Photo of Prof Sylvie Urbe

Prof Sylvie Urbe

Cellular and Molecular Physiology

    Publications

    2019

    Data Mining for Traffic Information. (Journal article)

    Clague, M. J., & Urbé, S. (2019). Data Mining for Traffic Information.. Traffic (Copenhagen, Denmark). doi:10.1111/tra.12702

    DOI: 10.1111/tra.12702

    New aspects of USP30 biology in the regulation of pexophagy (Journal article)

    Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz-Jones, E. V., Clague, M. J., & Urbe, S. (2019). New aspects of USP30 biology in the regulation of pexophagy. AUTOPHAGY. doi:10.1080/15548627.2019.1615304

    DOI: 10.1080/15548627.2019.1615304

    Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019) (Journal article)

    Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019). NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(5), 321. doi:10.1038/s41580-019-0112-8

    DOI: 10.1038/s41580-019-0112-8

    Breaking the chains: deubiquitylating enzyme specificity begets function (Journal article)

    Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(6), 338-352. doi:10.1038/s41580-019-0099-1

    DOI: 10.1038/s41580-019-0099-1

    2018

    A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation (Journal article)

    Pruneda, J. N., Bastidas, R. J., Bertsoulaki, E., Swatek, K. N., Santhanam, B., Clague, M. J., . . . Komander, D. (2018). A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. NATURE MICROBIOLOGY, 3(12), 1377-1384. doi:10.1038/s41564-018-0271-y

    DOI: 10.1038/s41564-018-0271-y

    Dual role of USP30 in controlling basal pexophagy and mitophagy (Journal article)

    Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz-Jones, E. V., Martinez, A., Kuehl, S., . . . Urbe, S. (2018). Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO REPORTS, 19(7). doi:10.15252/embr.201745595

    DOI: 10.15252/embr.201745595

    HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion (Journal article)

    MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. (2018). HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion. JOURNAL OF CELL BIOLOGY, 217(7), 2549-2564. doi:10.1083/jcb.201710051

    DOI: 10.1083/jcb.201710051

    The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity (Journal article)

    Fielding, A. B., Concannon, M., Darling, S., Rusilowicz-Jones, E. V., Sacco, J. J., Prior, I. A., . . . Coulson, J. M. (2018). The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. ONCOGENE, 37(17), 2326-2342. doi:10.1038/s41388-017-0092-0

    DOI: 10.1038/s41388-017-0092-0

    2017

    Molecular basis of USP7 inhibition by selective small-molecule inhibitors (Journal article)

    Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., . . . Komander, D. (2017). Molecular basis of USP7 inhibition by selective small-molecule inhibitors. NATURE, 550(7677), 481-+. doi:10.1038/nature24451

    DOI: 10.1038/nature24451

    Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases (Journal article)

    Clague, M. J., & Urbe, S. (2017). Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases. FEBS JOURNAL, 284(12), 1753-1766. doi:10.1111/febs.14007

    DOI: 10.1111/febs.14007

    Quantitative proteomic analysis of Parkin substrates in Drosophila neurons (Journal article)

    Martinez, A., Lectez, B., Ramirez, J., Popp, O., Sutherland, J. D., Urbe, S., . . . Mayor, U. (2017). Quantitative proteomic analysis of Parkin substrates in Drosophila neurons. MOLECULAR NEURODEGENERATION, 12. doi:10.1186/s13024-017-0170-3

    DOI: 10.1186/s13024-017-0170-3

    2016

    The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer (Journal article)

    Clague, M. J., wymant, J. M., Hiscox, S., Westwell, A. D., Urbe, S., & Jones, A. T. (2016). The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. Journal of Cancer.

