Dr Dorina Timofte DVM PhD MRCVS ECVM Diplomate

Senior Lecturer in Veterinary Clinical Microbiology Veterinary Pathology and Public Health

    Publications

    Selected Publications

    1. Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015 (Journal article - 2016)
    2. Detection and Molecular Characterization of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 beta-Lactamases from Bovine Mastitis Isolates in the United Kingdom (Journal article - 2014)
    3. Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom (Journal article - 2016)
    4. Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016 (Journal article - 2017)
    5. Genetic Features of mcr-1 Mediated Colistin Resistance in CMY-2-Producing Escherichia coli From Romanian Poultry (Journal article - 2019)
    6. Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK. (Journal article - 2019)
    7. Diversity, Virulence, and Clinical Significance of Extended-Spectrum beta-Lactamase- and pAmpC-Producing Escherichia coli From Companion Animals (Journal article - 2019)

    2019

    Genetic Features of mcr-1 Mediated Colistin Resistance in CMY-2-Producing Escherichia coli From Romanian Poultry (Journal article)

    Maciuca, I. E., Cummins, M. L., Cozma, A. P., Rimbu, C. M., Guguianu, E., Panzaru, C., . . . Timofte, D. (2019). Genetic Features of mcr-1 Mediated Colistin Resistance in CMY-2-Producing Escherichia coli From Romanian Poultry. FRONTIERS IN MICROBIOLOGY, 10. doi:10.3389/fmicb.2019.02267

    DOI: 10.3389/fmicb.2019.02267

    Emergence of carriage of CTX-M-15 in faecal Escherichia coli in horses at an equine hospital in the UK; increasing prevalence over a decade (2008-2017) (Journal article)

    Isgren, C. M., Edwards, T., Pinchbeck, G. L., Winward, E., Adams, E. R., Norton, P., . . . Williams, N. J. (2019). Emergence of carriage of CTX-M-15 in faecal Escherichia coli in horses at an equine hospital in the UK; increasing prevalence over a decade (2008-2017). BMC VETERINARY RESEARCH, 15. doi:10.1186/s12917-019-2011-9

    DOI: 10.1186/s12917-019-2011-9

    Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of Pseudomonas aeruginosa (Journal article)

    Scott, A., Pottenger, S., Timofte, D., Moore, M., Wright, L., Kukavica-Ibrulj, I., . . . Fothergill, J. L. (2019). Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of Pseudomonas aeruginosa. VETERINARY RECORD, 185(7). doi:10.1136/vr.105075

    DOI: 10.1136/vr.105075

    Diversity, Virulence, and Clinical Significance of Extended-Spectrum beta-Lactamase- and pAmpC-Producing Escherichia coli From Companion Animals (Journal article)

    Bortolami, A., Zendri, F., Maciuca, E. I., Wattret, A., Ellis, C., Schmidt, V., . . . Timofte, D. (2019). Diversity, Virulence, and Clinical Significance of Extended-Spectrum beta-Lactamase- and pAmpC-Producing Escherichia coli From Companion Animals. FRONTIERS IN MICROBIOLOGY, 10. doi:10.3389/fmicb.2019.01260

    DOI: 10.3389/fmicb.2019.01260

    The diversity, evolution and ecology of Salmonella in venomous snakes (Journal article)

    Hinton, J. C. D. (2019). The diversity, evolution and ecology of Salmonella in venomous snakes. PLoS Neglected Tropical Diseases.

    Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs (Journal article)

    Frosini, S. -M., Bond, R., Rantala, M., Gronthal, T., Rankin, S. C., O'Shea, K., . . . Loeffler, A. (2019). Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs. BMC MICROBIOLOGY, 19. doi:10.1186/s12866-019-1449-z

    DOI: 10.1186/s12866-019-1449-z

    Susceptibility testing during lambing season (Journal article)

    Duncan, J., Timofte, D., Grove-White, D., & Angell, J. (2019). Susceptibility testing during lambing season. VETERINARY RECORD, 184(7), 224. doi:10.1136/vr.l1671

    DOI: 10.1136/vr.l1671

    Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK. (Journal article)

