Professor Bill Greenhalf PhD
Reader Molecular & Clinical Cancer Medicine
- +44 (0)151 706 4184 / +44 (0)151 795 8030
- Work email Greenhaf@liverpool.ac.uk
- Personal Websitewww.liv.ac.uk%5Csurgery%5Cbill.html
Publications
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2024
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies. (Journal article)
Costigan, D., Fenn, J., Yen, S., Ilott, N., Bullers, S., Hale, J., . . . Thornton, E. E. (2024). A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.. Mucosal immunology, 17(1), 111-123. doi:10.1016/j.mucimm.2023.11.005Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19. (Journal article)
Devine, K., Russell, C. D., Blanco, G. R., Walker, B. R., Homer, N. Z. M., Denham, S. G., . . . ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group. (2024). Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.. Clinical endocrinology. doi:10.1111/cen.15012Accelarated immune ageing is associated with COVID-19 disease severity. (Journal article)
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-zType 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment. (Journal article)
Overbeek, K. A., Poulsen, J. L., Lanzillotta, M., Vinge-Holmquist, O., Macinga, P., Demirci, A. F., . . . PrescrAIP Study Group. (2024). Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, S1542-3565(23)01042-X. doi:10.1016/j.cgh.2023.12.0102023
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury. (Journal article)
Taquet, M., Skorniewska, Z., Zetterberg, H., Geddes, J. R., Mummery, C. J., Chalmers, J. D., . . . PHOSP-COVID Study Collaborative Group . (2024). Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.. Brain communications, 6(1), fcad357. doi:10.1093/braincomms/fcad357Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. (Journal article)
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (Journal article)
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L. -P., . . . Williams, N. (2023). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1). doi:10.1093/ije/dyad165A multi-country analysis of COVID-19 hospitalizations by vaccination status. (Journal article)
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis. (Journal article)
Eiseler, K., Neppl, L., Schmidt, A. W., Rauscher, B., Ewers, M., Masson, E., . . . Witt, H. (2023). Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 23(8), 957-963. doi:10.1016/j.pan.2023.11.002Long COVID research: an update from the PHOSP-COVID Scientific Summit. (Journal article)
Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., & PHOSP-COVID Collaborative Group. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit.. The Lancet. Respiratory medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. (Journal article)
C-MORE/PHOSP-COVID Collaborative Group. (2023). Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.. The Lancet. Respiratory medicine, S2213-2600(23)00262-X. doi:10.1016/s2213-2600(23)00262-xLiver injury in hospitalized patients with COVID-19: An International observational cohort study. (Journal article)
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. (Journal article)
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2A second update on mapping the human genetic architecture of COVID-19. (Journal article)
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort. (Journal article)
Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs, 47(9), 1490-1502. doi:10.1111/aor.14542Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19 (Journal article)
Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (Journal article)
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . PHOSP-COVID, S. C. G. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. LANCET RESPIRATORY MEDICINE, 11(8), 673-684. doi:10.1016/S2213-2600(23)00124-8GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023) (Journal article)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-zRacial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance. (Journal article)
Katona, B. W., Klute, K., Brand, R. E., Everett, J. N., Farrell, J. J., Hawthorne, K., . . . PRECEDE Consortium. (2023). Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance.. Cancer prevention research (Philadelphia, Pa.), 16(6), 343-352. doi:10.1158/1940-6207.capr-22-0529The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer (Journal article)
Campa, D., Gentiluomo, M., Stein, A., Aoki, M. N., Oliverius, M., Vodickova, L., . . . Canzian, F. (2023). The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 186. doi:10.1016/j.critrevonc.2023.104020Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways (Journal article)
Quinn, L. M., Haldenby, S., Antzcak, P., Fowler, A., Bullock, K., Kenny, J., . . . Goldring, C. (n.d.). Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways. Scientific Reports, 13(1). doi:10.1038/s41598-023-33096-0Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.c.6511738Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.c.6511738.v1Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424323.v1Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424323Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424320Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424320.v1Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424317.v1Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424317Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424314.v1Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424314Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424311Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424311.v1Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424308.v1Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424308Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424305Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties (Other)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2023). Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. doi:10.1158/0008-5472.22424305.v1Genetic and non-genetic risk factors for early-onset pancreatic cancer. (Journal article)
Nodari, Y., Gentiluomo, M., Mohelnikova-Duchonova, B., Kreivenaite, E., Milanetto, A. C., Skieceviciene, J., . . . Campa, D. (2023). Genetic and non-genetic risk factors for early-onset pancreatic cancer.. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, S1590-8658(23)00514-5. doi:10.1016/j.dld.2023.02.023Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation (Journal article)
Ferguson, R., Aughton, K., Evans, A., Shaw, V., Armstrong, J., Ware, A., . . . Greenhalf, W. (2023). Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation. CURRENT ISSUES IN MOLECULAR BIOLOGY, 45(3), 2505-2520. doi:10.3390/cimb45030164The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. (Journal article)
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer (Journal article)
Ahmed, A. A., Greenhalf, W., Palmer, D. H., Williams, N., Worthington, J., Arshad, T., . . . Neidle, S. (2023). The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer. MOLECULES, 28(6). doi:10.3390/molecules28062452GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma (Journal article)
de Andres, M. P., Jackson, R. J., Felipe, I., Zagorac, S., Pilarsky, C., Schlitter, A. M., . . . Real, F. X. (2023). GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma. GUT, 72(3), 535-548. doi:10.1136/gutjnl-2021-325803Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins (Preprint)
Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning (Journal article)
Nene, N. R. R., Ney, A., Nazarenko, T., Blyuss, O., Johnston, H. E. E., Whitwell, H. J. J., . . . Timms, J. F. F. (2023). Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning. COMMUNICATIONS MEDICINE, 3(1). doi:10.1038/s43856-023-00237-5SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (Journal article)
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.1044022022
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial (Journal article)
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9Genetically Determined Telomere Length Is Associated with Pancreatic Neuroendocrine Neoplasms Onset. (Journal article)
Gentiluomo, M., Capurso, G., Morelli, L., Ermini, S., Pasquali, C., Latiano, A., . . . Campa, D. (2022). Genetically Determined Telomere Length Is Associated with Pancreatic Neuroendocrine Neoplasms Onset.. Neuroendocrinology, 112(12), 1168-1176. doi:10.1159/000524659Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients. (Journal article)
Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins (Preprint)
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial (Journal article)
Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer (Journal article)
Oldfield, L., Stott, M., Hanson, R., Jackson, R. J., Reynolds, W., Chandran-Gorner, V., . . . Costello, E. (2022). United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer. BMJ OPEN, 12(10). doi:10.1136/bmjopen-2022-068010Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (Journal article)
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. (Journal article)
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (Journal article)
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number (Journal article)
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (Journal article)
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (Journal article)
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/Standardization of EUS imaging and reporting in high-risk individuals of pancreatic adenocarcinoma: consensus statement of the Pancreatic Cancer Early Detection Consortium. (Journal article)
Gonda, T. A., Farrell, J., Wallace, M., Khanna, L., Janec, E., Kwon, R., . . . PRECEDE Consortium. (2022). Standardization of EUS imaging and reporting in high-risk individuals of pancreatic adenocarcinoma: consensus statement of the Pancreatic Cancer Early Detection Consortium.. Gastrointestinal endoscopy, 95(4), 723-732.e7. doi:10.1016/j.gie.2021.10.025Linking COVID-19 and Acute Pancreatitis Through the Pathogenic Effects of the SARS-CoV-2 S Protein Subunit 1 on Pancreatic Stellate Cells and Macrophages (Journal article)
Neoptolemos, J. P., & Greenhalf, W. (2022). Linking COVID-19 and Acute Pancreatitis Through the Pathogenic Effects of the SARS-CoV-2 S Protein Subunit 1 on Pancreatic Stellate Cells and Macrophages. FUNCTION, 3(2). doi:10.1093/function/zqac009Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection (Journal article)
FitzGerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., . . . Khoo, S. (2022). Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciac199SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes (Journal article)
Oldfield, L., Evans, A., Rao, R. G., Jenkinson, C., Purewal, T., Psarelli, E. E., . . . Costello, E. (2022). Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes. EBIOMEDICINE, 75. doi:10.1016/j.ebiom.2021.103802Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-2176292021
