Dr Roz Jenkins BSc (Hons), PhD

Research Fellow and Lab Manager, CDSS/ITM Proteomics Facility Pharmacology & Therapeutics

Publications

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2024

Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality. (Journal article)

Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G., & Toh, C. -H. (2024). Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.. Blood advances, bloodadvances.2023012473. doi:10.1182/bloodadvances.2023012473

DOI: 10.1182/bloodadvances.2023012473

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers. (Journal article)

Clarke, E., Varela, L., Jenkins, R. E., Lozano-Andrés, E., Cywińska, A., Przewozny, M., . . . Wauben, M. H. M. (2024). Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers.. Biochemistry and biophysics reports, 37, 101635. doi:10.1016/j.bbrep.2023.101635

DOI: 10.1016/j.bbrep.2023.101635

2023

A systems approach reveals species differences in hepatic stress response capacity (Journal article)

Russomanno, G., Sison-Young, R., Livoti, L. A., Coghlan, H., Jenkins, R. E., Kunnen, S. J., . . . Copple, I. M. (2023). A systems approach reveals species differences in hepatic stress response capacity. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad085

DOI: 10.1093/toxsci/kfad085

Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. (Journal article)

Anderson, J. R., Johnson, E., Jenkins, R., Jacobsen, S., Green, D., Walters, M., . . . Peffers, M. J. (2023). Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.. International journal of molecular sciences, 24(19), 14888. doi:10.3390/ijms241914888

DOI: 10.3390/ijms241914888

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory ‘multi-omics’ study to identify composite biomarkers (Preprint)

DOI: 10.1101/2023.08.02.551609

Multi-omic temporal landscape of plasma and synovial fluid-derived extracellular vesicles using an experimental model of equine osteoarthritis (Preprint)

DOI: 10.1101/2023.08.01.551464

Ras protein abundance correlates with Ras isoform mutation patterns in cancer (Journal article)

Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. A. (2023). Ras protein abundance correlates with Ras isoform mutation patterns in cancer. ONCOGENE, 42(15), 1224-1232. doi:10.1038/s41388-023-02638-1

DOI: 10.1038/s41388-023-02638-1

TEMPORAL PROTEOMIC LANDSCAPE OF PLASMA AND SYNOVIAL FLUID DERIVED EXTRACELLULAR VESICLES USING AN EXPERIMENTAL MODEL OF EQUINE OSTEOARTHRITIS (Journal article)

Anderson, J., Jenkins, R., Welting, T., Green, D., Johnson, E., Jocobsen, S., & Peffers, M. J. (2023). TEMPORAL PROTEOMIC LANDSCAPE OF PLASMA AND SYNOVIAL FLUID DERIVED EXTRACELLULAR VESICLES USING AN EXPERIMENTAL MODEL OF EQUINE OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE, 31, S345. Retrieved from https://www.webofscience.com/

2022

Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis. (Journal article)

Clarke, E. J., Johnson, E., Caamaño Gutierrez, E., Andersen, C., Berg, L. C., Jenkins, R. E., . . . Peffers, M. J. (2022). Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis.. Frontiers in veterinary science, 9, 1057667. doi:10.3389/fvets.2022.1057667

DOI: 10.3389/fvets.2022.1057667

Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine Osteoarthritis (Preprint)

DOI: 10.1101/2022.09.30.510176

A systems approach reveals species differences in hepatic stress response capacity (Preprint)

DOI: 10.1101/2022.04.13.488145

2021

Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis (Journal article)

Smiga, M., Smalley, J. W., Slezak, P., Brown, J. L., Sieminska, K., Jenkins, R. E., . . . Olczak, T. (2021). Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(21). doi:10.3390/ijms222112084

DOI: 10.3390/ijms222112084

Ras protein abundance correlates with Ras isoform mutation patterns in cancer (Preprint)

DOI: 10.1101/2021.11.04.467300

The application of cytokeratin-18 as a biomarker for drug-induced liver injury (Journal article)

Korver, S., Bowen, J., Pearson, K., Gonzalez, R. J., French, N., Park, K., . . . Goldring, C. (2021). The application of cytokeratin-18 as a biomarker for drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 95(11), 3435-3448. doi:10.1007/s00204-021-03121-0

DOI: 10.1007/s00204-021-03121-0

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification (Journal article)

Howell, L., Jenkins, R. E., Lynch, S., Duckworth, C., Kevin Park, B., & Goldring, C. (2021). Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. ARCHIVES OF TOXICOLOGY, 95(7), 2413-2430. doi:10.1007/s00204-021-03075-3

