2024
McCarron, K. R., Elcocks, H., Mortiboys, H., Urbé, S., & Clague, M. J. (2024). The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.. The Biochemical journal, 481(4), 265-278. doi:10.1042/bcj20230492DOI: 10.1042/bcj20230492
2023
Clancy, A., Rusilowicz-Jones, E. V., Wallace, I., Swatek, K. N., Urbé, S., & Clague, M. J. (2023). ISGylation-independent protection of cell growth by USP18 following interferon stimulation.. The Biochemical journal, 480(19), 1571-1581. doi:10.1042/bcj20230301DOI: 10.1042/bcj20230301
Barone, F. G., Urbe, S., & Clague, M. J. (2023). Segregation of pathways leading to pexophagy. LIFE SCIENCE ALLIANCE, 6(5). doi:10.26508/lsa.202201825DOI: 10.26508/lsa.202201825
Elcocks, H., Brazel, A. J., McCarron, K. R., Kaulich, M., Husnjak, K., Mortiboys, H., . . . Urbé, S. (2023). FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.. The EMBO journal, e112799. doi:10.15252/embj.2022112799DOI: 10.15252/embj.2022112799
Zanin, N., de Lesegno, C. V., Podkalicka, J., Meyer, T., Troncoso, P. G., Bun, P., . . . Lamaze, C. (2023). STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. NATURE CELL BIOLOGY, 25(3), 425-+. doi:10.1038/s41556-022-01085-6DOI: 10.1038/s41556-022-01085-6
2022
Protein degradation on the global scale (Journal article)
V. Rusilowicz-Jones, E., Urbe, S., & Clague, M. J. (2022). Protein degradation on the global scale. MOLECULAR CELL, 82(8), 1414-1423. doi:10.1016/j.molcel.2022.02.027DOI: 10.1016/j.molcel.2022.02.027
Rusilowicz-Jones, E. V., Barone, F. G., Lopes, F. M., Stephen, E., Mortiboys, H., Urbe, S., & Clague, M. J. (2022). Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. LIFE SCIENCE ALLIANCE, 5(2). doi:10.26508/lsa.202101287DOI: 10.26508/lsa.202101287
2021
Membrane compartmentalisation of the ubiquitin system. (Journal article)
Rusilowicz-Jones, E. V., Brazel, A. J., Frigenti, F., Urbé, S., & Clague, M. J. (2021). Membrane compartmentalisation of the ubiquitin system.. Seminars in cell & developmental biology. doi:10.1016/j.semcdb.2021.11.016DOI: 10.1016/j.semcdb.2021.11.016
Pollock, L., Jardine, J., Urbe, S., & Clague, M. J. (2021). The PINK1 repertoire: Not just a one trick pony. BIOESSAYS, 43(11). doi:10.1002/bies.202100168DOI: 10.1002/bies.202100168
Ruiz, E. J., Pinto-Fernandez, A., Turnbull, A. P., Lan, L., Charlton, T. M., Scott, H. C., . . . Behrens, A. (2021). USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. ELIFE, 10. doi:10.7554/eLife.71596DOI: 10.7554/eLife.71596
Rusilowicz-Jones, E., Barone, F., Lopes, F. M., Stephen, E., Mortiboys, H., Urbé, S., & Clague, M. (2021). Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. doi:10.1101/2021.04.28.441730DOI: 10.1101/2021.04.28.441730
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K. J., . . . Clague, M. J. (2021). The deubiquitylase USP9X controls ribosomal stalling. JOURNAL OF CELL BIOLOGY, 220(3). doi:10.1083/jcb.202004211DOI: 10.1083/jcb.202004211
The deubiquitylase USP9X controls ribosomal stalling (vol 220, e202004211, 2021) (Journal article)
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K. J., . . . Clague, M. J. (2021). The deubiquitylase USP9X controls ribosomal stalling (vol 220, e202004211, 2021). JOURNAL OF CELL BIOLOGY, 220(3). doi:10.1083/jcb.20200421102102021cDOI: 10.1083/jcb.20200421102102021c
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . Tong, C. -K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). AUTOPHAGY, 17(1), 1-382. doi:10.1080/15548627.2020.1797280DOI: 10.1080/15548627.2020.1797280