    The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability (Journal article)

    Heride, C., Rigden, D. J., Bertsoulaki, E., Cucchi, D., De Smaele, E., Clague, M. J., & Urbe, S. (2016). The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability. JOURNAL OF CELL SCIENCE, 129(21), 4001-4013. doi:10.1242/jcs.188516

    DOI: 10.1242/jcs.188516

    Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6 (Journal article)

    Perrody, E., Abrami, L., Feldman, M., Kunz, B., Urbe, S., & van der Goot, F. G. (2016). Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6. ELIFE, 5. doi:10.7554/eLife.19083

    DOI: 10.7554/eLife.19083

    Bimodal antagonism of PKA signalling by ARHGAP36 (Journal article)

    Eccles, R. L., Czajkowski, M. T., Barth, C., Mueller, P. M., McShane, E., Grunwald, S., . . . Rocks, O. (2016). Bimodal antagonism of PKA signalling by ARHGAP36. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12963

    DOI: 10.1038/ncomms12963

    The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL (Journal article)

    Nelson, J. K., Sorrentino, V., Trezza, R. A., Heride, C., Urbe, S., Distel, B., & Zelcer, N. (2016). The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL. CIRCULATION RESEARCH, 118(3), 410-419. doi:10.1161/CIRCRESAHA.115.307298

    DOI: 10.1161/CIRCRESAHA.115.307298

    2015

    Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors (Journal article)

    Sacco, J. J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. M. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. ONCOTARGET, 6(15), 13757-13771. doi:10.18632/oncotarget.3765

    DOI: 10.18632/oncotarget.3765

    The demographics of the ubiquitin system (Journal article)

    Clague, M. J., Heride, C., & Urbe, S. (2015). The demographics of the ubiquitin system. TRENDS IN CELL BIOLOGY, 25(7), 417-426. doi:10.1016/j.tcb.2015.03.002

    DOI: 10.1016/j.tcb.2015.03.002

    Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells (Journal article)

    Malec, V., Coulson, J. M., Urbe, S., & Clague, M. J. (2015). Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. JOURNAL OF PROTEOME RESEARCH, 14(12), 5263-5272. doi:10.1021/acs.jproteome.5b00692

    DOI: 10.1021/acs.jproteome.5b00692

    USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death (Journal article)

    Liang, J. -R., Martinez, A., Lane, J. D., Mayor, U., Clague, M. J., & Urbe, S. (2015). USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO REPORTS, 16(5), 618-627. doi:10.15252/embr.201439820

    DOI: 10.15252/embr.201439820

    2014

    The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells (Journal article)

    Sacco, J., Yau, T. Y., Darling, S., Patel, V., Liu, H., Urbe, S., . . . Coulson, J. (2014). The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. Oncogene, 33(33), 4265-4272. doi:10.1038/onc.2013.512

    DOI: 10.1038/onc.2013.512

    The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival (Journal article)

    Wymant, J., Hiscox, S., Westwell, A., Urbe, S., Clague, M., & Jones, A. T. (2014). The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival. EUROPEAN JOURNAL OF CANCER, 50, S115. doi:10.1016/S0959-8049(14)50425-X

    DOI: 10.1016/S0959-8049(14)50425-X

    Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors (Journal article)

    Sacco, J. J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. M. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 1-15.

    Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling (Journal article)

    Tang, W. Y. Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. J. (2014). Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling. CELL REPORTS, 8(6), 1722-1730. doi:10.1016/j.celrep.2014.08.026

    DOI: 10.1016/j.celrep.2014.08.026

    Plasticity of mammary cell boundaries governed by EGF (Journal article)

    Tang, W. Y. Y., Beckett, A., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. (2014). Plasticity of mammary cell boundaries governed by EGF. Cell Reports.

    Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor. (Journal article)

    Nishi, R., Wijnhoven, P., Tjeertes, J., le Sage, C., Clague, M., Urbe, S., & Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor.. Nature Cell Biology.

    Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity (Journal article)

    Nishi, R., Wijnhoven, P., le Sage, C., Tjeertes, J., Galanty, Y., Forment, J. V., . . . Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. NATURE CELL BIOLOGY, 16(10), 1016-1026. doi:10.1038/ncb3028

    DOI: 10.1038/ncb3028

    USP8 Controls the Trafficking and Sorting of Lysosomal Enzymes (Journal article)

    MacDonald, E., Urbe, S., & Clague, M. J. (2014). USP8 Controls the Trafficking and Sorting of Lysosomal Enzymes. TRAFFIC, 15(8), 879-888. doi:10.1111/tra.12180

    DOI: 10.1111/tra.12180

    Ubiquitin code assembly and disassembly. (Journal article)