    Reynolds, M. E., Phan, H. T. T., George, S., Hubbard, A. T. M., Stoesser, N., Maciuca, I. E., . . . Timofte, D. (2019). Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK.. The Journal of antimicrobial chemotherapy. doi:10.1093/jac/dkz017

    DOI: 10.1093/jac/dkz017

    2018

    A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area (Journal article)

    Sandoval Barron, E., Swift, B., Chantrey, J., Christley, R., Gardner, R., Jewell, C., . . . Bennett, M. (2018). A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area. Scientific Reports, 8(1). doi:10.1038/s41598-018-35652-5

    DOI: 10.1038/s41598-018-35652-5

    Are the Hands of Veterinary Staff a Reservoir for Antimicrobial-Resistant Bacteria? A Randomized Study to Evaluate Two Hand Hygiene Rubs in a Veterinary Hospital (Journal article)

    Espadale, E., Pinchbeck, G., Williams, N. J., Timofte, D., McIntyre, K. M., & Schmidt, V. M. (2018). Are the Hands of Veterinary Staff a Reservoir for Antimicrobial-Resistant Bacteria? A Randomized Study to Evaluate Two Hand Hygiene Rubs in a Veterinary Hospital. MICROBIAL DRUG RESISTANCE, 24(10), 1607-1616. doi:10.1089/mdr.2018.0183

    DOI: 10.1089/mdr.2018.0183

    Corneal abrasion and microbial contamination in horses following general anaesthesia for non-ocular surgery (Journal article)

    Scarabelli, S., Timofte, D., Malalana, F., & Bardell, D. (2018). Corneal abrasion and microbial contamination in horses following general anaesthesia for non-ocular surgery. VETERINARY ANAESTHESIA AND ANALGESIA, 45(3), 278-284. doi:10.1016/j.vaa.2017.12.002

    DOI: 10.1016/j.vaa.2017.12.002

    Sequential bacterial sampling of the midline incision in horses undergoing exploratory laparotomy (Journal article)

    Isgren, C. M., Salem, S. E., Townsend, N. B., Timofte, D., Maddox, T. W., & Archer, D. C. (2019). Sequential bacterial sampling of the midline incision in horses undergoing exploratory laparotomy. EQUINE VETERINARY JOURNAL, 51(1), 38-44. doi:10.1111/evj.12958

    DOI: 10.1111/evj.12958

    2017

    Illumina short-read and MinION long-read WGS to characterize the molecular epidemiology of an NDM-1 Serratia marcescens outbreak in Romania (Journal article)

    Phan, H. T. T., Stoesser, N., Maciuca, I. E., Toma, F., Szekely, E., Flonta, M., . . . Timofte, D. (2018). Illumina short-read and MinION long-read WGS to characterize the molecular epidemiology of an NDM-1 Serratia marcescens outbreak in Romania. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(3), 672-679. doi:10.1093/jac/dkx456

    DOI: 10.1093/jac/dkx456

    Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016 (Journal article)

    Bortolami, A., Williams, N. J., McGowan, C. M., Kelly, P. G., Archer, D. C., Corro, M., . . . Timofte, D. (2017). Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-05559-8

    DOI: 10.1038/s41598-017-05559-8

    Three cases of imported eyeworm infection in dogs: a new threat for the United Kingdom (Journal article)

    Graham-Brown, J., Gilmore, P., Colella, V., Moss, L., Dixon, C., Andrews, M., . . . Williams, D. (2017). Three cases of imported eyeworm infection in dogs: a new threat for the United Kingdom. VETERINARY RECORD, 181(13). doi:10.1136/vr.104378

    DOI: 10.1136/vr.104378

    Characterization of Livestock-Associated Methicillin-Resistant Staphylococcus aureus CC398 and mecC-positive CC130 from Zoo Animals in the United Kingdom (Journal article)

    Bortolami, A., Verin, R., Chantrey, J., Corro, M., Ashpole, I., Lopez, J., & Timofte, D. (2017). Characterization of Livestock-Associated Methicillin-Resistant Staphylococcus aureus CC398 and mecC-positive CC130 from Zoo Animals in the United Kingdom. MICROBIAL DRUG RESISTANCE, 23(7), 908-914. doi:10.1089/mdr.2017.0161