2020
Rusilowicz-Jones, E. V., Jardine, J., Kallinos, A., Pinto-Fernandez, A., Guenther, F., Giurrandino, M., . . . Clague, M. J. (2020). USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation. Life Science Alliance, 3(8). doi:10.26508/lsa.202000768DOI: 10.26508/lsa.202000768
Rusilowicz-Jones, E. V., Jardine, J., Kallinos, A., Pinto-Fernandez, A., Guenther, F., Giurrandino, M., . . . Clague, M. J. (2020). USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. LIFE SCIENCE ALLIANCE, 3(8). doi:10.26508/lsa.202000768DOI: 10.26508/lsa.202000768
Clague, M. J., & Urbe, S. (2020). Data mining for traffic information. TRAFFIC, 21(1), 162-168. doi:10.1111/tra.12702DOI: 10.1111/tra.12702
2019
Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz-Jones, E. V., Clague, M. J., & Urbe, S. (2019). New aspects of USP30 biology in the regulation of pexophagy. AUTOPHAGY. doi:10.1080/15548627.2019.1615304DOI: 10.1080/15548627.2019.1615304
Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(6), 338-352. doi:10.1038/s41580-019-0099-1DOI: 10.1038/s41580-019-0099-1
Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019) (Journal article)
Clague, M. J., Urbe, S., & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function (vol 20, pg 1, 2019). NATURE REVIEWS MOLECULAR CELL BIOLOGY, 20(5), 321. doi:10.1038/s41580-019-0112-8DOI: 10.1038/s41580-019-0112-8
2018
Pruneda, J., Robert, B., Bertsoulaki, E., Swatek, K., Santhanam, B., Clague, M. J., . . . Komander, D. (2018). A chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. Nature Microbiology, 3, 1377-1384. doi:10.1038/s41564-018-0271-yDOI: 10.1038/s41564-018-0271-y
MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. N. (2018). HRS-WASH axis governs Actin mediated endosomal recycling and cell invasion. The Journal of Cell Biology, 217(7), 2549-2564. doi:10.1083/jcb.201710051DOI: 10.1083/jcb.201710051
Marcassa, E., Kallinos, A., Jardine, J., Rusilowicz, E., Martinez, A., Kuehl, S., . . . Urbe, S. (2018). Dual role of USP 30 in controlling basal pexophagy and mitophagy. EMBO Reports, 19(07), 14 pages. doi:10.15252/embr.201745595DOI: 10.15252/embr.201745595
The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity (Journal article)
Fielding, A. B., Concannon, M., Darling, S., Rusilowicz, E., Sacco, J., Prior, I. A., . . . Coulson, J. M. (2018). The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. Oncogene, 37(17), 2326-2342. doi:10.1038/s41388-017-0092-0DOI: 10.1038/s41388-017-0092-0
2017
Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., . . . Komander, D. (2017). Molecular basis of USP7 inhibition by selective small-molecule inhibitors. NATURE, 550(7677), 481-486. doi:10.1038/nature24451DOI: 10.1038/nature24451
Clague, M. J., & Urbe, S. (2017). Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases. FEBS JOURNAL, 284(12), 1753-1766. doi:10.1111/febs.14007DOI: 10.1111/febs.14007
Martinez, A., Lectez, B., Ramirez, J., Popp, O., Sutherland, J. D., Urbé, S., . . . Mayor, U. (2017). Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.. Molecular neurodegeneration, 12, 1-19. doi:10.1186/s13024-017-0170-3DOI: 10.1186/s13024-017-0170-3
2016
Clague, M. J., wymant, J. M., Hiscox, S., Westwell, A. D., Urbe, S., & Jones, A. T. (2016). The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. Journal of Cancer.