    Heride, C., Urbe, S., Clague, M., & Heride, C. (2014). Ubiquitin code assembly and disassembly.. Unknown Journal, 6(24), 215-220. Retrieved from http://dx.doi.org/10.1016/j.cub.2014.02.002

    2013

    Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes (Chapter)

    Liu, H., Urbé, S., & Clague, M. J. (2013). Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes. In Vesicle Trafficking in Cancer (pp. 245-259). Springer New York. doi:10.1007/978-1-4614-6528-7_12

    DOI: 10.1007/978-1-4614-6528-7_12

    Deubiquitylases From Genes to Organism (Journal article)

    Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013). Deubiquitylases From Genes to Organism. Physiological Reviews, 93(3), 1289-1315. doi:10.1152/physrev.00002.2013

    DOI: 10.1152/physrev.00002.2013

    Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB (Journal article)

    Ali, N., Zhang, L., Taylor, S., Mironov, A., Urbe, S., & Woodman, P. (2013). Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB. CURRENT BIOLOGY, 23(6), 453-461. doi:10.1016/j.cub.2013.02.033

    DOI: 10.1016/j.cub.2013.02.033

    The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells (Journal article)

    Sacco, J. J., Yau, T. Y., Darling, S., Patel, V., Liu, H., Urbe, S., . . . Coulson, J. M. (2014). The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. ONCOGENE, 33(33), 4265-4272. doi:10.1038/onc.2013.512

    DOI: 10.1038/onc.2013.512

    The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit (Journal article)

    Faronato, M., Patel, V., Darling, S., Dearden, L., Clague, M. J., Urbe, S., & Coulson, J. M. (2013). The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit. CELL CYCLE, 12(12), 1964-1977. doi:10.4161/cc.25035

    DOI: 10.4161/cc.25035

    2012

    Cellular functions of the DUBs (Journal article)

    Clague, M. J., Coulson, J. M., & Urbe, S. (2012). Cellular functions of the DUBs. JOURNAL OF CELL SCIENCE, 125(2), 277-286. doi:10.1242/jcs.090985

    DOI: 10.1242/jcs.090985

    Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15 (Journal article)

    Hayes, S. D., Liu, H., MacDonald, E., Sanderson, C. M., Coulson, J. M., Clague, M. J., & Urbe, S. (2012). Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(51), 43007-43018. doi:10.1074/jbc.M112.386938

    DOI: 10.1074/jbc.M112.386938

    Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation (Journal article)

    Clague, M. J., Liu, H., & Urbe, S. (2012). Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation. DEVELOPMENTAL CELL, 23(3), 457-467. doi:10.1016/j.devcel.2012.08.011

    DOI: 10.1016/j.devcel.2012.08.011

    Selective protein degradation in cell signalling (Journal article)

    Liu, H., Urbe, S., & Clague, M. J. (2012). Selective protein degradation in cell signalling. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 23(5), 509-514. doi:10.1016/j.semcdb.2012.01.014

    DOI: 10.1016/j.semcdb.2012.01.014

    Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)

    Urbe, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. MOLECULAR BIOLOGY OF THE CELL, 23(6), 1095-1103. doi:10.1091/mbc.E11-08-0668

    DOI: 10.1091/mbc.E11-08-0668

    Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)

    Urbé, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Molecular Biology of the Cell, 23(6), 1095-1103. doi:10.1091/mbc.e11-08-0668

    DOI: 10.1091/mbc.e11-08-0668

    2011

    Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus (Journal article)

    Thorne, C., Eccles, R. L., Coulson, J. M., Urbe, S., & Clague, M. J. (2011). Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus. TRAFFIC, 12(11), 1563-1574. doi:10.1111/j.1600-0854.2011.01261.x

    DOI: 10.1111/j.1600-0854.2011.01261.x

    Moving In With Ubiquitin (Journal article)

    Urbe, S. (2011). Moving In With Ubiquitin. TRAFFIC, 12(2), 135-136. doi:10.1111/j.1600-0854.2010.01143.x

    DOI: 10.1111/j.1600-0854.2010.01143.x

    Structural variability of the ubiquitin specific protease DUSP-UBL double domains (Journal article)

