2023
Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism (Journal article)
Cai, W., Chvanov, M., Awais, M., Meng, X., Latawiec, D., Brown, J., . . . Sutton, R. (2023). Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism. Pancreatology, 23, e20-e21. doi:10.1016/j.pan.2023.06.453DOI: 10.1016/j.pan.2023.06.453
Mitochondrial P53 inhibition ameliorates acute pancreatitis through reduction of mitochondrial injury and cell necrosis (Conference Paper)
Awais, M., Cai, W., Latawiec, D., Mukherjee, R., Chvanov, M., Tepikin, A., . . . Sutton, R. (2023). Mitochondrial P53 inhibition ameliorates acute pancreatitis through reduction of mitochondrial injury and cell necrosis. In BRITISH JOURNAL OF SURGERY Vol. 110. doi:10.1093/bjs/znad101.101DOI: 10.1093/bjs/znad101.101
2021
Pharmacological Therapy for Acute Pancreatitis (Chapter)
Mukherjee, R., Awais, M., Cai, W., Huang, W., Szatmary, P., & Sutton, R. (2021). Pharmacological Therapy for Acute Pancreatitis. In Unknown Book (pp. 83-94). Wiley. doi:10.1002/9781119570097.ch12DOI: 10.1002/9781119570097.ch12
Ouyang, Y., Wen, L., Armstrong, J. A., Chvanov, M., Latawiec, D., Cai, W., . . . Criddle, D. N. (2021). Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. CELLS, 10(5). doi:10.3390/cells10051035DOI: 10.3390/cells10051035
2020
De Faveri, F., Chvanov, M., Voronina, S., Moore, D., Pollock, L., Haynes, L., . . . Tepikin, A. (2020). LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy, 16(7), 1314-1331. doi:10.1080/15548627.2019.1679514DOI: 10.1080/15548627.2019.1679514
Chvanov, M., Voronina, S., Zhang, X., Telnova, S., Chard, R., Ouyang, Y., . . . Tepikin, A. V. (2020). Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis. CELLS, 9(6). doi:10.3390/cells9061407DOI: 10.3390/cells9061407
2019
Endocytic vacuoles in pancreatic acinar cells: actination, dynamics, rupture and exocytosis. (Journal article)
Voronina, S., De Faveri, F., Chvanov, M., Moore, D., Sherwood, M., Awais, M., . . . Tepikin, A. (2019). Endocytic vacuoles in pancreatic acinar cells: actination, dynamics, rupture and exocytosis.. Pancreatology, 19, S17. doi:10.1016/j.pan.2019.05.036DOI: 10.1016/j.pan.2019.05.036
2018
Chvanov, M., De Faveri, F., Moore, D., Sherwood, M. W., Awais, M., Voronina, S., . . . Tepikin, A. V. (2018). Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis. JOURNAL OF PHYSIOLOGY, 596(13), 2547-2564. doi:10.1113/JP275879DOI: 10.1113/JP275879
Armstrong, J. A., Cash, N. J., Ouyang, Y., Morton, J. C., Chvanov, M., Latawiec, D., . . . Criddle, D. N. (2018). Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(21), 8032-8047. doi:10.1074/jbc.RA118.003200DOI: 10.1074/jbc.RA118.003200
Javed, M. A., Wen, L., Awais, M., Latawiec, D., Huang, W., Chvanov, M., . . . Sutton, R. (2018). TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death. PANCREAS, 47(1), 18-24. doi:10.1097/MPA.0000000000000953DOI: 10.1097/MPA.0000000000000953
2017
Noda, N., Awais, R., Sutton, R., Awais, M., & Ozawa, T. (2017). Dynamic monitoring of p53 translocation to mitochondria for the analysis of specific inhibitors using luciferase-fragment complementation. BIOTECHNOLOGY AND BIOENGINEERING, 114(12), 2818-2827. doi:10.1002/bit.26407DOI: 10.1002/bit.26407
SEL1233 Maintains Mitochondrial Integrity, Inhibits Necrotic Cell Death, and Ameliorates Experimental Acute Pancreatitis (Conference Paper)
Awais, M., Zhang, X., Latawiec, D., Criddle, D. N., Sanvoisin, J., Austin, C., . . . Sutton, R. (2017). SEL1233 Maintains Mitochondrial Integrity, Inhibits Necrotic Cell Death, and Ameliorates Experimental Acute Pancreatitis. In PANCREAS Vol. 46 (pp. 1389). Retrieved from https://www.webofscience.com/