Mapping the human genetic architecture of COVID-19 (Journal article)
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-xEarly detection of pancreatic ductal adenocarcinomas with an ensemble learning model based on a panel of protein serum biomarkers (Preprint)
Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk (Journal article)
Lu, Y., Gentiluomo, M., Macauda, A., Gioffreda, D., Gazouli, M., Petrone, M. C., . . . Canzian, F. (2021). Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk. FRONTIERS IN ONCOLOGY, 11. doi:10.3389/fonc.2021.771312Recommendations for a More Organized and Effective Approach to the Early Detection of Pancreatic Cancer From the PRECEDE (Pancreatic Cancer Early Detection) Consortium. (Journal article)
Gonda, T. A., Everett, J. N., Wallace, M., Simeone, D. M., & PRECEDE Consortium. (2021). Recommendations for a More Organized and Effective Approach to the Early Detection of Pancreatic Cancer From the PRECEDE (Pancreatic Cancer Early Detection) Consortium.. Gastroenterology, 161(6), 1751-1757. doi:10.1053/j.gastro.2021.08.036The value of open-source clinical science in pandemic response: lessons from ISARIC (Journal article)
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-XThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA (Journal article)
Aughton, K., Elander, N. O., Evans, A., Jackson, R., Campbell, F., Costello, E., . . . Greenhalf, W. (2021). hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA. CANCERS, 13(22). doi:10.3390/cancers13225758Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study (Journal article)
Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., . . . Griffiths, G. (2021). Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(12), 3286-3295. doi:10.1093/jac/dkab318Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study (Journal article)
Rosato, V., Gomez-Rubio, P., Molina-Montes, E., Marquez, M., Lohr, M., O'Rorke, M., . . . Investigators, P. S. (2021). Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study. EUROPEAN JOURNAL OF CANCER PREVENTION, 30(6), 423-430. doi:10.1097/CEJ.0000000000000588Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study (Journal article)
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk. (Journal article)
Peduzzi, G., Gentiluomo, M., Tavano, F., Arcidiacono, P. G., Ermini, S., Vodicka, P., . . . Campa, D. (2021). Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. doi:10.1158/1055-9965.epi-21-0353LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (Conference Paper)
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK (Journal article)
Vaselli, N. M., Setiabudi, W., Subramaniam, K., Adams, E. R., Turtle, L., Iturriza-Gomara, M., . . . Hungerford, D. (2021). Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06443-7Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (Journal article)
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2Concordance of human equilibrative nucleoside transporter‐1 expressions between murine ( 10D7G2 ) and rabbit ( SP120 ) antibodies and association with clinical outcomes of adjuvant chemotherapy for pancreatic cancer: A collaborative study from the JASPAC 01 trial (Journal article)
Okamura, Y., Boku, N., Ghaneh, P., Greenhalf, W., Yasukawa, S., Narimatsu, H., . . . Uesaka, K. (2021). Concordance of human equilibrative nucleoside transporter‐1 expressions between murine ( 10D7G2 ) and rabbit ( SP120 ) antibodies and association with clinical outcomes of adjuvant chemotherapy for pancreatic cancer: A collaborative study from the JASPAC 01 trial. Cancer Reports. doi:10.1002/cnr2.1507Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/SAVER: sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia-a phase II randomised control trial study protocol (Journal article)
McCarthy, C., Sacco, J., Fedele, S., Ho, M., Porter, S., Liloglou, T., . . . Shaw, R. (2021). SAVER: sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia-a phase II randomised control trial study protocol. TRIALS, 22(1). doi:10.1186/s13063-021-05373-8Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. (Journal article)
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-xGoing viral: misinformation in the time of COVID-19 (Journal article)
Going viral: misinformation in the time of COVID-19 (2021). LANCET RHEUMATOLOGY, 3(6), E393. doi:10.1016/S2665-9913(21)00104-1Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction (Journal article)
Galeotti, A. A., Gentiluomo, M., Rizzato, C., Obazee, O., Neoptolemos, J. P., Pasquali, C., . . . Campa, D. (2021). Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. JOURNAL OF MEDICAL GENETICS, 58(6), 369-377. doi:10.1136/jmedgenet-2020-106961The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements (Journal article)
Ashworth, M., Small, B., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2021). The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-85052-5Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol (Journal article)
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer (Journal article)
Lopez de Maturana, E., Rodriguez, J. A., Alonso, L., Lao, O., Molina-Montes, E., Martin-Antoniano, I. A., . . . Malats, N. (2021). A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer. GENOME MEDICINE, 13(1). doi:10.1186/s13073-020-00816-4Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses (Journal article)
Molina-Montes, E., Coscia, C., Gomez-Rubio, P., Fernandez, A., Boenink, R., Rava, M., . . . Malats, N. (2021). Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. GUT, 70(2), 319-329. doi:10.1136/gutjnl-2019-319990Digital quantification of GATA6 expression from immunohistochemistry is associated with overall survival after surgery for pancreatic cancer in the ESPAC trials. (Conference Paper)
Grant, R. C., Duan, K., Jackson, R., Greenhalf, W., Costello-Goldring, E., Ghaneh, P., . . . Fischer, S. (2021). Digital quantification of GATA6 expression from immunohistochemistry is associated with overall survival after surgery for pancreatic cancer in the ESPAC trials.. In CANCER RESEARCH Vol. 81. Retrieved from https://www.webofscience.com/2020
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study (Journal article)
Debernardi, S., O'Brien, H., Algahmdi, A. S., Malats, N., Stewart, G. D., Pljesa-Ercegovac, M., . . . Crnogorac-Jurcevic, T. (2020). A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study. PLOS MEDICINE, 17(12). doi:10.1371/journal.pmed.1003489Early detection of pancreatic cancer (Journal article)
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., . . . Costello, E. (2020). Early detection of pancreatic cancer. The Lancet Gastroenterology and Hepatology, 5(7), 698-710. doi:10.1016/S2468-1253(19)30416-9Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. (Journal article)
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2020). Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.. Cancer Research, 80(13), 2861-2873. doi:10.1158/0008-5472.can-19-3534Blood Levels of Adiponectin and IL-1Ra Could Facilitate Earlier Detection of PDAC by Distinguishing Individuals With Type 3c Diabetes From Those With Type 2 Diabetes (Conference Paper)
Oldfield, L., Rao, R., Purewal, T., Greenhalf, W., Halloran, C., & Costello, E. (2019). Blood Levels of Adiponectin and IL-1Ra Could Facilitate Earlier Detection of PDAC by Distinguishing Individuals With Type 3c Diabetes From Those With Type 2 Diabetes. In PANCREAS Vol. 48 (pp. 1502). Retrieved from https://www.webofscience.com/International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club (Journal article)
Greenhalf, W., Lévy, P., Gress, T., Rebours, V., Brand, R. E., Pandol, S., . . . Neoptolemos, J. (2020). International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. Pancreatology. doi:10.1016/j.pan.2020.05.011Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships (Journal article)
Molina-Montes, E., Van Hoogstraten, L., Gomez-Rubio, P., Lohr, M., Sharp, L., Molero, X., . . . Malats, N. (2020). Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 29(5), 1009-1018. doi:10.1158/1055-9965.EPI-19-1027A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020) (Journal article)
McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-61783-9A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis. (Journal article)
McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.. Scientific reports, 10(1). doi:10.1038/s41598-020-58790-1Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer (Journal article)
Mahajan, U. M., Goni, E., Langhoff, E., Li, Q., Costello, E., Greenhalf, W., . . . Mayerle, J. (2020). Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer. JNCI CANCER SPECTRUM, 4(1). doi:10.1093/jncics/pkz0602019
Familial pancreatic adenocarcinoma: A retrospective analysis of germline genetic testing in a French multicentre cohort (Journal article)
Schwartz, M., Korenbaum, C., Benfoda, M., Mary, M., Colas, C., Coulet, F., . . . Hammel, P. (2019). Familial pancreatic adenocarcinoma: A retrospective analysis of germline genetic testing in a French multicentre cohort. CLINICAL GENETICS, 96(6), 579-584. doi:10.1111/cge.13629Natural history of SPINK1 germline mutation related-pancreatitis (Journal article)
Muller, N., Sarantitis, I., Rouanet, M., de Mestier, L., Halloran, C. M., & Greenhalf, W. (2019). Natural history of SPINK1 germline mutation related-pancreatitis. EBioMedicine, 48, 581-591. doi:10.1016/j.ebiom.2019.09.032Pancreas-specific plasma amylase for assessment and diagnosis of chronic pancreatitis: New insights on an old topic (Journal article)
Olesen, S. S., Krarup, H., Poulsen, J. L., Christensen, J. H., Sheel, A. R. G., Sutton, R., . . . Drewes, A. M. (2019). Pancreas-specific plasma amylase for assessment and diagnosis of chronic pancreatitis: New insights on an old topic. United European Gastroenterology Journal. doi:10.1177/2050640619846011Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study (Journal article)
Campa, D., Matarazzi, M., Greenhalf, W., Bijlsma, M., Saum, K. -U., Pasquali, C., . . . Canzian, F. (2019). Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study. INTERNATIONAL JOURNAL OF CANCER, 144(6), 1275-1283. doi:10.1002/ijc.31928Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches (Journal article)
Gomez-Rubio, P., Pinero, J., Molina-Montes, E., Gutierrez-Sacristan, A., Marquez, M., Rava, M., . . . Investigators, P. S. (2019). Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches. INTERNATIONAL JOURNAL OF CANCER, 144(7), 1540-1549. doi:10.1002/ijc.31866Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer. (Journal article)