DOI: 10.1007/s00204-021-03075-3

Absolute Quantitation of GTPase Protein Abundance (Journal article)

Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. (2021). Absolute Quantitation of GTPase Protein Abundance. RAS ACTIVITY AND SIGNALING, 2262, 65-90. doi:10.1007/978-1-0716-1190-6_4

DOI: 10.1007/978-1-0716-1190-6_4

The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells (Journal article)

Ide, K., Takahashi, S., Sakai, K., Taga, Y., Ueno, T., Dickens, D., . . . Sakai, T. (2021). The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. Journal of Biological Chemistry, 100819. doi:10.1016/j.jbc.2021.100819

DOI: 10.1016/j.jbc.2021.100819

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells. (Journal article)

Eagle, G. L., Herbert, J. M. J., Zhuang, J., Oates, M., Khan, U. T., Kitteringham, N. R., . . . Falciani, F. (2021). Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells.. Scientific Reports, 11(1), 2932. doi:10.1038/s41598-021-82609-2

DOI: 10.1038/s41598-021-82609-2

2020

Characterization of Clozapine-Responsive Human T Cells (Journal article)

Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646

DOI: 10.4049/jimmunol.2000646

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124

DOI: 10.1093/toxsci/kfaa124

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. (Journal article)

Jolly, C. E., Douglas, O., Kamalian, L., Jenkins, R. E., Beckett, A. J., Penman, S. L., . . . Chadwick, A. E. (2020). The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.. Toxicology and applied pharmacology, 403, 115163. doi:10.1016/j.taap.2020.115163

DOI: 10.1016/j.taap.2020.115163

2019

Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701

DOI: 10.1002/hep.30701

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells (Journal article)

Austin, J. A., Jenkins, R. E., Austin, G. M., Glenn, M. A., Dunn, K., Scott, L., . . . Clark, R. E. (2019). Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells. BIOCHEMICAL JOURNAL, 476, 2255-2269. doi:10.1042/BCJ20190121

DOI: 10.1042/BCJ20190121

2018

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)

Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030

DOI: 10.1016/j.jprot.2018.02.030

In chronic myeloid leukaemia cells, the oncoprotein CIP2A binds directly to and alters expression of many cellular proteins, independent of effects on protein phosphatase 2A (PP2A) (Conference Paper)

Austin, J. A., Lucas, C. M., Jenkins, R. E., Dunn, K., Scott, L. J., Glenn, M. A., . . . Clark, R. E. (2018). In chronic myeloid leukaemia cells, the oncoprotein CIP2A binds directly to and alters expression of many cellular proteins, independent of effects on protein phosphatase 2A (PP2A). In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 52-53). Retrieved from https://www.webofscience.com/

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study (Journal article)

Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. TOXICOLOGICAL SCIENCES, 162(2), 655-666. doi:10.1093/toxsci/kfx289

DOI: 10.1093/toxsci/kfx289

2017

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291

DOI: 10.1021/acs.chemrestox.7b00291

Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans (Journal article)

Johnson, J. R., Edwards, M. R., Davies, H., Newman, D., Holden, W., Jenkins, R. E., . . . Barclay, J. W. (2017). Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans. GENETICS, 207(3), 1023-1039. doi:10.1534/genetics.117.300119

DOI: 10.1534/genetics.117.300119

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients (Journal article)

Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

DOI: 10.1021/acs.chemrestox.7b00063

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells (Journal article)

Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069

DOI: 10.1093/toxsci/kfx069

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. (Journal article)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209

DOI: 10.4049/jimmunol.1700209

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways (Journal article)

Brandi, J., Dando, I., Dalla Pozza, E., Biondani, G., Jenkins, R., Elliott, V., . . . Palmieri, M. (2017). Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. JOURNAL OF PROTEOMICS, 150, 310-322. doi:10.1016/j.jprot.2016.10.002

DOI: 10.1016/j.jprot.2016.10.002

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile (Journal article)

Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-y

DOI: 10.1007/s00204-016-1694-y

2016

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients (Journal article)

Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253

DOI: 10.1021/acs.chemrestox.6b00253

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease (Journal article)

Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports, 6. doi:10.1038/srep25187

DOI: 10.1038/srep25187

Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus (Journal article)

Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879

DOI: 10.1158/1078-0432.ccr-15-0879

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites (Journal article)

Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292

DOI: 10.1021/acs.jmedchem.5b01292

Secretome protein signature of human pancreatic cancer stem-like cells (Journal article)