2016
Javed, M. A., Wen, L., Awais, M., Chvanov, M., Bordet, T., Michaud, M., . . . Sutton, R. (2016). TRO40303 reduces mitochondrial injury and ameliorates experimental acute pancreatitis. International Journal of Surgery, 36, S33. doi:10.1016/j.ijsu.2016.08.244DOI: 10.1016/j.ijsu.2016.08.244
Mukherjee, R., Mareninova, O. A., Odinokova, I. V., Huang, W., Murphy, J., Chvanov, M., . . . Unit, N. I. H. R. P. B. R. (2016). Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. GUT, 65(08), 1333-1346. doi:10.1136/gutjnl-2014-308553DOI: 10.1136/gutjnl-2014-308553
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis (Journal article)
Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801DOI: 10.1021/acs.jmedchem.5b01801
Epithelial-mesenchymal transition, IP<sub>3</sub> receptors and ER-PM junctions: translocation of Ca<SUP>2+</SUP> signalling complexes and regulation of migration (Journal article)
Okeke, E., Parker, T., Dingsdale, H., Concannon, M., Awais, M., Voronina, S., . . . Tepikin, A. V. (2016). Epithelial-mesenchymal transition, IP<sub>3</sub> receptors and ER-PM junctions: translocation of Ca<SUP>2+</SUP> signalling complexes and regulation of migration. BIOCHEMICAL JOURNAL, 473, 757-767. doi:10.1042/BJ20150364DOI: 10.1042/BJ20150364
Translational Insights Into Peroxisome Proliferator-Activated Receptors in Experimental Acute Pancreatitis (Journal article)
Huang, W., Szatmary, P., Wan, M., Bharucha, S., Awais, M., Tang, W., . . . Sutton, R. (2016). Translational Insights Into Peroxisome Proliferator-Activated Receptors in Experimental Acute Pancreatitis. PANCREAS, 45(2), 167-178. doi:10.1097/MPA.0000000000000472DOI: 10.1097/MPA.0000000000000472
Protective Effects of Necrostatin-1 in Experimental Acute Pancreatitis (Conference Paper)
Ouyang, Y., Wen, L., Latawiec, D., Armstrong, J., Awais, M., Gough, P. J., . . . Criddle, D. (2016). Protective Effects of Necrostatin-1 in Experimental Acute Pancreatitis. In PANCREAS Vol. 45 (pp. 1532). Retrieved from https://www.webofscience.com/
2015
Wen, L., Voronina, S., Javed, M. A., Awais, M., Szatmary, P., Latawiec, D., . . . Sutton, R. (2015). Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. GASTROENTEROLOGY, 149(2), 481-492.e7. doi:10.1053/j.gastro.2015.04.015DOI: 10.1053/j.gastro.2015.04.015
ORAI INHIBITION PREVENTS CYTOSOLIC CA2+OVERLOAD AND ACUTE PANCREATITIS (Conference Paper)
Wen, L., Voronina, S., Javed, M. A., Awais, M., Szatmary, P., Latawiec, D., . . . Sutton, R. (2015). ORAI INHIBITION PREVENTS CYTOSOLIC CA2+OVERLOAD AND ACUTE PANCREATITIS. In GUT Vol. 64 (pp. A303-A304). doi:10.1136/gutjnl-2015-309861.656DOI: 10.1136/gutjnl-2015-309861.656
The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death (Journal article)
Ouyang, Y., Voronina, S., Chvanov, M., Wen, L., Latawiec, D., Awais, M., . . . Criddle, D. N. (2015). The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death. Pancreatology, 15(3), S8. doi:10.1016/j.pan.2015.05.065DOI: 10.1016/j.pan.2015.05.065
An Efficient Method is Required to Transfect Non-dividing Cells with Genetically Encoded Optical Probes for Molecular Imaging (Journal article)
Awais, M., Voronina, S. G., & Sutton, R. (2015). An Efficient Method is Required to Transfect Non-dividing Cells with Genetically Encoded Optical Probes for Molecular Imaging. ANALYTICAL SCIENCES, 31(4), 293-298. doi:10.2116/analsci.31.293DOI: 10.2116/analsci.31.293
Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis (Journal article)
Awais, M., Shore, E., Gibson, R., Javed, M. A., Wen, L., Latawiec, D., . . . Sutton, R. (2015). Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis. PANCREAS, 44(8), 1360. Retrieved from https://www.webofscience.com/
