Dr Aphrodite Vasilaki BSc, PhD, FHEA

Senior Lecturer Musculoskeletal Biology II

    Publications

    2020

    Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice (Journal article)

    Bhaskaran, S., Pollock, N., Macpherson, P. C., Ahn, B., Piekarz, K. M., Staunton, C. A., . . . Van Remmen, H. (2020). Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. AGING CELL. doi:10.1111/acel.13225

    DOI: 10.1111/acel.13225

    Low protein intake during reproduction compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles (Journal article)

    Kanakis, I., Alameddine, M., Scalabrin, M., van't Hof, R. J., Liloglou, T., Ozanne, S. E., . . . Vasilaki, A. (2020). Low protein intake during reproduction compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles. The FASEB Journal. doi:10.1096/fj.202001131R

    DOI: 10.1096/fj.202001131R

    Low protein intake compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles (Journal article)

    Kanakis, I., Alameddine, M., Scalabrin, M., van ‘t Hof, R., Liloglou, T., Ozanne, S., . . . Vasilaki, A. (2020). Low protein intake compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles. doi:10.1101/2020.05.02.073759

    DOI: 10.1101/2020.05.02.073759

    Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration (Journal article)

    Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., . . . Castro, J. P. (2020). Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. REDOX BIOLOGY, 32. doi:10.1016/j.redox.2020.101507

    DOI: 10.1016/j.redox.2020.101507

    2019

    HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo (Journal article)

    Staunton, C. A., Owen, E. D., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2019). HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-51035-w

    DOI: 10.1038/s41598-019-51035-w

    Redox responses in skeletal muscle following denervation (Journal article)

    Vasilaki, A. (n.d.). Redox responses in skeletal muscle following denervation. Redox Biology.

    Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle (Conference Paper)

    Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2019). Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle. In FASEB JOURNAL Vol. 33. Retrieved from http://gateway.webofknowledge.com/

    Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells (Conference Paper)

    Pollock, N., Scalabrin, M., Staunton, C. A., Vasilaki, A., Van Remmen, H., Richardson, A., . . . Jackson, M. J. (2019). Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells. In FASEB JOURNAL Vol. 33. Retrieved from http://gateway.webofknowledge.com/

    Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system (Conference Paper)

    Jackson, M., McArdle, A., Pollock, N., Staunton, C., Stretton, C., & Vasilaki, A. (2019). Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 49 (pp. 46). Retrieved from http://gateway.webofknowledge.com/

    Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice (Journal article)

    Deepa, S. S., Van Remmen, H., Brooks, S. V., Faulkner, J. A., Larkin, L., McArdle, A., . . . Richardson, A. (2019). Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. Free Radical Biology and Medicine, 132, 19-23. doi:10.1016/j.freeradbiomed.2018.06.032

    DOI: 10.1016/j.freeradbiomed.2018.06.032

    2018

    Aberrant redox signaling in age-related muscle decline (Conference Paper)

    McArdle, A., Pollock, N., Staunton, C. A., Owen, E., Shigdar, S., Scalabrin, M., . . . Jackson, M. J. (2018). Aberrant redox signaling in age-related muscle decline. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 120 (pp. S13-S14). doi:10.1016/j.freeradbiomed.2018.04.059

    DOI: 10.1016/j.freeradbiomed.2018.04.059

    Redox responses to denervation in skeletal muscle (Conference Paper)

    Scalabrin, M., Pollock, N., McArdle, A., Jackson, M. J., & Vasilaki, A. (2018). Redox responses to denervation in skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 120 (pp. S36). doi:10.1016/j.freeradbiomed.2018.04.122

    DOI: 10.1016/j.freeradbiomed.2018.04.122

    CHARACTERISATION OF NF-KB ACTIVATION IN REGENERATING FIBRES OF OLD MICE (Conference Paper)

    Owen, E. D., Pollock, N., Jackson, M. J., Vasilaki, A., & McArdle, A. (2018). CHARACTERISATION OF NF-KB ACTIVATION IN REGENERATING FIBRES OF OLD MICE. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Do senescent cells drive the ageing phenotype of skeletal muscle in vivo? (Conference Paper)

    Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    EFFECT OF DENERVATION ON REDOX-REGULATION IN SKELETAL MUSCLE (Conference Paper)

