Professor Sir Munir Pirmohamed MB ChB (Hons), MRCP, PhD, FRCP, FRCP(E), FBPharmacolS

Professor (Clin,Hcc) Molecular and Clinical Pharmacology

    Research

    Research Group Membership
    Research Grants

    A prospective investigation of β-lactam allergy in patients with cystic fibrosis to define drug immunogenicity

    CYSTIC FIBROSIS TRUST (UK)

    December 2011 - August 2016

    A pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    June 2012 - November 2019

    The response of the liver to chemical stress, a molecular and proteomic investigation of paracetamol-induced hepatotoxicity.

    WELLCOME TRUST (UK)

    September 2001 - September 2005

    Genetic predisposition to clozapine agranulocytosis

    MERSEY CARE NHS TRUST (UK)

    March 2011 - March 2019

    North West Coast CLAHRC

    DEPARTMENT OF HEALTH (UK) (NIHR), LIVERPOOL CLINICAL COMMISSIONING GROUP (UK), MERSEY CARE NHS TRUST (UK)

    January 2014 - September 2020

    PhD Studentship.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    October 2004 - September 2007

    NHS informatics support to improve research recruitment

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    January 2013 - March 2014

    The role of multidrug transporters in causing pharmacoresistance in epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2010 - January 2013

    Chemical, clinical and molecular aspects of adverse drug reactions in man.

    WELLCOME TRUST (UK)

    January 1999 - August 2001

    Psoriasis stratification to optimise relevant therapy (PSORT)

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2014 - August 2020

    The Interactions Between Clostridium Difficile, Intestinal Microbiota and the Host Response in Hospitalised Patients.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2012 - March 2018

    Fighting Drug Failure (Marie Curie Fellowship)

    EUROPEAN COMMISSION

    October 2009 - September 2013

    Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)

    THE MOULTON CHARITABLE FOUNDATION (UK)

    June 2014 - January 2018

    North of England Pharmacology Research Programme

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    May 2011 - June 2015

    Genetic mechanisms of HIV-related lipodystrophy.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2002 - September 2005

    Folate Augmentation of Treatment - Evaluation for Depression: a randomised controlled trial (FoIATED).

    DEPARTMENT OF HEALTH (UK) (NIHR)

    October 2006 - June 2011

    The immunological response consequences of metabolic drug activation by dendritic cells.

    WELLCOME TRUST (UK)

    April 2006 - April 2009

    Designing and analysing multi-arm multi-stage clinical trials with one or more endpoints

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2012 - June 2016

    TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)

    DEPARTMENT OF HEALTH (UK) (NIHR)

    January 2012 - February 2020

    Genetics of non-steroidal anti-inflammatory drugs (NSAIDs)-induced peptic ulceration: a genome wide association study.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    July 2010 - June 2011

    Utilisation of the COTOX trial to study the biological mechanisms of co-trimoxazole hypersensitivity in HIV disease.

    MEDICAL RESEARCH COUNCIL (MRC)

    January 1999 - January 2002

    Mechanisms of toxicity of protease inhibitions.

    AVERT (UK)

    October 1998 - September 2001

    Exploring oxidative stress pathways in epilepsy

    REPUBLIC OF IRAQ MINISTRY OF EDUCATION

    October 2014 - September 2017

    Randomisation within the database: a feasibility trial evaluating the comparative effects of statins in a research network of general practices RETRO-PRO

    WELLCOME TRUST (UK)

    January 2010 - December 2017

    Non-Attrition HAART nanoparticle therapies for HIV/AIDS Drug Delivery

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    May 2009 - October 2012

    Bench Fees for Azizan Binti Ab Ghani

    MINISTRY OF HEALTH MALAYSIA (MALAYSIA)

    September 2010 - August 2014

    Hepatoxicity of antituberculosis drugs: An investigation of mechanisms.

    MEDICAL RESEARCH COUNCIL (MRC)

    May 2001 - April 2004

    Inflammatory bowel disease in children

    CROHNS IN CHILDHOOD RESEARCH ASSOCIATION (UK)

    December 2013 - February 2017

    Prospective registry of inflammatory bowel diseases

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    September 2010 - August 2011

    Variability in response to warfarin: a prospective analysis of pharmacogenetic and environmental factors.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2004 - October 2009

    The role of transporter proteins in the efficacy of imatinib and newer tyrosine kinase inhibitors in chronic myeloid leukaemia.

    KAY KENDALL LEUKAEMIA FUND (UK)

    June 2008 - June 2013

    Adverse Drug Reactions in Children.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    December 2007 - April 2013

    Pharmacogenetics of Methadone response

    NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL (AUSTRALIA)

    September 2010 - February 2013

    Department of Health Sponsored chair in pharmacogenetics.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2007 - March 2019

    Investigation into the role of mycobacterial antigens in early mortality in patients treated for TB.

    WELLCOME TRUST (UK)

    November 2005 - December 2010

    MerseyBeat - Best Evidence, Application and Translation of research

    LIVERPOOL PRIMARY CARE TRUST (UK)

    March 2008 - September 2019

    A pharmacogenomic approach to coumarin anticoagulant therapy (PACT)

    EUROPEAN COMMISSION

    October 2008 - March 2013

    Paediatric Pharmacology studies

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    July 2014 - June 2017

    Applying innovative technologies to improve the benefit-risk ratio of drugs: developing a national resource underpinned by the infrastructure of the MRC Centre for Drug Safety Science

    MEDICAL RESEARCH COUNCIL (MRC)

    April 2015 - March 2016

    EURIPIDES - EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances

    EUROPEAN COMMISSION

    February 2008 - January 2013

    The role of peripheral and liver-associated T lymphocytes in pathogenesis of alcholic liver disease.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    May 2004 - October 2005

    Epidemiology of adverse drug reactions in hospitals.