Brandi, J., Dalla Pozza, E., Dando, I., Biondani, G., Robotti, E., Jenkins, R., . . . Cecconi, D. (2016). Secretome protein signature of human pancreatic cancer stem-like cells. JOURNAL OF PROTEOMICS, 136, 1-12. doi:10.1016/j.jprot.2016.01.017

DOI: 10.1016/j.jprot.2016.01.017

2015

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)

Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(06), 1261-1273. doi:10.1038/ki.2015.286

DOI: 10.1038/ki.2015.286

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article)

Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423

DOI: 10.1038/srep16423

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (Journal article)

Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136

DOI: 10.1093/toxsci/kfv136

Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036

DOI: 10.1016/j.jaci.2015.02.036

Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia (Journal article)

Eagle, G., Zhuang, J., Jenkins, R., Till, K., Jithesh, P., Lin, K., . . . Pettitt, A. (2015). Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia. Molecular and Cellular Proteomics, 14(4), 933-945. doi:10.1074/mcp.M114.044479

DOI: 10.1074/mcp.M114.044479

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes (Journal article)

Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. Journal of Hepatology, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016

DOI: 10.1016/j.jhep.2014.10.016

Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase (Journal article)

Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k

DOI: 10.1021/tx500458k

2014

Antigen exposure required for T cell activation (Journal article)

Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115

DOI: 10.1186/2045-7022-4-s3-p115

Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model (Journal article)

Nattrass, R., Faulkner, L., Jenkins, R., Nicolas, J., Vocanson, M., Rozieres, A., . . . Naisbitt, D. (2014). Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model. Clinical and translational allergy, 4(Suppl 3), P41. doi:10.1186/2045-7022-4-s3-p41

DOI: 10.1186/2045-7022-4-s3-p41

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis (Journal article)

Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113

DOI: 10.1186/2045-7022-4-s3-p113

Phenotypic analysis of primary colorectal cancer to inform management of metastatic disease (Conference Paper)

Sutton, P., Jones, R., Rowe, C., Jenkins, R., Malik, H., Vimalachandran, D., . . . Kitteringham, N. (2014). Phenotypic analysis of primary colorectal cancer to inform management of metastatic disease. In LANCET Vol. 383 (pp. 98). Retrieved from https://www.webofscience.com/

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article)

Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079

DOI: 10.1124/jpet.114.215079

2013

Safety pharmacology - Current and emerging concepts (Journal article)

Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

DOI: 10.1016/j.taap.2013.04.039

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC) (Journal article)

Hammoudi, A., Song, F., Reed, K. R., Jenkins, R. E., Meniel, V. S., Watson, A. J. M., . . . Jenkins, J. R. (2013). Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 440(3), 364-370. doi:10.1016/j.bbrc.2013.08.076

DOI: 10.1016/j.bbrc.2013.08.076

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)

Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 72(2), 359-368. doi:10.1007/s00280-013-2199-5

DOI: 10.1007/s00280-013-2199-5

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. (Journal article)

Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414

DOI: 10.1002/hep.26414

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)

Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v

DOI: 10.1021/tx400041v

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI: 10.1021/tx400124m

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. BRITISH JOURNAL OF CANCER, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

DOI: 10.1038/bjc.2013.150

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. British Journal of Cancer, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

DOI: 10.1038/bjc.2013.150

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

DOI: 10.1021/tx4000107

Human Leukocyte Antigen (HLA)-B☆57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B☆57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

DOI: 10.1002/hep.26077

2012

Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation (Journal article)

Goldring, C., Rowe, C., Jenkins, R. E., Kitteringham, N. R., & Park, K. B. (n.d.). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102

DOI: 10.5584/jiomics.v2i2.102

Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. (Journal article)

Holmberg, C., Quante, M., Steele, I., Kumar, J. D., Balabanova, S., Duval, C., . . . Varro, A. (2012). Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.. Carcinogenesis, 33(8), 1553-1562. doi:10.1093/carcin/bgs180

DOI: 10.1093/carcin/bgs180

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI: 10.1124/jpet.111.190900

PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion (Journal article)

Edwards, M. R., Johnson, J. R., Rankin, K., Jenkins, R. E., Maguire, C., Morgan, A., . . . Barclay, J. W. (2012). PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion. JOURNAL OF NEUROSCIENCE, 32(20), 7042-7051. doi:10.1523/JNEUROSCI.4029-11.2012

DOI: 10.1523/JNEUROSCI.4029-11.2012

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. (Journal article)

Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0

DOI: 10.1016/s1734-1140(12)70863-0

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

2011

In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin (Journal article)

Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, J. G., . . . Park, B. K. (2011). In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin. Toxicology, 290(2-3), 142-143. doi:10.1016/j.tox.2011.09.072

DOI: 10.1016/j.tox.2011.09.072

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI: 10.1124/jpet.111.183871

MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility (Journal article)

Polanski, R., Maguire, M., Nield, P. C., Jenkins, R. E., Park, B. K., Krawczynska, K., . . . Boyd, M. T. (2011). MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility. CARCINOGENESIS, 32(8), 1133-1142. doi:10.1093/carcin/bgr070

DOI: 10.1093/carcin/bgr070

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis (Journal article)

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI: 10.4049/jimmunol.1100647

Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression (Journal article)

Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947

DOI: 10.3748/wjg.v17.i15.1947

Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction (Journal article)

Tonack, S., Jenkinson, C., Elliot, V., Dajani, K., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2011). Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction. Pancreas, 40, 1358.

2010

Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites (Journal article)

Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, G. L., . . . Park, B. K. (2010). Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites. Toxicology, 278(3), 357-358. doi:10.1016/j.tox.2010.08.108

DOI: 10.1016/j.tox.2010.08.108

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer (Journal article)

Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626

DOI: 10.1136/gut.2009.196626

Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach (Journal article)

Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach. Journal of Proteome Research, 9(8), 4313-4314. doi:10.1021/pr100603e

DOI: 10.1021/pr100603e

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells (Journal article)

Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. CARCINOGENESIS, 31(9), 1541-1551. doi:10.1093/carcin/bgq137

DOI: 10.1093/carcin/bgq137

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver (Journal article)

Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018

DOI: 10.1016/j.jprot.2010.03.018

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway (Journal article)

Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545

DOI: 10.1074/jbc.M109.096545

Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein (Journal article)

Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

DOI: 10.1038/jid.2009.271

2009

A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ (Journal article)

Tonack, S., Aspinall-O'Dea, M., Jenkins, R. E., Elliot, V., Murray, S., Lane, C. S., . . . Costello, E. (2009). A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ. JOURNAL OF PROTEOMICS, 73(2), 352-356. doi:10.1016/j.jprot.2009.07.009

DOI: 10.1016/j.jprot.2009.07.009

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo (Journal article)

Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

DOI: 10.1002/prca.200800222

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility (Journal article)

Nedjadi, T., Kitteringham, N., Campbell, F., Jenkins, R. E., Park, B. K., Navarro, P., . . . Costello, E. (2009). S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. BRITISH JOURNAL OF CANCER, 101(7), 1145-1154. doi:10.1038/sj.bjc.6605289

DOI: 10.1038/sj.bjc.6605289

Proteomic Analysis of Metastatic Laryngeal Squamous Cell Carcinoma (Journal article)

Goodyear, P., Jenkins, R., Kitteringham, N., Boyd, M., Hamlett, J., & Jones, T. (2009). Proteomic Analysis of Metastatic Laryngeal Squamous Cell Carcinoma. Clinical Oncology, 21(8), 645.

A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine (Journal article)

Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r

DOI: 10.1021/tx900095r

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation (Journal article)

Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r

DOI: 10.1021/tx900034r

Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics. (Journal article)

Kitteringham, N. R., Jenkins, R. E., Lane, C. S., Elliott, V. L., & Park, B. K. (2009). Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(13), 1229-1239. doi:10.1016/j.jchromb.2008.11.013

DOI: 10.1016/j.jchromb.2008.11.013

Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer (Journal article)

Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., . . . Costello, E. (2009). Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer. JOURNAL OF PROTEOME RESEARCH, 8(1), 142-148. doi:10.1021/pr800451h

DOI: 10.1021/pr800451h

An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype (Conference Paper)

Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.

2008

Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding (Journal article)

Prescott, G. R., Jenkins, R. E., Walsh, C. M., & Morgan, A. (2008). Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 377(3), 809-814. doi:10.1016/j.bbrc.2008.10.069

DOI: 10.1016/j.bbrc.2008.10.069

Proteomic analysis of metastatic laryngeal squamous cell carcinoma (Journal article)

Goodyear, P. W. A., Boyd, M. T., Jenkins, R., Hamlett, J., Kitteringham, N., & Jones, T. M. (2008). Proteomic analysis of metastatic laryngeal squamous cell carcinoma. Clinical Otolaryngology, 33(6), 642. doi:10.1111/j.1749-4486.2008.01843_5.x

