Photo of Dr Kevin Hamill

Dr Kevin Hamill PhD

Senior Lecturer Eye and Vision Science

    Publications

    Selected Publications

    1. Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions. (Journal article - 2013)
    2. Fibronectin Expression Determines Skin Cell Motile Behavior (Journal article - 2012)
    3. Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrin. (Journal article - 2011)
    4. Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization. (Journal article - 2009)
    5. Alpha Actinin-1 Regulates Cell-Matrix Adhesion Organization in Keratinocytes: Consequences for Skin Cell Motility (Journal article - 2015)

    2019

    Development and validation of an inducible LaNt alpha 31 overexpressing mouse model (Conference Paper)

    Sugden, C. J., Troughton, L. D., Liu, K., Bou-Gharious, G., & Hamill, K. J. (2019). Development and validation of an inducible LaNt alpha 31 overexpressing mouse model. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A36-A37). Retrieved from http://gateway.webofknowledge.com/

    Application of SPF moisturisers is inferior to sunscreens in coverage of facial and eyelid regions (Journal article)

    Lourenco, E. A. J., Shaw, L., Pratt, H., Duffy, G. L., Czanner, G., Zheng, Y., . . . McCormick, A. G. (2019). Application of SPF moisturisers is inferior to sunscreens in coverage of facial and eyelid regions. PLOS ONE, 14(4). doi:10.1371/journal.pone.0212548

    DOI: 10.1371/journal.pone.0212548

    2018

    LaNt alpha 31, a novel regulator of basement membrane assembly (Conference Paper)

    Troughton, L. D., Iorio, V., Barrera, V., & Hamill, K. J. (2018). LaNt alpha 31, a novel regulator of basement membrane assembly. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A32-A33). Retrieved from http://gateway.webofknowledge.com/

    Differential Distribution of Laminin N-Terminus alpha 31 Across the Ocular Surface: Implications for Corneal Wound Repair (vol 59, pg 4082, 2018) (Journal article)

    Barrera, V., Troughton, L. D., Iorio, V., Liu, S., Oyewole, O., Sheridan, C. M., & Hamill, K. J. (2018). Differential Distribution of Laminin N-Terminus alpha 31 Across the Ocular Surface: Implications for Corneal Wound Repair (vol 59, pg 4082, 2018). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(11), 4463. doi:10.1167/iovs.18-24037a

    DOI: 10.1167/iovs.18-24037a

    A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma (Conference Paper)

    Troughton, L. D., Barrera, V., Brown, L., Zech, T., Willoughby, C. E., Risk, J. M., & Hamill, K. J. (2018). A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 138 (pp. S147). Retrieved from http://gateway.webofknowledge.com/

    The Relationship Between Mechanical Properties, Ultrastructural Changes, and Intrafibrillar Bond Formation in Corneal UVA/Riboflavin Cross-linking Treatment for Keratoconus (Journal article)

    Chang, S. -H., Mohammadvali, A., Chen, K. -J., Ji, Y. -R., Young, T. -H., Wang, T. -J., . . . Elsheikh, A. (2018). The Relationship Between Mechanical Properties, Ultrastructural Changes, and Intrafibrillar Bond Formation in Corneal UVA/Riboflavin Cross-linking Treatment for Keratoconus. JOURNAL OF REFRACTIVE SURGERY, 34(4), 264-+. doi:10.3928/1081597X-20180220-01

    DOI: 10.3928/1081597X-20180220-01

    2017

    Gene-based antiangiogenic applications for corneal neovascularization (Journal article)

    Liu, S., Romano, V., Steger, B., Kaye, S. B., Hamill, K. J., & Willoughby, C. E. (2018). Gene-based antiangiogenic applications for corneal neovascularization. SURVEY OF OPHTHALMOLOGY, 63(2), 193-213. doi:10.1016/j.survophthal.2017.10.006

    DOI: 10.1016/j.survophthal.2017.10.006

    Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF beta-2 (Conference Paper)

    Willoughby, C. E., Lester, K., Whysall, K., Choudhary, A., Hamill, K. J., & Sheridan, C. (2017). Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF beta-2. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from http://gateway.webofknowledge.com/

    UV imaging reveals facial areas that are prone to skin cancer are disproportionately missed during sunscreen application (Journal article)

    Pratt, H., Hassanin, K., Troughton, L. D., Czanner, G., Zheng, Y., McCormick, A. G., & Hamill, K. J. (2017). UV imaging reveals facial areas that are prone to skin cancer are disproportionately missed during sunscreen application. PLOS ONE, 12(10). doi:10.1371/journal.pone.0185297

    DOI: 10.1371/journal.pone.0185297

    2016

    LaNt alpha 31, a LAMA3 gene derived new protein, co-distributes with laminin in the extracellular matrix and induces early hemidesmosome maturation in corneal epithelial cells (Conference Paper)

