Professor Sir Munir Pirmohamed MB ChB (Hons), MRCP, PhD, FRCP, FRCP(E), FBPharmacolS

Professor (Clin,Hcc) Molecular and Clinical Pharmacology

    Research

    Research Group Membership

    Research Grants

    Postdoctoral Fellowship - Dr Richard Turner

    HEALTH EDUCATION ENGLAND (UK)

    February 2018 - July 2022

    Pharmacogenetics & Stratified Medicine Network

    PRECISION MEDICINE CATAPULT LIMITED (UK)

    October 2016 - September 2017

    Warfarin Global Health Research Group (WarPATH)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    June 2017 - November 2021

    Support for the Pharmacology Research Portfolio

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    April 2019 - March 2021

    A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2017 - July 2018

    A multimodal imaging platform with real-time super-resolution for research across the life sciences

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2018 - April 2019

    Alcohol dependence and associated disease: determinants, pathogenesis and treatment (Andrew Thompson)

    MEDICAL RESEARCH COUNCIL (MRC)

    February 2018 - March 2021

    Immune-checkpoint therapy in non-small cell lung carcinoma: molecular characterisation of tumour microenvironment to improve anti-PD1/PD-L1 drug class.

    MEDICAL RESEARCH COUNCIL (MRC)

    August 2017 - February 2021

    MRC Innovation Fellowship (Boyd)

    MEDICAL RESEARCH COUNCIL (MRC)

    August 2017 - February 2021

    The role of transporters in the uptake of AV-101

    VISTAGEN THERAPEUTICS, INC (USA)

    September 2017 - June 2021

    UK pharmacogentics and stratified medicine network

    NORTHERN HEALTH SCIENCE ALLIANCE LIMITED (UK)

    October 2016 - September 2018

    Support for the Pharmacogenetics and Stratified Medicine Network

    NHS ENGLAND (UK)

    October 2017 - October 2018

    Magic Study

    ALDER HEY CHILDREN'S CHARITY (UK)

    March 2017 - February 2018

    Bench Fees - Wedad Alhassan K Mawkili - 201309650

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    February 2018 - January 2022

    Support for the Pharmacogenetics and Stratified Medicine Network

    DEPARTMENT OF HEALTH (UK) (NIHR)

    November 2017 - July 2019

    PGX Network Sponsorship

    UCB BIOPHARMA SPRL (BELGIUM), UCB PHARMA LTD (UK)

    October 2016 - September 2018

    Can the SAVSNET informatics systems be used to improve signal identification and reporting of adverse drug reactions?

    DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS (UK)

    February 2019 - February 2022

    UK pharmacogenetics and stratified medicine network

    ACADEMIC HEALTH SCIENCE NETWORK NW COAST (NWCAHSN) (UK)

    October 2016 - September 2017

    Exploring the interaction of gut microbiome, genetic and immunological factors in gastrointestinal toxicity of immune checkpoint inhibitors.

    MEDICAL RESEARCH COUNCIL (MRC)

    February 2018 - March 2021

    Support for the Pharmacogenetics and Stratified Medicine Network

    BRISTOL-MYERS SQUIBB PHARMACEUTICALS LTD (UK)

    March 2018 - August 2018

    Personalised Medicine Approaches for Space Exploration

    EUROPEAN SPACE AGENCY (FRANCE)

    April 2018 - October 2019

    Development of screening approaches to assess to intrinsic immunogenicity of drugs and novel chemicals

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    March 2018 - March 2021

    Systems pharmacology approaches to drug-induced hypersensitivity reactions

    MALAYSIAN GOVERNMENT (MALAYSIA)

    March 2015 - February 2018

    Developing personalised renal function monitoring (CLAHRC)

    LIVERPOOL HEART AND CHEST NHS FOUNDATION TRUST (UK)

    April 2015 - December 2018

    Drug induced liver injury due to tuberculosis treatment: predictive biomarkers and genetic associations

    DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)

    March 2015 - September 2019

    Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen.