DOI: 10.1111/j.1749-4486.2008.01843_5.x

PROTEOMIC ANALYSIS OF SERUM AND PANCREATIC JUICE FROM PANCREATIC DUCTAL ADENOCARCINOMA PATIENS USING ITRAQ LABELLING (Journal article)

Tonack, S., Aspinall-O'Dea, M., Sheikh, A., Jenkins, R., Elliott, V., Neoptolemos, J., & Costello, E. (2008). PROTEOMIC ANALYSIS OF SERUM AND PANCREATIC JUICE FROM PANCREATIC DUCTAL ADENOCARCINOMA PATIENS USING ITRAQ LABELLING. Pancreas, 37(4), 498. doi:10.1097/01.mpa.0000335401.70046.eb

DOI: 10.1097/01.mpa.0000335401.70046.eb

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system (Journal article)

Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472

DOI: 10.1002/hep.22472

MDM2 regulates dihydrofolate reductase activity through monoubiquitination (Journal article)

Maguire, M., Nield, P. C., Devling, T., Jenkins, R. E., Park, B. K., Polanski, R., . . . Boyd, M. T. (2008). MDM2 regulates dihydrofolate reductase activity through monoubiquitination. CANCER RESEARCH, 68(9), 3232-3242. doi:10.1158/0008-5472.CAN-07-5271

DOI: 10.1158/0008-5472.CAN-07-5271

Albumin and immunoglobulin depletion of human plasma (Journal article)

Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma. Methods Mol Biol, 425, 15-25.

Albumin and immunoglobulin depletion of human plasma. (Chapter)

Jenkins, R. E., Kitteringham, N. R., Greenough, C., & Park, B. K. (2008). Albumin and immunoglobulin depletion of human plasma.. In Unknown Book (Vol. 425, pp. 15-25). doi:10.1007/978-1-60327-210-0_2

DOI: 10.1007/978-1-60327-210-0_2

Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. (Journal article)

Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843

DOI: 10.1002/pmic.200700843

2007

Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts. (Journal article)

Pennington, S. R., Foster, B. J., Hawley, S. R., Jenkins, R. E., Zolle, O., White, M. R. H., . . . Simpson, A. W. M. (2007). Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.. The Journal of biological chemistry, 282(44), 32112-32120. doi:10.1074/jbc.m705067200

DOI: 10.1074/jbc.m705067200

INVOLVEMENT OF S100A6 (CALCYCLIN) IN PANCREATIC CANCER PROGRESSION (Journal article)

Nedjadi, T., Smith, R., Jenkins, R. E., & Costello, E. (2007). INVOLVEMENT OF S100A6 (CALCYCLIN) IN PANCREATIC CANCER PROGRESSION. Pancreas, 35(4), 419. doi:10.1097/01.mpa.0000297757.44337.a8

DOI: 10.1097/01.mpa.0000297757.44337.a8

Interaction between pancreatic cancer cells and tumour stromal monocytes (Journal article)

Sheikh, A. A., Vimalachandran, D., Jenkins, R., Campbell, F., Dodson, A. R., Neoptolemos, J. P., & Costello, E. (2007). Interaction between pancreatic cancer cells and tumour stromal monocytes. PANCREAS, 35(4), 427. doi:10.1097/01.mpa.0000297784.25519.d5

DOI: 10.1097/01.mpa.0000297784.25519.d5

Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene (Journal article)

Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001

DOI: 10.1016/j.bbagen.2007.05.001

Characterization of a bifunctional catalase-peroxidase of Burkholderia cenocepacia (Journal article)

Charalabous, P., Risk, J. M., Jenkins, R., Birss, A. J., Hart, C. A., & Smalley, J. W. (2007). Characterization of a bifunctional catalase-peroxidase of Burkholderia cenocepacia. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 50(1), 37-44. doi:10.1111/j.1574-695X.2007.00224.x

DOI: 10.1111/j.1574-695X.2007.00224.x

The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells (Journal article)

Sheikh, A. A., Vimalachandran, D., Thompson, C. C., Jenkins, R. E., Nedjadi, T., Shekouh, A., . . . Costello, E. (2007). The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. PROTEOMICS, 7(11), 1929-1940. doi:10.1002/pmic.200700072

DOI: 10.1002/pmic.200700072

Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility (Journal article)

Thompson, C. C., Ashcroft, F. J., Patel, S., Saraga, G., Vimalachandran, D., Prime, W., . . . Costello, E. (2007). Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. GUT, 56(1), 95-106. doi:10.1136/gut.2005.083691