2014
GSK-7975A prevents alcoholic acute pancreatitis by blocking store-operated Ca2+ entry (Journal article)
Wen, L., Javed, M. A., Chvanov, M., Awais, M., Barrett, J., Begg, M., . . . Sutton, R. (2014). GSK-7975A prevents alcoholic acute pancreatitis by blocking store-operated Ca2+ entry. Pancreatology, 14(3), S10. doi:10.1016/j.pan.2014.05.409DOI: 10.1016/j.pan.2014.05.409
Orai1 inhibition prevents calcium toxicity and acute pancreatitis (Journal article)
Wen, L., Voronina, S., Collier, D., Javed, M. A., Chvanov, M., Awais, M., . . . Sutton, R. (2014). Orai1 inhibition prevents calcium toxicity and acute pancreatitis. Pancreatology, 14(3), S100-S101. doi:10.1016/j.pan.2014.05.719DOI: 10.1016/j.pan.2014.05.719
GSK-7975A Prevents Experimental Alcoholic Acute Pancreatitis by Blocking Store-Operated Ca<SUP>2+</SUP> Entry (Journal article)
Wen, L., Javed, M. A., Chvanov, M., Awais, M., Barrett, J., Begg, M., . . . Sutton, R. (2014). GSK-7975A Prevents Experimental Alcoholic Acute Pancreatitis by Blocking Store-Operated Ca<SUP>2+</SUP> Entry. PANCREAS, 43(8), 1421. Retrieved from https://www.webofscience.com/
TRO40303 Reduces Mitochondrial Injury in Response to Fatty Acid Ethyl Esters and Ameliorates Alcoholic Pancreatitis (Journal article)
Javed, M. A., Wen, L., Awais, M., Bordet, T., Michaud, M., Schaller, S., . . . Sutton, R. (2014). TRO40303 Reduces Mitochondrial Injury in Response to Fatty Acid Ethyl Esters and Ameliorates Alcoholic Pancreatitis. PANCREAS, 43(8), 1370. Retrieved from https://www.webofscience.com/
The Role of Neutrophil Extracellular Traps in Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/
2013
Inhibition of pancreatitis-associated cell death using a human pancreatic acinar cell model (Journal article)
Javed, M. A., Mukherjee, R., Wen, L., Huang, W., Chvanov, M., Awais, M., . . . Sutton, R. (2013). Inhibition of pancreatitis-associated cell death using a human pancreatic acinar cell model. Pancreatology, 13(3), S20. doi:10.1016/j.pan.2013.04.062DOI: 10.1016/j.pan.2013.04.062
Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells (Journal article)
Dingsdale, H., Okeke, E., Awais, M., Haynes, L., Criddle, D. N., Sutton, R., & Tepikin, A. V. (2013). Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells. BIOCHEMICAL JOURNAL, 451, 25-32. doi:10.1042/BJ20121864DOI: 10.1042/BJ20121864
Involvement of the MPTP in minocycline-induced mitochondrial dysfunction in murine pancreatic acinar cells (Journal article)
Javed, M. A., Li, W., Collier, D., Jin, T., Huang, W., Awais, M., . . . Sutton, R. (2013). Involvement of the MPTP in minocycline-induced mitochondrial dysfunction in murine pancreatic acinar cells. Pancreatology, 13(2), e37. doi:10.1016/j.pan.2012.12.184DOI: 10.1016/j.pan.2012.12.184
Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis (Journal article)
Awais, M., Javed, M. A., Wen, L., Gibson, R., Shore, E., Kershaw, N., . . . Sutton, R. (2013). Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis. PANCREAS, 42(8), 1338. Retrieved from https://www.webofscience.com/
Inhibition of Pancreatitis-Associated Cell Death Using a Human Pancreatic Acinar Cell Model (Conference Paper)
Javed, M. A., Mukherjee, R., Wen, L., Huang, W., Chvanov, M., Awais, M., . . . Sutton, R. (2013). Inhibition of Pancreatitis-Associated Cell Death Using a Human Pancreatic Acinar Cell Model. In PANCREAS Vol. 42 (pp. 1356). Retrieved from https://www.webofscience.com/
Orail Inhibition Prevents Calcium Toxicity and Acute Pancreatitis (Conference Paper)
