional analysis of a novel cancer-associated gene

Connective Tissue Fibrosis: Understanding basic biological mechanisms and the development of targeted therapies

Developing and applying computational methods to understand the genetics of ageing

Development of treatment for Osteoarthritis by blocking metalloproteinases

Environmental regulation of mRNA decay in adult stem cells

Epac as a novel target for airway muscle relaxation in ageing and asthmatic airways.

Investigating epigenetic changes associated with dry age-related macular degeneration

Investigating the role of mesenchymal stem cell populations in the pathogenesis of systemic idiopathic juvenile arthritis

Modelling the cellular interactions within the lining of the synovial joint

Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects

The molecular biology of back pain

The role of bronchoconstriction induced oxidative damage, signalling and circadian clocks in smooth muscle remodelling in asthma and COPD

The role of oxidised microRNAs in pulmonary fibrosis

The role of neuromuscular junction (NMJ) degeneration in age-related loss of skeletal muscle mass and function

Understanding the biomechanics of evolutionary transitions in the fossil record: hard tissues and soft evidence