    Scalabrin, M., Pollock, N., McArdle, A., Jackson, M. J., & Vasilaki, A. (2018). EFFECT OF DENERVATION ON REDOX-REGULATION IN SKELETAL MUSCLE. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Maternal Protein Restriction Mediates the Development of the Musculoskeletal System in the Offspring (Conference Paper)

    Vasilaki, A., Kanakis, I., Giakoumaki, I., Pollock, N., McArdle, A., Sayer, A. A., & Whysall, K. (2018). Maternal Protein Restriction Mediates the Development of the Musculoskeletal System in the Offspring. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Novel intravital assessment of muscle cytosol H(2)0(2) content supports a key role for motor unit remodelling in sarcopenia. (Conference Paper)

    Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2018). Novel intravital assessment of muscle cytosol H(2)0(2) content supports a key role for motor unit remodelling in sarcopenia.. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction (Conference Paper)

    Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle. (Journal article)

    Sakellariou, G. K., McDonagh, B., Porter, H., Giakoumaki, I. I., Earl, K. E., Nye, G. A., . . . Jackson, M. J. (2018). Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle.. Antioxidants and Redox Signaling, 28(4), 275-295. doi:10.1089/ars.2017.7249

    DOI: 10.1089/ars.2017.7249

    Age-related changes in skeletal muscle: changes to life-style as a therapy (Journal article)

    McCormick, R., & Vasilaki, A. (2018). Age-related changes in skeletal muscle: changes to life-style as a therapy. BIOGERONTOLOGY, 19(6), 519-536. doi:10.1007/s10522-018-9775-3

    DOI: 10.1007/s10522-018-9775-3

    2017

    Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging (Journal article)

    Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. J. (2017). Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging. FREE RADICAL BIOLOGY AND MEDICINE, 112, 84-92. doi:10.1016/j.freeradbiomed.2017.07.017

    DOI: 10.1016/j.freeradbiomed.2017.07.017

    Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing (Journal article)

    Vasilaki, A., Richardson, A., Van Remmen, H., Brooks, S. V., Larkin, L., McArdle, A., & Jackson, M. J. (2017). Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing. JOURNAL OF PHYSIOLOGY-LONDON, 595(20), 6409-6415. doi:10.1113/JP274336

    DOI: 10.1113/JP274336

    NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function (Conference Paper)

    Horton, N. S., Copple, I. M., Vasilaki, A., Jackson, M. J., McArdle, A., & Pekovic-Vaughan, V. (2017). NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 (pp. S48). doi:10.1016/j.freeradbiomed.2017.04.174

    DOI: 10.1016/j.freeradbiomed.2017.04.174

    Neuromuscular regeneration following whole muscle transplantation (Conference Paper)

    Pollock, N., Davis, C. S., Hassett, C. A., Staunton, C. A., Vasilaki, A., Jackson, M. J., . . . McArdle, A. (2017). Neuromuscular regeneration following whole muscle transplantation. In FASEB JOURNAL Vol. 31. Retrieved from http://gateway.webofknowledge.com/

    The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush. (Conference Paper)

    Staunton, C. A., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2017). The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.. In FASEB JOURNAL Vol. 31. Retrieved from http://gateway.webofknowledge.com/

    2016

    Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia? (Conference Paper)

    Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. J. (2016). Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S86-S87). doi:10.1016/j.freeradbiomed.2016.10.216

    DOI: 10.1016/j.freeradbiomed.2016.10.216

    The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice (Conference Paper)

    Staunton, C. A., Pollock, N., McCormick, R., Vasilaki, A., Barrett-Jolley, R., Jackson, M., & McArdle, A. (2016). The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S89). doi:10.1016/j.freeradbiomed.2016.10.222

    DOI: 10.1016/j.freeradbiomed.2016.10.222

    Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy (Journal article)

    Sakellariou, G. K., Pearson, T., Lightfoot, A. P., Nye, G. A., Wells, N., Giakoumaki, I. I., . . . McArdle, A. (2016). Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy. Scientific Reports, 6. doi:10.1038/srep33944

    DOI: 10.1038/srep33944

    Cellular mechanisms underlying oxidative stress in human exercise (Journal article)

    Jackson, M. J., Vasilaki, A., & McArdle, A. (2016). Cellular mechanisms underlying oxidative stress in human exercise. FREE RADICAL BIOLOGY AND MEDICINE, 98, 13-17. doi:10.1016/j.freeradbiomed.2016.02.023

