Photo of Dr Michael Cross

Dr Michael Cross

Senior Lecturer Molecular and Clinical Pharmacology

    Publications

    2018

    Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process (Journal article)

    Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547

    DOI: 10.1021/acs.molpharmaceut.8b00547

    Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (Journal article)

    Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., . . . Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. ARCHIVES OF TOXICOLOGY, 92(2), 557-569. doi:10.1007/s00204-018-2152-9

    DOI: 10.1007/s00204-018-2152-9

    Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells (Journal article)

    Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2018). Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. JOURNAL OF CELLULAR PHYSIOLOGY, 233(01), 186-200. doi:10.1002/jcp.26064

    DOI: 10.1002/jcp.26064

    2017

    Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation (Chapter)

    LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology (pp. 651-712). Elsevier. doi:10.1016/b978-0-12-801238-3.64267-8

    DOI: 10.1016/b978-0-12-801238-3.64267-8

    RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells (Journal article)

    Alghanem, A. F., Wilkinson, E. L., Emmett, M. S., Aljasir, M. A., Holmes, K., Rothermel, B. A., . . . Cross, M. J. (2017). RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis, 20(3), 341-358. doi:10.1007/s10456-017-9542-0

    DOI: 10.1007/s10456-017-9542-0

    2016

    Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability (Journal article)

    Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2016). Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability. BIOLOGY OPEN, 5(10), 1362-1370. doi:10.1242/bio.020362

    DOI: 10.1242/bio.020362

    Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues (Journal article)

    Ravenscroft, S. M., Pointon, A., Williams, A. W., Cross, M. J., & Sidaway, J. E. (2016). Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues. TOXICOLOGICAL SCIENCES, 152(1), 99-112. doi:10.1093/toxsci/kfw069

    DOI: 10.1093/toxsci/kfw069

    2015

    Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury (Journal article)

    Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979

    DOI: 10.1111/bph.12979

    Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells. (Journal article)

    Nithianandarajah-Jones, G. N., & Cross, M. J. (2015). Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells.. Methods in molecular biology (Clifton, N.J.), 1332, 133-142. doi:10.1007/978-1-4939-2917-7_9

    DOI: 10.1007/978-1-4939-2917-7_9

    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. (Journal article)

    Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.

    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 (Journal article)

    Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2. Free Radical Biology and Medicine, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003

    DOI: 10.1016/j.freeradbiomed.2014.11.003

    Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)

    Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110

    DOI: 10.5966/sctm.2014-0110

    2014

    The role of ERK5 in endothelial cell function (Journal article)

    Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276

    DOI: 10.1042/BST20140276

    Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist (Journal article)

    Thaventhiran, T., Alhumeed, N., Yeang, H. X. A., Sethu, S., Downey, J. S., Alghanem, A. F., . . . Sathish, J. G. (2014). Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MABS, 6(5), 1290-1299. doi:10.4161/mabs.29758

    DOI: 10.4161/mabs.29758

    2013

    Safety pharmacology - Current and emerging concepts (Journal article)

    Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

    DOI: 10.1016/j.taap.2013.04.039

    2012

    ERK5: Structure, regulation and function (Journal article)

    Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007

    DOI: 10.1016/j.cellsig.2012.07.007

    2011

    Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis (Journal article)

    Uniewicz, K. A., Cross, M. J., & Fernig, D. G. (2011). Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(1), 12-23. doi:10.1074/jbc.M110.190801

    DOI: 10.1074/jbc.M110.190801

    2010

    Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design (Journal article)

    Holmes, K., Williams, C. M., Chapman, E. A., & Cross, M. J. (2010). Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design. BMC Research Notes, 3(1), 53. doi:10.1186/1756-0500-3-53

    DOI: 10.1186/1756-0500-3-53

    ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells (Journal article)

    Roberts, O. L., Holmes, K., Muller, J., Cross, D. A. E., & Cross, M. J. (2010). ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of Cell Science, 123(18), 3189-3200. doi:10.1242/jcs.072801

    DOI: 10.1242/jcs.072801

    VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ (Journal article)

    Holmes, K., Chapman, E., See, V., & Cross, M. J. (n.d.). VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ. PLoS ONE, 5(7), e11435. doi:10.1371/journal.pone.0011435

    DOI: 10.1371/journal.pone.0011435

    2009

    ERK5 and the regulation of endothelial cell function (Journal article)

