Enzymes used in Proteoglycan Biosynthesis



UDP-Glucose dehydrogenase
Glucuronyltransferase I
Heparan sulfate-glucuronyl/N-acetyl-glucosaminyl transferase
Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase
Glycosaminoglycan N-acetylglucosamine N-deacetylase/N-sulphotransferase 1
Glycosaminoglycan N-acetylglucosamine N-deacetylase/N-sulphotransferase 2
Heparan-sulfate Glucosaminyl 3-O-sulfotransferase
Heparan-sulfate 6-sulfotransferase
Glucuronyl C5-epimerase
Heparan-sulfate 2-sulfotransferase
Chondroitin 6-sulfotransferase
Keratan sulfate Gal-6-sulfotransferase
Possible keratan sulfate N-Acetylglucosamine-6-O-sulfotransferase
Hyaluronan synthase


UDP-Glucose dehydrogenase E.C.1.1.1.22
Human cDNA Spicer et al (1998) J. Biol. Chem. 273(39):25117-24
gb:AF061016
sw:O60701

Mouse cDNA Spicer et al (1998) J. Biol. Chem. 273(39):25117-24
gb:AF061017
sw:O70475

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Glucuronyltransferase I
Human cDNA Kitagawa (1998) J. Biol. Chem. 273(12):6615-8
gb:AB009598

Hamster cDNA Wei et al (1999) J. Biol. Chem.274(12):7857-64
gb:AF113703

Human cDNA Herman and Horvitz (1998) unpublished
gb:AJ005865

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Heparan sulfate-glucuronyl/N-acetyl-glucosaminyl transferase
Bovine cDNA Lind et al (1998) J. Biol. Chem. 273(41):26265-8
gb:AF089748
sw:O77783

Human EXT2 multiple exostoses tumor suppressor gene Stickens et al (1996) Nature Genet.14:25-32
gb:U62740
sw:Q93063

Human EXT2 multiple exostoses tumor suppressor gene Wuyts et al (1996) Hum. Mol. Genet. 5(10):1547-57
gb:U64511
sw:Q93063

Human EXT2 multiple exostoses tumor suppressor gene Clines et al (1997) Genome Res. 7(4):359-67
gb:U67837
exon1 exon2 exon3 exon4 exon5 exon6 exon7 exon8 exon9 exon10 exon11 exon12 exon13
sw:P70428

Human EXT2 multiple exostoses tumor suppressor gene Deng et al (1997) unpublished
gb:U72263
sw:O15288

Mouse EXT2 multiple exostoses tumor suppressor gene Clines et al (1996) unpublished Stickens et al (1996) unpublished
gb:U72141
sw:P70428

C. elegans homolog of EXT gene Clines et al (1997) Genome Res. 7(4):359-67

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Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase
Bovine cDNA Toma et al (1998) unpublished
gb:AF064825

Human/Mouse cDNA Aikawa and Esko (1999) J. Biol. Chem. 274(5):2690-5
gb:AF074924 gb:AF074926 gb:AF074925


Mouse cDNA Kusche-Gullberg et al (1998) J. Biol. Chem. 273(19):11902-7
gb:AF049894
sw:O70353

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Glycosaminoglycan N-acetylglucosamine N-deacetylase/N-sulphotransferase 1
Human cDNA Dixon et al (1995) Genomics 26:239-241
gb:U18918
sw:P52848
gb:U18932 (3'UTR)

Human cDNA LaBell et al (1994) unpublished
gb:U17970
sw:P52848

Human cDNA Humphries et al (1997) Biochem. J. 325(Pt 2):351-7
gb:U36600
sw:P52848

Rat cDNA Hashimoto et al (1992) J. Biol. Chem. 267:15744-15750
gb:M92042
sw:Q02353 (suhp_rat)

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Glycosaminoglycan N-acetylglucosamine N-deacetylase/N-sulphotransferase 2
Murine cDNA Orellana et al (1994) J. Biol. Chem. 269:2270-2276
gb:U02304
sw:P52850

Murine cDNA Eriksson et al (1994) J. Biol. Chem. 269:10438-10443
gb:X75885
sw:P52850

Human cDNA Humphries et al (1998) Biochem. J. 332:303-7
gb:U36601
sw:P52849

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Heparan-sulfate Glucosaminyl 3-O-sulfotransferase E.C.2.8.2.23
Human cDNA Shworak et al (1997) J. Biol. Chem. 272(44):28008-19
gb:AF019386
sw:O14792

Mouse cDNA Shworak et al (1997) J. Biol. Chem. 272(44):28008-19
gb:AF019385
sw:O35310

Human cDNA Shworak et al (1999)J Biol Chem. 274(8):5170-84
gb:AF105374, AF105375, AF105376, AF105377, and AF105378.

