Prof Malcolm Jackson BSc, PhD, DSc, FRCPath

Professor Musculoskeletal Biology II

    Research

    Research Interest 1

    Molecular and cellular physiology of oxidative stress and adaptation: Influences of nutrition, disease and ageing.

    Research Grants
    • Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles
    • Site-specific failure of redox homeostasis as a cause of age-related loss of skeletal muscle mass and function
    • University of Liverpool Institutional Discipline Bridging.
    • CIMA centre capital equipment
    • The role of copper and zinc in osteoporosis.
    • Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.
    • Molecular mechanisms of preservation of muscle with age by HSP70.
    • Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.
    • European research on functional effects of dietary antioxydants (EUROFEDA).
    • Centre of Excellence in musculoskeletal ageing research (MRC CIMA)
    • Value in People Award 2005.
    • Correction of marginal dietary selenium intake and cancer risk in the UK.
    • Capacity building award in integrative mammalian biology
    • Insulin resistance mediates age-related loss of muscle mass and function
    • Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols
    • Functional markers of selenium status in man (AN0545).
    • Angiotensin 11 blockade in the proximal renal tubular cell : mechanisms of injury, metabolism and renoprotection.
    • YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships
    • Liverpool Imaging Partnership: Molecular physiology and drug response
    • Hydrogen peroxide generation regulates proximal tubular cell responses to excessive protein exposure.
    • Free radical generation by skeletal muscle: signals for adaptation to contractile activity?
    • Selenium, immune status and viral handling.
    • New non-angiotensinII type 1 receptor-mediated mechanisms of inducing oxidative stress and modulating stress-related gene expression in renal proximal tubular cells implications for transplant patients with chronic allograft nephropathy.
    • The role of heat shock proteins in ageing-related loss of muscle function.
    • A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.
    • Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences
    • Glutathione Metabolism in Muscle and Kidney in Severe Systemic Inflammation.
    • Admin. and Secretarial Support to the NWCRF Sci.Comte.
    • Protein overload, oxidative metabolism and the proximal tubules.
    • Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.
    • Generation of reactive oxygen species by skeletal muscle mitochondria as a target for interventions to prevent age-related loss of muscle mass and function
    • Cystatin C in age-related macular degeneration: mechanism of action and consequences on cellular processes.
    • Cross-Linked Actin Networks (CLANs). Are they a morphological fingerprint of trabecular meshwork cell malfunction in glaucoma that may be targeted as a new treatment direction?
    • Translational research into Frailty for the benefit of Older People
    • Novel renal proximal tubular pathways of injury: Angiotensin II induces fibrosis via Angiiotensin II receptors other than type I.
    • Assessment of individual variability in functional responses to selenium.
    • Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging
    • YEAR 1 Wellcome Trust ISSF Non-Clinical Fellowships
    • Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?
    • Wellcome VIP - Pearson
    • A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing
    • Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly
    • The effects of dietary selenium supplementation on depression in older subjects.
    • Nitric oxide-superoxide interactions in the regulation of skeletal muscle adaptations and damage following contractile activity.
    • Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres
    • Wellcome VIP Award - Victoria Kearns
    Research Collaborations

    Dr. Arlan Richardson/Dr. Holly Van Remmen

    External: University of Texas Health Science Center, San Antonio

    NIH-funded research into skeletal muscle aging

    Dr. John Faulkner

    External: University of Michigan

    NIH-funded research into skeletal muscle aging


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