    DOI: 10.1016/j.freeradbiomed.2016.02.023

    Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article)

    Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-x

    DOI: 10.1007/s00335-016-9643-x

    Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis (Journal article)

    McCormick, R., Pearson, T., & Vasilaki, A. (2016). Manipulation of environmental oxygen modifies reactive oxygen and nitrogen species generation during myogenesis. Redox Biology, 8, 243-251. doi:10.1016/j.redox.2016.01.011

    DOI: 10.1016/j.redox.2016.01.011

    The effect of lengthening contractions on neuromuscular junction structure in adult and old mice (Journal article)

    Vasilaki, A., Pollock, N., Giakoumaki, I., Goljanek-Whysall, K., Sakellariou, G. K., Pearson, T., . . . McArdle, A. (2016). The effect of lengthening contractions on neuromuscular junction structure in adult and old mice. AGE, 38(4), 259-272. doi:10.1007/s11357-016-9937-7

    DOI: 10.1007/s11357-016-9937-7

    Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle (Conference Paper)

    Jackson, M. J., Vasilaki, A., Pollock, N., Staunton, C., McDonagh, B., & McArdle, A. (2016). Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S13). doi:10.1016/j.freeradbiomed.2016.04.059

    DOI: 10.1016/j.freeradbiomed.2016.04.059

    Role of reactive oxygen species (ROS) in degeneration of ageing muscle (Conference Paper)

    Vasilaki, A., McArdle, A., & Jackson, M. (2016). Role of reactive oxygen species (ROS) in degeneration of ageing muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S8). doi:10.1016/j.freeradbiomed.2016.04.047

    DOI: 10.1016/j.freeradbiomed.2016.04.047

    Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage (Journal article)

    McDonagh, B., Scullion, S. M., Vasilaki, A., Pollock, N., McArdle, A., & Jackson, M. J. (2016). Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage. Free Radical Biology and Medicine, 94, 27-35. doi:10.1016/j.freeradbiomed.2016.02.008

    DOI: 10.1016/j.freeradbiomed.2016.02.008

    Effect of partial denervation mitochondrial ROS generation in skeletal muscle (Conference Paper)

    Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. (2016). Effect of partial denervation mitochondrial ROS generation in skeletal muscle. In FASEB JOURNAL Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    Maternal protein intake as a determinant of the total number of motor units and muscle fibres in mice (Conference Paper)

    Vasilaki, A., Glakoumaki, I., Pollock, N., Goljanek-Whysall, K., McArdle, A., & Sayer, A. A. (2016). Maternal protein intake as a determinant of the total number of motor units and muscle fibres in mice. In FASEB JOURNAL Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice (Conference Paper)

    Staunton, C. A., Pollock, N., Lightfoot, A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2016). The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice. In FASEB JOURNAL Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    2015

    Manipulation of Environmental Oxygen Modifies Reactive Oxygen Species Generation during Myogenesis (Conference Paper)

    McCormick, R., McArdle, A., Jackson, M., & Vasilaki, A. (2015). Manipulation of Environmental Oxygen Modifies Reactive Oxygen Species Generation during Myogenesis. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 86 (pp. S39-S40). doi:10.1016/j.freeradbiomed.2015.07.137

    DOI: 10.1016/j.freeradbiomed.2015.07.137

    Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype (Journal article)

    Sataranatarajan, K., Qaisar, R., Davis, C., Sakellariou, G., Vasilaki, A., Zhang, Y., . . . Van Remmen, H. (2015). Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype. Redox Biology, 5, 140-148. doi:10.1016/j.redox.2015.04.005

    DOI: 10.1016/j.redox.2015.04.005

    Does Manipulation of Environmental Oxygen Modify Reactive Oxygen (ROS) Species Generation During Myogenesis? (Conference Paper)

    McCormick, R., Jackson, M., McArdle, A., & Vasilaki, A. (2015). Does Manipulation of Environmental Oxygen Modify Reactive Oxygen (ROS) Species Generation During Myogenesis?. In FASEB JOURNAL Vol. 29. Retrieved from http://gateway.webofknowledge.com/

    Effect of Muscle Fiber Denervation on Mitochondrial Hydrogen Peroxide Generation in Adjacent Innervated Muscle Fibres: Role in Sarcopenia? (Conference Paper)