    Elliott, P. R., Liu, H., Pastok, M. W., Grossmann, G. J., Rigden, D. J., Clague, M. J., . . . Barsukov, I. L. (2011). Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS LETTERS, 585(21), 3385-3390. doi:10.1016/j.febslet.2011.09.040

    DOI: 10.1016/j.febslet.2011.09.040

    2010

    Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation (Journal article)

    Polson, H. E. J., de lartigue, J., Rigden, D. J., Reedijk, M., Urbe, S., Clague, M. J., & Tooze, S. A. (2010). Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. AUTOPHAGY, 6(4), 506-522. doi:10.4161/auto.6.4.11863

    DOI: 10.4161/auto.6.4.11863

    Emerging roles of deubiquitinases in cancer-associated pathways (Journal article)

    Sacco, J. J., Coulson, J. M., Clague, M. J., & Urbé, S. (2010). Emerging roles of deubiquitinases in cancer-associated pathways. IUBMB Life, NA. doi:10.1002/iub.300

    DOI: 10.1002/iub.300

    Ubiquitin: Same Molecule, Different Degradation Pathways (Journal article)

    Clague, M. J., & Urbe, S. (2010). Ubiquitin: Same Molecule, Different Degradation Pathways. CELL, 143(5), 682-685. doi:10.1016/j.cell.2010.11.012

    DOI: 10.1016/j.cell.2010.11.012

    2009

    Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells (Journal article)

    Buus, R., Faronato, M., Hammond, D. E., Urbé, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. Current Biology, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040

    DOI: 10.1016/j.cub.2009.07.040

    Breaking the chains: structure and function of the deubiquitinases (Journal article)

    Komander, D., Clague, M. J., & Urbe, S. (2009). Breaking the chains: structure and function of the deubiquitinases. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 10(8), 550-563. doi:10.1038/nrm2731

    DOI: 10.1038/nrm2731

    Phosphoinositides and the endocytic pathway (Journal article)

    Clague, M. J., Urbe, S., & de Lartigue, J. (2009). Phosphoinositides and the endocytic pathway. EXPERIMENTAL CELL RESEARCH, 315(9), 1627-1631. doi:10.1016/j.yexcr.2008.10.005

    DOI: 10.1016/j.yexcr.2008.10.005

    Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937)) (Journal article)

    Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbé, S. (2009). Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937)). Journal of Biological Chemistry, 284(12), 8207.

    The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. VOLUME 282 (2007) PAGES 30929-30937. (Journal article)

    Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbé, S. (2009). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. VOLUME 282 (2007) PAGES 30929-30937.. The Journal of biological chemistry, 284(12), 8207.

    Ab initio protein modelling reveals novel human MIT domains (Journal article)

    Rigden, D. J., Liu, H., Hayes, S. D., Urbe, S., & Clague, M. J. (2009). Ab initio protein modelling reveals novel human MIT domains. FEBS LETTERS, 583(5), 872-878. doi:10.1016/j.febslet.2009.02.012

    DOI: 10.1016/j.febslet.2009.02.012

    Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes (Journal article)

    Popoff, V., Mardones, G. A., Bai, S. -K., Chambon, V., Tenza, D., Burgos, P. V., . . . Johannes, L. (2009). Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes. TRAFFIC, 10(12), 1868-1880. doi:10.1111/j.1600-0854.2009.00993.x

    DOI: 10.1111/j.1600-0854.2009.00993.x

    Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells (Journal article)

    Buus, R., Faronato, M., Hammond, D. E., Urbe, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. CURRENT BIOLOGY, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040

    DOI: 10.1016/j.cub.2009.07.040

    PIKfyve Regulation of Endosome-Linked Pathways (Journal article)

    de Lartigue, J., Polson, H., Feldman, M., Shokat, K., Tooze, S. A., Urbe, S., & Clague, M. J. (2009). PIKfyve Regulation of Endosome-Linked Pathways. TRAFFIC, 10(7), 883-893. doi:10.1111/j.1600-0854.2009.00915.x

    DOI: 10.1111/j.1600-0854.2009.00915.x

    Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1 (Journal article)

    Liu, H., Buus, R., Clague, M. J., & Urbe, S. (2009). Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1. PLOS ONE, 4(5). doi:10.1371/journal.pone.0005544

    DOI: 10.1371/journal.pone.0005544

    2008

    Multivesicular bodies (Journal article)