    DOI: 10.1089/mdr.2017.0161

    Imported leishmaniasis in a dog in a sandfly-populated area in northeastern Romania (Journal article)

    Pavel, G., Timofte, D., Mocanu, D., Malancus, R., & Solcan, C. (2017). Imported leishmaniasis in a dog in a sandfly-populated area in northeastern Romania. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 29(5), 683-685. doi:10.1177/1040638717708391

    DOI: 10.1177/1040638717708391

    2016

    Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom (Journal article)

    Timofte, D., Maciuca, I. E., Williams, N. J., Wattret, A., & Schmidt, V. (2016). Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom. MICROBIAL DRUG RESISTANCE, 22(7), 609-615. doi:10.1089/mdr.2016.0036

    DOI: 10.1089/mdr.2016.0036

    European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections (Journal article)

    Marques, C., Gama, L. T., Belas, A., Bergstrom, K., Beurlet, S., Briend-Marchal, A., . . . Pomba, C. (2016). European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections. BMC VETERINARY RESEARCH, 12. doi:10.1186/s12917-016-0840-3

    DOI: 10.1186/s12917-016-0840-3

    Interaction of chlorhexidine with trisEDTA or miconazole in vitro against canine meticillin-resistant and -susceptible Staphylococcus pseudintermedius isolates from two UK regions (Journal article)

    Clark, S. -M., Loeffler, A., Schmidt, V. M., Chang, Y. -M., Wilson, A., Timofte, D., & Bond, R. (2016). Interaction of chlorhexidine with trisEDTA or miconazole in vitro against canine meticillin-resistant and -susceptible Staphylococcus pseudintermedius isolates from two UK regions. VETERINARY DERMATOLOGY, 27(5), 340-+. doi:10.1111/vde.12357

    DOI: 10.1111/vde.12357

    Prevalence and antimicrobial susceptibility of bacterial isolates from horses with synovial sepsis: A cross-sectional study of 95 cases (Journal article)

    Robinson, C. S., Timofte, D., Singer, E. R., Rimmington, L., & Rubio-Martinez, L. M. (2016). Prevalence and antimicrobial susceptibility of bacterial isolates from horses with synovial sepsis: A cross-sectional study of 95 cases. VETERINARY JOURNAL, 216, 117-121. doi:10.1016/j.tvjl.2016.07.004

    DOI: 10.1016/j.tvjl.2016.07.004

    Case of canine ocular thelaziosis in the UK (Journal article)

    Graham-Brown, J., Gilmore, P., Williams, D., Barber, J., Andrews, M., & Timofte, D. (2016). Case of canine ocular thelaziosis in the UK. VETERINARY RECORD, 179(2). doi:10.1136/vr.i3743

    DOI: 10.1136/vr.i3743

    Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015 (Journal article)

    Timofte, D., Panzaru, C. V., Maciuca, I. E., Dan, M., Mare, A. D., Man, A., & Toma, F. (2016). Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015. EUROSURVEILLANCE, 21(25), 5-12. doi:10.2807/1560-7917.ES.2016.21.25.30262

    DOI: 10.2807/1560-7917.ES.2016.21.25.30262

    Prevalence of antimicrobial resistance amongst Staphylococcus pseudintermedius isolates detected from clinical infections in dogs and cats during 2004-2015 in the North West UK (Conference Paper)

    Schmidt, V. M., Trevan, M., Buckley, L. M., & Timofte, D. (2016). Prevalence of antimicrobial resistance amongst Staphylococcus pseudintermedius isolates detected from clinical infections in dogs and cats during 2004-2015 in the North West UK. In WCVD8. Bordeaux.

    Prevalence of antimicrobial resistance amongst canine Pseudomonas aeruginosa clinical isolates between 2011-2015 (Conference Paper)

    Schmidt, V. M., Timofte, D., Botham, L., & Buckley, L. M. (2016). Prevalence of antimicrobial resistance amongst canine Pseudomonas aeruginosa clinical isolates between 2011-2015. In BSAVA. Birmingham.