Heride, C., Rigden, D. J., Bertsoulaki, E., Cucchi, D., De Smaele, E., Clague, M. J., & Urbe, S. (2016). The centrosomal Deubiquitylase USP21 regulates Gli1 transcriptional activity and stability. Journal of Cell Science, 129(21), 4001-4013. doi:10.1242/jcs.188516DOI: 10.1242/jcs.188516
Perrody, E., Abrami, L., Feldman, M., Kunz, B., Urbe, S., & van der Goot, F. G. (2016). Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6. eLife, 5. doi:10.7554/eLife.19083DOI: 10.7554/eLife.19083
Eccles, R. L., Czajkowski, M. T., Barth, C., Müller, P. M., McShane, E., Grunwald, S., . . . Rocks, O. (2016). Bimodal antagonism of PKA signalling by ARHGAP36. Nature Communications, 7. doi:10.1038/ncomms12963DOI: 10.1038/ncomms12963
The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL (Journal article)
Nelson, J. K., Sorrentino, V., Trezza, R. A., Heride, C., Urbe, S., Distel, B., & Zelcer, N. (2016). The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL. Circulation Research, 118(3), 410-419. doi:10.1161/CIRCRESAHA.115.307298DOI: 10.1161/CIRCRESAHA.115.307298
2015
Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells (Journal article)
Malec, V., Coulson, J. M., Urbe, S., & Clague, M. J. (2015). Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. JOURNAL OF PROTEOME RESEARCH, 14(12), 5263-5272. doi:10.1021/acs.jproteome.5b00692DOI: 10.1021/acs.jproteome.5b00692
The demographics of the ubiquitin system (Journal article)
Clague, M., Heride, C., & Urbe, S. (2015). The demographics of the ubiquitin system. Trends in Cell Biology, 25(7), 417-426. doi:10.1016/j.tcb.2015.03.002DOI: 10.1016/j.tcb.2015.03.002
USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death (Journal article)
Liang, J. R., Martinez Zarate, A., Lane, J. D., Mayor, U., Clague, M., & Urbe, S. (2015). USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO Reports, 16(5), 618-627. doi:10.15252/embr.201439820DOI: 10.15252/embr.201439820
Sacco, J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 13757-13771. doi:10.18632/oncotarget.3765DOI: 10.18632/oncotarget.3765
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors (Journal article)
Sacco, J. J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. M. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 1-15.
2014
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity (Journal article)
Nishi, R., Wijnhoven, P., le Sage, C., Tjeertes, J., Galanty, Y., Forment, J. V., . . . Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nature Cell Biology, 16(10), 1016-1026. doi:10.1038/ncb3028DOI: 10.1038/ncb3028
Tang, W. Y., Beckett, A., Prior, I., Coulson, J., Urbe, S., & Clague, M. (2014). Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling. Cell Reports, 8(06), 1722-1730. doi:10.1016/j.celrep.2014.08.026DOI: 10.1016/j.celrep.2014.08.026
Sacco, J., Yau, T. Y., Darling, S., Patel, V., Liu, H., Urbe, S., . . . Coulson, J. (2014). The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. Oncogene, 33(33), 4265-4272. doi:10.1038/onc.2013.512DOI: 10.1038/onc.2013.512
The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival (Journal article)
Wymant, J., Hiscox, S., Westwell, A., Urbe, S., Clague, M., & Jones, A. T. (2014). The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival. EUROPEAN JOURNAL OF CANCER, 50, S115. doi:10.1016/S0959-8049(14)50425-XDOI: 10.1016/S0959-8049(14)50425-X
Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor. (Journal article)
Nishi, R., Wijnhoven, P., Tjeertes, J., le Sage, C., Clague, M., Urbe, S., & Jackson, S. P. (2014). Systematic characterization of deubiquitylating enzymes for DNA repair identifies UCHL5 as a DNA end-resection factor.. Nature Cell Biology.