    EUROPEAN COMMISSION

    January 2016 - December 2020

    Bench Fees for Gospel Nwikue.

    RIVERS STATE SUSTAINABLE DEVELOPMENT AGENCY (NIGERIA)

    February 2015 - January 2018

    Liverpool Health Genomics Laboratory

    LIVERPOOL HEALTH PARTNERS (UK)

    March 2015 - February 2018

    North West England MRC Fellowship Scheme in Clinical Pharmacology and Therapeutics

    ELI LILLY AND COMPANY LTD (UK), MEDICAL RESEARCH COUNCIL (MRC), NOVARTIS PHARMACEUTICALS UK LTD (UK), ROCHE PRODUCTS LTD (UK), UCB PHARMA LTD (UK)

    May 2016 - October 2021

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    Identification of efficacy predictors for clopidogrel using integrated systems pharmacology approach

    DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)

    February 2016 - July 2018

    A prospective investigation of β-lactam allergy in patients with cystic fibrosis to define drug immunogenicity

    CYSTIC FIBROSIS TRUST (UK)

    December 2011 - August 2016

    A pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    June 2012 - November 2019

    The response of the liver to chemical stress, a molecular and proteomic investigation of paracetamol-induced hepatotoxicity.

    WELLCOME TRUST (UK)

    September 2001 - September 2005

    Genetic predisposition to clozapine agranulocytosis

    MERSEY CARE NHS TRUST (UK)

    March 2011 - March 2019

    North West Coast CLAHRC

    DEPARTMENT OF HEALTH (UK) (NIHR), LIVERPOOL CLINICAL COMMISSIONING GROUP (UK), MERSEY CARE NHS TRUST (UK)

    January 2014 - March 2021

    PhD Studentship.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    October 2004 - September 2007

    NHS informatics support to improve research recruitment

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    January 2013 - March 2014

    The role of multidrug transporters in causing pharmacoresistance in epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2010 - January 2013

    Chemical, clinical and molecular aspects of adverse drug reactions in man.

    WELLCOME TRUST (UK)

    January 1999 - August 2001

    Psoriasis stratification to optimise relevant therapy (PSORT)

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2014 - May 2021

    The Interactions Between Clostridium Difficile, Intestinal Microbiota and the Host Response in Hospitalised Patients.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2012 - March 2018

    Fighting Drug Failure (Marie Curie Fellowship)

    EUROPEAN COMMISSION

    October 2009 - September 2013

    Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)

    THE MOULTON CHARITABLE FOUNDATION (UK)

    June 2014 - January 2018

    North of England Pharmacology Research Programme

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    May 2011 - June 2015

    Genetic mechanisms of HIV-related lipodystrophy.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2002 - September 2005

    Folate Augmentation of Treatment - Evaluation for Depression: a randomised controlled trial (FoIATED).

    DEPARTMENT OF HEALTH (UK) (NIHR)

    October 2006 - June 2011

    The immunological response consequences of metabolic drug activation by dendritic cells.

    WELLCOME TRUST (UK)

    April 2006 - April 2009

    Designing and analysing multi-arm multi-stage clinical trials with one or more endpoints

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2012 - June 2016

    TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    January 2012 - February 2020

    Genetics of non-steroidal anti-inflammatory drugs (NSAIDs)-induced peptic ulceration: a genome wide association study.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    July 2010 - June 2011

    Utilisation of the COTOX trial to study the biological mechanisms of co-trimoxazole hypersensitivity in HIV disease.

    MEDICAL RESEARCH COUNCIL (MRC)

    January 1999 - January 2002

    Mechanisms of toxicity of protease inhibitions.

    AVERT (UK)

    October 1998 - September 2001

    Exploring oxidative stress pathways in epilepsy

    REPUBLIC OF IRAQ MINISTRY OF EDUCATION

    October 2014 - September 2017

    Randomisation within the database: a feasibility trial evaluating the comparative effects of statins in a research network of general practices RETRO-PRO

    WELLCOME TRUST (UK)

    January 2010 - December 2017

    Non-Attrition HAART nanoparticle therapies for HIV/AIDS Drug Delivery

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    May 2009 - October 2012

    Bench Fees for Azizan Binti Ab Ghani

    MINISTRY OF HEALTH MALAYSIA (MALAYSIA)

    September 2010 - August 2014

    Hepatoxicity of antituberculosis drugs: An investigation of mechanisms.