    Clague, M. J., & Urbe, S. (2008). Multivesicular bodies. CURRENT BIOLOGY, 18(10), R402-R404. doi:10.1016/j.cub.2008.02.068

    DOI: 10.1016/j.cub.2008.02.068

    Deciphering histone 2A deubiquitination (Journal article)

    Clague, M. J., Coulson, J. M., & Urbe, S. (2008). Deciphering histone 2A deubiquitination. GENOME BIOLOGY, 9(1). doi:10.1186/gb-2008-9-1-202

    DOI: 10.1186/gb-2008-9-1-202

    2007

    Ubiquitin and Protein Sorting to the Lysosome (Chapter)

    McCullough, J., Clague, M. J., & Urb, S. (n.d.). Ubiquitin and Protein Sorting to the Lysosome. In Protein Degradation Series (pp. 76-102). Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002/9783527619320.ch4b

    DOI: 10.1002/9783527619320.ch4b

    Ubiquitin and Protein Sorting to the Lysosome (Chapter)

    McCullough, J., Clague, M. J., & Urbé, S. (n.d.). Ubiquitin and Protein Sorting to the Lysosome. In Protein Degradation (pp. 76-102). Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002/9783527620227.ch4

    DOI: 10.1002/9783527620227.ch4

    The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (Journal article)

    Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbe, S. (2007). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(42), 30929-30937. doi:10.1074/jbc.M704009200

    DOI: 10.1074/jbc.M704009200

    The emerging shape of the ESCRT machinery (Journal article)

    Williams, R. L., & Urbe, S. (2007). The emerging shape of the ESCRT machinery. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 8(5), 355-368. doi:10.1038/nrm2162

    DOI: 10.1038/nrm2162

    2006

    Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery (Journal article)

    McCullough, J., Row, P. E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M. J., & Urbe, S. (2006). Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. CURRENT BIOLOGY, 16(2), 160-165. doi:10.1016/j.cub.2005.11.073

    DOI: 10.1016/j.cub.2005.11.073

    Control of growth factor receptor dynamics by reversible ubiquitination (Journal article)

    Urbe, S., McCullough, J., Row, P. E., Prior, I. A., Welchman, R., & Clague, M. J. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. BIOCHEMICAL SOCIETY TRANSACTIONS, 34, 754-756. doi:10.1042/BST0340754

    DOI: 10.1042/BST0340754

    Endocytosis: the DUB version (Journal article)

    Clague, M. J., & Urbe, S. (2006). Endocytosis: the DUB version. TRENDS IN CELL BIOLOGY, 16(11), 551-559. doi:10.1016/j.tcb.2006.09.002

    DOI: 10.1016/j.tcb.2006.09.002

    Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome-related functions (Journal article)

    Lorenzo, O., Urbe, S., & Clague, M. J. (2006). Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome-related functions. JOURNAL OF CELL SCIENCE, 119(14), 2953-2959. doi:10.1242/jcs.03040

    DOI: 10.1242/jcs.03040

    The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation (Journal article)

    Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbe, S. (2006). The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(18), 12618-12624. doi:10.1074/jbc.M512615200

    DOI: 10.1074/jbc.M512615200

    2005

    Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3 (Journal article)

    Lorenzo, O., Urbe, S., & Clague, M. J. (2005). Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. JOURNAL OF CELL SCIENCE, 118(9), 2005-2012. doi:10.1242/jcs.02325

    DOI: 10.1242/jcs.02325

    Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties (Journal article)

    Row, P. E., Clague, M. J., & Urbe, S. (2005). Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. BIOCHEMICAL JOURNAL, 389, 629-636. doi:10.1042/BJ20050067

    DOI: 10.1042/BJ20050067

    Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation (Journal article)

    Abella, J. V., Peschard, P., Naujokas, M. A., Lin, T., Saucier, C., Urbe, S., & Park, M. (2005). Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. MOLECULAR AND CELLULAR BIOLOGY, 25(21), 9632-9645. doi:10.1128/MCB.25.21.9632-9645.2005

    DOI: 10.1128/MCB.25.21.9632-9645.2005

    Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction (Journal article)

