Papers in  Peer-Reviewed Journals:


Thornton S, Coupland SE, Olohan L, Sibbring JS, Kenny JG, Hertz-Fowler C, Liu X, Haldenby S, Heimann H, Hussain R, Kipling N, Taktak A, Kalirai H. (doi: 10.3390/cancers12041039)

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma. Cancers (Basel). 12(4). pii: E1039. (2020)


Damato B, Eleuteri A, Hussain R, Kalirai H, Thornton S, Taktak A, Heimann H, Coupland SE. (doi: 10.1167/iovs.61.4.35)

Parsimonious Models for Predicting Mortality from Choroidal Melanoma. Invest Ophthalmol Vis Sci. 61(4):35. (2020)


Cunha Rola A, Taktak A, Eleuteri A, Kalirai H, Heimann H, Hussain R, Bonnett LJ, Hill CJ, Traynor M, Jager MJ, Marinkovic M, Luyten GPM, Dogrusöz M, Kilic E, de Klein A, Smit K, van Poppelen NM, Damato BE, Afshar A, Guthoff RF, Scheef BO, Kakkassery V, Saakyan S, Tsygankov A, Mosci C, Ligorio P, Viaggi S, Le Guin CHD, Bornfeld N, Bechrakis NE, Coupland SE. (doi: 10.3390/cancers12020477)

Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study. Cancers (Basel); 12(2). pii: E477 (2020)


Hussain R, Czanner G, Taktak A, Damato B, Praidou A, Heimann H.  (DOI: 10.1097/IAE.0000000000002763)

Mortality of patients with uveal melanoma detected by diebetic retinopathy screening.  Retina.  [Epub ahead of print] (2020)


Thornton S, Coupland SE, Heimann H, Hussain R, Groenewald C, Kacperek A, Damato B, Taktak A, Eleuteri A, Kalirai H.  (doi: 10.1136/bjophthalmol-2019-315363)

Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis. Br J Ophthalmol. [Epub ahead of print] (2020)


Kenawy N, Kalirai H, Sacco JJ, Lake SL, Heegaard S, Larsen AC, Finger PT, Milman T, Chin K, Mosci C, Lanza F, Moulin A, Schmitt CA, Caujolle JP, Maschi C, Marinkovic M, Taktak AF, Heimann H, Damato BE, Coupland SE.

(doi: 10.1111/pcmr.12767)

Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome. Pigment, Cell and Melanoma Research, Epub (2019)


A. Eleuteri, A.F.G. Taktak, S.E. Coupland, H. Heimann, H. Kalirai, B.E. Damato (doi: 10.1016/j.compbiomed.2018.09.024)

Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. Computers in Biology and Medicine, Epub (2018)


N. Farquhar, S. Thornton, S. E. Coupland, J. M. Coulson, J. J. Sacco, Y. Krishna, H. Heimann, A. Taktak, C. M. Cebulla, M. H. Abdul-Rahman, H. Kalirai (doi: 10.1002/cjp2.86)

Patterns of BAP1 protein expression provide insight into prognostic significance and the biology of uveal melanoma The Journal of Pathology: Clinical Research, pp 1-13, Online publication (2017).


M. Angi, H. Kalirai, A. Taktak, R. Hussain, C. Groenewald, B. E. Damato, H. Heimann, S. E. Coupland (doi: 10.1136/bjophthalmol-2017-310361)

Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach British Journal of Ophthalmology, 101, 8, 1143-1146 (2017).


S. E. Coupland, A. Taktak, B. E. Damato (doi: 10.1001/jamaophthalmol.2017.1391)

Incorporating clinical, histological, and genetic parameters for choroidal melanoma prognostication JAMA Ophthalmology, 135, 7, 818-819 (2017).


J. E. Medcalf, C. P. Johnson, A. Taktak, S. Grabherr (doi: 10.1007/s12024-016-9819-4)

Variation in the anatomy of vertebral artery cervical loop segment - a potential predisposing factor for traumatic basal subarachnoid hemorrhage? Forensic Sci Med Pathol, 12 444-450 (2016).


S. W. DeParis, A. Taktak, A. Eleuteri, W. Enanoria, H. Heimann, S. E. Coupland, B. E. Damato (doi: 10.1167/iovs.16-19654)

External validation of the Liverpool uveal melanoma progonsticator online, Invest Ophthalmol Vis Sci, 57 6116-6122 (2016).


L. Ireland, A. Santos, M. S. Ahmed, C. Rainer, S. R. Nielsen, V. Quaranta, U. Weyer-Czernilofski, D. D. Engle, P. A. Perez-Mancera, , S. E. Coupland, A. Taktak, T. Bogenrieder, D. A. Tuveson, F. Campbell, M. C. Schmid, A. Mielgo (doi: 10.1158/0008-5472.CAN-16-1201)

Chemoresistence in pancreatic cancer is driven by stroma-derived insulin-like growth factors, Cancer Research, 76, 23 (2016).


