Prof Anne McArdle BSc (Hons.) PhD

Professor Musculoskeletal Biology II

    Research

    Research Grants

    Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2013 - March 2016

    Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2011 - January 2015

    Centre of Excellence in musculoskeletal ageing research (MRC CIMA)

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2012 - December 2017

    Translational research into Frailty for the benefit of Older People

    THE DOWAGER COUNTESS ELEANOR PEEL TRUST (UK)

    February 2009 - April 2012

    Molecular mechanisms of preservation of muscle with age by HSP70.

    EUROPEAN COMMISSION

    August 2002 - July 2004

    Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2002 - February 2006

    Insulin resistance mediates age-related loss of muscle mass and function

    RESEARCH INTO AGEING

    February 2007 - February 2010

    Pilot Study to investigate the role of glutamine in the early protective stress response.

    INTENSIVE CARE SOCIETY (UK)

    July 2006 - July 2009

    Role of defective mitochondrial function in the loss of skeletal muscle and weakness that occurs in patients with chronic renal failure

    MERSEY KIDNEY FIRST (UK)

    June 2011 - November 2013

    Capacity building award in integrative mammalian biology

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2007 - October 2015

    Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols

    MEDICAL RESEARCH COUNCIL (MRC), THE ME ASSOCIATION (UK)

    September 2012 - April 2016

    Free radical generation by skeletal muscle: signals for adaptation to contractile activity?

    WELLCOME TRUST (UK)

    February 2001 - February 2004

    The role of heat shock proteins in ageing-related loss of muscle function.

    RESEARCH INTO AGEING

    April 1998 - April 2001

    Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    August 2001 - July 2002

    The role of heat shock proteins in glutamine-induced protection of skeletal muscle during sepsis.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2005 - December 2008

    The role of Heat Shock Factor activation in the age related failure of regeneration in skeletal muscles of old mice.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2006 - September 2009

    Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.

    RESEARCH INTO AGEING

    October 2001 - September 2006

    Are reactive oxygen species a mediator of skeletal muscle damage and weakness in IIM?

    THE MYOSITIS ASSOCIATION (TMA) (USA)

    January 2015 - December 2020

    Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2015 - June 2018