    MEDICAL RESEARCH COUNCIL (MRC)

    May 2001 - April 2004

    Inflammatory bowel disease in children

    CROHNS IN CHILDHOOD RESEARCH ASSOCIATION (UK)

    December 2013 - February 2017

    Prospective registry of inflammatory bowel diseases

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    September 2010 - August 2011

    Variability in response to warfarin: a prospective analysis of pharmacogenetic and environmental factors.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2004 - October 2009

    The role of transporter proteins in the efficacy of imatinib and newer tyrosine kinase inhibitors in chronic myeloid leukaemia.

    KAY KENDALL LEUKAEMIA FUND (UK)

    June 2008 - June 2013

    Adverse Drug Reactions in Children.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    December 2007 - April 2013

    Pharmacogenetics of Methadone response

    NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL (AUSTRALIA)

    September 2010 - February 2013

    Department of Health Sponsored chair in pharmacogenetics.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2007 - March 2019

    Investigation into the role of mycobacterial antigens in early mortality in patients treated for TB.

    WELLCOME TRUST (UK)

    November 2005 - December 2010

    MerseyBeat - Best Evidence, Application and Translation of research

    LIVERPOOL PRIMARY CARE TRUST (UK)

    March 2008 - September 2019

    A pharmacogenomic approach to coumarin anticoagulant therapy (PACT)

    EUROPEAN COMMISSION

    October 2008 - March 2013

    Paediatric Pharmacology studies

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    July 2014 - June 2017

    Applying innovative technologies to improve the benefit-risk ratio of drugs: developing a national resource underpinned by the infrastructure of the MRC Centre for Drug Safety Science

    MEDICAL RESEARCH COUNCIL (MRC)

    April 2015 - March 2016

    EURIPIDES - EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances

    EUROPEAN COMMISSION

    February 2008 - January 2013

    The role of peripheral and liver-associated T lymphocytes in pathogenesis of alcholic liver disease.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    May 2004 - October 2005

    Epidemiology of adverse drug reactions in hospitals.

    MEDICINES CONTROL AGENCY

    April 2001 - November 2003

    The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2013 - August 2013

    Investigation into the mechanisms of lamotrigine cutaneous toxicity.

    MACMILLAN CANCER SUPPORT (UK)

    February 1998 - March 2001

    Genetic markers for carbamazepine-induced hypersensitivty syndrome

    EPILEPSY RESEARCH UK (UK)

    June 2012 - November 2013

    P-glycoprotein and efficacy of imatinib (Glivec).

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    June 2002 - October 2003

    Liverpool Health Partners - Drugs Theme Project Manager

    LIVERPOOL HEALTH PARTNERS (UK)

    April 2013 - September 2015

    Effects of NRTIs on adipose function.

    PENNINE ACUTE HOSPITALS NHS TRUST (UK)

    January 2006 - June 2009

    An investigation of the functional and regulatory role of GST-PI during chemical stress.

    WELLCOME TRUST (UK)

    September 2000 - April 2004

    Effects within HAART on markers of adipose function.

    PENNINE ACUTE HOSPITALS NHS TRUST (UK)

    December 2005 - June 2009

    Pharmacogenetics of antimicrobial drug-induced liver injury.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    October 2004 - April 2008

    Pharmacogenetics of GABAergic mechanisms of benefit and harm in epilepsy.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    February 2005 - November 2010

    North West Hub for Trial Methodology Research (NWHTMR)

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2008 - August 2014

    Clerical assistant to work on EU-PACT study

    DEPARTMENT OF HEALTH (UK) (NIHR)

    July 2012 - March 2013

    WEB-RADR

    EUROPEAN COMMISSION

    September 2014 - August 2017

    Pharmacogenetics of NSAIDs

    DELTA STATE UNIVERSITY (NIGERIA)