DOI: 10.1136/gut.2005.083691

2006

The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells (Conference Paper)

Vimalachandran, D., Sheikh, A., Tweedle, E., Khattak, I., Thompson, C. C., Jenkins, R. E., . . . Costello, E. (2006). The expression of S100A8 in tumour-associated monocytes is directly associated with the Smad4 status of pancreatic cancer cells. In PANCREAS Vol. 33 (pp. 506). doi:10.1097/00006676-200611000-00233

DOI: 10.1097/00006676-200611000-00233

Use of proteomics in development of biomarkers and early markers of toxicity (Journal article)

Pennington, S., Kitteringham, N., Jenkins, R., Hunt, T., Webb, S., & Hunter, C. (2006). Use of proteomics in development of biomarkers and early markers of toxicity. Toxicology Letters, 164, S316. doi:10.1016/j.toxlet.2006.07.322

DOI: 10.1016/j.toxlet.2006.07.322

Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements (Journal article)

Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209

DOI: 10.1242/jeb.02209

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags (Journal article)

Jenkins, R. E., Kitteringham, N. R., Hunter, C. L., Webb, S., Hunt, T. J., Elsby, R., . . . Park, B. K. (2006). Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags. PROTEOMICS, 6(6), 1934-1947. doi:10.1002/pmic.200500432

DOI: 10.1002/pmic.200500432

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes (Journal article)

Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005

DOI: 10.1152/ajpcell.00133.2005

Protein chip technology in proteomics analysis (Chapter)

Jenkins, R. E., & Pennington, S. R. (2006). Protein chip technology in proteomics analysis. In J. E. Van Eyk, & M. J. Dunn (Eds.), Proteomic and genomic analysis of cardiovascular disease (pp. 235-254). Weinheim: Wiley-VCH Verlag Gmbh & Co..

2005

Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2 (Journal article)

Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.

Quantitative profiling of cytochromes P450 by isotope coded affinity tagging (Journal article)

Jenkins, R. E., Kitteringham, N. R., Hunt, T. J., Boucher, B. J., Minkoff, M. S., Elsby, R., . . . Park, B. K. (2005). Quantitative profiling of cytochromes P450 by isotope coded affinity tagging. Toxicology, 213(3), 260-261.

Quantitative profiling of cytochromes P450 by isotope coded affinity tagging (Journal article)

Separation-independent approaches for protein expression profiling (Chapter)

Jenkins, R. E., & Pennington, S. R. (2005). Separation-independent approaches for protein expression profiling. In M. Dunn (Ed.), Encyclopaedia of Genetics, Genomics, Proteomics and Bioinformatics (pp. 1209-1220). Hoboken: John Wiley & Sons.

2004

A method for the rapid depletion of albumin and immunoglobulin from human plasma (Journal article)

Greenough, C., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Park, B. K., & Pennington, S. R. (2004). A method for the rapid depletion of albumin and immunoglobulin from human plasma. PROTEOMICS, 4(10), 3107-3111. doi:10.1002/pmic.200300815

DOI: 10.1002/pmic.200300815

2003

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver. (Journal article)

Kitteringham, N. R., Powell, H., Jenkins, R. E., Hamlett, J., Lovatt, C., Elsby, R., . . . Park, B. K. (2003). Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.. Proteomics, 3(2), 191-207. doi:10.1002/pmic.200390028

DOI: 10.1002/pmic.200390028

2002

Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ:: interaction with actin, clathrin and tubulin (Journal article)

Ivings, L., Pennington, S. R., Jenkins, R., Weiss, J. L., & Burgoyne, R. D. (2002). Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ:: interaction with actin, clathrin and tubulin. BIOCHEMICAL JOURNAL, 363, 599-608. doi:10.1042/0264-6021:3630599

DOI: 10.1042/0264-6021:3630599

Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ: interaction with actin, clathrin and tubulin (Journal article)

IVINGS, L., PENNINGTON, S. R., JENKINS, R., WEISS, J. L., & BURGOYNE, R. D. (2002). Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin δ: interaction with actin, clathrin and tubulin. Biochemical Journal, 363(3), 599-608. doi:10.1042/bj3630599

DOI: 10.1042/bj3630599

2001

Regulation of growth factor induced gene expression by calcium signalling: Integrated mRNA and protein expression analysis (Journal article)