USP8 controls the trafficking and sorting of lysosomal enzymes. (Journal article)
MacDonald, E., Urbe, S., & Clague, M. (2014). USP8 controls the trafficking and sorting of lysosomal enzymes.. Traffic, 15(8), 879-888. doi:10.1111/tra.12180DOI: 10.1111/tra.12180
Ubiquitin code assembly and disassembly. (Journal article)
Heride, C., Urbe, S., Clague, M., & Heride, C. (2014). Ubiquitin code assembly and disassembly.. Unknown Journal, 6(24), 215-220. Retrieved from http://dx.doi.org/10.1016/j.cub.2014.02.002
2013
Deubiquitylases From Genes to Organism (Journal article)
Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013). Deubiquitylases From Genes to Organism. Physiological Reviews, 93(3), 1289-1315. doi:10.1152/physrev.00002.2013DOI: 10.1152/physrev.00002.2013
Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes (Chapter)
Liu, H., Urbé, S., & Clague, M. J. (2013). Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes. In Vesicle Trafficking in Cancer (pp. 245-259). Springer New York. doi:10.1007/978-1-4614-6528-7_12DOI: 10.1007/978-1-4614-6528-7_12
The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit (Journal article)
Faronato, M., Patel, V., Darling, S., Dearden, L., Clague, M. J., Urbe, S., & Coulson, J. M. (2013). The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit. CELL CYCLE, 12(12), 1964-1977. doi:10.4161/cc.25035DOI: 10.4161/cc.25035
Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB (Journal article)
Ali, N., Zhang, L., Taylor, S., Mironov, A., Urbe, S., & Woodman, P. (2013). Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB. CURRENT BIOLOGY, 23(6), 453-461. doi:10.1016/j.cub.2013.02.033DOI: 10.1016/j.cub.2013.02.033
Plasticity of mammary cell boundaries governed by EGF (Journal article)
Tang, Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. J. (2013). Plasticity of mammary cell boundaries governed by EGF. MOLECULAR BIOLOGY OF THE CELL, 24. Retrieved from https://www.webofscience.com/
2012
Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15 (Journal article)
Hayes, S. D., Liu, H., MacDonald, E., Sanderson, C. M., Coulson, J. M., Clague, M. J., & Urbe, S. (2012). Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(51), 43007-43018. doi:10.1074/jbc.M112.386938DOI: 10.1074/jbc.M112.386938
Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation (Journal article)
Clague, M. J., Liu, H., & Urbe, S. (2012). Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation. DEVELOPMENTAL CELL, 23(3), 457-467. doi:10.1016/j.devcel.2012.08.011DOI: 10.1016/j.devcel.2012.08.011
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)
Urbé, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Molecular Biology of the Cell, 23(6), 1095-1103. doi:10.1091/mbc.e11-08-0668DOI: 10.1091/mbc.e11-08-0668
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)
Urbe, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. MOLECULAR BIOLOGY OF THE CELL, 23(6), 1095-1103. doi:10.1091/mbc.E11-08-0668DOI: 10.1091/mbc.E11-08-0668
Cellular functions of the DUBs (Journal article)
Clague, M. J., Coulson, J. M., & Urbe, S. (2012). Cellular functions of the DUBs. JOURNAL OF CELL SCIENCE, 125(2), 277-286. doi:10.1242/jcs.090985DOI: 10.1242/jcs.090985
Selective protein degradation in cell signalling (Journal article)
Liu, H., Urbe, S., & Clague, M. J. (2012). Selective protein degradation in cell signalling. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 23(5), 509-514. doi:10.1016/j.semcdb.2012.01.014DOI: 10.1016/j.semcdb.2012.01.014
2011
Structural variability of the ubiquitin specific protease DUSP-UBL double domains (Journal article)
Elliott, P. R., Liu, H., Pastok, M. W., Grossmann, G. J., Rigden, D. J., Clague, M. J., . . . Barsukov, I. L. (2011). Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS LETTERS, 585(21), 3385-3390. doi:10.1016/j.febslet.2011.09.040DOI: 10.1016/j.febslet.2011.09.040
Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus (Journal article)
Thorne, C., Eccles, R. L., Coulson, J. M., Urbe, S., & Clague, M. J. (2011). Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus. TRAFFIC, 12(11), 1563-1574. doi:10.1111/j.1600-0854.2011.01261.xDOI: 10.1111/j.1600-0854.2011.01261.x
2010
Ubiquitin: Same Molecule, Different Degradation Pathways (Journal article)
Clague, M. J., & Urbe, S. (2010). Ubiquitin: Same Molecule, Different Degradation Pathways. CELL, 143(5), 682-685. doi:10.1016/j.cell.2010.11.012DOI: 10.1016/j.cell.2010.11.012
Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells. (Journal article)
Urbe, S. (2010). Molecular mechanisms of secretory granule biogenesis in neuroendocrine cells..