Wen, L., Collier, D., Voronina, S., Javed, M. A., Awais, M., Begg, M., . . . Sutton, R. (2013). Orail Inhibition Prevents Calcium Toxicity and Acute Pancreatitis. In PANCREAS Vol. 42 (pp. 1388). Retrieved from https://www.webofscience.com/
TRO40303 Reduces Mitochondrial Injury and Ameliorates Experimental AP (Conference Paper)
Javed, M. A., Wen, L., Awais, M., Chvanov, M., Ghaneh, P., Halloran, C., . . . Sutton, R. (2013). TRO40303 Reduces Mitochondrial Injury and Ameliorates Experimental AP. In PANCREAS Vol. 42 (pp. 1356). Retrieved from https://www.webofscience.com/
2012
Involvement of the MPTP in Minocycline-Induced Mitochondrial Dysfunction in Murine Pancreatic Acinar Cells (Conference Paper)
Javed, M. A., Li, W., Collier, D., Jin, T., Huang, W., Awais, M., . . . Sutton, R. (2012). Involvement of the MPTP in Minocycline-Induced Mitochondrial Dysfunction in Murine Pancreatic Acinar Cells. In PANCREAS Vol. 41 (pp. 1370). Retrieved from https://www.webofscience.com/
Novel simple method for the isolation of pancreatic stellate cells (Conference Paper)
Nunes, Q., Latawiec, D., Huang, W., Awais, M., Fernig, D., & Sutton, R. (2012). Novel simple method for the isolation of pancreatic stellate cells. In BRITISH JOURNAL OF SURGERY Vol. 99 (pp. 31). Retrieved from https://www.webofscience.com/
2011
Illuminating intracellular signaling and molecules for single cell analysis. (Journal article)
Awais, M., & Ozawa, T. (2011). Illuminating intracellular signaling and molecules for single cell analysis.. Molecular bioSystems, 7(5), 1376-1387. doi:10.1039/c0mb00328jDOI: 10.1039/c0mb00328j
Illuminating Intracellular Signaling and Molecules for Single Cell Analysis. (Journal article)
Awais, M., & Ozawa, T. (2011). Illuminating Intracellular Signaling and Molecules for Single Cell Analysis.. Molecular Biosystems, 7(1376-1).
Novel Simple Method for the Isolation of Pancreatic Stellate Cells (Journal article)
Nunes, Q., Latawiec, D., Awais, M., Fernig, D., & Sutton, R. (2011). Novel Simple Method for the Isolation of Pancreatic Stellate Cells. PANCREAS, 40(8), 1344-1345. Retrieved from https://www.webofscience.com/
Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells (Journal article)
Booth, D. M., Murphy, J. A., Mukherjee, R., Awais, M., Neoptolemos, J. P., Gerasimenko, O. V., . . . Criddle, D. N. (2011). Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells. GASTROENTEROLOGY, 140(7), 2116-2125. doi:10.1053/j.gastro.2011.02.054DOI: 10.1053/j.gastro.2011.02.054
2010
Fluorescence and Bioluminescence Genetically Encoded Probes for Imaging Protein Conformational Changes and Interactions in Living Cells and Animals (Journal article)
Awais, M. (2010). Fluorescence and Bioluminescence Genetically Encoded Probes for Imaging Protein Conformational Changes and Interactions in Living Cells and Animals. JALA: Journal of the Association for Laboratory Automation, 15(5), 396-404. doi:10.1016/j.jala.2010.04.001DOI: 10.1016/j.jala.2010.04.001
2009
Hida, N., Awais, M., Takeuchi, M., Ueno, N., Tashiro, M., Takagi, C., . . . Ozawa, T. (2009). High-sensitivity real-time imaging of dual protein-protein interactions in living subjects using multicolor luciferases.. PloS one, 4(6), e5868. doi:10.1371/journal.pone.0005868DOI: 10.1371/journal.pone.0005868
High-sensitivity real-time imaging of dual protein-protein interactions in living subjects using multicolor luciferases (Journal article)
Hida, N., Awais, M., Takeuchi, M., Ueno, N., Tashiro, M., Takagi, C., . . . Ozawa, T. (2009). High-sensitivity real-time imaging of dual protein-protein interactions in living subjects using multicolor luciferases. PLoS ONE, 4(6), 55868.