Sheel, A. R. G., Harrison, S., Sarantitis, I., Nicholson, J. A., Hanna, T., Grocock, C., . . . Greenhalf, W. (2019). Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer.. The American Journal of Gastroenterology (Elsevier), 114(1), 155-164. doi:10.1038/s41395-018-0395-yRadiant-BC Platform Trial: Development of an efficient multiarm multi-stage early phase trial of radiosurgery with immunotherapy and systemic therapies in breast cancer patients with brain metastases using a flexible Bayesian framework (Conference Paper)
Yap, C., Kong, A., Slade, D., Jackson, R., Savage, J., Sanghera, P., . . . Palmieri, C. (2019). Radiant-BC Platform Trial: Development of an efficient multiarm multi-stage early phase trial of radiosurgery with immunotherapy and systemic therapies in breast cancer patients with brain metastases using a flexible Bayesian framework. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/hENT1 RNA and Protein in Combination May Act as Predictive Biomarkers for Survival for Patients Treated With Adjuvant Gemcitabine in Pancreatic Cancer (Conference Paper)
Hale, J., Evans, A., Aughton, K., Elander, N. O., Ghaneh, P., Neoptolemos, J. P., . . . Greenhalf, W. (2019). hENT1 RNA and Protein in Combination May Act as Predictive Biomarkers for Survival for Patients Treated With Adjuvant Gemcitabine in Pancreatic Cancer. In PANCREAS Vol. 48 (pp. 1436-1437). Retrieved from https://www.webofscience.com/2018
S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes (Journal article)
Nedjadi, T., Evans, A., Sheikh, A., Barerra, L., Al-Ghamdi, S., Oldfield, L., . . . Costello, E. (2018). S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes. BMC CANCER, 18. doi:10.1186/s12885-018-5161-4Immune Cell and Stromal Signature Associated with Progression-free Survival of Patients with Resected Pancreatic Ductal Adenocarcinoma (Journal article)
Mahajan, U. M., Langhoff, E., Goni, E., Costello, E., Greenhalf, W., Halloran, C. M., . . . Mayerle, J. (2018). Immune Cell and Stromal Signature Associated with Progression-free Survival of Patients with Resected Pancreatic Ductal Adenocarcinoma. Gastroenterology, 155(05), 1625-1639.E2. doi:10.1053/j.gastro.2018.08.009ACELARATE: A randomised phase III, open label, clinical study comparing NUC-1031 with gemcitabine in patients with metastatic pancreatic carcinoma (Conference Paper)
Palmer, D. H., Ross, P. J., Silcocks, P., Greenhalf, W., Faluyi, O., Ma, Y. T., . . . Bridgewater, J. (2018). ACELARATE: A randomised phase III, open label, clinical study comparing NUC-1031 with gemcitabine in patients with metastatic pancreatic carcinoma. In ANNALS OF ONCOLOGY Vol. 29. Retrieved from https://www.webofscience.com/Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker. (Journal article)
Martinez-Bosch, N., Barranco, L. E., Orozco, C. A., Moreno, M., Visa, L., Iglesias, M., . . . Navarro, P. (2018). Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.. Oncotarget, 9(68), 32984-32996. doi:10.18632/oncotarget.26034Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms (vol 39, pg 360, 2018) (Journal article)
Obazee, O., Capurso, G., Tavano, F., Archibugi, L., De Bonis, A., Greenhalf, W., . . . Campa, D. (2018). Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms (vol 39, pg 360, 2018). CARCINOGENESIS, 39(7), 969. doi:10.1093/carcin/bgy067Therapeutic developments in pancreatic cancer: current and future perspectives (Journal article)
Neoptolemos, J. P., Kleeff, J., Michl, P., Costello, E., Greenhalf, W., & Palmer, D. H. (2018). Therapeutic developments in pancreatic cancer: current and future perspectives. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 15(6), 333-348. doi:10.1038/s41575-018-0005-xPATHOS: A phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for human papillomavirus (HPV)-positive oropharyngeal cancer. (Conference Paper)
Evans, M., Knott, S., Hurt, C., Patterson, J., Robinson, M., Hutcheson, K. A., . . . Jones, T. (2018). PATHOS: A phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for human papillomavirus (HPV)-positive oropharyngeal cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.15_suppl.TPS6097Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy (Journal article)
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Canc, E. S. G. P. (2018). Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy. British Journal of Cancer, 118, 1084-1088. doi:10.1038/s41416-018-0005-1Development of Novel Therapeutic Response Biomarkers (Chapter)
Elander, N., Aughton, K., & Greenhalf, W. (2018). Development of Novel Therapeutic Response Biomarkers. In Pancreatic Cancer (pp. 1273-1304). Springer New York. doi:10.1007/978-1-4939-7193-0_59Secondary Screening for Inherited Pancreatic Ductal Adenocarcinoma (Chapter)
Sheel, A., Nicholson, J., Sarantitis, I., Neoptolemos, J. P., & Greenhalf, W. (2018). Secondary Screening for Inherited Pancreatic Ductal Adenocarcinoma. In Pancreatic Cancer (pp. 1401-1434). Springer New York. doi:10.1007/978-1-4939-7193-0_63Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predict survival in pancreatic cancer. (Journal article)
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Greenhalf, W. (2018). Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predict survival in pancreatic cancer.. British Journal of Cancer, 118(7), 947-954. doi:10.1038/s41416-018-0004-2Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives (Journal article)
Molina-Montes, E., Gomez-Rubio, P., Marquez, M., Rava, M., Lohr, M., Michalski, C. W., . . . Investigators, P. S. (2018). Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47(2), 473-483. doi:10.1093/ije/dyx269Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms (Journal article)
Obazee, O., Capurso, G., Tavano, F., Archibugi, L., De Bonis, A., Greenhalf, W., . . . Campa, D. (2018). Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms. CARCINOGENESIS, 39(3), 360-367. doi:10.1093/carcin/bgx150Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer (Journal article)
Bauer, A. S., Nazarov, P. V., Giese, N. A., Beghelli, S., Heller, A., Greenhalf, W., . . . Hoheisel, J. D. (2018). Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. INTERNATIONAL JOURNAL OF CANCER, 142(5), 1010-1021. doi:10.1002/ijc.31087ACELARATE: A phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with gemcitabine in patients with metastatic pancreatic carcinoma. (Conference Paper)
Palmer, D. H., Ross, P. J., Silcocks, P., Greenhalf, W., Faluyi, O. O., Ma, Y. T., . . . Neoptolemos, J. P. (2018). ACELARATE: A phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with gemcitabine in patients with metastatic pancreatic carcinoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.4_suppl.TPS537Cytoplasmic HuR Status Predicts Disease-Free Survival in Resected Pancreatic Cancer: A Post-Hoc Analysis from the International Multi-Institutional Phase III ESPAC-3 Clinical Trial (Journal article)
Halloran, C. M. (2018). Cytoplasmic HuR Status Predicts Disease-Free Survival in Resected Pancreatic Cancer: A Post-Hoc Analysis from the International Multi-Institutional Phase III ESPAC-3 Clinical Trial. Annals of Surgery, 267(2), 364-369. doi:10.1097/SLA.0000000000002088Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation (Journal article)
Campa, D., Pastore, M., Capurso, G., Hackert, T., Di Leo, M., Izbicki, J. R., . . . Canzian, F. (2018). Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. INTERNATIONAL JOURNAL OF CANCER, 142(2), 290-296. doi:10.1002/ijc.31047Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease. (Conference Paper)
Rao, R. G., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2018). Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 82). Retrieved from https://www.webofscience.com/2017
Detecting Pancreatic Cancer Earlier: Identifying Type 3c Diabetes in Individuals Newly Diagnosed With Type 2 Diabetes (Conference Paper)
Oldfield, L., Rao, R., Purewal, T., Neoptolemos, J. P., Halloran, C. M., Greenhalf, W., & Costello, E. (2017). Detecting Pancreatic Cancer Earlier: Identifying Type 3c Diabetes in Individuals Newly Diagnosed With Type 2 Diabetes. In PANCREAS Vol. 46 (pp. 1425). Retrieved from https://www.webofscience.com/Nrf2 in Pancreatic Cancer Chemotherapy Response and the Use of Brusatol as a Chemotherapeutic Agent (Conference Paper)
Williams, D., Gana, T., Sivapalan, L., Butler, O., Jackson, R., Perez-Mancera, P., . . . Costello, E. (2017). Nrf2 in Pancreatic Cancer Chemotherapy Response and the Use of Brusatol as a Chemotherapeutic Agent. In PANCREAS Vol. 46 (pp. 1443). Retrieved from http://gateway.webofknowledge.com/The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies (Conference Paper)
Rao, R. G., Costello, E., Halloran, C. M., Oldfield, L., Greenhalf, W., Ghaneh, P., . . . Mann, K. (2017). The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies. In PANCREAS Vol. 46 (pp. 1403-1404). Retrieved from https://www.webofscience.com/THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS (Conference Paper)
McWilliam, S. J., Antoine, D. J., Rosala-Hallas, A., Jones, A., MacLean, C., Prayle, A., . . . Pirmohamed, M. (2017). THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S353). Indiana Convention Center, Indianapolis, Indiana. doi:10.1002/ppul.23840GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer (Journal article)
Martinelli, P., Pau, E. C. D. S., Cox, T., Sainz, B., Dusetti, N., Greenhalf, W., . . . Real, F. X. (2017). GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. Gut, 66(9), 1665-1676. doi:10.1136/gutjnl-2015-311256Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium (Journal article)
Campa, D., Obazee, O., Pastore, M., Panzuto, F., Lico, V., Greenhalf, W., . . . Canzian, F. (2017). Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 26(8), 1349-1351. doi:10.1158/1055-9965.EPI-17-0075Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk (Journal article)
Gomez-Rubio, P., Rosato, V., Marquez, M., Bosetti, C., Molina-Montes, E., Rava, M., . . . Malats, N. (2017). A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk. ANNALS OF ONCOLOGY, 28(7), 1618-1624. doi:10.1093/annonc/mdx167DRD2 is critical for pancreatic cancer and promises pharmacological therapy by already established antagonists (Conference Paper)
Jandaghi, P., Najafabadi, H. S., Bauer, A., Papadakis, A. I., Fassan, M., Hall, A., . . . Hoheisel, J. D. (2017). DRD2 is critical for pancreatic cancer and promises pharmacological therapy by already established antagonists. In CANCER RESEARCH Vol. 77. doi:10.1158/1538-7445.AM2017-1135Biomarker prediction of efficacy to vandetanib plus gemcitabine in a phase II double blind multicenter randomized placebo controlled trial in locally advanced or metastatic pancreatic carcinoma. (Conference Paper)
Neoptolemos, J. P., Palmer, D., Greenhalf, W., Ghaneh, P., Jackson, R., Evans, A., . . . Middleton, G. W. (2017). Biomarker prediction of efficacy to vandetanib plus gemcitabine in a phase II double blind multicenter randomized placebo controlled trial in locally advanced or metastatic pancreatic carcinoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 35. doi:10.1200/JCO.2017.35.15_suppl.4104Designing a bio-inspired biomimetic <i>in vitro</i> system for the optimization of <i>ex vivo</i> studies of pancreatic cancer (Journal article)