    Pollock, N., Vasilaki, A., McArdle, A., & Jackson, M. (2015). Effect of Muscle Fiber Denervation on Mitochondrial Hydrogen Peroxide Generation in Adjacent Innervated Muscle Fibres: Role in Sarcopenia?. In FASEB JOURNAL Vol. 29. Retrieved from http://gateway.webofknowledge.com/

    Effect of Resveratrol on Chemokine Induced Atrophy (Conference Paper)

    McCormick, R., Ford, C., Jackson, M., McArdle, A., & Vasilaki, A. (2015). Effect of Resveratrol on Chemokine Induced Atrophy. In FASEB JOURNAL Vol. 29. Retrieved from http://gateway.webofknowledge.com/

    In vivo Studies of Motor Nerve Re-growth in Adult and Old Mice Following Contraction-induced Injury (Conference Paper)

    Vasilaki, A., Sakellariou, G., Kayani, A., Jackson, M., & McArdle, A. (2015). In vivo Studies of Motor Nerve Re-growth in Adult and Old Mice Following Contraction-induced Injury. In FASEB JOURNAL Vol. 29. Retrieved from http://gateway.webofknowledge.com/

    2014

    Redox and epigenetic regulation of the APE1 gene in the hippocampus of piglets: The effect of early life exposures (Journal article)

    Langie, S. A. S., Kowalczyk, P., Tomaszewski, B., Vasilaki, A., Maas, L. M., Moonen, E. J., . . . Mathers, J. C. (2014). Redox and epigenetic regulation of the APE1 gene in the hippocampus of piglets: The effect of early life exposures. DNA Repair, 18, 52-62. doi:10.1016/j.dnarep.2014.03.011

    DOI: 10.1016/j.dnarep.2014.03.011

    Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. (Journal article)

    Sakellariou, G. K., Davis, C. S., Shi, Y., Ivannikov, M. V., Zhang, Y., Vasilaki, A., . . . Brooks, S. V. (2014). Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.. The FASEB Journal, 28(4), 1666-1681. doi:10.1096/fj.13-240390

    DOI: 10.1096/fj.13-240390

    Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases (Journal article)

    Sakellariou, G. K., Jackson, M. J., & Vasilaki, A. (2014). Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases. FREE RADICAL RESEARCH, 48(1), 12-29. doi:10.3109/10715762.2013.830718

    DOI: 10.3109/10715762.2013.830718

    Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases (Journal article)

    Sakellariou, G. K., Jackson, M. J., & Vasilaki, A. (2014). Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases. Free Radical Research, 48(1), 12-29. doi:10.3109/10715762.2013.830718

    DOI: 10.3109/10715762.2013.830718

    2013

    Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions (Journal article)

    Palomero, J., Vasilaki, A., Pye, D., McArdle, A., & Jackson, M. J. (2013). Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305(4), R351-R358. doi:10.1152/ajpregu.00530.2012

    DOI: 10.1152/ajpregu.00530.2012

    Role of reactive oxygen species in the defective regeneration seen in aging muscle (Journal article)

    Vasilaki, A., & Jackson, M. J. (2013). Role of reactive oxygen species in the defective regeneration seen in aging muscle. FREE RADICAL BIOLOGY AND MEDICINE, 65, 317-323. doi:10.1016/j.freeradbiomed.2013.07.008

    DOI: 10.1016/j.freeradbiomed.2013.07.008

    Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model (Journal article)

    Robinson, S. M., Mann, J., Vasilaki, A., Mathers, J., Burt, A. D., Oakley, F., . . . Mann, D. A. (2013). Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. JOURNAL OF HEPATOLOGY, 59(2), 318-326. doi:10.1016/j.jhep.2013.04.014

    DOI: 10.1016/j.jhep.2013.04.014

    Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity (Journal article)

    Sakellariou, G. K., Vasilaki, A., Palomero, J., Kayani, A., Zibrik, L., McArdle, A., & Jackson, M. J. (2013). Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity. ANTIOXIDANTS & REDOX SIGNALING, 18(6), 603-621. doi:10.1089/ars.2012.4623

    DOI: 10.1089/ars.2012.4623

    2012

    Tissue-dependent changes in oxidative damage with male reproductive effort in house mice (Journal article)