    Iorio, V., Troughton, L. D., & Hamill, K. J. (2016). LaNt alpha 31, a LAMA3 gene derived new protein, co-distributes with laminin in the extracellular matrix and induces early hemidesmosome maturation in corneal epithelial cells. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A27-A28). Retrieved from http://gateway.webofknowledge.com/

    LaNt alpha 31: a new regulator of corneal epithelial cell migration (Conference Paper)

    Troughton, L. D., Iorio, V., Barrera, V., Sharif, U., & Hamill, K. J. (2016). LaNt alpha 31: a new regulator of corneal epithelial cell migration. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A28). Retrieved from http://gateway.webofknowledge.com/

    2015

    Mimicking the Extracellular Matrix The Intersection of Matrix Biology and Biomaterials (Book)

    Hudalla, G. H., & Murphy, W. L. (2015). Mimicking the Extracellular Matrix The Intersection of Matrix Biology and Biomaterials. Royal Society of Chemistry.

    LaNt alpha 31: a new regulator of corneal epithelial cell behaviour? (Conference Paper)

    Iorio, V., Troughton, L. D., & Hamill, K. J. (2015). LaNt alpha 31: a new regulator of corneal epithelial cell behaviour?. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 56. Retrieved from http://gateway.webofknowledge.com/

    Laminins: Roles and Utility in Wound Repair (Journal article)

    Iorio, V., Troughton, L. D., & Hamill, K. J. (2015). Laminins: Roles and Utility in Wound Repair. ADVANCES IN WOUND CARE, 4(4), 250-263. doi:10.1089/wound.2014.0533

    DOI: 10.1089/wound.2014.0533

    Alpha Actinin-1 Regulates Cell-Matrix Adhesion Organization in Keratinocytes: Consequences for Skin Cell Motility (Journal article)

    Hamill, K. J., Hiroyasu, S., Colburn, Z. T., Ventrella, R. V., Hopkinson, S. B., Skalli, O., & Jones, J. C. R. (2015). Alpha Actinin-1 Regulates Cell-Matrix Adhesion Organization in Keratinocytes: Consequences for Skin Cell Motility. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 135(4), 1043-1052. doi:10.1038/jid.2014.505

    DOI: 10.1038/jid.2014.505

    Lung-Specific Loss of alpha 3 Laminin Worsens Bleomycin-Induced Pulmonary Fibrosis (Journal article)

    Morales-Nebreda, L. I., Rogel, M. R., Eisenberg, J. L., Hamill, K. J., Soberanes, S., Nigdelioglu, R., . . . Budinger, G. R. S. (2015). Lung-Specific Loss of alpha 3 Laminin Worsens Bleomycin-Induced Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52(4), 503-512. doi:10.1165/rcmb.2014-0057OC

    DOI: 10.1165/rcmb.2014-0057OC

    2014

    Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair (Journal article)

    Hopkinson, S. B., Hamill, K. J., Wu, Y., Eisenberg, J. L., Hiroyasu, S., & Jones, J. C. (2014). Focal Contact and Hemidesmosomal Proteins in Keratinocyte Migration and Wound Repair. Adv Wound Care, 3(3), 247-263. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955972/

    2013

    A role for anti-BP180 autoantibodies in chronic rhinosinusitis. (Journal article)

    Jeffe, J. S., Seshadri, S., Hamill, K. J., Huang, J. H., Carter, R., Suh, L., . . . Tan, B. K. (2013). A role for anti-BP180 autoantibodies in chronic rhinosinusitis.. The Laryngoscope, 123(9), 2104-2111. doi:10.1002/lary.24016

    DOI: 10.1002/lary.24016

    Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions. (Journal article)

    Hamill, K. J., Hopkinson, S. B., Skalli, O., & Jones, J. C. R. (2013). Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(2), 546-556. doi:10.1096/fj.12-217406

    DOI: 10.1096/fj.12-217406

    Laminin-332 and α3β1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin. (Journal article)

    Kligys, K., Wu, Y., Hamill, K. J., Lewandowski, K. T., Hopkinson, S. B., Budinger, G. R. S., & Jones, J. C. R. (2013). Laminin-332 and α3β1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin.. American journal of respiratory cell and molecular biology, 49(5), 731-740. doi:10.1165/rcmb.2012-0509OC

    DOI: 10.1165/rcmb.2012-0509OC

    2012

    Fibronectin Expression Determines Skin Cell Motile Behavior (Journal article)

    Hamill, K. J., Hopkinson, S. B., Hoover, P., Todorović, V., Green, K. J., & Jones, J. C. R. (2012). Fibronectin Expression Determines Skin Cell Motile Behavior. Journal of Investigative Dermatology, 132(2), 448-457. doi:10.1038/jid.2011.297

    DOI: 10.1038/jid.2011.297

    2011

    Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing. (Journal article)

    Tsuruta, D., Hashimoto, T., Hamill, K. J., & Jones, J. C. R. (2011). Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing.. Journal of dermatological science, 62(1), 1-7. doi:10.1016/j.jdermsci.2011.01.005