    MEDICINES CONTROL AGENCY

    April 2001 - November 2003

    The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2013 - August 2013

    Investigation into the mechanisms of lamotrigine cutaneous toxicity.

    MACMILLAN CANCER SUPPORT (UK)

    February 1998 - March 2001

    Genetic markers for carbamazepine-induced hypersensitivty syndrome

    EPILEPSY RESEARCH UK (UK)

    June 2012 - November 2013

    P-glycoprotein and efficacy of imatinib (Glivec).

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    June 2002 - October 2003

    Liverpool Health Partners - Drugs Theme Project Manager

    LIVERPOOL HEALTH PARTNERS (UK)

    April 2013 - September 2015

    Effects of NRTIs on adipose function.

    PENNINE ACUTE HOSPITALS NHS TRUST (UK)

    January 2006 - June 2009

    An investigation of the functional and regulatory role of GST-PI during chemical stress.

    WELLCOME TRUST (UK)

    September 2000 - April 2004

    Effects within HAART on markers of adipose function.

    PENNINE ACUTE HOSPITALS NHS TRUST (UK)

    December 2005 - June 2009

    Pharmacogenetics of antimicrobial drug-induced liver injury.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    October 2004 - April 2008

    Pharmacogenetics of GABAergic mechanisms of benefit and harm in epilepsy.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    February 2005 - November 2010

    North West Hub for Trial Methodology Research (NWHTMR)

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2008 - August 2014

    Clerical assistant to work on EU-PACT study

    DEPARTMENT OF HEALTH (UK) (NIHR)

    July 2012 - March 2013

    WEB-RADR

    EUROPEAN COMMISSION

    September 2014 - August 2017

    Pharmacogenetics of NSAIDs

    DELTA STATE UNIVERSITY (NIGERIA)

    October 2011 - September 2014

    Drugs used in the treatment of alcohol dependency – a UK wide drug utilisation study

    MERSEY CARE NHS TRUST (UK)

    July 2012 - September 2015

    Clostridium difficile infection – developing biomarkers of pathogenicity and disease relapse

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    March 2010 - March 2011

    A retrospective cohort study of children and young people taking warfarin at Alder Hey

    CHILDRENS RESEARCH FUND (UK)

    January 2010 - December 2010

    Development and implementation of a model to improve alcohol services in primary and secondary care.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 1998 - May 2001

    Platelet polymorphism study.

    BLACKPOOL VICTORIA HOSPITAL NHS TRUST (UK)

    October 2006 - September 2007

    Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

    EUROPEAN COMMISSION

    October 2011 - September 2016

    NIHR Senior Investigator Award

    DEPARTMENT OF HEALTH (UK) (NIHR)

    April 2008 - March 2020

    Pharmacogenetics of statin-induced muscle toxicity: Exploration using the UK general practice research database (GRPD).

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2009 - February 2013

    The Pharmacology of Nevirapine in Malawian Patients: Implications for Dosing and Understanding of Hypersensitivity Reactions.

    WELLCOME TRUST (UK)

    September 2006 - October 2009

    Definition of chemical and immunological signals associated with the development of contact dermatitis.

    BRITISH SKIN FOUNDATION (UK)

    January 2006 - December 2008

    Metformin and genetic polymorphisms of organic cation transporters.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    May 2005 - December 2008

    Quantitative high-throughput proteomics for biomedical research.

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2005 - March 2008

    Cost-effectiveness of pre-prescription pharmacogenetic testing for irinotecan.

    NATIONAL ASSEMBLY FOR WALES (UK)

    February 2007 - September 2008

    Do transporter proteins contribute to clinical resistance to imatinib in chronic myeloid leukaemia? A combined study in Liverpool and Glasgow, correlating transporter expression and function with imatinib uptake and efflux.

    LEUKAEMIA RESEARCH FUND

    August 2004 - June 2008

    SANAD and MESS-Linked DNA bank and relational database.

    WELLCOME TRUST (UK)

    June 2004 - May 2005

    NIHR Portfolio Pharmacology studies

    THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

    February 2012 - March 2014

    SAFE-T

    EUROPEAN COMMISSION

    January 2011 - June 2015

    Cell culture laboratory.

    WELLCOME TRUST (UK)

    June 2000 - April 2001

    Investigation of the role of ABCB5 in corticosteroid transport and response in IBD

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    November 2009 - February 2012

    PREDICTION-ADR: Personalisation of tREatment In Cardiovascular disease through next generation sequencing in Adverse Drug Reactions

    EUROPEAN COMMISSION

    September 2013 - February 2017

    Antiepileptic drug transport at the blood-brain barrier; more than just P-glycoprotein

    EPILEPSY RESEARCH UK (UK)

    October 2010 - September 2014

    Individual susceptibility to Clostridium Difficile Toxin Disease.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    January 2000 - August 2004

    PAMPERS - Paediatric Accelerator Mass Spectrometry Evaluation Research Study

    INSTYTUT FARMACEUTYCZNY (POLAND), MEDICAL RESEARCH COUNCIL (MRC)

    September 2011 - December 2014

    High Throughput Sequencing Hub for the North of England

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2009 - December 2012

    BRC safety of antimicrobials theme.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    September 2007 - March 2012

    Andrew Swale - NIHR fellowship

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    April 2012 - September 2013

    Support for the Pharmacology Research Portfolio

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    August 2014 - March 2018

    Research Collaborations

    Drs Panos Deloukas/Alison Coffey

    External: Wellcome Trust Sanger Institute

    Large scale genotyping on pharmacogenetics projects

    Dr Michael Johnson

    External: Imperial College of Science, Technology

    Collaboration on epilepsy pharmacogenetics, and collection of DNA samples from epielpsy patients