Prof Sarah Coupland MBBS, PhD, FRCPath, FARVO, FSB

George Holt Chair in Pathology, Honorary Consultant Histopathologist Molecular and Clinical Cancer Medicine

    Research

    Research Interest 1

    Ocular oncology
    Lymphoma; intraocular and ocular adnexal lymphomas
    Uveal melanoma, conjunctival melanoma
    Cutaneous melanoma

    Research Group Membership
    Research Grants

    Uveal melanoma - PhD Studentship

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    September 2010 - December 2020

    Biosample collection from the SUAVE trial in uveal melanoma – TRANS-SUAVE

    CANCER RESEARCH UK (UK)

    November 2010 - October 2013

    Investigation into Malt Lymphoma Project.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    November 2006 - July 2009

    Metastasis in uveal melanoma study

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    January 2012 - December 2012

    Personalised epigenetic therapy for follicular lymphoma

    CANCER RESEARCH UK (UK)

    February 2013 - January 2016

    Multiplex ligation-dependent probe amplification (MLPA) analysis in metastasizing cutaneous malignant melanoma.

    NORTH WEST CANCER RESEARCH FUND

    April 2008 - June 2009

    Multiplex Ligation-Dependent Probe Amplification (MLPA) in Uveal Melanoma.

    FIGHT FOR SIGHT (UK)

    January 2008 - December 2009

    Risk stratification: modelling and accessibility

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    June 2010 - May 2011

    Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    January 2012 - December 2020

    Molecular genetics of ocular tumours

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    December 2010 - November 2015

    Genetic abnormalities in conjunctival melanoma: a multicentre study

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    February 2011 - August 2017

    Stretching the supply routes: ErbB2 gene amplification and endocytic recycling in metastatic breast cancer

    BREAST CANCER NOW (UK)

    January 2015 - January 2019

    Identification of regulators of metastasis in uveal melanoma

    NORTH WEST CANCER RESEARCH FUND

    October 2010 - March 2013

    The development and characterisation of in vitro and in vivo models of uveal melanoma

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    October 2012 - December 2015

    Multiplex Ligation-Dependent Probe Amplification (MLPA) in Uveal Melanoma.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    January 2010 - June 2010

    PACIFICO Phase III multicentre trial comparing two different Rituximab-Chemotherapy induction regimens for Follicular Lymphoma in Older patients (PACIFIC)

    CANCER RESEARCH UK (UK)

    November 2008 - July 2020

    Applying innovative technologies to improve the benefit-risk ratio of drugs: developing a national resource underpinned by the infrastructure of the MRC Centre for Drug Safety Science

    MEDICAL RESEARCH COUNCIL (MRC)

    April 2015 - March 2016

    Novel isogenic models of BAP1-deficient uveal melanoma for drug discovery

    FIGHT FOR SIGHT (UK)

    October 2014 - September 2018

    The role of exosomes in uveal melanoma

    THE PATHOLOGICAL SOCIETY (UK)

    October 2014 - July 2020

    Multiplex ligation-dependent probe amplification (MLPA) assessment of clinical uveal melanoma (UM) samples

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    March 2009 - February 2015

    Identification of regulators of metastasis in uveal melanoma (UM)

    CANCER RESEARCH UK (UK)

    July 2010 - March 2014

    Multiplex ligation-dependent probe amplification (MLPA)in Uveal Melanoma.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    September 2007 - August 2010

    The role of chemokines and integrins in the localisation of B-cell Non-Hodgkin’s Lymphomas (B-NHL)

    LYMPHOMA RESEARCH TRUST

    January 2013 - December 2013

    CR-UK Cancer Research Centre - Infrastructure Grant 2012-14

    CANCER RESEARCH UK (UK)

    November 2012 - March 2015

    Ocular oncology research

    CLATTERBRIDGE CENTRE FOR ONCOLOGY, ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK), THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)

    February 2008 - January 2020

    Bench fees for Rasha Swadi

    REPUBLIC OF IRAQ MINISTRY OF EDUCATION

    October 2014 - September 2018

    The North West Cancer Research Cancer Centre

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    April 2014 - September 2021

    Biosample collection from the ITEM trial in Uveal Melanoma.

    CANCER RESEARCH UK (UK)

    September 2008 - February 2011

    Bench fees to support PhD student Omar Alishlash

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    January 2013 - December 2015

    Impact of tumour-associated myeloid cells on cancer stemness and chemotherapy-resistance

    NORTH WEST CANCER RESEARCH FUND

    March 2013 - December 2016

    NITRO Trial: Neoadjuvant IntraviTreal Ranibizumab treatment in high risk Ocular melanoma patients: A two stage single centre Phase II single arm study.

    CANCER RESEARCH UK (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    October 2011 - September 2015

    Research Collaborations

    Henrik Vorum, Bent Honoré, Steen Fiil Urbak

    External: University of Aarhus, Denmark

    Examining proteomics of uveal melanomas with and without monosomy 3

    Paul Finger

    External: American Joint Committee Against Cancer (AJCC)

    Committee member revising and designing staging systems of the tumours in and around the eye

    Prof. B. Damato

    Internal

    Prof. A Pettit

    Internal