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation (Journal article)
Polson, H. E. J., de lartigue, J., Rigden, D. J., Reedijk, M., Urbe, S., Clague, M. J., & Tooze, S. A. (2010). Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. AUTOPHAGY, 6(4), 506-522. doi:10.4161/auto.6.4.11863DOI: 10.4161/auto.6.4.11863
Emerging roles of deubiquitinases in cancer‐associated pathways (Journal article)
Sacco, J. J., Coulson, J. M., Clague, M. J., & Urbé, S. (2010). Emerging roles of deubiquitinases in cancer‐associated pathways. IUBMB Life, 62(2), 140-157. doi:10.1002/iub.300DOI: 10.1002/iub.300
2009
Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes (Journal article)
Popoff, V., Mardones, G. A., Bai, S. -K., Chambon, V., Tenza, D., Burgos, P. V., . . . Johannes, L. (2009). Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes. TRAFFIC, 10(12), 1868-1880. doi:10.1111/j.1600-0854.2009.00993.xDOI: 10.1111/j.1600-0854.2009.00993.x
Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells (Journal article)
Buus, R., Faronato, M., Hammond, D. E., Urbé, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. Current Biology, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040DOI: 10.1016/j.cub.2009.07.040
Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells (Journal article)
Buus, R., Faronato, M., Hammond, D. E., Urbe, S., & Clague, M. J. (2009). Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. CURRENT BIOLOGY, 19(17), 1463-1466. doi:10.1016/j.cub.2009.07.040DOI: 10.1016/j.cub.2009.07.040
Breaking the chains: structure and function of the deubiquitinases (Journal article)
Komander, D., Clague, M. J., & Urbe, S. (2009). Breaking the chains: structure and function of the deubiquitinases. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 10(8), 550-563. doi:10.1038/nrm2731DOI: 10.1038/nrm2731
PIKfyve Regulation of Endosome-Linked Pathways (Journal article)
de Lartigue, J., Polson, H., Feldman, M., Shokat, K., Tooze, S. A., Urbe, S., & Clague, M. J. (2009). PIKfyve Regulation of Endosome-Linked Pathways. TRAFFIC, 10(7), 883-893. doi:10.1111/j.1600-0854.2009.00915.xDOI: 10.1111/j.1600-0854.2009.00915.x
Phosphoinositides and the endocytic pathway (Journal article)
Clague, M. J., Urbe, S., & de Lartigue, J. (2009). Phosphoinositides and the endocytic pathway. EXPERIMENTAL CELL RESEARCH, 315(9), 1627-1631. doi:10.1016/j.yexcr.2008.10.005DOI: 10.1016/j.yexcr.2008.10.005
Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1 (Journal article)
Liu, H., Buus, R., Clague, M. J., & Urbe, S. (2009). Regulation of ErbB2 Receptor Status by the Proteasomal DUB POH1. PLOS ONE, 4(5). doi:10.1371/journal.pone.0005544DOI: 10.1371/journal.pone.0005544
Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937)) (Journal article)
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbé, S. (2009). Erratum: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (The Journal of Biological Chemistry (2007) vol. 282 (30929-30937)). Journal of Biological Chemistry, 284(12), 8207.