S. Middle, S. E. Coupland, A. Taktak, V. Kidgell, J. Slupsky, A. R. Pettitt, K. J. Till (doi: 10.1186/s40164-015-0004-3)

Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins, Experimental Hematology & Oncology, 4, 10 (2015) 


R. Caines, A. Eleuteri, H. Kalirai, A.C. Fisher, H. Heimann, B.E. Damato, S.E. Coupland, A.F.G. Taktak (Link)

Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma, Molecular Vision, 21, 1-11 (2015) 


A.F.G. Taktak (Link)

Medical signal and information processing. Int J Biomedical Engineering and Technology; Editorial. 13, 4, 301-302 (2013).


S.L. Lake, B. E. Damato, H. Kalirai, A.R. Dodson, A.F.G. Taktak, B.H. Lloyd, S.E. Coupland (doi: 10.1016/j.ajpath.2012.11.036)

Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival, Am J Path, 182, 3, 678-687 (2013).


O.K. Idowu, Q. Ding, A.F.G. Taktak, C.R. Chandrasekar, Q. Yin (doi:10.3109/1354750X.2012.699554)

Clinical implication of pre-treatment Nuetrophil lymphocyte ratio in soft tissue sarcoma, Biomarkers, 17,6, 539-544 (2012).


F. Jmor, H. Kalirai, A.F.G. Taktak, B. E. Damato, S.E. Coupland (doi: 10.1111/j.1755-3768.2010.02038.x

HSP-27 protein expression in uveal melanoma: correlation with survival, Acta Ophthalmologica, 90,6, 534-539 (2012).


A. Eleuteri, B.E. Damato, S.E. Coupland, A.F.G. Taktak (Link)

Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. Int J Biomedical Engineering and Technology, 8,1, 18-35 (2012). 


S.L. Lake, F. Jmor, J. Dopierala, A.F.G. Taktak, S.E. Coupland, B. E. Damato (doi: 10.1167/iovs.10-6934)

Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600 gene mutation and gene copy number changes. Invest Ophthalmol Vis Sci, 52,8 5598-5604 (2011).


S.L. Lake, B.E. Damato, J. Dopierala, M.M. Baudo, A.F.G. Taktak, S.E. Coupland (doi: 10.1167/iovs.10-6845)

Multiplex ligation-dependent probe amplification analysis of uveal melanoma with extraocular extension demonstrates heterogeneity of gross chromosomal abnormalities. Invest Ophthalmol Vis Sci, 52,8, 55595564 (2011).


B.E. Damato, A. Eleuteri, A.F.G. Taktak, S.E. Coupland (doi: 10:1016/j.preteyeres.2011.05.003)

Estimating prognosis for survival after treatment of choroidal melanoma. Prog Retin Eye Res, 30,5, 285-295 (2011).


S. Harigopal, H.P. Satish, A.F.G. Taktak, K.W.Southern, N.J. Shaw (doi: 10.1136/adc.2010.191437)

Oxygen saturation profiles in healthy preterm infants. Archives of Disease in Childhood Fetal and Neonatal Edition, 96,5, F339-F342 (2011).


M. Angi, B. Damato, H. Kalirai, A. Dodson, A. Taktak, S. Coupland (doi: 10.1111/j.1755-3768.2009.01769.x)

Immunohistochemical assessment of mitotic count in uveal melanoma. Acta Ophtalmologica, 89, e155-e160 (2011)


J. Dopierala, B.E. Damato, S.L. Lake, A.F.G. Taktak, S.E. Coupland (doi: 10.1167/iovs.09-5004)

Heterogeneity of genetic abnormalities in uveal melanoma assessed by multiplex ligation-dependent probe amplification. Invest Ophthalmol Vis Sci. 51,10, 4898-4905 (2010).


S.L. Lake, S.E. Coupland, A.F.G. Taktak and B.E. Damato. (doi:10.1167/iovs.09-5083)

Whole genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma. Invest Ophthalmol Vis Sci. 51,10, 4884-4891 (2010).


R.N.G. Naguib, A.F.G. Taktak (Link)

Decision support in Medicine. Int J Biomedical Engineering and Technology; Editorial. 3, 3/4, 209-211 (2010)


P.J.G. Lisboa, T.A. Etchells, I.H. Jarman, C.T. Arsene, M.S. Aung, A. Eleuteri, A.F.G. Taktak, F. Ambrogi, P. Boracchi, E. Biganzoli

( doi:10.1109/TNN.2009.2023654)

Partial logistic artificial neural network for competing risks regularized with automatic relevance determination. IEEE Transactions on Neural Networks, 20,9, 1403-1416 (2009)


A.F.G. Taktak, A. Eleuteri, M.H. Aung, P.J.G.  Lisboa, L. Desjardins, B.E. Damato

Survival analysis in cancer using partial logistic neural network model with Bayesian regularisation framework: a validation study. Int J Knowledge Engineering and Soft Data Paradigms, 1,3, 277-295 (2009) 