    Regan-Klapisz, E., Sorokina, I., Voortman, J., de Keizer, P., Roovers, R. C., Verheesen, P., . . . Henegouwen, P. M. P. V. E. (2005). Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. JOURNAL OF CELL SCIENCE, 118(19), 4437-4450. doi:10.1242/jcs.02571

    DOI: 10.1242/jcs.02571

    Ubiquitin and endocytic protein sorting (Journal article)

    Urbe, S. (2005). Ubiquitin and endocytic protein sorting. ESSAYS IN BIOCHEMISTRY, VOL 41: THE UBIQUITIN-PROTEASOME SYSTEM, 41, 81-98. doi:10.1042/EB0410081

    DOI: 10.1042/EB0410081

    Ubiquitin and endocytic protein sorting (Journal article)

    Urbé, S. (2005). Ubiquitin and endocytic protein sorting. Essays in Biochemistry, 41, 81-98. doi:10.1042/bse0410081

    DOI: 10.1042/bse0410081

    2004

    AMSH is an endosome-associated ubiquitin isopeptidase (Journal article)

    McCullough, J., Clague, M. J., & Urbe, S. (2004). AMSH is an endosome-associated ubiquitin isopeptidase. JOURNAL OF CELL BIOLOGY, 166(4), 487-492. doi:10.1083/jcb.200401141

    DOI: 10.1083/jcb.200401141

    The Met receptor degradation pathway - Requirement for Lys(48)-linked polyubiquitin independent of proteasome activity (Journal article)

    Carter, S., Urbe, S., & Clague, M. J. (2004). The Met receptor degradation pathway - Requirement for Lys(48)-linked polyubiquitin independent of proteasome activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51), 52835-52839. doi:10.1074/jbc.M407769200

    DOI: 10.1074/jbc.M407769200

    2003

    Endosomal dynamics of Met determine signaling output (Journal article)

    Hammond, D. E., Carter, S., McCullough, J., Urbe, S., Vande Woude, G., & Clague, M. J. (2003). Endosomal dynamics of Met determine signaling output. MOLECULAR BIOLOGY OF THE CELL, 14(4), 1346-1354. doi:10.1091/mbc.E02-09-0578

    DOI: 10.1091/mbc.E02-09-0578

    Hrs function: viruses provide the clue (Journal article)

    Clague, M. J., & Urbe, S. (2003). Hrs function: viruses provide the clue. TRENDS IN CELL BIOLOGY, 13(12), 603-606. doi:10.1016/j.tcb.2003.10.002

    DOI: 10.1016/j.tcb.2003.10.002

    The UIM domain of Hrs couples receptor sorting to vesicle formation (Journal article)

    Urbe, S., Sachse, M., Row, P. E., Preisinger, C., Barr, F. A., Strous, G., . . . Clague, M. J. (2003). The UIM domain of Hrs couples receptor sorting to vesicle formation. JOURNAL OF CELL SCIENCE, 116(20), 4169-4179. doi:10.1242/jcs.00723

    DOI: 10.1242/jcs.00723

    2002

    Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes (Journal article)

    Sachse, M., Urbe, S., Oorschot, V., Strous, G. J., & Klumperman, J. (2002). Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. MOLECULAR BIOLOGY OF THE CELL, 13(4), 1313-1328. doi:10.1091/mbc.01-10-0525

    DOI: 10.1091/mbc.01-10-0525

    2001

    The interface of receptor trafficking and signalling. (Journal article)

    Clague, M. J., & Urbé, S. (2001). The interface of receptor trafficking and signalling.. Journal of cell science, 114(Pt 17), 3075-3081.

    The interface of receptor trafficking and signalling (Journal article)

    Clague, M. J., & Urbe, S. (2001). The interface of receptor trafficking and signalling. JOURNAL OF CELL SCIENCE, 114(17), 3075-3081. Retrieved from http://gateway.webofknowledge.com/

    Relationships between EEA1 binding partners and their role in endosome fusion. (Journal article)

    Mills, I. G., Urbé, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion.. Journal of cell science, 114(Pt 10), 1959-1965.