Ab initio protein modelling reveals novel human MIT domains (Journal article)
Rigden, D. J., Liu, H., Hayes, S. D., Urbe, S., & Clague, M. J. (2009). Ab initio protein modelling reveals novel human MIT domains. FEBS LETTERS, 583(5), 872-878. doi:10.1016/j.febslet.2009.02.012DOI: 10.1016/j.febslet.2009.02.012
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (vol 282, pg 30929, 2007) (Journal article)
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbe, S. (2009). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (vol 282, pg 30929, 2007). JOURNAL OF BIOLOGICAL CHEMISTRY, 284(12), 8207. Retrieved from https://www.webofscience.com/
2008
Multivesicular bodies (Journal article)
Clague, M. J., & Urbe, S. (2008). Multivesicular bodies. CURRENT BIOLOGY, 18(10), R402-R404. doi:10.1016/j.cub.2008.02.068DOI: 10.1016/j.cub.2008.02.068
Deciphering histone 2A deubiquitination (Journal article)
Clague, M. J., Coulson, J. M., & Urbe, S. (2008). Deciphering histone 2A deubiquitination. GENOME BIOLOGY, 9(1). doi:10.1186/gb-2008-9-1-202DOI: 10.1186/gb-2008-9-1-202
2007
Ubiquitin and Protein Sorting to the Lysosome (Chapter)
McCullough, J., Clague, M. J., & Urbé, S. (2007). Ubiquitin and Protein Sorting to the Lysosome. In Unknown Book (pp. 76-102). Wiley. doi:10.1002/9783527619320.ch4bDOI: 10.1002/9783527619320.ch4b
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation (Journal article)
Row, P. E., Liu, H., Hayes, S., Welchman, R., Charalabous, P., Hofmann, K., . . . Urbe, S. (2007). The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(42), 30929-30937. doi:10.1074/jbc.M704009200DOI: 10.1074/jbc.M704009200
The emerging shape of the ESCRT machinery (Journal article)
Williams, R. L., & Urbe, S. (2007). The emerging shape of the ESCRT machinery. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 8(5), 355-368. doi:10.1038/nrm2162DOI: 10.1038/nrm2162
2006
Endocytosis:: the DUB version (Journal article)
Clague, M. J., & Urbe, S. (2006). Endocytosis:: the DUB version. TRENDS IN CELL BIOLOGY, 16(11), 551-559. doi:10.1016/j.tcb.2006.09.002DOI: 10.1016/j.tcb.2006.09.002
Control of growth factor receptor dynamics by reversible ubiquitination (Journal article)
Urbe, S., McCullough, J., Row, P. E., Prior, I. A., Welchman, R., & Clague, M. J. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. BIOCHEMICAL SOCIETY TRANSACTIONS, 34, 754-756. doi:10.1042/BST0340754DOI: 10.1042/BST0340754
Ubiquitin and Protein Sorting to the Lysosome (Chapter)
McCullough, J., Clague, M. J., & Urbé, S. (2006). Ubiquitin and Protein Sorting to the Lysosome. In Unknown Book (pp. 76-102). Wiley. doi:10.1002/9783527620227.ch4DOI: 10.1002/9783527620227.ch4
Systematic analysis of myotubularins:: heteromeric interactions, subcellular localisation and endosome-related functions (Journal article)
Lorenzo, O., Urbe, S., & Clague, M. J. (2006). Systematic analysis of myotubularins:: heteromeric interactions, subcellular localisation and endosome-related functions. JOURNAL OF CELL SCIENCE, 119(14), 2953-2959. doi:10.1242/jcs.03040DOI: 10.1242/jcs.03040
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation (Journal article)
Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S. (2006). The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(18), 12618-12624. doi:10.1074/jbc.M512615200DOI: 10.1074/jbc.M512615200
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery (Journal article)
McCullough, J., Row, P. E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M. J., & Urbé, S. (2006). Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. CURRENT BIOLOGY, 16(2), 160-165. doi:10.1016/j.cub.2005.11.073DOI: 10.1016/j.cub.2005.11.073
2005
Ubiquitin and endocytic protein sorting (Journal article)
Urbé, S. (2005). Ubiquitin and endocytic protein sorting. ESSAYS IN BIOCHEMISTRY, VOL 41: THE UBIQUITIN-PROTEASOME SYSTEM, 41, 81-98. doi:10.1042/EB0410081DOI: 10.1042/EB0410081
Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation (Journal article)