Jenkins, R. E., Hawley, S. R., Promwikorn, W., Brown, J., Hamlett, J., & Pennington, S. R. (2001). Regulation of growth factor induced gene expression by calcium signalling: Integrated mRNA and protein expression analysis. Proteomics, 1(9), 1092-1104. doi:3.0.CO;2-S">10.1002/1615-9861(200109)1:9<1092::AID-PROT1092>3.0.CO;2-S

DOI: 10.1002/1615-9861(200109)1:9<1092::AID-PROT1092>3.0.CO;2-S

Regulation of growth factor induced gene expression by calcium signalling: integrated mRNA and protein expression analysis. (Journal article)

Jenkins, R. E., Hawley, S. R., Promwikorn, W., Brown, J., Hamlett, J., & Pennington, S. R. (2001). Regulation of growth factor induced gene expression by calcium signalling: integrated mRNA and protein expression analysis.. Proteomics, 1(9), 1092-1104. doi:3.0.co;2-s">10.1002/1615-9861(200109)1:9<1092::aid-prot1092>3.0.co;2-s

DOI: 10.1002/1615-9861(200109)1:9<1092::aid-prot1092>3.0.co;2-s

Arrays for protein expression profiling: Towards a viable alternative to two-dimensional gel electrophoresis? (Journal article)

Jenkins, R. E., & Pennington, S. R. (2001). Arrays for protein expression profiling: Towards a viable alternative to two-dimensional gel electrophoresis?. PROTEOMICS, 1(1), 13-29. doi:3.3.co;2-a">10.1002/1615-9861(200101)1:1<13::aid-prot13>3.3.co;2-a

DOI: 10.1002/1615-9861(200101)1:1<13::aid-prot13>3.3.co;2-a

Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis? (Journal article)

Jenkins, R. E., & Pennington, S. R. (2001). Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis?. Proteomics, 1(1), 13-29. doi:3.0.co;2-j">10.1002/1615-9861(200101)1:1<13::aid-prot13>3.0.co;2-j

DOI: 10.1002/1615-9861(200101)1:1<13::aid-prot13>3.0.co;2-j

Novel approaches to protein expression analysis (Chapter)

Jenkins, R. E., & Pennington, S. R. (2001). Novel approaches to protein expression analysis. In S. R. Pennington, & M. J. Dunn (Eds.), Proteomics: A new era in the analysis of protein function (pp. 207-224). Oxford: Bios Scientific Publishers.

1998

Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis. (Journal article)

Jenkins, R. E., Taylor, M. J., Gilvary, N. J., & Bianco, A. E. (1998). Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7550-7555. doi:10.1073/pnas.95.13.7550

DOI: 10.1073/pnas.95.13.7550

1996

Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential. (Journal article)

Jenkins, R. E., Taylor, M. J., Gilvary, N., & Bianco, A. E. (1996). Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential.. Parasite immunology, 18(1), 29-42. doi:10.1046/j.1365-3024.1996.d01-10.x

DOI: 10.1046/j.1365-3024.1996.d01-10.x

Protective immunity induced by vaccination with Onchocerca volvulus tropomyosin in rodents. (Journal article)

Taylor, M. J., Jenkins, R. E., & Bianco, A. E. (1996). Protective immunity induced by vaccination with Onchocerca volvulus tropomyosin in rodents.. Parasite immunology, 18(5), 219-225. doi:10.1046/j.1365-3024.1996.d01-93.x

DOI: 10.1046/j.1365-3024.1996.d01-93.x

Vaccination generates serum-mediated protection against Onchocerca lienalis microfilariae in the mouse. (Journal article)

Folkard, S. G., Jenkins, R. E., & Bianco, A. E. (1996). Vaccination generates serum-mediated protection against Onchocerca lienalis microfilariae in the mouse.. Tropical medicine & international health : TM & IH, 1(3), 359-362. doi:10.1046/j.1365-3156.1996.d01-48.x

DOI: 10.1046/j.1365-3156.1996.d01-48.x

1995

Onchocerca spp: a "family" of secreted acidic proteins expressed by infective larvae in blackflies. (Journal article)

Bianco, A. E., Wu, Y., & Jenkins, R. E. (1995). Onchocerca spp: a "family" of secreted acidic proteins expressed by infective larvae in blackflies.. Experimental parasitology, 81(3), 344-354. doi:10.1006/expr.1995.1125

DOI: 10.1006/expr.1995.1125

Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis. (Journal article)

Taylor, M. J., Abdel-Wahab, N., Wu, Y., Jenkins, R. E., & Bianco, A. E. (1995). Onchocerca volvulus larval antigen, OvB20, induces partial protection in a rodent model of onchocerciasis.. Infection and immunity, 63(11), 4417-4422. doi:10.1128/iai.63.11.4417-4422.1995