B.E. Damato, A. Eleuteri, A.C. Fisher, S.E. Coupland and A.F.G. Taktak ( doi:10.1016/j.ophtha.2008.01.032)

Artificial neural networks estimating survival probability after treatment of choroidal melanoma. Ophthalmology, 115,9, 1598 - 1607 (2008)


A.F.G. Taktak, A. Eleuteri, S.P. Lake, A.C. Fisher (doi:10.1016/j.compbiomed.2008.04.005)

A web-based tool for the assessment of discrimination and calibration properties of prognostic models. Computers in Biology and Medicine, 38,7, pp 785-791 (2008)


A. Taktak, L. Antolini, M. Aung, P. Boracchi, I. Campbell, B. Damato, E. Ifeachor, N. Lama, P. Lisboa, C. Setzkorn, V. Stalbovskaya, E. Biganzoli (doi:10.1016/j.compbiomed.2006.10.001)

Double-blind evaluation and benchmarking of survival models in a multi-centre study. Computers in Biology and Medicine, 37, pp 1108-1120 (2007)


C.Setzkorn, A. Taktak, B. Damato (doi:10.1016/j.biosystems.2006.03.002

On the use of multi-objective evolutionary algorithms for survival analysis. Biosystems, 87,1, pp 31-48 (2007)


A.C. Fisher, A.F.G. Taktak, R.P. Hagan, M.C. Brown (doi:10.1007/s10633-006-9000-6)

Automated post hoc removal of power-line and frame-pulse contamination from retinal and cortical evoked potentials (EPs). Documenta Ophthalmologica, 112, 169-175 (2006)


P.J.G. Lisboa, A.F.G. Taktak (doi:10.1016/j.neunet.2005.10.007)

The use of artificial neural networks in decision support in cancer: A Systematic Review. Neural Networks, 19, pp 408-415 (2006).


A.S. Jones, A.F.G. Taktak, T.R. Helliwell, J.E. Fenton, M.A. Birchall, D.J. Husband and A.C. Fisher (doi:10.1007/s00405-006-0021-2)

An artificial neural network improves prediction of observed survival in patients with laryngeal squomous carcinoma. European Archives of Oto-Rhino-Laryngology, 263, pp 541-547 (2006).


S.Y. Belal, A.F.G. Taktak, A. Nevill and A. Spencer (doi: 10.1088/0967-3334/26/4/019)

An intelligent ventilation and oxygenation management system in neonatal intensive care using fuzzy trend template fitting. Physiological Measurement, 26, pp 555-570 (2005).


A.F.G. Taktak, A.C. Fisher and B.E. Damato (doi: 10.1088/0031-9155/49/1/006)

Modelling survival after treatment of intraocular melanoma using artificial neural networks and Bayes theorem. Physics in Medicine and Biology, 49,1, pp 87 – 98 (2004).


S. Belal, A. Taktak, A. Nevill, S. Spencer, D. Roden and S. Bevan (doi:10.1016/S0933-3657(01)00099-9)

Automatic detection of distorted plethysmogram pulses in neonates and paediatric patients using an adaptive-network-based fuzzy inference system. Artificial Intelligence in Medicine, 24, pp 149-165 (2002).


S. Belal, A. Taktak, A. Nevill, S. Spencer (doi: 10.1088/0967-3334/22/2/311)

A fuzzy system for detecting distorted plethysmogram pulses in neonates and paediatric patients. Physiological Measurement, 22, 2, pp397-412 (2001).


A. Taktak, S. Simpson, S. Patel, G. Meyer (doi: 10.1088/0967-3334/21/3/401)

Neural networks analysis of oxygenation signals in infants during sleep. Physiological Measurement, 21, 3, pp N11-N22, (2000).


A. Taktak, P. Record, R. Gadd, P. Rolfe (doi:10.1016/1350-4533(95)00086-0)

Data recovery from reduced electrode connection in electrical impedance tomography. Medical Engineering & Physics, 18, 6, pp 519-522 (1996).


A. Taktak, A. Spencer, P. Record, R. Gadd, P. Rolfe (doi:10.1016/0378-3782(95)01700-3)

Feasibility of neonatal lung monitoring using electrical impedance tomography. Early Human Development, vol 44, issue 2,  pp 131-138 (1996).


P. Record, A. Taktak

Reproducibility of EIT images in vivo. Medical & Biological Engineering & Computing; Editorial, 34, 5, p 344, (1996).


A. Taktak, P. Record, R. Gadd, P. Rolfe

Interface impedance measurements of paediatric electrodes. Innovation et Technologie en Biologie et Medicine, 16, 2, pp 126-135 (1995).


A. Taktak, P. Record, R. Gadd, P. Rolfe

Practical factors in neonatal lung imaging using electrical impedance tomography. Medical & Biological Engineering & Computing, 33 pp 202-205 (1995).



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