Abella, J. V., Peschard, P., Naujokas, M. A., Lin, T., Saucier, C., Urbé, S., & Park, M. (2005). Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. MOLECULAR AND CELLULAR BIOLOGY, 25(21), 9632-9645. doi:10.1128/MCB.25.21.9632-9645.2005DOI: 10.1128/MCB.25.21.9632-9645.2005
Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction (Journal article)
Regan-Klapisz, E., Sorokina, I., Voortman, J., de Keizer, P., Roovers, R. C., Verheesen, P., . . . Henegouwen, P. M. P. V. E. (2005). Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. JOURNAL OF CELL SCIENCE, 118(19), 4437-4450. doi:10.1242/jcs.02571DOI: 10.1242/jcs.02571
Ubiquitin and endocytic protein sorting (Journal article)
Urbé, S. (2005). Ubiquitin and endocytic protein sorting. Essays in Biochemistry, 41, 81-98. doi:10.1042/bse0410081DOI: 10.1042/bse0410081
Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex:: a common node in signalling networks with signal-specific properties (Journal article)
Row, P. E., Clague, M. J., & Urbé, S. (2005). Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex:: a common node in signalling networks with signal-specific properties. BIOCHEMICAL JOURNAL, 389, 629-636. doi:10.1042/BJ20050067DOI: 10.1042/BJ20050067
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3 (Journal article)
Lorenzo, O., Urbé, S., & Clague, M. J. (2005). Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. JOURNAL OF CELL SCIENCE, 118(9), 2005-2012. doi:10.1242/jcs.02325DOI: 10.1242/jcs.02325
2004
The Met receptor degradation pathway -: Requirement for Lys<SUP>48</SUP>-linked polyubiquitin independent of proteasome activity (Journal article)
Carter, S., Urbé, S., & Clague, M. J. (2004). The Met receptor degradation pathway -: Requirement for Lys<SUP>48</SUP>-linked polyubiquitin independent of proteasome activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51), 52835-52839. doi:10.1074/jbc.M407769200DOI: 10.1074/jbc.M407769200
AMSH is an endosome-associated ubiquitin isopeptidase (Journal article)
McCullough, J., Clague, M. J., & Urbé, S. (2004). AMSH is an endosome-associated ubiquitin isopeptidase. JOURNAL OF CELL BIOLOGY, 166(4), 487-492. doi:10.1083/jcb.200401141DOI: 10.1083/jcb.200401141
2003
The UIM domain of Hrs couples receptor sorting to vesicle formation (Journal article)
Urbé, S., Sachse, M., Row, P. E., Preisinger, C., Barr, F. A., Strous, G., . . . Clague, M. J. (2003). The UIM domain of Hrs couples receptor sorting to vesicle formation. JOURNAL OF CELL SCIENCE, 116(20), 4169-4179. doi:10.1242/jcs.00723DOI: 10.1242/jcs.00723
Endosomal dynamics of Met determine signaling output (Journal article)
Hammond, D. E., Carter, S., McCullough, J., Urbé, S., Vande Woude, G., & Clague, M. J. (2003). Endosomal dynamics of Met determine signaling output. MOLECULAR BIOLOGY OF THE CELL, 14(4), 1346-1354. doi:10.1091/mbc.E02-09-0578DOI: 10.1091/mbc.E02-09-0578
Hrs function:: viruses provide the clue (Journal article)
Clague, M. J., & Urbé, S. (2003). Hrs function:: viruses provide the clue. TRENDS IN CELL BIOLOGY, 13(12), 603-606. doi:10.1016/j.tcb.2003.10.002DOI: 10.1016/j.tcb.2003.10.002
2002
Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes (Journal article)
Sachse, M., Urbé, S., Oorschot, V., Strous, G. J., & Klumperman, J. (2002). Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. MOLECULAR BIOLOGY OF THE CELL, 13(4), 1313-1328. doi:10.1091/mbc.01-10-0525DOI: 10.1091/mbc.01-10-0525
2001
Characterization of MTMR3:: an inositol lipid 3-phosphatase with novel substrate specificity (Journal article)
Walker, D. M., Urbé, S., Dove, S. K., Tenza, D., Raposo, G., & Clague, M. J. (2001). Characterization of MTMR3:: an inositol lipid 3-phosphatase with novel substrate specificity. CURRENT BIOLOGY, 11(20), 1600-1605. doi:10.1016/S0960-9822(01)00501-2DOI: 10.1016/S0960-9822(01)00501-2
The interface of receptor trafficking and signalling. (Journal article)
Clague, M. J., & Urbé, S. (2001). The interface of receptor trafficking and signalling.. Journal of cell science, 114(Pt 17), 3075-3081. doi:10.1242/jcs.114.17.3075DOI: 10.1242/jcs.114.17.3075
