Photo of Dr Lesley Iwanejko

Dr Lesley Iwanejko PhD GDL BVC PGCertHE SFHEA

Senior Lecturer in Genetics Musculoskeletal Biology II

    Research

    Oxidative DNA Damage/Repair, the Circadian Clock and inflammaging in Sarcopenia and Inflammatory Lung Disease

    My background is in studying DNA damage and recombination, specifically in relation to ageing, specifically sarcopenia. I currently have projects investigating potential therapeutic targets and regimes in the recently identified signalling pathway that links repair of oxidative DNA damage by OGG1 and NFkB induced inflammation in both the lung and skeletal muscle.

    Research Grants

    Bench fees 201285405

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    October 2017 - September 2019

    Cloning and characterisation of enzymes required for the in vitro synthesis of the antimalarial artemisinin.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2002 - August 2003

    A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.

    MINISTRY AGRIC/FISHERIES/FOOD

    April 1998 - May 2001

    Sensing and the biological response in plants (SENSIBLE).

    EUROPEAN COMMISSION

    April 2006 - March 2010

    Research Collaborations

    Ann McArdle

    Project: Oxidative DNA damage and repair in sarcopenia.
    Internal

    CIMA funded project to study the role of 8oxoG:OGG1:NFkB signalling and myokine synthesis in sarcopenia in aged mouse models.

    Dr Daryl Shanley

    Project: Systems modelling oxidative DNA dmage, repair and myokine expression in sarcopenia
    External: University of Newcastle

    CIMA funded project to model the role of 8oxoG:OGG1:NFkB signalling and myokine synthesis in sarcopenia.

    Vanja Pekovich-Vaughan

    Project: Circadian Clock and Oxidative DNA Damage/Repair in Asthma and COPD
    Internal

    We are studying links between the Circadian Clock, repair oxidative DNA damage and inflammation in asthma and COPD.