    Relationships between EEA1 binding partners and their role in endosome fusion (Journal article)

    Mills, I. G., Urbe, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion. JOURNAL OF CELL SCIENCE, 114(10), 1959-1965. Retrieved from http://gateway.webofknowledge.com/

    Characterization of MTMR3: an inositol lipid 3-phosphatase with novel substrate specificity (Journal article)

    Walker, D. M., Urbe, S., Dove, S. K., Tenza, D., Raposo, G., & Clague, M. J. (2001). Characterization of MTMR3: an inositol lipid 3-phosphatase with novel substrate specificity. CURRENT BIOLOGY, 11(20), 1600-1605. doi:10.1016/S0960-9822(01)00501-2

    DOI: 10.1016/S0960-9822(01)00501-2

    Down-regulation of MET, the receptor for hepatocyte growth factor (Journal article)

    Hammond, D. E., Urbe, S., Woude, G. F. V., & Clague, M. J. (2001). Down-regulation of MET, the receptor for hepatocyte growth factor. ONCOGENE, 20(22), 2761-2770. doi:10.1038/sj.onc.1204475

    DOI: 10.1038/sj.onc.1204475

    Homotypic fusion of immature secretory granules during maturation requires syntaxin 6 (Journal article)

    Wendler, F., Page, L., Urbe, S., & Tooze, S. A. (2001). Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. MOLECULAR BIOLOGY OF THE CELL, 12(6), 1699-1709. doi:10.1091/mbc.12.6.1699

    DOI: 10.1091/mbc.12.6.1699

    2000

    Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate (Journal article)

    Urbe, S., Mills, I. G., Stenmark, H., Kitamura, N., & Clague, M. J. (2000). Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. MOLECULAR AND CELLULAR BIOLOGY, 20(20), 7685-7692. doi:10.1128/MCB.20.20.7685-7692.2000

    DOI: 10.1128/MCB.20.20.7685-7692.2000

    1999

    Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins (Journal article)

    Clague, M. J., Jones, A. T., Mills, I. G., Walker, D. M., & Urbe, S. (1999). Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. BIOCHEMICAL SOCIETY TRANSACTIONS, 27(4), 662-666. doi:10.1042/bst0270662

    DOI: 10.1042/bst0270662

    1998

    Homotypic fusion of immature secretory granules during maturation in a cell-free assay (Journal article)

    Urbe, S., Page, L. J., & Tooze, S. A. (1998). Homotypic fusion of immature secretory granules during maturation in a cell-free assay. JOURNAL OF CELL BIOLOGY, 143(7), 1831-1844. doi:10.1083/jcb.143.7.1831

    DOI: 10.1083/jcb.143.7.1831

    Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells. (Journal article)

    Urbe, S. (2010). Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells..

    1997

    Formation of secretory vesicles in the biosynthetic pathway (Journal article)

    Urbe, S., Tooze, S. A., & Barr, F. A. (1997). Formation of secretory vesicles in the biosynthetic pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1358(1), 6-22. doi:10.1016/S0167-4889(97)00050-5

    DOI: 10.1016/S0167-4889(97)00050-5

    pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules (Journal article)

    Urbe, S., Dittie, A. S., & Tooze, S. A. (1997). pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules. BIOCHEMICAL JOURNAL, 321, 65-74. doi:10.1042/bj3210065

    DOI: 10.1042/bj3210065

    1996

    Rab11 regulates recycling through the pericentriolar recycling endosome (Journal article)

    Ullrich, O., Reinsch, S., Urbe, S., Zerial, M., & Parton, R. G. (1996). Rab11 regulates recycling through the pericentriolar recycling endosome. JOURNAL OF CELL BIOLOGY, 135(4), 913-924. doi:10.1083/jcb.135.4.913

    DOI: 10.1083/jcb.135.4.913

    1994

    VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION (Journal article)

    CLAGUE, M. J., URBE, S., ANIENTO, F., & GRUENBERG, J. (1994). VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(1), 21-24. Retrieved from http://gateway.webofknowledge.com/

    1993

    RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS (Journal article)

    URBE, S., HUBER, L. A., ZERIAL, M., TOOZE, S. A., & PARTON, R. G. (1993). RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS. FEBS LETTERS, 334(2), 175-182. doi:10.1016/0014-5793(93)81707-7

    DOI: 10.1016/0014-5793(93)81707-7