Down-regulation of MET, the receptor for hepatocyte growth factor (Journal article)
Hammond, D. E., Urbé, S., Woude, G. F. V., & Clague, M. J. (2001). Down-regulation of MET, the receptor for hepatocyte growth factor. ONCOGENE, 20(22), 2761-2770. doi:10.1038/sj.onc.1204475DOI: 10.1038/sj.onc.1204475
Relationships between EEA1 binding partners and their role in endosome fusion. (Journal article)
Mills, I. G., Urbé, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion.. Journal of cell science, 114(Pt 10), 1959-1965. doi:10.1242/jcs.114.10.1959DOI: 10.1242/jcs.114.10.1959
Homotypic fusion of immature secretory granules during maturation requires syntaxin 6 (Journal article)
Wendler, F., Page, L., Urbé, S., & Tooze, S. A. (2001). Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. MOLECULAR BIOLOGY OF THE CELL, 12(6), 1699-1709. doi:10.1091/mbc.12.6.1699DOI: 10.1091/mbc.12.6.1699
Relationships between EEA1 binding partners and their role in endosome fusion (Journal article)
Mills, I. G., Urbé, S., & Clague, M. J. (2001). Relationships between EEA1 binding partners and their role in endosome fusion. JOURNAL OF CELL SCIENCE, 114(10), 1959-1965. Retrieved from https://www.webofscience.com/
The interface of receptor trafficking and signalling (Journal article)
Clague, M. J., & Urbé, S. (2001). The interface of receptor trafficking and signalling. JOURNAL OF CELL SCIENCE, 114(17), 3075-3081. Retrieved from https://www.webofscience.com/
2000
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate (Journal article)
Urbé, S., Mills, I. G., Stenmark, H., Kitamura, N., & Clague, M. J. (2000). Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. MOLECULAR AND CELLULAR BIOLOGY, 20(20), 7685-7692. doi:10.1128/MCB.20.20.7685-7692.2000DOI: 10.1128/MCB.20.20.7685-7692.2000
1999
Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins (Journal article)
Clague, M. J., Jones, A. T., Mills, I. G., Walker, D. M., & Urbé, S. (1999). Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. BIOCHEMICAL SOCIETY TRANSACTIONS, 27(4), 662-666. doi:10.1042/bst0270662DOI: 10.1042/bst0270662
1998
Homotypic fusion of immature secretory granules during maturation in a cell-free assay (Journal article)
Urbé, S., Page, L. J., & Tooze, S. A. (1998). Homotypic fusion of immature secretory granules during maturation in a cell-free assay. JOURNAL OF CELL BIOLOGY, 143(7), 1831-1844. doi:10.1083/jcb.143.7.1831DOI: 10.1083/jcb.143.7.1831
1997
Formation of secretory vesicles in the biosynthetic pathway (Journal article)
Urbe, S., Tooze, S. A., & Barr, F. A. (1997). Formation of secretory vesicles in the biosynthetic pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1358(1), 6-22. doi:10.1016/S0167-4889(97)00050-5DOI: 10.1016/S0167-4889(97)00050-5
pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules (Journal article)
Urbe, S., Dittie, A. S., & Tooze, S. A. (1997). pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules. BIOCHEMICAL JOURNAL, 321, 65-74. doi:10.1042/bj3210065DOI: 10.1042/bj3210065
1996
Rab11 regulates recycling through the pericentriolar recycling endosome (Journal article)
Ullrich, O., Reinsch, S., Urbe, S., Zerial, M., & Parton, R. G. (1996). Rab11 regulates recycling through the pericentriolar recycling endosome. JOURNAL OF CELL BIOLOGY, 135(4), 913-924. doi:10.1083/jcb.135.4.913DOI: 10.1083/jcb.135.4.913
1994
VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION (Journal article)
CLAGUE, M. J., URBE, S., ANIENTO, F., & GRUENBERG, J. (1994). VACUOLAR ATPASE ACTIVITY IS REQUIRED FOR ENDOSOMAL CARRIER VESICLE FORMATION. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(1), 21-24. Retrieved from https://www.webofscience.com/
1993
RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS (Journal article)
URBE, S., HUBER, L. A., ZERIAL, M., TOOZE, S. A., & PARTON, R. G. (1993). RAB11, A SMALL GTPASE ASSOCIATED WITH BOTH CONSTITUTIVE AND REGULATED SECRETORY PATHWAYS IN PC12-CELLS. FEBS LETTERS, 334(2), 175-182. doi:10.1016/0014-5793(93)81707-7DOI: 10.1016/0014-5793(93)81707-7