Dr Dorina Timofte DVM PhD MRCVS ECVM Diplomate

Senior Lecturer in Veterinary Clinical Microbiology Veterinary Pathology and Public Health

    Research

    Surveillance of multidrug-resistant pathogens and molecular mechanisms of antimicrobial resistance in clinical isolates from companion animals

    Current research includes molecular epidemiology of antimicrobial resistance (AMR) in man and companion animals and in particular, antimicrobial resistance mechanisms in Enterobacteriaceae. Rare or unusual clinical isolates obtained from the diagnostic resource are also investigated and used for publication as “case reports” or as part of epidemiological studies to determine the spread and severity of AMR.

    As a result of my research activity in this field, I am an Associate Member of the Dept of Infection Biology, Institute of Infection and Global Health.

    Implementing detection of carbapenamase-producing Gram-negative bacteria in Romanian hospitals

    My veterinary work has now extended into surveillance of AMR in man, with a special focus on hospital acquired infection in Romanian hospitals.

    Much of the knowledge exchange I deliver from my research activities is detailed in the previous section and needs no repetition.

    A very important development of the Liverpool-Iasi link has led to me becoming a Romanian Government advisor to develop programmes to reduce antimicrobial resistance development in Romania where it is a very severe threat, as in many other developing countries. I am a founder member of a Romanian Health Department Working Group which is developing national guidelines for surveillance of carbapenem-resistant Gram-negative bacteria (CRGNB) in Romanian hospitals. This group is focused on the implementation of a national surveillance system to rapidly identify infected or colonized patients and allow implementation of appropriate infection control measures to prevent further AMR spread within hospitals.

    Infection control in veterinary hospitals


    Research Grants

    Resistance of canine Staphylococcus pseudintermedius to selected topical and systemic antimicrobials in the UK

    PETSAVERS (UK)

    April 2017 - May 2019

    The emerging problem of antimicrobial resistance in equines: Investigating carriage and infections with multidrug resistant bacteria in horses

    THE HORSE TRUST (UK)

    August 2016 - March 2020

    Molecular characterisation of Extended Spectrum β-lactamase-producing Enterobacteriaceae in broiler chickens and abattoir workers in Romania

    BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)

    September 2012 - February 2013

    Implementing detection of carbapenemase producing Enterobacteriaceae and nonfermentative bacteria in Romanian hospitals – learning from the western experience

    SOCIETY FOR GENERAL MICROBIOLOGY

    June 2014 - September 2015

    Detection of ESBL and MRSA – technology transfer to diagnostic laboratories in Romania

    SOCIETY FOR GENERAL MICROBIOLOGY

    June 2012 - April 2013

    Research Collaborations

    Dr Nicolle Stoesser, Prof. Derreck Crook

    Project: Using Whole Genome Sequencing in deciphering the diversity of NDM-1 plasmids in a Serratia marcescens outbreak at a single hospital in Romania
    External: Nuffield Department of Medicine, University of Oxford


    Prof. Luca Guardabassi, Dr Carmen Espinosa

    Project: PREscriber Perspectives on Antibiotic use and Resistance Education in Europe –A joint European Research project
    External: PREPARE-VET group

    A joint European Research project-which aims to identify specific unmet needs in undergraduate education on appropriate antibiotic prescribing through surveying students from veterinary schools across Europe

    Dr Linda Falgenhauer, Prof. Dr. Trinad Chakraborty.

    Project: Antimicrobial resistance in ST410 CTX-M-15-producing E. coli isolates from Germany and UK
    External: Institute of Medical Microbiology,Justus Liebig University Giessen, Germany

    Characterisation of antimicrobial resistance in ST410 CTX-M-15-producing E. coli isolates from Germany and UK from dogs by whole genome sequencing

    Prof. Nicola Williams; Dr. Gina Pinchbeck

    Project: Surveillance of antimicrobial resistance in animal pathogens, infection control and molecular epidemiology of multidrug-resistant pathogens
    Internal

    Co-supervision of PhD students; Work on detection and characterisation of Extended spectrum beta-lactamases in Enterobacteriaceae from companion animals clinical and environmental isolates.

    The Institute of Cardiovascular Disease IBCV, Iasi, Romania and The Emergency Institute for Cardiovascular Disease and Transplant, Targu Mures, Romania

    Project: Implementing detection of carbapenemase producing Enterobacteriaceae and non-fermentative bacteria in Romanian hospitals
    External

    Detection of carbapenemase producing Enterobacteriaceae and non-fermentative bacteria in Romanian hospitals

    The Institute of Cardiovascular Disease (IBCV) Iasi, Romania

    Project: Implementing detection of carbapenemase producing Enterobacteriaceae and non-fermentative bacteria in Romanian hospitals
    External

    Detection of carbapenemase producing Enterobacteriaceae and non-fermentative bacteria in Romanian hospitals

    Iasi Veterinary School, Romania

    Project: Teaching and research
    External

    Dorina has been awarded a Visiting Professorship at Iasi Veterinary School, Romania from July 2012 in recognition of her contribution to teaching and research in the Iasi School of Veterinary Science, the academic institution where DT has worked before moving to the UK in 2004.