Totti, S., Vernardis, S. I., Meira, L., Perez-Mancere, P. A., Costello, E., Greenhalf, W., . . . Velliou, E. G. (2017). Designing a bio-inspired biomimetic <i>in vitro</i> system for the optimization of <i>ex vivo</i> studies of pancreatic cancer. DRUG DISCOVERY TODAY, 22(4), 690-701. Retrieved from https://www.webofscience.com/Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial (Journal article)
Middleton, G., Palmer, D. H., Greenhalf, W., Ghaneh, P., Jackson, R., Cox, T., . . . Neoptolemos, J. P. (2017). Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology, 18(4), 486-499. doi:10.1016/S1470-2045(17)30084-0Immunohistochemical hENT1 expression as a prognostic biomarker in patients with resected pancreatic ductal adenocarcinoma undergoing adjuvant gemcitabine-based chemotherapy (Journal article)
Bird, N. T. E., Elmasry, M., Jones, R., Psarelli, E., Dodd, J., Malik, H., . . . Palmer, D. (2017). Immunohistochemical hENT1 expression as a prognostic biomarker in patients with resected pancreatic ductal adenocarcinoma undergoing adjuvant gemcitabine-based chemotherapy. BRITISH JOURNAL OF SURGERY, 104(4), 328-336. doi:10.1002/bjs.10482Reduced risk of pancreatic cancer associated with asthma and nasal allergies (Journal article)
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Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice (Journal article)
Jandaghi, P., Najafabadi, H. S., Bauer, A. S., Papadakis, A. I., Fassan, M., Hall, A., . . . Hoheisel, J. D. (2016). Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice. Gastroenterology, 151(6), 1218-1231. doi:10.1053/j.gastro.2016.08.040Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis (Journal article)
Fjeld, K., Beer, S., Johnstone, M., Zimmer, C., Moessner, J., Ruffert, C., . . . Rosendahl, J. (2016). Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLOS ONE, 11(11). doi:10.1371/journal.pone.0165567Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma. (Journal article)
Connor, A. A., Denroche, R. E., Jang, G. H., Timms, L., Kalimuthu, S. N., Selander, I., . . . Gallinger, S. (2016). Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.. JAMA oncology, 3(6), 774-783. doi:10.1001/jamaoncol.2016.3916The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer (Journal article)
Kleeff, J., Costello, E., Jackson, R., Halloran, C., Greenhalf, W., Ghaneh, P., . . . Neoptolemos, J. P. (2016). The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer. BRITISH JOURNAL OF CANCER, 115(7), 887-894. doi:10.1038/bjc.2016.277Early epigenetic downregulation of microRNA-192 expression promotes pancreatic cancer progression (Journal article)
Botla, S. K., Savant, S., Jandaghi, P., Bauer, A. S., Mucke, O., Moskalev, E. A., . . . Hoheisel, J. D. (2016). Early epigenetic downregulation of microRNA-192 expression promotes pancreatic cancer progression. Cancer Research, 76(14), 4149-4159. doi:10.1158/0008-5472.CAN-15-0390A Personalized Approach to Adjuvant Therapy: Cytoplasmic HuR Status Predicts Disease Free Survival After Resection for Pancreatic Ductal Adenocarcinoma (Conference Paper)
Tatarian, T., Grigoli, A., Leiby, B. E., Jimbo, M., Dabbish, N., Jiang, W., . . . Brody, J. R. (2016). A Personalized Approach to Adjuvant Therapy: Cytoplasmic HuR Status Predicts Disease Free Survival After Resection for Pancreatic Ductal Adenocarcinoma. In GASTROENTEROLOGY Vol. 150 (pp. S1211). doi:10.1016/S0016-5085(16)34095-1Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus (Journal article)
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma (Journal article)
Middleton, G., Greenhalf, W., Costello, E., Shaw, V., Cox, T., Ghaneh, P., . . . Neoptolemos, J. P. (2016). Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma. British Journal of Cancer, 114, 510-518. doi:10.1038/bjc.2015.468Xanthogranulomatous pancreatitis associated with a mucinous cystic neoplam (Journal article)
Hanna, T., Abdul-Rahman, Z., Greenhalf, W., Farooq, A., & Neoptolemos, J. P. (2016). Xanthogranulomatous pancreatitis associated with a mucinous cystic neoplam. PATHOLOGY INTERNATIONAL, 66(3), 174-176. doi:10.1111/pin.12356Choline Kinase Alpha (CHK alpha) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors (Journal article)
Mazarico, J. M., Sanchez-Arevalo Lobo, V. J., Favicchio, R., Greenhalf, W., Costello, E., Carrillo-de Santa Pau, E., . . . Real, F. X. (2016). Choline Kinase Alpha (CHK alpha) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. MOLECULAR CANCER THERAPEUTICS, 15(2), 323-333. doi:10.1158/1535-7163.MCT-15-0214UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis (Journal article)
Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665Accurate Admission Transcriptomic Signature of the Severity of Acute Pancreatitis (Other)
Nunes, Q. M., Lane, B., Huang, W., Altaf, K., Rainbow, L., Armstrong, J., . . . Sutton, R. (2016). Accurate Admission Transcriptomic Signature of the Severity of Acute Pancreatitis. In PANCREAS (Vol. 45, Iss. 10, pp. 1530). Retrieved from https://www.webofscience.com/Changes in the Expression of RRM Subunits Induce Gemcitabine Resistance in a Growth Dependent Manner (Journal article)
Mann, K. S., Brumskill, S., Ghaneh, P., & Greenhalf, W. (2016). Changes in the Expression of RRM Subunits Induce Gemcitabine Resistance in a Growth Dependent Manner. PANCREAS, 45(10), 1523. Retrieved from https://www.webofscience.com/Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes (Journal article)
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2016). Exploring the Protein Profile of Pancreatic Cancer-Associated Diabetes. PANCREAS, 45(10), 1531-1532. Retrieved from https://www.webofscience.com/Single-Nucleotide Polymorphism to Associate Cancer Risk (Journal article)
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<i>TERT</i> gene harbors multiple variants associated with pancreatic cancer susceptibility (Journal article)
Campa, D., Rizzato, C., Stolzenberg-Solomon, R., Pacetti, P., Vodicka, P., Cleary, S. P., . . . Canzian, F. (2015). <i>TERT</i> gene harbors multiple variants associated with pancreatic cancer susceptibility. INTERNATIONAL JOURNAL OF CANCER, 137(9), 2175-2183. doi:10.1002/ijc.29590Actinomycin D Sensitizes Chemotherapy Resistant Suit-2 Pancreatic Cancer Cell Lines to Gemcitabine (Journal article)
Mann, K., Rogoyski, B., Ghaneh, P., Rubbi, C., & Greenhalf, W. (2015). Actinomycin D Sensitizes Chemotherapy Resistant Suit-2 Pancreatic Cancer Cell Lines to Gemcitabine. Pancreas, 44(8), 1395-1396. Retrieved from https://journals.lww.com/Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Journal article)
Radon, T. P., Massat, N. J., Jones, R., Alrawashdeh, W., Dumartin, L., Ennis, D., . . . Crnogorac-Jurcevic, T. (2015). Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma. CLINICAL CANCER RESEARCH, 21(15), 3512-3521. doi:10.1158/1078-0432.CCR-14-2467Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms (Journal article)
Cioffi, M., Trabulo, S., Hidalgo, M., Costello, E., Greenhalf, W., Erkan, M., . . . Heeschen, C. (2015). Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms. Clinical Cancer Research, 21(10), 2325-2337. doi:10.1158/1078-0432.CCR-14-1399Biomarkers for early diagnosis of pancreatic cancer (Journal article)
Jenkinson, C., Earl, J., Ghaneh, P., Halloran, C., Carrato, A., Greenhalf, B., . . . Costello-Goldring, E. (2015). Biomarkers for early diagnosis of pancreatic cancer. Expert Review of Gastroenterology & Hepatology, 9(03), 305-315. doi:10.1586/17474124.2015.965145Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer (Journal article)
Jenkinson, C., Elliott, V., Menon, U., Apostolidou, S., Fourkala, O. E., Gentry-Maharaj, A., . . . Costello, E. (2015). Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer. JOURNAL OF PROTEOMICS, 113, 400-402. doi:10.1016/j.jprot.2014.10.001A Single p53 Mutation May Predict Survival in Intraductal Papillary Mucinous Neoplasms of the Pancreas (Journal article)
Nicholson, J., Howes, N., Harrison, S., Hanna, T., Yan, L., Lane, B., . . . Greenhalf, W. (2015). A Single p53 Mutation May Predict Survival in Intraductal Papillary Mucinous Neoplasms of the Pancreas. PANCREAS, 44(8), 1402. Retrieved from https://www.webofscience.com/Cathepsin D Expression in Pancreatic Ductal Adenocarcinoma (PDAC) Cells Increases Proliferation and Reduces Survival of Pancreatic Cancer Patients (Conference Paper)
Mahajan, U. M., Langhoff, E., Costello, E., Greenhalf, W., Halloran, C., Schwaiger, T., . . . Mayerle, J. (2015). Cathepsin D Expression in Pancreatic Ductal Adenocarcinoma (PDAC) Cells Increases Proliferation and Reduces Survival of Pancreatic Cancer Patients. In GASTROENTEROLOGY Vol. 148 (pp. S13). Retrieved from https://www.webofscience.com/Clinical and Biological Features of Patients of Acute Pancreatitis With Transient Organ Failure or Acute Peripancreatic Fluid Collection (Journal article)
Huang, W., Iglesia-Garcia, D., Szatmary, P., Fleming-Bird, L., Altaf, K., Nunes, Q., . . . Sutton, R. (2015). Clinical and Biological Features of Patients of Acute Pancreatitis With Transient Organ Failure or Acute Peripancreatic Fluid Collection. PANCREAS, 44(8), 1379-1380. Retrieved from https://www.webofscience.com/Cumulative Acute Pancreatitis Outcome Score for Clinical Trials in Acute Pancreatitis (Journal article)
Huang, W., Szatmary, P., Iglesia-Garcia, D., Sud, A., Lane, B., Nunes, Q., . . . Sutton, R. (2015). Cumulative Acute Pancreatitis Outcome Score for Clinical Trials in Acute Pancreatitis. PANCREAS, 44(8), 1380. Retrieved from https://www.webofscience.com/Cytidine Deaminase (CDA) Transcript Analysis Complements hENT1 Protein Staining in Predicting Gemcitabine Response in the ESPAC-3 Pancreatic Cancer Cohort (Journal article)
Elander, N., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Costello, E., Palmer, D., . . . Greenhalf, W. (2015). Cytidine Deaminase (CDA) Transcript Analysis Complements hENT1 Protein Staining in Predicting Gemcitabine Response in the ESPAC-3 Pancreatic Cancer Cohort. PANCREAS, 44(8), 1371. Retrieved from https://www.webofscience.com/Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development? (Conference Paper)
Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Timms, J. F., Gentry-Maharaj, A., . . . Costello, E. (2015). Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development?. In PANCREAS Vol. 44 (pp. 1383). Retrieved from https://www.webofscience.com/Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/Early Prediction of Persistent Organ Failure in Patients With Acute Pancreatitis (Journal article)