2007
Optical probes to identify the glucocorticoid receptor ligands in living cells. (Journal article)
Awais, M., Sato, M., & Umezawa, Y. (2007). Optical probes to identify the glucocorticoid receptor ligands in living cells.. Steroids, 72(14), 949-954. doi:10.1016/j.steroids.2007.08.006DOI: 10.1016/j.steroids.2007.08.006
New advances in nanomedicine: diagnosis and preventive medicine. (Journal article)
Wei, C., Nagai, T., Wei, W., Nemoto, T., Awais, M., Niwa, O., . . . Baba, Y. (2007). New advances in nanomedicine: diagnosis and preventive medicine.. The Medical clinics of North America, 91(5), 871-879. doi:10.1016/j.mcna.2007.05.002DOI: 10.1016/j.mcna.2007.05.002
A fluorescent indicator to visualize ligand-induced receptor/coactivator interactions for screening of peroxisome proliferator-activated receptor gamma ligands in living cells. (Journal article)
Awais, M., Sato, M., & Umezawa, Y. (2007). A fluorescent indicator to visualize ligand-induced receptor/coactivator interactions for screening of peroxisome proliferator-activated receptor gamma ligands in living cells.. Biosensors & bioelectronics, 22(11), 2564-2569. doi:10.1016/j.bios.2006.10.013DOI: 10.1016/j.bios.2006.10.013
Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells. (Journal article)
Awais, M., Sato, M., & Umezawa, Y. (2007). Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells.. Chembiochem : a European journal of chemical biology, 8(7), 737-743. doi:10.1002/cbic.200700001DOI: 10.1002/cbic.200700001
Integrated molecule-format bioluminescent probe for visualizing androgenicity of ligands based on the intramolecular association of androgen receptor with its recognition Peptide. (Journal article)
Kim, S. B., Awais, M., Sato, M., Umezawa, Y., & Tao, H. (2007). Integrated molecule-format bioluminescent probe for visualizing androgenicity of ligands based on the intramolecular association of androgen receptor with its recognition Peptide.. Analytical chemistry, 79(5), 1874-1880. doi:10.1021/ac061934uDOI: 10.1021/ac061934u
2006
Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. (Journal article)
Furukawa, T., Bai, C. -X., Kaihara, A., Ozaki, E., Kawano, T., Nakaya, Y., . . . Kurokawa, J. (2006). Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.. Molecular pharmacology, 70(6), 1916-1924. doi:10.1124/mol.106.028134DOI: 10.1124/mol.106.028134
A fluorescent indicator to visualize activities of the androgen receptor ligands in single living cells. (Journal article)
Awais, M., Sato, M., Lee, X., & Umezawa, Y. (2006). A fluorescent indicator to visualize activities of the androgen receptor ligands in single living cells.. Angewandte Chemie (International ed. in English), 45(17), 2707-2712. doi:10.1002/anie.200503185DOI: 10.1002/anie.200503185
2004
A genetically encoded fluorescent indicator capable of discriminating estrogen agonists from antagonists in living cells. (Journal article)
Awais, M., Sato, M., Sasaki, K., & Umezawa, Y. (2004). A genetically encoded fluorescent indicator capable of discriminating estrogen agonists from antagonists in living cells.. Analytical chemistry, 76(8), 2181-2186. doi:10.1021/ac030410gDOI: 10.1021/ac030410g