    Roberts, O. L., Holmes, K., Müller, J., Cross, D. A. E., & Cross, M. J. (2009). ERK5 and the regulation of endothelial cell function. Biochemical Society Transactions, 37(6), 1254-1259. doi:10.1042/bst0371254

    DOI: 10.1042/bst0371254

    Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis (Journal article)

    Mellberg, S., Dimberg, A., Bahram, F., Hayashi, M., Rennel, E., Ameur, A., . . . Claesson‐Welsh, L. (2009). Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. The FASEB Journal, 23(5), 1490-1502. doi:10.1096/fj.08-123810

    DOI: 10.1096/fj.08-123810

    2007

    Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition (Journal article)

    Holmes, K., Roberts, O. L., Thomas, A. M., & Cross, M. J. (2007). Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cellular Signalling, 19(10), 2003-2012. doi:10.1016/j.cellsig.2007.05.013

    DOI: 10.1016/j.cellsig.2007.05.013

    Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer (Journal article)

    Rennel, E., Mellberg, S., Dimberg, A., Petersson, L., Botling, J., Ameur, A., . . . Gerwins, P. (2007). Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer. Experimental Cell Research, 313(7), 1285-1294. doi:10.1016/j.yexcr.2007.01.021

    DOI: 10.1016/j.yexcr.2007.01.021

    Vascular Endothelial Growth Factor Receptor-2: Structure, function, intracellular signaling and therapeutic inhibition (Journal article)

    Holmes, K., Roberts, O. L., Thomas, A. M., & Cross, M. J. (2007). Vascular Endothelial Growth Factor Receptor-2: Structure, function, intracellular signaling and therapeutic inhibition. Unknown Journal, 10(19), 2003-2012.

    2004

    The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration (Journal article)

    Holmqvist, K., Cross, M. J., Rolny, C., Hägerkvist, R., Rahimi, N., Matsumoto, T., . . . Welsh, M. (2004). The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration. Journal of Biological Chemistry, 279(21), 22267-22275. doi:10.1074/jbc.m312729200

    DOI: 10.1074/jbc.m312729200

    2003

    Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways (Journal article)

    Eriksson, K., Magnusson, P., Dixelius, J., Claesson-Welsh, L., & Cross, M. J. (2003). Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways. FEBS Letters, 536(1-3), 19-24. doi:10.1016/s0014-5793(03)00003-6

    DOI: 10.1016/s0014-5793(03)00003-6

    Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin (Journal article)

    Lundin, L., Rönnstrand, L., Cross, M., Hellström, C., Lindahl, U., & Claesson-Welsh, L. (2003). Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin. Experimental Cell Research, 287(1), 190-198.

    Endostatin action and intracellular signaling: -Catenin as a potential target? (Journal article)

    Dixelius, J., Cross, M. J., Matsumoto, T., & Claesson-Welsh, L. (2003). Endostatin action and intracellular signaling: -Catenin as a potential target?. Unknown Journal, 1(196), 1-12.

    Regulation of endothelial cell differentiation and transformation by H-Ras (Journal article)

    Rennel, E., Cross, M. J., Klint, P., Bai, X., Arbiser, J., & Gerwins, P. (2003). Regulation of endothelial cell differentiation and transformation by H-Ras. Experimental Cell Research, 291(1), 189-200.

    VEGF receptor signal transduction (Journal article)

    Cross, M. J., Dixelius, J., Matsumoto, T., & Claesson-Welsh, L. (2003). VEGF receptor signal transduction. Unknown Journal, 9(28), 488-494.

    2002

    Endostatin regulates endothelial cell adhesion and cytoskeletal organization (Journal article)

    Dixelius, J., Cross, M., Matsumoto, T., Sasaki, T., Timpl, R., & Claesson-Welsh, L. (2002). Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Research, 62(7), 1844-1947.

    The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells (Journal article)

    Cross, M. J., Lu, L., Magnusson, P., Nyqvist, D., Holmqvist, K., Welsh, M., & Claesson-Welsh, L. (2002). The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell, 13(8), 2881-2893. doi:10.1091/mbc.e02-02-0103

    DOI: 10.1091/mbc.e02-02-0103

    2000

    Tyrosine 766 in the fibroblast growth factor receptor is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A2, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells (Journal article)

    Cross, M. J., Hodgkin, M. N., Roberts, S., Landgren, E., Wakelam, M. J. O., & Claesson-Welsh, L. (2000). Tyrosine 766 in the fibroblast growth factor receptor is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A2, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. Journal of Cell Science, 113(4), 643-651.