Huang, W., Szatmary, P., Iglesia-Garcia, D., Fleming-Bird, L., Parente, S., Primo, G., . . . Sutton, R. (2015). Early Prediction of Persistent Organ Failure in Patients With Acute Pancreatitis. PANCREAS, 44(8), 1380. Retrieved from https://www.webofscience.com/Incidence of post-ERCP pancreatitis from direct pancreatic juice collection in hereditary pancreatitis and familial pancreatic cancer before and after the introduction of prophylactic pancreatic stents and rectal diclofenac. (Journal article)
Nicholson, J., Greenhalf, B., Jackson, R., Cox, T., Butler, J., Hanna, T., . . . Neoptolemos, J. (2015). Incidence of post-ERCP pancreatitis from direct pancreatic juice collection in hereditary pancreatitis and familial pancreatic cancer before and after the introduction of prophylactic pancreatic stents and rectal diclofenac.. Pancreas, 44(02), 260-265. doi:10.1097/MPA.0000000000000246Inhibition of Hedgehog Pathway in 2D and 3D Co-cultures of CAFs and PDAC Cell Lines (Journal article)
Brumskill, S., Barrera, L., Campbell, F., Halloran, C., Greenhalf, W., Ghirelli, C., . . . Costello, E. (2015). Inhibition of Hedgehog Pathway in 2D and 3D Co-cultures of CAFs and PDAC Cell Lines. PANCREAS, 44(8), 1363-1364. Retrieved from https://www.webofscience.com/Pancreatic Human Fibroblast Expression Profiling Reveals Novel microRNAs and mRNAs in the Diseased Pancreas (Journal article)
Barrera, L., Lane, B., Brumskill, S., Oldfield, F., Nunes, Q., Campbell, F., . . . Costello, E. (2015). Pancreatic Human Fibroblast Expression Profiling Reveals Novel microRNAs and mRNAs in the Diseased Pancreas. PANCREAS, 44(8), 1361-1362. Retrieved from https://www.webofscience.com/Pancreatic Mass in a Young <i>CFTR</i> Carrier With a Heterozygous p.R117H <i>CFTR</i> Gene Mutation and Homozygous 7T (Journal article)
Hanna, T., Abdul-Rahman, Z., Greenhalf, W., Costello, E., & Neoptolemos, J. P. (2015). Pancreatic Mass in a Young <i>CFTR</i> Carrier With a Heterozygous p.R117H <i>CFTR</i> Gene Mutation and Homozygous 7T. PANCREAS, 44(2), 343-345. doi:10.1097/MPA.0000000000000244Pattern and Impact of Organ Failure on Human Acute Pancreatitis (Journal article)
Szatmary, P., Huang, W., Liu, T., de la Iglesia-Garcia, D., Parente, S., Primo, G., . . . Sutton, R. (2015). Pattern and Impact of Organ Failure on Human Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/Pattern of Infective Complications in Human Acute Pancreatitis (Journal article)
Szatmary, P., Huang, W., de la Iglesia-Garcia, D., Parente, S., Primo, G., Greenhalf, W., & Sutton, R. (2015). Pattern of Infective Complications in Human Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes (Journal article)
Oldfield, L., Jenkinson, C., Purewal, T., Sutton, R., Neoptolemos, J. P., Greenhalf, W., & Costello, E. (2015). Potential Biomarkers of Pancreatic Ductal Adenocarcinoma-Associated Diabetes. PANCREAS, 44(8), 1404-1405. Retrieved from https://www.webofscience.com/2014
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis (Journal article)
Huang, W., Booth, D., Cane, M. C., Chvanov, M., Javed, M. A., Elliott, V., . . . Criddle, D. (2014). Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut, 63(8), 1313-1324. doi:10.1136/gutjnl-2012-304058Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial (Journal article)
Middleton, G., Silcocks, P., Cox, T. F., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. P. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0Predictive cytokine biomarkers for survival in patients with advanced pancreatic cancer randomized to sequential chemoimmunotherapy comprising gemcitabine and capecitabine (GemCap) followed by the telomerase vaccine GV1001 compared to concurrent chemoimmunotherapy in the TeloVac phase III trial (Conference Paper)
Neoptolemos, J. P., Greenhalf, W., Cox, T. F., Costello, E., Shaw, V., Valle, J. W., . . . Middleton, G. (2014). Predictive cytokine biomarkers for survival in patients with advanced pancreatic cancer randomized to sequential chemoimmunotherapy comprising gemcitabine and capecitabine (GemCap) followed by the telomerase vaccine GV1001 compared to concurrent chemoimmunotherapy in the TeloVac phase III trial. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 4121). doi:10.1200/jco.2014.32.15_suppl.4121Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease. (Journal article)
Shaw, V. E., Lane, B., Jenkinson, C., Cox, T., Greenhalf, W., Halloran, C. M., . . . Costello, E. (2014). Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease.. Molecular cancer, 13, 114. doi:10.1186/1476-4598-13-114Serum cytokine biomarker panels for discriminating Pancreatic Cancer from Benign Pancreatic Disease (Journal article)
Shaw, V. E., Lane, B., Jenkinson, C., Cox, T. F., Greenhalf, W., Halloran, C. M., . . . Costello, E. (2014). Serum cytokine biomarker panels for discriminating Pancreatic Cancer from Benign Pancreatic Disease. Molecular Cancer, 13. Retrieved from https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-114Combination Therapy With Gemcitabine and a Novel Plk1 Inhibitor Causes Caspase-Independent Cell Death in Pancreatic Cancer Cells (Journal article)
Jones, O. P., Greenhalf, W., Halloran, C., Neoptolemos, J. P., & Ghaneh, P. (2014). Combination Therapy With Gemcitabine and a Novel Plk1 Inhibitor Causes Caspase-Independent Cell Death in Pancreatic Cancer Cells. PANCREAS, 43(8), 1372. Retrieved from https://www.webofscience.com/Dissecting the Role of Hedgehog Signalling in the Interaction Between Pancreatic Stellate Cells and Pancreatic Tumour Cells Using 2D and 3D Modelling (Journal article)
Brumskill, S., Barrera, L., Campbell, F., Halloran, C., Greenhalf, W., Campbell, M. -A., & Costello, E. (2014). Dissecting the Role of Hedgehog Signalling in the Interaction Between Pancreatic Stellate Cells and Pancreatic Tumour Cells Using 2D and 3D Modelling. PANCREAS, 43(8), 1346. Retrieved from https://www.webofscience.com/Keeping on top of data samples with LIMS (Journal article)
Greenhalf, W., & Boother, J. (2014). Keeping on top of data samples with LIMS. Manufacturing Chemist, 85(7-8).Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. (Journal article)
Greenhalf, W., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., Lamb, R. F., . . . Büchler, M. W. (2014). Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.. Journal of the National Cancer Institute, 106(1). doi:10.1093/jnci/djt347Risk of Other Cancers in Familial Pancreatic Cancer (Journal article)
Hanna, T., Nicholson, J., Harrison, S., Johnstone, M., Ghaneh, P., Sutton, R., . . . Greenhalf, W. (2014). Risk of Other Cancers in Familial Pancreatic Cancer. PANCREAS, 43(8), 1363. Retrieved from https://www.webofscience.com/The Diagnosis of Chronic Pancreatitis: A Systematic Review and Meta-analysis (Journal article)
Johnstone, M., Jackson, R., Hanna, T., Nicholson, J., Neoptolemos, J. P., Greenhalf, W., & Sutton, R. (2014). The Diagnosis of Chronic Pancreatitis: A Systematic Review and Meta-analysis. PANCREAS, 43(8), 1372. Retrieved from https://www.webofscience.com/2013
iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)
Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. BRITISH JOURNAL OF CANCER, 108(9), 1846-1853. doi:10.1038/bjc.2013.150Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival (Journal article)
Rachakonda, P. S., Bauer, A. S., Xie, H., Campa, D., Rizzato, C., Canzian, F., . . . Kumar, R. (2013). Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival. PLOS ONE, 8(4). doi:10.1371/journal.pone.0060870ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium. (Journal article)
Rizzato, C., Campa, D., Pezzilli, R., Soucek, P., Greenhalf, W., Capurso, G., . . . Canzian, F. (2013). ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium.. Oncology reports, 29(4), 1637-1644. doi:10.3892/or.2013.2285A multistate modelling approach for pancreatic cancer development in genetically high-risk families (Journal article)
Kolamunnage-Dona, R., Vitone, L., Greenhalf, W., Henderson, R., & Williamson, P. R. (2013). A multistate modelling approach for pancreatic cancer development in genetically high-risk families. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 62(2), 201-212. doi:10.1111/j.1467-9876.2012.01051.xGenetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium (Journal article)
Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., . . . Canzian, F. (2013). Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Digestive and Liver Disease, 45(2), 95-99. doi:10.1016/j.dld.2012.09.014Fatty Acid Ethyl Ester Synthase Inhibition Ameliorates Ethanol-Induced Ca<SUP>2+</SUP>-Dependent Mitochondrial Dysfunction and Acute Pancreatitis (Journal article)
Huang, W., Booth, D. M., Cane, M. C., Chvanov, M., Javed, M. A., Elliot, V. L., . . . Criddle, D. N. (2013). Fatty Acid Ethyl Ester Synthase Inhibition Ameliorates Ethanol-Induced Ca<SUP>2+</SUP>-Dependent Mitochondrial Dysfunction and Acute Pancreatitis. PANCREAS, 42(8), 1355. Retrieved from https://www.webofscience.com/Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium (Journal article)
Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., . . . Canzian, F. (2013). Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. DIGESTIVE AND LIVER DISEASE, 45(2), 95-99. doi:10.1016/j.dld.2012.09.014Isolation of Quiescent and Activated Human Pancreatic Stellate Cells for MicroRNA Profiling (Journal article)
Barrera, L., Oldfield, F., Nunes, Q., Campbell, F., Lane, B., Andrews, T., . . . Costello, E. (2013). Isolation of Quiescent and Activated Human Pancreatic Stellate Cells for MicroRNA Profiling. PANCREAS, 42(8), 1339. Retrieved from https://www.webofscience.com/Micro RNA Profiling in Acute Pancreatitis (Conference Paper)
Altaf, K., Lane, B., Rainbow, L., Halloran, C., Greenhalf, W., & Sutton, R. (2013). Micro RNA Profiling in Acute Pancreatitis. In PANCREAS Vol. 42 (pp. 1337). Retrieved from https://www.webofscience.com/Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival (Journal article)
Rachakonda, P. S., Bauer, A. S., Xie, H., Campa, D., Rizzato, C., Canzian, F., . . . Kumar, R. (n.d.). Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival. PLoS ONE, 8(4), e60870. doi:10.1371/journal.pone.0060870hENT1 Tumor Expression Predicts Longer Survival in Patients with Resection for Pancreatic Ductal Adenocarcinoma Randomized to Adjuvant Gemcitabine in the ESPAC Trials (Journal article)
Greenhalf, W., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., Garner, E., . . . he European Study Group for Pancreatic Cancer, F. (2013). hENT1 Tumor Expression Predicts Longer Survival in Patients with Resection for Pancreatic Ductal Adenocarcinoma Randomized to Adjuvant Gemcitabine in the ESPAC Trials. JNCI, Accept.2012
Common genetic variants in the <i>CLDN2</i> and <i>PRSS1-PRSS2</i> loci alter risk for alcohol-related and sporadic pancreatitis (Journal article)
