Photo of Prof Malcolm Jackson

Prof Malcolm Jackson BSc, PhD, DSc, FRCPath

Professor Musculoskeletal Biology II

    Research

    Skeletal muscle redox regulation and ageing

    Molecular and cellular physiology of oxidative stress and adaptation: Influences of nutrition, disease and ageing. Muscle group

    The effects of microgravity on skeletal muscle and responses to exercise.
    CIMA centre
    Research Grants

    Aquaporins: A hole in our understanding of ROS signalling

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    September 2019 - August 2022

    Microgravity as a model for accelerated skeletal muscle ageing

    UK SPACE AGENCY (UK)

    November 2018 - October 2021

    CIMA Centre Renewal

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2017 - May 2024

    Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice

    NATIONAL INSTITUTES OF HEALTH (NIH) (USA)

    September 2016 - August 2021

    Disruption of redox relays in the age-related failure of muscle responses to contractile activity

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2017 - March 2020

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    Gene editing of Age related Macular Degeneration risk factor in retinal pigment epithelial cells: could modulation of proteolytic control lead to new therapeutic interventions for Age related Macular Degeneration?

    MACULAR DISEASE SOCIETY (UK)

    November 2016 - November 2019

    Microgravity as a model for accelerated skeletal muscle ageing

    UK SPACE AGENCY (UK)

    October 2017 - April 2018

    Paraneoplastic neurological syndromes (PNS). Strengthening the European Network.

    EUROPEAN COMMISSION

    January 2006 - June 2009

    Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2013 - March 2016

    Site-specific failure of redox homeostasis as a cause of age-related loss of skeletal muscle mass and function

    MEDICAL RESEARCH COUNCIL (MRC)

    May 2008 - May 2011

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    CIMA centre capital equipment

    MEDICAL RESEARCH COUNCIL (MRC)

    April 2014 - May 2017

    The role of copper and zinc in osteoporosis.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    February 1997 - July 2001

    Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.

    RESEARCH INTO AGEING

    October 2001 - September 2006

    Molecular mechanisms of preservation of muscle with age by HSP70.

    EUROPEAN COMMISSION

    August 2002 - July 2004

    Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    August 2001 - July 2002

    European research on functional effects of dietary antioxydants (EUROFEDA).

    EUROPEAN COMMISSION

    January 2000 - December 2002

    Centre of Excellence in musculoskeletal ageing research (MRC CIMA)

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2012 - December 2017

    Value in People Award 2005.

    WELLCOME TRUST (UK)

    October 2005 - September 2009

    Correction of marginal dietary selenium intake and cancer risk in the UK.

    WORLD CANCER RESEARCH FUND (UK)

    October 2002 - April 2006

    Capacity building award in integrative mammalian biology

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2007 - October 2015

    Insulin resistance mediates age-related loss of muscle mass and function

    RESEARCH INTO AGEING

    February 2007 - February 2010

    Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols

    MEDICAL RESEARCH COUNCIL (MRC), THE ME ASSOCIATION (UK)

    September 2012 - April 2016

    Functional markers of selenium status in man (AN0545).

    MINISTRY AGRIC/FISHERIES/FOOD

    April 1998 - March 2001

    Angiotensin 11 blockade in the proximal renal tubular cell : mechanisms of injury, metabolism and renoprotection.

    MERSEY KIDNEY FIRST (UK)

    January 2001 - December 2007

    YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships

    WELLCOME TRUST (UK)

    October 2012 - June 2020

    Liverpool Imaging Partnership: Molecular physiology and drug response

    MEDICAL RESEARCH COUNCIL (MRC)

    February 2013 - February 2017

    Hydrogen peroxide generation regulates proximal tubular cell responses to excessive protein exposure.

    MERSEY KIDNEY FIRST (UK)

    January 2006 - December 2008

    Free radical generation by skeletal muscle: signals for adaptation to contractile activity?

    WELLCOME TRUST (UK)

    February 2001 - February 2004

    Selenium, immune status and viral handling.

    FOOD STANDARDS AGENCY (UK)

    January 2005 - September 2010

    New non-angiotensinII type 1 receptor-mediated mechanisms of inducing oxidative stress and modulating stress-related gene expression in renal proximal tubular cells implications for transplant patients with chronic allograft nephropathy.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    March 2007 - May 2007

    The role of heat shock proteins in ageing-related loss of muscle function.

    RESEARCH INTO AGEING

    April 1998 - April 2001

    A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.

    MINISTRY AGRIC/FISHERIES/FOOD

    April 1998 - May 2001

    Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2015 - January 2016

    Glutathione Metabolism in Muscle and Kidney in Severe Systemic Inflammation.

    WELLCOME TRUST (UK)

    August 1998 - September 2001

    Admin. and Secretarial Support to the NWCRF Sci.Comte.

    NORTH WEST CANCER RESEARCH FUND

    January 1990 - December 2019

    Protein overload, oxidative metabolism and the proximal tubules.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    April 2004 - November 2007

    Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2002 - February 2006

    Generation of reactive oxygen species by skeletal muscle mitochondria as a target for interventions to prevent age-related loss of muscle mass and function

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2011 - November 2013

    Cystatin C in age-related macular degeneration: mechanism of action and consequences on cellular processes.

    RESEARCH INTO AGEING

    October 2010 - December 2013

    Cross-Linked Actin Networks (CLANs). Are they a morphological fingerprint of trabecular meshwork cell malfunction in glaucoma that may be targeted as a new treatment direction?

    THE GUIDE DOGS FOR THE BLIND ASSOCIATION (UK)

    April 2006 - March 2009

    Translational research into Frailty for the benefit of Older People

    THE DOWAGER COUNTESS ELEANOR PEEL TRUST (UK)

    February 2009 - April 2012

    Novel renal proximal tubular pathways of injury: Angiotensin II induces fibrosis via Angiiotensin II receptors other than type I.

    MERSEY KIDNEY FIRST (UK)

    May 2007 - December 2010

    Assessment of individual variability in functional responses to selenium.

    FOOD STANDARDS AGENCY (UK)

    October 2001 - March 2003

    Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2014 - June 2014

    YEAR 1 Wellcome Trust ISSF Non-Clinical Fellowships

    WELLCOME TRUST (UK)

    October 2011 - May 2018

    Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    November 1998 - November 2001

    Wellcome VIP - Pearson

    WELLCOME TRUST (UK)

    May 2011 - August 2011

    A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    September 2011 - August 2014

    Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2011 - January 2015

    The effects of dietary selenium supplementation on depression in older subjects.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    November 2003 - July 2006

    Nitric oxide-superoxide interactions in the regulation of skeletal muscle adaptations and damage following contractile activity.

    WELLCOME TRUST (UK)

    January 2004 - October 2009

    Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2015 - June 2018

    Wellcome VIP Award - Victoria Kearns

    WELLCOME TRUST (UK)

    July 2011 - September 2011

    Research Collaborations

    Dr. Arlan Richardson/Dr. Holly Van Remmen

    External: University of Texas Health Science Center, San Antonio

    NIH-funded research into skeletal muscle aging

    Dr. John Faulkner/ Dr Susan Brooks

    External: University of Michigan

    NIH-funded research into skeletal muscle aging