    DOI: 10.1016/j.jdermsci.2011.01.005

    Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury. (Journal article)

    Urich, D., Eisenberg, J. L., Hamill, K. J., Takawira, D., Chiarella, S. E., Soberanes, S., . . . Jones, J. C. R. (2011). Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.. Journal of cell science, 124(Pt 17), 2927-2937. doi:10.1242/jcs.080911

    DOI: 10.1242/jcs.080911

    Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrin. (Journal article)

    Hamill, K. J., Hopkinson, S. B., Jonkman, M. F., & Jones, J. C. R. (2011). Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrin.. The Journal of biological chemistry, 286(30), 26768-26780. doi:10.1074/jbc.M110.203646

    DOI: 10.1074/jbc.M110.203646

    2010

    Adhesion and migration, the diverse functions of the laminin alpha3 subunit. (Journal article)

    Hamill, K. J., Paller, A. S., & Jones, J. C. R. (2010). Adhesion and migration, the diverse functions of the laminin alpha3 subunit.. Dermatologic clinics, 28(1), 79-87. doi:10.1016/j.det.2009.10.009

    DOI: 10.1016/j.det.2009.10.009

    2009

    BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities. (Journal article)

    Hamill, K. J., Hopkinson, S. B., DeBiase, P., & Jones, J. C. R. (2009). BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.. Molecular biology of the cell, 20(12), 2954-2962. doi:10.1091/mbc.E09-01-0051

    DOI: 10.1091/mbc.E09-01-0051

    Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization. (Journal article)

    Hamill, K. J., Langbein, L., Jones, J. C. R., & McLean, W. H. I. (2009). Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization.. The Journal of biological chemistry, 284(51), 35588-35596. doi:10.1074/jbc.M109.052811

    DOI: 10.1074/jbc.M109.052811

    Laminin deposition in the extracellular matrix: a complex picture emerges. (Journal article)

    Hamill, K. J., Kligys, K., Hopkinson, S. B., & Jones, J. C. R. (2009). Laminin deposition in the extracellular matrix: a complex picture emerges.. Journal of cell science, 122(Pt 24), 4409-4417. doi:10.1242/jcs.041095

    DOI: 10.1242/jcs.041095

    2008

    Fluorescently tagged laminin subunits facilitate analyses of the properties, assembly and processing of laminins in live and fixed lung epithelial cells and keratinocytes. (Journal article)

    Hopkinson, S. B., DeBiase, P. J., Kligys, K., Hamill, K., & Jones, J. C. R. (2008). Fluorescently tagged laminin subunits facilitate analyses of the properties, assembly and processing of laminins in live and fixed lung epithelial cells and keratinocytes.. Matrix biology : journal of the International Society for Matrix Biology, 27(7), 640-647. doi:10.1016/j.matbio.2008.06.003

    DOI: 10.1016/j.matbio.2008.06.003

    Hemidesmosomes and their Components: Adhesion versus Signaling in Health and Disease (Chapter)

    Kligys, K., Hamill, K., & Jones, J. C. R. (n.d.). Hemidesmosomes and their Components: Adhesion versus Signaling in Health and Disease. In Cell Junctions (pp. 109-133). Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002/9783527622092.ch6

    DOI: 10.1002/9783527622092.ch6

    2005

    The alpha-3 polypeptide chain of laminin 5: insight into wound healing responses from the study of genodermatoses. (Journal article)

    Hamill, K. J., & McLean, W. H. (2005). The alpha-3 polypeptide chain of laminin 5: insight into wound healing responses from the study of genodermatoses.. Clinical and experimental dermatology, 30(4), 398-404. doi:10.1111/j.1365-2230.2005.01842.x

    DOI: 10.1111/j.1365-2230.2005.01842.x

    The genetic basis of pachyonychia congenita. (Journal article)

    Smith, F. J. D., Liao, H., Cassidy, A. J., Stewart, A., Hamill, K. J., Wood, P., . . . McLean, W. H. I. (2005). The genetic basis of pachyonychia congenita.. The journal of investigative dermatology. Symposium proceedings, 10(1), 21-30. doi:10.1111/j.1087-0024.2005.10204.x

    DOI: 10.1111/j.1087-0024.2005.10204.x

    2004

    An unusual N-terminal deletion of the laminin  3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome (Journal article)

    McLean, W. H. I. (n.d.). An unusual N-terminal deletion of the laminin  3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome. Human Molecular Genetics, 13(3), 365. doi:10.1093/hmg/ddh031

    DOI: 10.1093/hmg/ddh031

    2003

    An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome. (Journal article)

    McLean, W. H. I., Irvine, A. D., Hamill, K. J., Whittock, N. V., Coleman-Campbell, C. M., Mellerio, J. E., . . . McGrath, J. A. (2003). An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome.. Human molecular genetics, 12(18), 2395-2409. doi:10.1093/hmg/ddg234

    DOI: 10.1093/hmg/ddg234