Whitcomb, D. C., LaRusch, J., Krasinskas, A. M., Klei, L., Smith, J. P., Brand, R. E., . . . Yu, L. (2012). Common genetic variants in the <i>CLDN2</i> and <i>PRSS1-PRSS2</i> loci alter risk for alcohol-related and sporadic pancreatitis. NATURE GENETICS, 44(12), 1349-1354. doi:10.1038/ng.2466Divisum may be preserving pancreatic function in CFTR patients-but at a cost. (Journal article)
Nicholson, J. A., Johnstone, M., & Greenhalf, W. (2012). Divisum may be preserving pancreatic function in CFTR patients-but at a cost.. The American journal of gastroenterology, 107(11), 1758-1759. doi:10.1038/ajg.2012.302New biomarkers and targets in pancreatic cancer and their application to treatment (Journal article)
Costello, E., Greenhalf, W., & Neoptolemos, J. P. (2012). New biomarkers and targets in pancreatic cancer and their application to treatment. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 9(8), 435-444. doi:10.1038/nrgastro.2012.119A multistate modelling approach for pancreatic cancer development in genetically high risk families (Journal article)
Kolamunnage-Dona, R., Vitone, L., Greenhalf, W., Henderson, R., & Williamson, P. R. (2012). A multistate modelling approach for pancreatic cancer development in genetically high risk families. Journal of the Royal Statistical Society: Series C (Applied Statistics). Retrieved from http://dx.doi.org/10.1111/j.1467-9876.2012.01051.xDiagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue (Journal article)
Bauer, A. S., Keller, A., Costello, E., Greenhalf, W., Bier, M., Borries, A., . . . Hoheisel, J. D. (2012). Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue. PLOS ONE, 7(4). doi:10.1371/journal.pone.00341512011
Pancreatic Cancer Susceptibility Loci and Their Role in Survival (Journal article)
Rizzato, C., Campa, D., Giese, N., Werner, J., Rachakonda, P. S., Kumar, R., . . . Canzian, F. (2011). Pancreatic Cancer Susceptibility Loci and Their Role in Survival. PLOS ONE, 6(11). doi:10.1371/journal.pone.0027921Combination therapy for the treatment of pancreatic cancer. (Journal article)
Greenhalf, W., & Thomas, A. (2011). Combination therapy for the treatment of pancreatic cancer.. Anti-cancer agents in medicinal chemistry, 11(5), 418-426. doi:10.2174/1871520117956773912010
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer (Journal article)
Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626PALB2 mutations in European familial pancreatic cancer families. (Journal article)
Slater, E. P., Langer, P., Niemczyk, E., Strauch, K., Butler, J., Habbe, N., . . . Bartsch, D. K. (2010). PALB2 mutations in European familial pancreatic cancer families.. Clinical genetics, 78(5), 490-494. doi:10.1111/j.1399-0004.2010.01425.xCurrent status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (Journal article)
Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. (Journal article)
Ripka, S., Neesse, A., Riedel, J., Bug, E., Aigner, A., Poulsom, R., . . . Michl, P. (2010). CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.. Gut, 59(8), 1101-1110. doi:10.1136/gut.2009.189720The variable phenotype of the p.A16V mutation of cationic trypsinogen (<i>PRSS1</i>) in pancreatitis families (Journal article)
Grocock, C. J., Rebours, V., Delhaye, M. N., Andren-Sandberg, A., Weiss, F. U., Mountford, R., . . . Greenhalf, W. (2010). The variable phenotype of the p.A16V mutation of cationic trypsinogen (<i>PRSS1</i>) in pancreatitis families. GUT, 59(3), 357-363. doi:10.1136/gut.2009.186817Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. (Journal article)
Dive, C., Smith, R. A., Garner, E., Ward, T., George-Smith, S. S., Campbell, F., . . . Neoptolemos, J. P. (2010). Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.. British journal of cancer, 102(3), 577-582. doi:10.1038/sj.bjc.6605494Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer (Journal article)
Dive, C., Smith, R. A., Garner, E., Ward, T., George-Smith, S. S., Campbell, F., . . . Neoptolemos, J. P. (2010). Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. British Journal of Cancer, 102(3), 577-582. doi:10.1038/sj.bjc.6605494Genetic Susceptibility (Chapter)
Greenhalf, W., & Neoptolemos, J. (2010). Genetic Susceptibility. In J. L. Abbruzzese, M. W. Buchler, R. Urrutia, & J. Neoptolemos (Eds.), Handbook of Pancreatic Cancer (Vol. In Pre). New York: Springer-Verlag.Inherited genetics of pancreatic cancer and secondary screening (Chapter)
Greenhalf, W., & Neoptolemos, J. (2010). Inherited genetics of pancreatic cancer and secondary screening. In J. L. Abbruzzese, M. W. Buchler, R. Urrutia, & J. Neoptolemos (Eds.), Handbook of Pancreatic Cancer (Vol. In Pri). New York: Springer-Verlag.Single-nucleotide polymorphism (SNP) analysis to associate cancer risk. (Journal article)
Earl, J., & Greenhalf, W. (2010). Single-nucleotide polymorphism (SNP) analysis to associate cancer risk.. Methods in molecular biology (Clifton, N.J.), 576, 171-196. doi:10.1007/978-1-59745-545-9_10The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families. (Journal article)
Grocock, C. J., Rebours, V., Delhaye, M. N., Andrén-Sandberg, A., Weiss, F. U., Mountford, R., . . . European Registry of Hereditary Pancreatitis Pancreatic Cancer. (2010). The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families.. Gut, 59(3), 357-363.2009
Medical Treatment of Chronic Pancreatitis (Chapter)
Mössner, J., Layer, P., Keller, J., Mullady, D. K., O'Keefe, S. J. D., Howes, N., . . . Raraty, M. G. T. (2009). Medical Treatment of Chronic Pancreatitis. In The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery: Second Edition (pp. 504-526). doi:10.1002/9781444300123.ch52Factors involved in carcinogenesis and prevention in hepatobiliary cancer (Chapter)
Ghaneh, P., Greenhalf, W., & Neoptolemos, J. P. (2009). Factors involved in carcinogenesis and prevention in hepatobiliary cancer. In Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach (pp. 421-432).Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer (Journal article)
Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., . . . Costello, E. (2009). Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer. JOURNAL OF PROTEOME RESEARCH, 8(1), 142-148. doi:10.1021/pr800451hScreening of high-risk families for pancreatic cancer. (Journal article)
Greenhalf, W., Grocock, C., Harcus, M., & Neoptolemos, J. (2009). Screening of high-risk families for pancreatic cancer.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 9(3), 215-222. doi:10.1159/000210262The inherited genetic component of sporadic pancreatic adenocarcinoma. (Journal article)
Milne, R. L., Greenhalf, W., Murta-Nascimento, C., Real, F. X., & Malats, N. (2009). The inherited genetic component of sporadic pancreatic adenocarcinoma.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 9(3), 206-214. doi:10.1159/0002102612008
New treatment options for advanced pancreatic cancer. (Journal article)
Middleton, G., Ghaneh, P., Costello, E., Greenhalf, W., & Neoptolemos, J. P. (2008). New treatment options for advanced pancreatic cancer.. Expert review of gastroenterology & hepatology, 2(5), 673-696. doi:10.1586/17474124.2.5.673Familial Pancreatic Cancer (Chapter)
Greenhalf, W., Vitone, L. J., & Neoptolemos, J. P. (2008). Familial Pancreatic Cancer. In Unknown Book (pp. 591-600). Wiley. doi:10.1002/9781444300123.ch59Medical Treatment of Chronic Pancreatitis (Chapter)
Mössner, J., Layer, P., Keller, J., Mullady, D. K., Oí'Keefe, S. J. D., Howes, N., . . . Raraty, M. G. T. (2008). Medical Treatment of Chronic Pancreatitis. In Unknown Book (pp. 504-526). Wiley. doi:10.1002/9781444300123.ch52Screening of Hereditary Pancreatic Cancer Families (Chapter)
Carlson, C., Greenhalf, W., & Brentnall, T. A. (2008). Screening of Hereditary Pancreatic Cancer Families. In Unknown Book (pp. 636-642). Wiley. doi:10.1002/9781444300123.ch64International registries of families at high risk of pancreatic cancer. (Journal article)
Greenhalf, W., Malats, N., Nilsson, M., Bartsch, D., & Neoptolemos, J. (2008). International registries of families at high risk of pancreatic cancer.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 8(6), 558-565. doi:10.1159/0001592142007
Familial pancreatic cancer: a review and latest advances. (Journal article)
Grocock, C. J., Vitone, L. J., Harcus, M. J., Neoptolemos, J. P., Raraty, M. G. T., & Greenhalf, W. (2007). Familial pancreatic cancer: a review and latest advances.. Advances in medical sciences, 52, 37-49.Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition (Journal article)
Burkitt, M., Magee, C., O'Connor, D., Campbell, F., Cornford, P., & Greenhalf, W. (2007). Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition. MOLECULAR CARCINOGENESIS, 46(6), 466-475. doi:10.1002/mc.20296Palladin mutation causes familial pancreatic cancer: absence in European families. (Journal article)
Slater, E., Amrillaeva, V., Fendrich, V., Bartsch, D., Earl, J., Vitone, L. J., . . . Greenhalf, W. (2007). Palladin mutation causes familial pancreatic cancer: absence in European families.. PLoS medicine, 4(4), e164. doi:10.1371/journal.pmed.0040164Absence of the palladin P239S mutation in European pancreatic cancer families. (Journal article)
Slater, E. P., Amrillaeva, V., Fendrich, V., Bartsch, D. K., for., FaPaCa., . . . Europac. (2007). Absence of the palladin P239S mutation in European pancreatic cancer families.. PLoS Medicine, 4(4), e164. Retrieved from http://medicine.plosjournals.org/Diabetes is a Risk Factor for Pancreatic Cancer. (Journal article)
Vitone, L. J., Charnley, R., Simon, P., Dodd, S., Grocock, C., Delhaye, M., . . . on, O. B. O. T. E. R. O. H. P. (2007). Diabetes is a Risk Factor for Pancreatic Cancer.. Pancreatology, 7, 221.Familial Pancreatic Cancer. (Chapter)
Greenhalf, W., Vitone, L. J., & Neoptolemos, J. P. (2007). Familial Pancreatic Cancer.. In H. Beger, M. Buchler, R. Kozarek, M. Lerch, J. P. Neoptolemos, A. Warshaw, . . . H. Beger (Eds.), The Pancreas : A Clinical and Surgical Text (pp. Section 5, Chapter 60). Ulm: Blackwell Publishing.Familial Pancreatic Cancer: a review and latest advances. (Journal article)
Grocock, C., Vitone, L. J., Harcus, M. J., Neoptolemos, J. P., Raraty, M. G., & Greenhalf, W. (2007). Familial Pancreatic Cancer: a review and latest advances.. Advances in Medical Sciences, 52, 37-49.Familial pancreatic cancer: a review and latest advances (Journal article)
Grocock, C. J., Vitone, L. J., Harcus, M. J., Neoptolemos, J. P., Raraty, M. G., & Greenhalf, W. (2007). Familial pancreatic cancer: a review and latest advances. Adv Med Sci, 52, 37-49. Retrieved from http://www.ncbi.nlm.nih.gov/Palladin mutation causes familial pancreatic cancer: absence in European families (Journal article)
Slater, E., Amrillaeva, V., Fendrich, V., Bartsch, D., Earl, J., Vitone, L. J., . . . Greenhalf, W. (2007). Palladin mutation causes familial pancreatic cancer: absence in European families. PLoS Med, 4(4), e164.The Association of the Palladin P239S Mutation and European Familial Pancreatic Cancer Families. (Journal article)