    Garratt, M., McArdle, F., Stockley, P., Vasilaki, A., Beynon, R. J., Jackson, M. J., & Hurst, J. L. (2012). Tissue-dependent changes in oxidative damage with male reproductive effort in house mice. FUNCTIONAL ECOLOGY, 26(2), 423-433. doi:10.1111/j.1365-2435.2011.01952.x

    DOI: 10.1111/j.1365-2435.2011.01952.x

    Tissue dependent changes in oxidative damage with male reproductive effort in house mice (Journal article)

    Garratt, M., McArdle, F., Stockley, P., Vasilaki, A., Beynon, R., Jackson, M. J., & Hurst, J. (2012). Tissue dependent changes in oxidative damage with male reproductive effort in house mice. Functional Ecology, 26, 423-433.

    Workshop report: Can an understanding of the mechanisms underlying age-related loss of muscle mass and function guide exercise and other intervention strategies? (Journal article)

    Jackson, M. J., McArdle, A., Vasilaki, A., & Kayani, A. (2012). Workshop report: Can an understanding of the mechanisms underlying age-related loss of muscle mass and function guide exercise and other intervention strategies?. Longevity & healthspan, 1, 5. doi:10.1186/2046-2395-1-5

    DOI: 10.1186/2046-2395-1-5

    2011

    Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase (Journal article)

    Sakellariou, G. K., Pye, D., Vasilaki, A., Zibrik, L., Palomero, J., Kabayo, T., . . . Jackson, M. J. (2011). Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. AGING CELL, 10(5), 749-760. doi:10.1111/j.1474-9726.2011.00709.x

    DOI: 10.1111/j.1474-9726.2011.00709.x

    Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase (Journal article)

    Sakellariou, G. K., Pye, D., Vasilaki, A., Zibrik, L., Palomero, J., Kabayo, T., . . . Jackson, M. J. (2011). Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. Aging Cell, 10(5), 749-760. doi:10.1111/j.1474-9726.2011.00709.x

    DOI: 10.1111/j.1474-9726.2011.00709.x

    Is oxidative stress a physiological cost of reproduction? An experimental test in house mice (Journal article)

    Garratt, M., Vasilaki, A., Stockley, P., McArdle, F., Jackson, M., & Hurst, J. L. (2011). Is oxidative stress a physiological cost of reproduction? An experimental test in house mice. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 278(1708), 1098-1106. doi:10.1098/rspb.2010.1818

    DOI: 10.1098/rspb.2010.1818

    Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase (Journal article)

    Sakellariou, G. K., Pye, D., Vasilaki, A., Zibrik, L., Palomero, J., Kabayo, T., . . . Jackson, M. J. (2011). Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. Aging Cell, 10, 749-760.

    2010

    The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase (Journal article)

    Vasilaki, A., van der Meulen, J. H., Larkin, L., Harrison, D. C., Pearson, T., Van Remmen, H., . . . McArdle, A. (2010). The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase. AGING CELL, 9(6), 979-990. doi:10.1111/j.1474-9726.2010.00635.x

    DOI: 10.1111/j.1474-9726.2010.00635.x

    The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase (Journal article)

    Vasilaki, A., van der Meulen, J. H., Larkin, L., Harrison, D. C., Pearson, T., Van Remmen, H., . . . McArdle, A. (2010). The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase. Aging Cell, 9(6), 979-990. doi:10.1111/j.1474-9726.2010.00635.x

    DOI: 10.1111/j.1474-9726.2010.00635.x

    2008

    Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappa B activation (Journal article)

    Brooks, S. V., Vasilaki, A., Larkin, L. M., McArdle, A., & Jackson, M. J. (2008). Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappa B activation. JOURNAL OF PHYSIOLOGY-LONDON, 586(16), 3979-3990. doi:10.1113/jphysiol.2008.155382

    DOI: 10.1113/jphysiol.2008.155382

    2007

    Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle (Journal article)

    Vasilaki, A., Simpson, D., McArdle, F., McLean, L., Beynon, R. J., Van Remmen, H., . . . Jackson, M. J. (2007). Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle. PROTEOMICS CLINICAL APPLICATIONS, 1(4), 362-372. doi:10.1002/prca.200600702

    DOI: 10.1002/prca.200600702

    Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle (Journal article)