DOI: 10.1128/iai.63.11.4417-4422.1995

1993

Localization, turnover and conservation of gp15/400 in different stages of Brugia malayi. (Journal article)

Selkirk, M. E., Gregory, W. F., Jenkins, R. E., & Maizels, R. M. (1993). Localization, turnover and conservation of gp15/400 in different stages of Brugia malayi.. Parasitology, 107 ( Pt 4), 449-457. doi:10.1017/s0031182000067810

DOI: 10.1017/s0031182000067810

1992

Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis. (Journal article)

Poole, C. B., Grandea, A. G., Maina, C. V., Jenkins, R. E., Selkirk, M. E., & McReynolds, L. A. (1992). Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis.. Proceedings of the National Academy of Sciences of the United States of America, 89(13), 5986-5990. doi:10.1073/pnas.89.13.5986

DOI: 10.1073/pnas.89.13.5986

1991

A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites. (Journal article)

Selkirk, M. E., Yazdanbakhsh, M., Freedman, D., Blaxter, M. L., Cookson, E., Jenkins, R. E., & Williams, S. A. (1991). A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites.. The Journal of biological chemistry, 266(17), 11002-11008. doi:10.1016/s0021-9258(18)99119-2

DOI: 10.1016/s0021-9258(18)99119-2

1990

Cuticular localisation and turnover of the major surface glycoprotein (gp29) of adult Brugia malayi. (Journal article)

Selkirk, M. E., Gregory, W. F., Yazdanbakhsh, M., Jenkins, R. E., & Maizels, R. M. (1990). Cuticular localisation and turnover of the major surface glycoprotein (gp29) of adult Brugia malayi.. Molecular and biochemical parasitology, 42(1), 31-43. doi:10.1016/0166-6851(90)90110-8

DOI: 10.1016/0166-6851(90)90110-8

Publications

2024

Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality. (Journal article)

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers. (Journal article)

2023

A systems approach reveals species differences in hepatic stress response capacity (Journal article)

Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. (Journal article)

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory ‘multi-omics’ study to identify composite biomarkers (Preprint)

Multi-omic temporal landscape of plasma and synovial fluid-derived extracellular vesicles using an experimental model of equine osteoarthritis (Preprint)

Ras protein abundance correlates with Ras isoform mutation patterns in cancer (Journal article)

TEMPORAL PROTEOMIC LANDSCAPE OF PLASMA AND SYNOVIAL FLUID DERIVED EXTRACELLULAR VESICLES USING AN EXPERIMENTAL MODEL OF EQUINE OSTEOARTHRITIS (Journal article)

2022

Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis. (Journal article)

Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine Osteoarthritis (Preprint)

A systems approach reveals species differences in hepatic stress response capacity (Preprint)

2021

Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i> (Journal article)

Ras protein abundance correlates with Ras isoform mutation patterns in cancer (Preprint)

The application of cytokeratin-18 as a biomarker for drug-induced liver injury (Journal article)

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification (Journal article)

Absolute Quantitation of GTPase Protein Abundance (Journal article)

The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells (Journal article)

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells. (Journal article)

2020

Characterization of Clozapine-Responsive Human T Cells (Journal article)

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. (Journal article)

2019

Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells (Journal article)

2018

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)

In chronic myeloid leukaemia cells, the oncoprotein CIP2A binds directly to and alters expression of many cellular proteins, independent of effects on protein phosphatase 2A (PP2A) (Conference Paper)

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study (Journal article)

2017

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans (Journal article)

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients (Journal article)

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells (Journal article)

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. (Journal article)

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways (Journal article)

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile (Journal article)

2016

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients (Journal article)

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease (Journal article)

Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus (Journal article)

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites (Journal article)

Secretome protein signature of human pancreatic cancer stem-like cells (Journal article)

2015

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article)

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (Journal article)

Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia (Journal article)

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes (Journal article)

Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase (Journal article)

2014

Antigen exposure required for T cell activation (Journal article)

Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model (Journal article)

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis (Journal article)

Phenotypic analysis of primary colorectal cancer to inform management of metastatic disease (Conference Paper)

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article)

2013

Safety pharmacology - Current and emerging concepts (Journal article)

Proteomic profiling of a mouse model of acute intestinal <i>Apc</i> deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC) (Journal article)

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. (Journal article)

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

2012

Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation (Journal article)

Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. (Journal article)

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion (Journal article)

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. (Journal article)

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)