Earl, J., Slater, E. P., Yan, L., Vitone, L. J., Grocock, C., Harcus, M., . . . Greenhalf, W. (2007). The Association of the Palladin P239S Mutation and European Familial Pancreatic Cancer Families.. Pancreatology, 7, 278.2006
Peutz-Jeghers syndrome and screening for pancreatic cancer. (Journal article)
Latchford, A., Greenhalf, W., Vitone, L. J., Neoptolemos, J. P., Lancaster, G. A., & Phillips, R. K. S. (2006). Peutz-Jeghers syndrome and screening for pancreatic cancer.. The British journal of surgery, 93(12), 1446-1455. doi:10.1002/bjs.5609An unfavourable prognosis for pancreatic cancer indicates fields of opportunity. (Journal article)
Greenhalf, W. (2006). An unfavourable prognosis for pancreatic cancer indicates fields of opportunity.. Gut, 55(11), 1533-1535. doi:10.1136/gut.2006.098814Evaluation of the <i>4q32-34</i> locus in European familial pancreatic (Journal article)
Earl, J., Yan, L., Vitone, L. J., Risk, J., Kemp, S. J., McFaul, C., . . . Bartsch, D. K. (2006). Evaluation of the <i>4q32-34</i> locus in European familial pancreatic. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 15(10), 1948-1955. doi:10.1158/1055-9965.EPI-06-0376Increasing survival rates of patients with pancreatic cancer by earlier identification. (Journal article)
Greenhalf, W., & Neoptolemos, J. P. (2006). Increasing survival rates of patients with pancreatic cancer by earlier identification.. Nature clinical practice. Oncology, 3(7), 346-347. doi:10.1038/ncponc0483Trypsinogen mutations in pancreatic disorders. (Journal article)
Vitone, L. J., Greenhalf, W., Howes, N. R., Raraty, M. G. T., & Neoptolemos, J. P. (2006). Trypsinogen mutations in pancreatic disorders.. Endocrinology and metabolism clinics of North America, 35(2), 271-viii. doi:10.1016/j.ecl.2006.02.006The inherited genetics of pancreatic cancer and prospects for secondary screening. (Journal article)
Vitone, L. J., Greenhalf, W., McFaul, C. D., Ghaneh, P., & Neoptolemos, J. P. (2006). The inherited genetics of pancreatic cancer and prospects for secondary screening.. Best practice & research. Clinical gastroenterology, 20(2), 253-283. doi:10.1016/j.bpg.2005.10.007Anticipation in familial pancreatic cancer. (Journal article)
McFaul, C. D., Greenhalf, W., Earl, J., Howes, N., Neoptolemos, J. P., Kress, R., . . . German National Case Collection for Familial Pancreatic Cancer (FaPaCa). (2006). Anticipation in familial pancreatic cancer.. Gut, 55(2), 252-258. doi:10.1136/gut.2005.065045Diabetes Mellitus and Pancreatic Cancer risk in HP (Hereditary Pancreatitis) (Journal article)
Vitone, L., Howes, N., Mountford, R., Murali-Krishnan, G., Neoptolemos, J. P., & Greenhalf, W. (2006). Diabetes Mellitus and Pancreatic Cancer risk in HP (Hereditary Pancreatitis). Pancreatology, 6, 196.Temporal and serum dependence of potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin (Journal article)
Magee, C. J., Burkitt, M., O'Connor, D. I., Campbell, F., Cornford, P., & Greenhalf, N. A. (2006). Temporal and serum dependence of potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin. Molecular Carcinogenesis.2005
<i>RNASEL</i> germline variants are associated with pancreatic cancer (Journal article)
Bartsch, D. K., Fendrich, V., Slater, E. P., Sina‐Frey, M., Rieder, H., Greenhalf, W., . . . Kress, R. (2005). <i>RNASEL</i> germline variants are associated with pancreatic cancer. International Journal of Cancer, 117(5), 718-722. doi:10.1002/ijc.21254RNASEL germline variants are associated with pancreatic cancer. (Journal article)
Bartsch, D. K., Fendrich, V., Slater, E. P., Sina-Frey, M., Rieder, H., Greenhalf, W., . . . Kress, R. (2005). RNASEL germline variants are associated with pancreatic cancer.. International journal of cancer, 117(5), 718-722. doi:10.1002/ijc.21254Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. (Journal article)
Cohn, J. A., Neoptolemos, J. P., Feng, J., Yan, J., Jiang, Z., Greenhalf, W., . . . Sommer, S. S. (2005). Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers.. Human mutation, 26(4), 303-307. doi:10.1002/humu.20232High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients (Journal article)
Vimalachandran, D., Greenhalf, W., Thompson, C., Lüttges, J., Prime, W., Campbell, F., . . . Costello, E. (2005). High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. CANCER RESEARCH, 65(8), 3218-3225. doi:10.1158/0008-5472.CAN-04-4311Cationic trypsinogen mutations and pancreatitis. (Journal article)
Howes, N., Greenhalf, W., Stocken, D. D., & Neoptolemos, J. P. (2005). Cationic trypsinogen mutations and pancreatitis.. Clinics in laboratory medicine, 25(1), 39-59. doi:10.1016/j.cll.2004.12.004Exclusion Mapping of the 4q32-34 Locus in 41 European FPC Families (Journal article)
Earl, J., Kress, R., Yan, L., Howes, N., Leslie, J., Vitone, L., . . . Greenhalf, W. (2005). Exclusion Mapping of the 4q32-34 Locus in 41 European FPC Families. Pancreatology, 5(Suppl), 106.Familial pancreatic cancer syndromes (Chapter)
Hahn, S., Vitone, L., Greenhalf, W., Bartsch, D., & Neoptolemos, J. P. (2005). Familial pancreatic cancer syndromes. In T. M. Gress, J. P. Neoptoelmos, N. R. Lemoine, & F. X. Real (Eds.), Exocrine pancreas cancer (pp. 44-61). Hannover: Felsenstein CCCP.Functional Analysis of S100A6 (Calcyclin) in Pancreatic Cancer Patients (Journal article)
Nedjadi, T., Vimalachandran, D., Thompson, C. C. M., Lüttges, J., Prime, W., Campbell, F., . . . Costello, E. (2005). Functional Analysis of S100A6 (Calcyclin) in Pancreatic Cancer Patients. Pancreatology, 5(Suppl), 45.Hereditary pancreatitis and secondary screening for early pancreatic cancer. (Journal article)
Vitone, L. J., Greenhalf, W., Howes, N. R., & Neoptolemos, J. P. (2005). Hereditary pancreatitis and secondary screening for early pancreatic cancer.. Roczniki Akademii Medycznej w Bialymstoku (1995), 50, 73-84.Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. (Journal article)
Yan, L., McFaul, C., Howes, N., Leslie, J., Lancaster, G., Wong, T., . . . Greenhalf, W. (2005). Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.. Gastroenterology, 128(7), 2124-2130. doi:10.1053/j.gastro.2005.03.006Molecular diagnosis of pancreatic cancer in pancreatic juice (Chapter)
Greenhalf, W., Vitone, L., & Neoptolemos, J. P. (2005). Molecular diagnosis of pancreatic cancer in pancreatic juice. In T. M. Gress, J. P. Neoptolemos, N. R. Lemoine, & F. X. Real (Eds.), Exocrine pancreas cancer (pp. 404-425). Hannover: Felenstein CCCP.Promoter Methylation Detected in Pancreatic Juice: Relationship with Cancer, Age and Survival (Journal article)
Yan, L., Vitone, L., Earl, J., Howes, N., Leslie, J., Lancaster, G., . . . Greenhalf, W. (2005). Promoter Methylation Detected in Pancreatic Juice: Relationship with Cancer, Age and Survival. Pancreatology, 5(Suppl), 89.Secondary screening for pancreatic cancer in high risk groups (Chapter)
Vitone, L., Greenhalf, W., & Neoptolemos, J. P. (2005). Secondary screening for pancreatic cancer in high risk groups. In T. M. Gress, J. P. Neoptolemos, N. R. Lemoine, & F. X. Real (Eds.), Exocrine pancreas cancer (pp. 310-329). Hannover: Felenstein CCCP.The Founder Effect in N29I Mutations is Greater than in R122H Mutations of the Cationic Trypsinogen Gene (Journal article)
Vitone, L., Greenhalf, W., Howes, N., Wong, T., Mountford, R., Blake, V., & Neoptolemos, J. P. (2005). The Founder Effect in N29I Mutations is Greater than in R122H Mutations of the Cationic Trypsinogen Gene. Pancreatology, 5(Suppl), 109.2004
Cationic trypsinogen mutations and pancreatitis. (Journal article)
Howes, N., Greenhalf, W., Stocken, D. D., & Neoptolemos, J. P. (2004). Cationic trypsinogen mutations and pancreatitis.. Gastroenterology clinics of North America, 33(4), 767-787. doi:10.1016/j.gtc.2004.07.003Screening Method (Patent)
Greenhalf, W., & O'Connor, D. I. (2004). Screening Method.No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma. (Journal article)
Grützmann, R., McFaul, C., Bartsch, D. K., Sina-Frey, M., Rieder, H., Koch, R., . . . Pilarsky, C. (2004). No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.. Cancer letters, 214(1), 63-68. doi:10.1016/j.canlet.2004.06.0125-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16<SUP>INK4A</SUP> greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells (Journal article)
Halloran, C. M., Ghaneh, P., Shore, S., Greenhalf, W., Zumstein, L., Wilson, D., . . . Costello, E. (2004). 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16<SUP>INK4A</SUP> greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. JOURNAL OF GENE MEDICINE, 6(5), 514-525. doi:10.1002/jgm.540Clinical and genetic characteristics of hereditary pancreatitis in Europe. (Journal article)
Howes, N., Lerch, M. M., Greenhalf, W., Stocken, D. D., Ellis, I., Simon, P., . . . European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC). (2004). Clinical and genetic characteristics of hereditary pancreatitis in Europe.. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2(3), 252-261. doi:10.1016/s1542-3565(04)00013-8Detection of p53 Mutations in Pancreatic Cancer and Chronic Pancreatitis (Journal article)
McFaul, C. D., Yan, L., Howes, N., Wong, T., Leslie, J. A., Threadgold, J., . . . Neoptolemos, J. P. (2004). Detection of p53 Mutations in Pancreatic Cancer and Chronic Pancreatitis. Pancreatology, 4(2), 144.FPC Families Unlinked to the 4q32-34 Locus (Journal article)
Earl, J., Yan, L., Kress, R., Leslie, J., McFaul, C. D., Rieder, H., . . . Neoptolemos, J. P. (2004). FPC Families Unlinked to the 4q32-34 Locus. Pancreatology, 4(2), 146.Genetic anticipation in familial pancreatic cancer (Journal article)
McFaul, C. D., Kress, R., Bartsch, D. K., Rieder, H., Sina-Frey, M., Neoptolemos, J. P., & Greenhalf, W. (2004). Genetic anticipation in familial pancreatic cancer. British Journal Of Cancer, 91, S40.Identification of a familial pancreatic cancer gene by focusing haplotype analysis using LOH in sporadic cancer (Journal article)
Leslie, J., McFaul, C., Earl, J., Azadeh, B., Prime, W., Bartsch, D., . . . Greenhalf, W. (2004). Identification of a familial pancreatic cancer gene by focusing haplotype analysis using LOH in sporadic cancer. British Journal Of Cancer, 91, S31.LOH Analysis in Sporadic Pancreatic Cancer to Identify Novel Familial Pancreatic Cancer Genes (Journal article)
Leslie, J. A., Earl, J., McFaul, C. D., Azadeh, B., Prime, W., Sibson, R., . . . Greenhalf, W. (2004). LOH Analysis in Sporadic Pancreatic Cancer to Identify Novel Familial Pancreatic Cancer Genes. Pancreatology, 4(2), 149.P53 mutations in patients with pancreatic cancer and chronic pancreatitis (Journal article)
Yan, L., McFaul, C., Malats, N., Threadgold, J., Howes, N., Leslie, J., . . . Greenhalf, W. (2004). P53 mutations in patients with pancreatic cancer and chronic pancreatitis. British Journal Of Cancer, 91, S31.2003