    Vasilaki, A., Simpson, D., McArdle, F., McLean, L., Beynon, R. J., Van Remmen, H., . . . Jackson, M. J. (2007). Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle. PROTEOMICS – Clinical Applications, 1(4), 362-372. doi:10.1002/prca.200600702

    DOI: 10.1002/prca.200600702

    2006

    Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells (Journal article)

    Vasilaki, A., Csete, M., Pye, D., Lee, S., Palomero, J., McArdle, F., . . . Jackson, M. J. (2006). Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. FREE RADICAL BIOLOGY AND MEDICINE, 41(11), 1719-1725. doi:10.1016/j.freeradbiomed.2006.09.008

    DOI: 10.1016/j.freeradbiomed.2006.09.008

    Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. (Journal article)

    Vasilaki, A., Csete, M., Pye, D., Lee, S., Palomero, J., McArdle, F., . . . Jackson, M. J. (2006). Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells.. Free radical biology & medicine, 41(11), 1719-1725.

    Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age (Journal article)

    Vasilaki, A., McArdle, F., Iwanejko, L. M., & McArdle, A. (2006). Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age. MECHANISMS OF AGEING AND DEVELOPMENT, 127(11), 830-839. doi:10.1016/j.mad.2006.08.004

    DOI: 10.1016/j.mad.2006.08.004

    Glutathione-peroxidase-1 null muscle progenitor cells are globally defective (Journal article)

    Lee, S., Shin, H. S., Shireman, P. K., Vasilaki, A., Van Remmen, H., & Csete, M. E. (2006). Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. FREE RADICAL BIOLOGY AND MEDICINE, 41(7), 1174-1184. doi:10.1016/j.freeradbiomed.2006.07.005

    DOI: 10.1016/j.freeradbiomed.2006.07.005

    Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. (Journal article)

    Lee, S., Shin, H. S., Shireman, P. K., Vasilaki, A., Van Remmen, H., & Csete, M. E. (2006). Glutathione-peroxidase-1 null muscle progenitor cells are globally defective.. Free radical biology & medicine, 41(7), 1174-1184. doi:10.1016/j.freeradbiomed.2006.07.005

    DOI: 10.1016/j.freeradbiomed.2006.07.005

    HSF expression in skeletal muscle during myogenesis: Implications for failed regeneration in old mice (Journal article)

    McArdle, A., Broome, C. S., Kayani, A. C., Tully, M. D., Close, G. L., Vasilaki, A., & Jackson, M. J. (2006). HSF expression in skeletal muscle during myogenesis: Implications for failed regeneration in old mice. EXPERIMENTAL GERONTOLOGY, 41(5), 497-500. doi:10.1016/j.exger.2006.02.002

    DOI: 10.1016/j.exger.2006.02.002

    Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity (Journal article)

    Vasilaki, A., Mansouri, A., Van Remmen, H., van der Meulen, J. H., Larkin, L., Richardson, A. G., . . . Jackson, M. J. (2006). Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity. AGING CELL, 5(2), 109-117. doi:10.1111/j.1474-9726.2006.00198.x

    DOI: 10.1111/j.1474-9726.2006.00198.x

    2005

    Intracellular generation of reactive oxygen species by contracting skeletal muscle cells (Journal article)

    McArdle, F., Pattwell, D. M., Vasilaki, A., McArdle, A., & Jackson, M. J. (2005). Intracellular generation of reactive oxygen species by contracting skeletal muscle cells. FREE RADICAL BIOLOGY AND MEDICINE, 39(5), 651-657. doi:10.1016/j.freeradbiomed.2005.04.010

    DOI: 10.1016/j.freeradbiomed.2005.04.010

    Skeletal muscle damage with exercise and aging (Journal article)

    Close, G. L., Kayani, A., Vasilaki, A., & McArdle, A. (2005). Skeletal muscle damage with exercise and aging. SPORTS MEDICINE, 35(5), 413-427. doi:10.2165/00007256-200535050-00004

    DOI: 10.2165/00007256-200535050-00004

    2004

    Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice (Journal article)

    McArdle, F., Spiers, S., Aldemir, H., Vasilaki, A., Beaver, A., Iwanejko, L., . . . Jackson, M. J. (2004). Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice. JOURNAL OF PHYSIOLOGY-LONDON, 561(1), 233-244. doi:10.1113/jphysiol.2004.069914

    DOI: 10.1113/jphysiol.2004.069914

    Vitamin E and the oxidative stress of exercise (Journal article)