    October 2011 - September 2014

    Drugs used in the treatment of alcohol dependency – a UK wide drug utilisation study

    MERSEY CARE NHS TRUST (UK)

    July 2012 - September 2015

    Clostridium difficile infection – developing biomarkers of pathogenicity and disease relapse

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    March 2010 - March 2011

    A retrospective cohort study of children and young people taking warfarin at Alder Hey

    CHILDRENS RESEARCH FUND (UK)

    January 2010 - December 2010

    Development and implementation of a model to improve alcohol services in primary and secondary care.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 1998 - May 2001

    Platelet polymorphism study.

    BLACKPOOL VICTORIA HOSPITAL NHS TRUST (UK)

    October 2006 - September 2007

    Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

    EUROPEAN COMMISSION

    October 2011 - September 2016

    NIHR Senior Investigator Award

    DEPARTMENT OF HEALTH (UK) (NIHR)

    April 2008 - March 2020

    Pharmacogenetics of statin-induced muscle toxicity: Exploration using the UK general practice research database (GRPD).

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2009 - February 2013

    The Pharmacology of Nevirapine in Malawian Patients: Implications for Dosing and Understanding of Hypersensitivity Reactions.

    WELLCOME TRUST (UK)

    September 2006 - October 2009

    Definition of chemical and immunological signals associated with the development of contact dermatitis.

    BRITISH SKIN FOUNDATION (UK)

    January 2006 - December 2008

    Metformin and genetic polymorphisms of organic cation transporters.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    May 2005 - December 2008

    Quantitative high-throughput proteomics for biomedical research.

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2005 - March 2008

    Cost-effectiveness of pre-prescription pharmacogenetic testing for irinotecan.

    NATIONAL ASSEMBLY FOR WALES (UK)

    February 2007 - September 2008

    Do transporter proteins contribute to clinical resistance to imatinib in chronic myeloid leukaemia? A combined study in Liverpool and Glasgow, correlating transporter expression and function with imatinib uptake and efflux.

    LEUKAEMIA RESEARCH FUND

    August 2004 - June 2008

    SANAD and MESS-Linked DNA bank and relational database.

    WELLCOME TRUST (UK)

    June 2004 - May 2005

    NIHR Portfolio Pharmacology studies

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    February 2012 - March 2014

    SAFE-T

    EUROPEAN COMMISSION

    January 2011 - June 2015

    Cell culture laboratory.

    WELLCOME TRUST (UK)

    June 2000 - April 2001

    Investigation of the role of ABCB5 in corticosteroid transport and response in IBD

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    November 2009 - February 2012

    PREDICTION-ADR: Personalisation of tREatment In Cardiovascular disease through next generation sequencing in Adverse Drug Reactions

    EUROPEAN COMMISSION

    September 2013 - February 2017

    Antiepileptic drug transport at the blood-brain barrier; more than just P-glycoprotein

    EPILEPSY RESEARCH UK (UK)

    October 2010 - September 2014

    Individual susceptibility to Clostridium Difficile Toxin Disease.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    January 2000 - August 2004

    PAMPERS - Paediatric Accelerator Mass Spectrometry Evaluation Research Study

    INSTYTUT FARMACEUTYCZNY (POLAND), MEDICAL RESEARCH COUNCIL (MRC)

    September 2011 - December 2014

    High Throughput Sequencing Hub for the North of England

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2009 - December 2012

    BRC safety of antimicrobials theme.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2007 - March 2012

    Andrew Swale - NIHR fellowship

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    April 2012 - September 2013

    Support for the Pharmacology Research Portfolio

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    August 2014 - March 2018

    Research Collaborations

    Drs Panos Deloukas/Alison Coffey

    External: Wellcome Trust Sanger Institute

    Large scale genotyping on pharmacogenetics projects

    Dr Michael Johnson

    External: Imperial College of Science, Technology

    Collaboration on epilepsy pharmacogenetics, and collection of DNA samples from epielpsy patients