Photo of Prof Malcolm Jackson

Prof Malcolm Jackson BSc, PhD, DSc, FRCPath

Professor Musculoskeletal Biology II

    Research

    Skeletal muscle redox regulation and ageing

    Molecular and cellular physiology of oxidative stress and adaptation: Influences of nutrition, disease and ageing. Muscle group

    The effects of microgravity on skeletal muscle and responses to exercise.
    CIMA centre
    Research Grants
    • Aquaporins: A hole in our understanding of ROS signalling
    • Microgravity as a model for accelerated skeletal muscle ageing
    • CIMA Centre Renewal
    • Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice
    • Disruption of redox relays in the age-related failure of muscle responses to contractile activity
    • 2014 allocation - Wellcome ISSF non clinical fellowships
    • Gene editing of Age related Macular Degeneration risk factor in retinal pigment epithelial cells: could modulation of proteolytic control lead to new therapeutic interventions for Age related Macular Degeneration?
    • Microgravity as a model for accelerated skeletal muscle ageing
    • Paraneoplastic neurological syndromes (PNS). Strengthening the European Network.
    • Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles
    • Site-specific failure of redox homeostasis as a cause of age-related loss of skeletal muscle mass and function
    • University of Liverpool Institutional Discipline Bridging.
    • CIMA centre capital equipment
    • The role of copper and zinc in osteoporosis.
    • Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.
    • Molecular mechanisms of preservation of muscle with age by HSP70.
    • Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.
    • European research on functional effects of dietary antioxydants (EUROFEDA).
    • Centre of Excellence in musculoskeletal ageing research (MRC CIMA)
    • Value in People Award 2005.
    • Correction of marginal dietary selenium intake and cancer risk in the UK.
    • Capacity building award in integrative mammalian biology
    • Insulin resistance mediates age-related loss of muscle mass and function
    • Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols
    • Functional markers of selenium status in man (AN0545).
    • Angiotensin 11 blockade in the proximal renal tubular cell : mechanisms of injury, metabolism and renoprotection.
    • YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships
    • Liverpool Imaging Partnership: Molecular physiology and drug response
    • Hydrogen peroxide generation regulates proximal tubular cell responses to excessive protein exposure.
    • Free radical generation by skeletal muscle: signals for adaptation to contractile activity?
    • Selenium, immune status and viral handling.
    • New non-angiotensinII type 1 receptor-mediated mechanisms of inducing oxidative stress and modulating stress-related gene expression in renal proximal tubular cells implications for transplant patients with chronic allograft nephropathy.
    • The role of heat shock proteins in ageing-related loss of muscle function.
    • A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.
    • Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences
    • Glutathione Metabolism in Muscle and Kidney in Severe Systemic Inflammation.
    • Admin. and Secretarial Support to the NWCRF Sci.Comte.
    • Protein overload, oxidative metabolism and the proximal tubules.
    • Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.
    • Generation of reactive oxygen species by skeletal muscle mitochondria as a target for interventions to prevent age-related loss of muscle mass and function
    • Cystatin C in age-related macular degeneration: mechanism of action and consequences on cellular processes.
    • Cross-Linked Actin Networks (CLANs). Are they a morphological fingerprint of trabecular meshwork cell malfunction in glaucoma that may be targeted as a new treatment direction?
    • Translational research into Frailty for the benefit of Older People
    • Novel renal proximal tubular pathways of injury: Angiotensin II induces fibrosis via Angiiotensin II receptors other than type I.
    • Assessment of individual variability in functional responses to selenium.
    • Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging
    • YEAR 1 Wellcome Trust ISSF Non-Clinical Fellowships
    • Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?
    • Wellcome VIP - Pearson
    • A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing
    • Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly
    • The effects of dietary selenium supplementation on depression in older subjects.
    • Nitric oxide-superoxide interactions in the regulation of skeletal muscle adaptations and damage following contractile activity.
    • Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres
    • Wellcome VIP Award - Victoria Kearns
    Research Collaborations

    Dr. Arlan Richardson/Dr. Holly Van Remmen

    External: University of Texas Health Science Center, San Antonio

    NIH-funded research into skeletal muscle aging

    Dr. John Faulkner/ Dr Susan Brooks

    External: University of Michigan

    NIH-funded research into skeletal muscle aging