    Jackson, M. J., Khassaf, M., Vasilaki, A., McArdle, F., & McArdle, A. (2004). Vitamin E and the oxidative stress of exercise. VITAMIN E AND HEALTH, 1031, 158-168. doi:10.1196/annals.1331.015

    DOI: 10.1196/annals.1331.015

    2003

    Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle (Journal article)

    Khassaf, M., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., . . . Jackson, M. J. (2003). Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON, 549(2), 645-652. doi:10.1113/jphysiol.2003.040303

    DOI: 10.1113/jphysiol.2003.040303

    Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle (Journal article)

    Khassaf, M., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., . . . Jackson, M. J. (2003). Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. Journal of Physiology, 549(2), 645-652. doi:10.1113/jphysiol.2003.040303

    DOI: 10.1113/jphysiol.2003.040303

    Damage to developing mouse skeletal muscle myotubes in culture: protective effect of heat shock proteins (Journal article)

    Maglara, A. A., Vasilaki, A., Jackson, M. J., & McArdle, A. (2003). Damage to developing mouse skeletal muscle myotubes in culture: protective effect of heat shock proteins. The Journal of Physiology, 548(3), 837-846. doi:10.1111/j.1469-7793.2003.00837.x

    DOI: 10.1111/j.1469-7793.2003.00837.x

    Damage to developing mouse skeletal muscle myotubes in culture: protective effect of heat shock proteins (Journal article)

    Maglara, A. A., Vasilaki, A., Jackson, M. J., & McArdle, A. (2003). Damage to developing mouse skeletal muscle myotubes in culture: protective effect of heat shock proteins. JOURNAL OF PHYSIOLOGY-LONDON, 548(3), 837-846. doi:10.1113/jphysiol.2002.034520

    DOI: 10.1113/jphysiol.2002.034520

    Skeletal muscles of aged male mice fail to adapt following contractile activity (Journal article)

    Vasilaki, A., Iwanejko, L., McArdle, F., Broome, C. S., Jackson, M. J., & McArdle, A. (2003). Skeletal muscles of aged male mice fail to adapt following contractile activity. BIOCHEMICAL SOCIETY TRANSACTIONS, 31, 455-456. doi:10.1042/BST0310455

    DOI: 10.1042/BST0310455

    Skeletal Muscle Ageing (Chapter)

    Broome, C. S., Vasilaki, A., & McArdle, A. (2003). Skeletal Muscle Ageing. In R. Aspinall (Ed.), Aging of Organs and Systems (pp. 73-100). Netherlands: Kluwer Academic Publishers.

    2002

    Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity (Journal article)

    Vasilaki, A., Jackson, M. J., & McArdle, A. (2002). Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity. MUSCLE & NERVE, 25(6), 902-905. doi:10.1002/mus.10094

    DOI: 10.1002/mus.10094

    Exercise and skeletal muscle ageing: cellular and molecular mechanisms (Journal article)

    McArdle, A., Vasilaki, A., & Jackson, M. (2002). Exercise and skeletal muscle ageing: cellular and molecular mechanisms. AGEING RESEARCH REVIEWS, 1(1), 79-93. doi:10.1016/S0047-6374(01)00368-2

    DOI: 10.1016/S0047-6374(01)00368-2

    2001

    Contractile activity-induced oxidative stress: cellular origin and adaptive responses (Journal article)

    McArdle, A., Pattwell, D., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001). Contractile activity-induced oxidative stress: cellular origin and adaptive responses. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 280(3), C621-C627. Retrieved from http://gateway.webofknowledge.com/

    Contractile activity-induced oxidative stress: Cellular origin and adaptive responses (Journal article)

    McArdle, A., Pattwell, D., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001). Contractile activity-induced oxidative stress: Cellular origin and adaptive responses. American Journal of Physiology - Cell Physiology, 280(3 49-3). doi:10.1152/ajpcell.2001.280.3.c621

    DOI: 10.1152/ajpcell.2001.280.3.c621

    Contractile activity-induced oxidative stress: cellular origin and adaptive responses (Journal article)

    McArdle, A., Pattwell, D., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001). Contractile activity-induced oxidative stress: cellular origin and adaptive responses. Am J Physiol Cell Physiol, 280(3)(3), C621-C627.