BRCA2 germline mutations in familial pancreatic carcinoma. (Journal article)
Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., Korte, B., . . . Bartsch, D. K. (2003). BRCA2 germline mutations in familial pancreatic carcinoma.. Journal of the National Cancer Institute, 95(3), 214-221. doi:10.1093/jnci/95.3.214BRCA2 germline mutations in familial pancreatic carcinoma (Journal article)
Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., Gerdes, B., . . . Bartsch, D. (2003). BRCA2 germline mutations in familial pancreatic carcinoma. Gastroenterology, 124(4), A548.BRCA2 germline mutations in familial pancreatic carcinoma (Journal article)
BRCA2 germline mutations in familial pancreatic carcinoma (2003). Gastroenterology, 124(4), A548.Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas (Journal article)
Evans, J. D., Cornford, P. A., Dodson, A., Greenhalf, W., Foster, C. S., & Neoptolemos, J. P. (2003). Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. Pancreatology, 1(3), 254-262. Retrieved from http://www.ncbi.nlm.nih.gov/Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers (Journal article)
Yan, J., Cohn, J., Neoptolemos, J., Feng, J., Jiang, Z., Greenhalf, W., . . . Sommer, S. (2003). Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. American Journal of Human Genetics, 73(5), 1252.Nuclear Sequestration of Hsp90 Sensitises Pancreatic Cancer (PC) Cells to Apoptosis that Can also Be Induced by Hsp90 Inhibition (Journal article)
Magee, C. J., Burkitt,, M., Evans,, J., Cornford, P., Spiller, D., White, M., . . . Greenhalf, W. (2003). Nuclear Sequestration of Hsp90 Sensitises Pancreatic Cancer (PC) Cells to Apoptosis that Can also Be Induced by Hsp90 Inhibition. Pancreatology, 3, 78.Nuclear sequestration of Hsp90 sensitises pancreatic cancer (PC) cells to apoptosis that can also be induced by Hsp90 inhibition and alters the balance of Apaf-1 isoforms to pro-apoptotic forms (Journal article)
Magee, C. J., Burkitt, M., Evans, J., Cornford, P., Spiller, D., White, M., . . . Greenhalf, W. (2003). Nuclear sequestration of Hsp90 sensitises pancreatic cancer (PC) cells to apoptosis that can also be induced by Hsp90 inhibition and alters the balance of Apaf-1 isoforms to pro-apoptotic forms. BRITISH JOURNAL OF SURGERY, 90(5), 635. Retrieved from https://www.webofscience.com/2002
The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. (Journal article)
Threadgold, J., Greenhalf, W., Ellis, I., Howes, N., Lerch, M. M., Simon, P., . . . Neoptolemos, J. P. (2002). The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.. Gut, 50(5), 675-681. doi:10.1136/gut.50.5.675Comprehensive detection of CFTR mutations in idiopathic chronic pancreatitis (Journal article)
Feng, J., Cohn,, J. A., Neoptolemus, J. P., Jiang, Z., Greenhalf, W., Ellis, I., & Somme, S. S. (2002). Comprehensive detection of CFTR mutations in idiopathic chronic pancreatitis. American Journal of Human Genetics, 71(4), 1833.Hereditary pancreatitis (HP) and the risk of pancreatic ductal adenocarcinoma (PDAC) (Journal article)
Howes, N., Lerch, M. M., Charnley, R., Mossner, J., Endres, S., Deviere, J., . . . Neoptolemos, J. P. (2002). Hereditary pancreatitis (HP) and the risk of pancreatic ductal adenocarcinoma (PDAC). Gut, 50, 155.2001
Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications. (Journal article)
Magee, C. J., Greenhalf, W., Howes, N., Ghaneh, P., & Neoptolemos, J. P. (2001). Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications.. Surgical oncology, 10(1-2), 1-23. doi:10.1016/s0960-7404(01)00016-0Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases. (Journal article)
Humphreys, M. J., Ghaneh, P., Greenhalf, W., Campbell, F., Clayton, T. M., Everett, P., . . . Neoptolemos, J. P. (2001). Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.. Gene therapy, 8(16), 1241-1247. doi:10.1038/sj.gt.3301518Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo. (Journal article)
Ghaneh, P., Greenhalf, W., Humphreys, M., Wilson, D., Zumstein, L., Lemoine, N. R., & Neoptolemos, J. P. (2001). Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo.. Gene therapy, 8(3), 199-208. doi:10.1038/sj.gt.3301394A new polymorphism for the RI22H mutation in hereditary pancreatitis. (Journal article)
Howes, N., Greenhalf, W., Rutherford, S., O'Donnell, M., Mountford, R., Ellis, I., . . . Neoptolemos, J. P. (2001). A new polymorphism for the RI22H mutation in hereditary pancreatitis.. Gut, 48(2), 247-250. doi:10.1136/gut.48.2.247Adenovirus-mediated transfer of p53 and p16INK4a results in pancreatic cancer regression in vitro and in vivo (Journal article)
Ghaneh, P., Greenhalf, W., Humphreys, M., Wilson, D., Zumstein, L., Lemoine, N. R., & Neoptolemos, J. P. (2001). Adenovirus-mediated transfer of p53 and p16INK4a results in pancreatic cancer regression in vitro and in vivo. Gene Therapy, 8(3), 199-208. doi:10.1038/sj.gt.3301394ARMS (TM) detection in real time of under-represented mutant K- ras sequence in patients at risk of pancreatic cancer (Journal article)
Callaghan, K., Howes, N., Greenhalf, W., Neoptolemos, J. P., & Fox, J. C. (2001). ARMS (TM) detection in real time of under-represented mutant K- ras sequence in patients at risk of pancreatic cancer. Pancreatology, 1(5), P217.Clinical and genetic characteristics of 101 families with hereditary pancreatitis on the EUROPAC Register (Journal article)
Ellis, I., Howes, N., Greenhalf, B., Mountford, R., O'Donnell, M., Lerch, M. M., . . . Neoptolemos, J. P. (2001). Clinical and genetic characteristics of 101 families with hereditary pancreatitis on the EUROPAC Register. Journal Of Medical Genetics, 38, S22.Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas (Journal article)
Evans, J. D., Cornford, P. A., Dodson, A., Greenhalf, W., Foster, C. S., & Neoptolemos, J. P. (2001). Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. PANCREATOLOGY, 1(3), 254-262. doi:10.1159/000055820Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients (Journal article)
Wong, T., Howes, N., Threadgold, J., Smart, H. L., Lombard, M. G., Gilmore, I., . . . Neoptolemos, J. P. (2001). Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients. PANCREATOLOGY, 1(5), 486-509. doi:10.1159/000055852Real-time KRAS mutational analysis in the diagnosis of early pancreatic ductal adenocarcinoma (Journal article)
Wong, T., Howes, N., Lombard, M. G., Smart, H. L., Gilmore, I., Sutton, R., . . . Neoptolemos, J. P. (2001). Real-time KRAS mutational analysis in the diagnosis of early pancreatic ductal adenocarcinoma. British Journal of Cancer, 85, 55.Regulation of expression of S100A4 in pancreatic ductal adenocarcinoma by the zinc finger BKLF (Journal article)
Herbert, C. W., Barraclough, B. R., & Greenhalf, W. (2001). Regulation of expression of S100A4 in pancreatic ductal adenocarcinoma by the zinc finger BKLF. British Journal of Cancer, 85, 55.Screening pancreatic juice for p53 mutations using a yeast functional assay (Journal article)
Threadgold, J., Howes, N., Ellis, I., Gilmore, I., Smart, H., Lombard, M., . . . Neoptolemos, J. P. (2001). Screening pancreatic juice for p53 mutations using a yeast functional assay. British Journal of Cancer, 85, 54.TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis (Other)
Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In Gastroenterology (Vol. 120, Iss. 5, pp. 167). [Paper].The role of Hsp90 in regulation of apoptosis in pancreatic cancer (Journal article)
Mason, A. B., Burkitt, M., Magee, C. J., O'Connor, D., & Greenhalf, W. (2001). The role of Hsp90 in regulation of apoptosis in pancreatic cancer. British Journal of Cancer, 85, 54.2000
Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. (Journal article)
Zhang, H., Cowan-Jacob, S. W., Simonen, M., Greenhalf, W., Heim, J., & Meyhack, B. (2000). Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells.. The Journal of biological chemistry, 275(15), 11092-11099. doi:10.1074/jbc.275.15.11092Screening for early pancreatic ductal adenocarcinoma in hereditary pancreatitis. (Journal article)
Howes, N., Greenhalf, W., & Neoptolemos, J. (2000). Screening for early pancreatic ductal adenocarcinoma in hereditary pancreatitis.. The Medical clinics of North America, 84(3), 719-xii. doi:10.1016/s0025-7125(05)70254-61999
A selection system for human apoptosis inhibitors using yeast. (Journal article)
Greenhalf, W., Lee, J., & Chaudhuri, B. (1999). A selection system for human apoptosis inhibitors using yeast.. Yeast (Chichester, England), 15(13), 1307-1321. doi:3.0.co;2-3">10.1002/(sici)1097-0061(19990930)15:13<1307::aid-yea455>3.0.co;2-3DOI: 10.1002/(sici)1097-0061(19990930)15:13<1307::aid-yea455>3.0.co;2-3
The EUROPAC register of familial pancreatic cancer (Journal article)
Ellis, I., O'Donnell, M., Howes, N., Threadgold, J., Greenhalf, W., Rutherford, S., . . . Neoptolemos, J. (1999). The EUROPAC register of familial pancreatic cancer. Journal of Medical Genetics, 36, S26.The potential for gene therapy in pancreatic cancer. (Journal article)
Humphreys, M. J., Greenhalf, W., Neoptolemos, J. P., & Ghaneh, P. (1999). The potential for gene therapy in pancreatic cancer.. International journal of pancreatology : official journal of the International Association of Pancreatology, 26(1), 5-21. doi:10.1385/ijgc:26:1:51998
Under respiratory growth conditions, Bcl-x(L) and Bcl-2 are unable to overcome yeast cell death triggered by a mutant Bax protein lacking the membrane anchor. (Journal article)
Clow, A., Greenhalf, W., & Chaudhuri, B. (1998). Under respiratory growth conditions, Bcl-x(L) and Bcl-2 are unable to overcome yeast cell death triggered by a mutant Bax protein lacking the membrane anchor.. European journal of biochemistry, 258(1), 19-28. doi:10.1046/j.1432-1327.1998.2580019.xThe p16(INK4A) protein and flavopiridol restore yeast cell growth inhibited by Cdk4. (Journal article)
Moorthamer, M., Panchal, M., Greenhalf, W., & Chaudhuri, B. (1998). The p16(INK4A) protein and flavopiridol restore yeast cell growth inhibited by Cdk4.. Biochemical and biophysical research communications, 250(3), 791-797. doi:10.1006/bbrc.1998.9348p53 and p16 gene therapy results in killing of pancreatic cancer cells (Journal article)
Ghaneh, P., Humphreys, M., Greenhalf, W., Lemoine, N., & Neoptolemos, J. P. (1998). p53 and p16 gene therapy results in killing of pancreatic cancer cells. British Journal of Surgery, 85(11), 1555.1996
Efficient flotation of yeast cells grown in batch culture. (Journal article)
Palmieri, M. C., Greenhalf, W., & Laluce, C. (1996). Efficient flotation of yeast cells grown in batch culture.. Biotechnology and bioengineering, 50(3), 248-256. doi:3.0.co;2-g">10.1002/(sici)1097-0290(19960505)50:3<248::aid-bit3>3.0.co;2-gDOI: 10.1002/(sici)1097-0290(19960505)50:3<248::aid-bit3>3.0.co;2-g