Mammary development and cancer
Embryonic lung development
Regulation of epithelial cell fate by HGF/SF
Regulation of cell fate by FGFs
Structure and function of the glycosaminoglycan heparan sulfate
Analysis of the assembly of molecular complexes
Optical biosensors, dual polarisation interferometry, quartz crystal microbalance-dissipation, reflection anisotropy spectroscopy.
Spectroscopic approaches to the solution structure of molecules
Fourier transform infra-red spectroscopy, phase modulated infra-red reflection anisotropy spectroscopy, synchrotron radiation circular dichroism, nmr.
Glycomics
Proteomics
Nanoscale science
Noble metal nanoparticles, synthesis of probes for single molecule biochemistry, biophysics and cell biology.
Magnetic nanoparticles and MRI for in vivo tracking of cell behaviour.
The laboratory is funded by BBSRC, EPSRC, European Union, Human Frontiers Science Programme, Cancer and Polio Research Fund, North West Cancer Research Fund