    2015

    High Prevalence of Escherichia coli-Producing CTX-M-15 Extended-Spectrum Beta-Lactamases in Poultry and Human Clinical Isolates in Romania (Journal article)

    Maciuca, I. E., Williams, N. J., Tuchilus, C., Dorneanu, O., Guguianu, E., Carp-Carare, C., . . . Timofte, D. (2015). High Prevalence of Escherichia coli-Producing CTX-M-15 Extended-Spectrum Beta-Lactamases in Poultry and Human Clinical Isolates in Romania. MICROBIAL DRUG RESISTANCE, 21(6), 651-662. doi:10.1089/mdr.2014.0248

    DOI: 10.1089/mdr.2014.0248

    Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit (Journal article)

    Timofte, D., Dan, M., Maciuca, I. E., Ciucu, L., Dabija, E. R., Guguianu, E., & Panzaru, C. V. (2015). Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 34(10), 2069-2074. doi:10.1007/s10096-015-2453-3

    DOI: 10.1007/s10096-015-2453-3

    Prevalence of antimicrobial sensitivity profile of bacterial isolates from horses with synovial sepsis (Conference Paper)

    Robinson, C., Timofte, D., Singer, E. R., Rimmington, L., & Rubio Martinez, L. (2015, July 2). Prevalence of antimicrobial sensitivity profile of bacterial isolates from horses with synovial sepsis. In 24th European College of Veterinary Surgeons Congress Vol. 24. Berlin, Germany.

    2014

    Detection and Molecular Characterization of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 beta-Lactamases from Bovine Mastitis Isolates in the United Kingdom (Journal article)

    Timofte, D., Maciuca, I. E., Evans, N. J., Williams, H., Wattret, A., Fick, J. C., & Williams, N. J. (2014). Detection and Molecular Characterization of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 beta-Lactamases from Bovine Mastitis Isolates in the United Kingdom. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 789-794. doi:10.1128/AAC.00752-13

    DOI: 10.1128/AAC.00752-13

    Detection of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 producing β-lactamases isolated from cases of bovine mastitis in the United Kingdom (Journal article)

    Timofte, D., Maciuca, I., Evans, N., Williams, H., Wattret, A., Fick, J., & Williams, N. (2014). Detection of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 producing β-lactamases isolated from cases of bovine mastitis in the United Kingdom. Antimicrobial Agents and Chemotherapy, 58(2), 789-794.

    Detection of the human-pandemic Escherichia coli B2-025b-ST131 in UK dogs (Journal article)

    Timofte, D., Maciuca, I. E., Kemmett, K., Wattret, A., & Williams, N. J. (2014). Detection of the human-pandemic Escherichia coli B2-025b-ST131 in UK dogs. VETERINARY RECORD, 174(14), 352-+. doi:10.1136/vr.101893

    DOI: 10.1136/vr.101893

    2013

    ULTRASTRUCTURAL LESIONS AND IMMUNOHISTOCHEMICAL ANALYSIS OF BCL-2 PROTEIN EXPRESSION IN THE KIDNEY OF CHICKENS WITH EXPERIMENTAL OCHRATOXICOSIS (Journal article)

    Solcan, C., Timofte, D., Floristean, V. C., Carter, S. D., & Solcan, G. (2013). ULTRASTRUCTURAL LESIONS AND IMMUNOHISTOCHEMICAL ANALYSIS OF BCL-2 PROTEIN EXPRESSION IN THE KIDNEY OF CHICKENS WITH EXPERIMENTAL OCHRATOXICOSIS. ACTA VETERINARIA HUNGARICA, 61(3), 344-353. doi:10.1556/AVet.2013.021

    DOI: 10.1556/AVet.2013.021

    2012

    Host and environmental reservoirs of infection for bovine digital dermatitis treponemes (Journal article)

    Evans, N. J., Timofte, D., Isherwood, D. R., Brown, J. M., Williams, J. M., Sherlock, K., . . . Carter, S. D. (2012). Host and environmental reservoirs of infection for bovine digital dermatitis treponemes. VETERINARY MICROBIOLOGY, 156(1-2), 102-109. doi:10.1016/j.vetmic.2011.09.029

    DOI: 10.1016/j.vetmic.2011.09.029

    Host and environmental reservoirs of infection for bovine digital dermatitis treponemes (Journal article)