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Heparan-sulfate 6-sulfotransferase
Human cDNA Habuchi et al (1998) J. Biol. Chem. 273(15):9208-13
gb:AB006179
sw:O60243

Hamster partial cDNA Habuchi et al (1998) J. Biol. Chem. 273(15):9208-13
gb:AB006180
sw:O70158

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Glucuronyl C5-epimerase
Bovine cDNA Li et al (1997) J. Biol. Chem. 272(44):28158-63
gb:AF003927
sw:O18756

Human cDNA Nagase et al (1998) DNA Res. 5:355-64
gb:AB020643

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Heparan-sulfate 2-sulfotransferase
Hamster cDNA Kobayashi et al (1997) J. Biol. Chem. 272(21):13980-5
gb:D88811
sw:O08889

Mouse cDNA Bullock et al (1998) Genes Dev. 12(12):1894-906
gb:AF060178
sw:O88464

Human cDNA Seki et al (1997) DNA Res. 4(5):345-9
gb:AB007917
sw:O75036

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Chondroitin 6-sulfotransferase E.C.2.8.2.17
Human cDNA Tsutsumi et al (1998) FEBS 441:235-41
gb:AB017915

Human cDNA Mazany et al (1998) Biochim. Biophys. Acta 1407(1):92-7
gb:U65637
sw:O43916

Human cDNA Fukuta et al (1998) Biochim. Biophys. Acta 1399(1):57-61
gb:AB012192
sw:O75099

Mouse cDNA Uchimura et al (1998) Glycobiology 8(5):489-96
gb:AB008937
sw:O88199
gb:AB008938

Chicken cDNA Fukuta et al (1995) J. Biol. Chem. 270:18575-18580
gb:D49915
sw:Q92179

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Keratan sulfate Gal-6-sulfotransferase
Human cDNA Fukuta et al (1997) J. Biol. Chem. 272(51):32321-8
gb:AB003791
sw:O43916

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Possible keratan sulfate N-Acetylglucosamine-6-O-sulfotransferase
Mouse cDNA Uchimura et al (1998) J. Biol. Chem. 273(35):22577-83
gb:AB011451
gb:Ab011452
sw:O88276

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Hyaluronan synthase
Mouse cDNA Itano and Kimata (1996) J. Biol. Chem 271(17):9875-8
gb:D82964
sw:Q61647

Mouse cDNA Fulop et al (1997) Arch. Biochem. Biophys. 337(2):261-6
gb:U69695
sw:P70312

Mouse cDNA promoter Yamada et al (1998) Biochem. J. 330:1223-7
gb:AB005226

Mouse cDNA promoter 3' flanking region Yamada et al (1998) Biochem. J. 330:1223-7
gb:AB005227

Mouse cDNA Spicer et al (1996) J. Biol. Chem. 271(38):23400-6
gb:U52524
sw:P70312

Human cDNA Shyjan et al (1996) J. Biol. Chem.271(38):23395-9
gb:U59269
sw:Q92839

Human cDNA Itano and Kimata (1996) Biochem. Biophys. Res. Commun. 222:816-20
gb:D84424
sw:Q14470

Group C Streptococcus equisimilis cDNA Kumari and Weigel (1997) J. Biol. Chem. 272(51):32539-46
gb:AF023876
sw:O50201

Pasteurella multocida cDNA DeAngelis et al (1998) J. Biol. Chem. 273(14):8454-8
gb:AF036004
sw:O68389


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Go to:

  • C. elegans database Sanger
  • Top Page, Guide to Cloned Glycosyltransferases
  • GalNAc transferases
  • GlcNAc transferases
  • GlcNAc-1-P transferases
  • Fuc transferases
  • Gal transferases
  • Glc transferases
  • glucuronyltransferases
  • Man transferases
  • oligosaccharyltransferases
  • NeuAc transferases
  • GPI transferases or other genes required for GPI biosynthesis
  • Prokaryotic glycosyltransferases
  • Further references
    •
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    This guide was written by Iain Wilson, Institut für Chemie der Universität für Bodenkultur, Gregor-Mendel-Straße 33, Wien. Revised 5. March 1999 by Monica Barclay. Copyright 1996.