    Evans, N. J., Timofte, D., Isherwood, D. R., Brown, J. M., Williams, J. M., Sherlock, K., . . . Carter, S. D. (2012). Host and environmental reservoirs of infection for bovine digital dermatitis treponemes. Veterinary Microbiology, 156(1-2), 102-109. doi:10.1016/j.vetmic.2011.09.029

    DOI: 10.1016/j.vetmic.2011.09.029

    2011

    Association between bovine digital dermatitis treponemes and a range of 'non-healing' bovine hoof disorders (Journal article)

    Evans, N. J., Blowey, R. W., Timofte, D., Isherwood, D. R., Brown, J. M., Murray, R., . . . Carter, S. D. (2011). Association between bovine digital dermatitis treponemes and a range of 'non-healing' bovine hoof disorders. VETERINARY RECORD, 168(8), 214. doi:10.1136/vr.c5487

    DOI: 10.1136/vr.c5487

    Characteristics of epileptic episodes in UK dog breeds: an epidemiological approach (Journal article)

    Short, A. D., Dunne, A., Lohi, H., Boulton, S., Carter, S. D., Timofte, D., & Ollier, W. E. R. (2011). Characteristics of epileptic episodes in UK dog breeds: an epidemiological approach. VETERINARY RECORD, 169(2), 48-+. doi:10.1136/vr.d1901

    DOI: 10.1136/vr.d1901

    Detection of extended-spectrum-beta-lactamase-positive Escherichia coli in bile isolates from two dogs with bacterial cholangiohepatitis. (Journal article)

    Timofte, D., Dandrieux, J., Wattret, A., Fick, J., & Williams, N. J. (2011). Detection of extended-spectrum-beta-lactamase-positive Escherichia coli in bile isolates from two dogs with bacterial cholangiohepatitis.. Journal of clinical microbiology, 49(9), 3411-3414. doi:10.1128/JCM.01045-11

    DOI: 10.1128/JCM.01045-11

    2010

    Association of treponemes with bovine ulcerative mammary dermatitis (Journal article)

    Evans, N. J., Timofte, D., Carter, S. D., Brown, J. M., Scholey, R., Read, D. H., & Blowey, R. W. (2010). Association of treponemes with bovine ulcerative mammary dermatitis. VETERINARY RECORD, 166(17), 532-533. doi:10.1136/vr.b4822

    DOI: 10.1136/vr.b4822

    Exonic mutations in the L2HGDH gene in Staffordshire bull terriers (Journal article)

    Short, A. D., Mellersh, C. S., Platt, H., Carter, S. D., Timofte, D., Lohi, H., & Ollier, W. E. R. (2010). Exonic mutations in the L2HGDH gene in Staffordshire bull terriers. VETERINARY RECORD, 167(12), 455-457. doi:10.1136/vr.c4476

    DOI: 10.1136/vr.c4476

    The association of treponemes with bovine ulcerative mammary dermatitis. (Journal article)

    Evans, N. J., Timofte, D., Brown, J. M., Blowey, R. W., & Carter, S. D. (2010). The association of treponemes with bovine ulcerative mammary dermatitis.. Vet Record, 166, 532-533.

    2009

    Association of Unique, Isolated Treponemes with Bovine Digital Dermatitis Lesions (Journal article)

    Evans, N. J., Brown, J. M., Demirkan, I., Singh, P., Getty, B., Timofte, D., . . . Carter, S. D. (2009). Association of Unique, Isolated Treponemes with Bovine Digital Dermatitis Lesions. JOURNAL OF CLINICAL MICROBIOLOGY, 47(3), 689-696. doi:10.1128/JCM.01914-08

    DOI: 10.1128/JCM.01914-08

    Fatal Borreliosis in Bat Caused by Relapsing Fever Spirochete, United Kingdom (Journal article)

    Evans, N. J., Bown, K., Timofte, D., Simpson, V. R., & Birtles, R. J. (2009). Fatal Borreliosis in Bat Caused by Relapsing Fever Spirochete, United Kingdom. EMERGING INFECTIOUS DISEASES, 15(8), 1331-1333. doi:10.3201/eid1508.090475

    DOI: 10.3201/eid1508.090475