2024
Kennedy, P. T., Saulters, E. L., Duckworth, A. D., Lim, Y. J., Woolley, J. F., Slupsky, J. R., . . . Dahal, L. N. (2024). Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.. Molecular therapy : the journal of the American Society of Gene Therapy, 32(2), 457-468. doi:10.1016/j.ymthe.2023.11.028DOI: 10.1016/j.ymthe.2023.11.028
Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA. (Journal article)
Duckworth, A. D., Slupsky, J. R., & Kalakonda, N. (2024). Highly Multiplexed and Simultaneous Characterization of Protein and RNA in Single Cells by Flow or Mass Cytometry Platforms Using Proximity Ligation Assay for RNA.. Methods in molecular biology (Clifton, N.J.), 2752, 143-165. doi:10.1007/978-1-0716-3621-3_10DOI: 10.1007/978-1-0716-3621-3_10
2023
Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL) (Journal article)
Lim, Y. J., Duckworth, A., Clarke, K., Oates, M., Gornall, M., Kalakonda, N., . . . Pettitt, A. (2023). Immunomodulatory Effects of Chemo-Immunotherapy ± Idelalisib in Chronic Lymphocytic Leukaemia (CLL). Blood, 142(Supplement 1), 1455. doi:10.1182/blood-2023-185063DOI: 10.1182/blood-2023-185063
Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib (Journal article)
Till, K. J., Abdullah, M., Alnassfan, T., Janet, G. Z., Marks, T., Coma, S., . . . Slupsky, J. R. (2023). Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-30148-3DOI: 10.1038/s41598-023-30148-3
2022
Hay, J., Tarafdar, A., Holroyd, A. K., Moka, H. A., Dunn, K. M., Alshayeb, A., . . . Michie, A. M. (2022). PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling. CANCERS, 14(23). doi:10.3390/cancers14236006DOI: 10.3390/cancers14236006
PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling (Preprint)
DOI: 10.1101/2022.09.04.506520
2021
Linley, A. J., Karydis, L. I., Mondru, A. K., D'Avola, A., Al Shmrany, H., Cicconi, S., . . . Slupsky, J. R. (2021). Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells. CLINICAL CANCER RESEARCH, 27(20), 5647-5659. doi:10.1158/1078-0432.CCR-21-0161DOI: 10.1158/1078-0432.ccr-21-0161
Linley, A. J., & Slupsky, J. R. (2021). Poor prognosis is ZAP70'ed into focus in CLL. BLOOD, 137(26), 3586-3587. doi:10.1182/blood.2021011270DOI: 10.1182/blood.2021011270
2020
Azar, A. A., Michie, A. M., Tarafdar, A., Malik, N., Menon, G. K., Till, K. J., . . . Slupsky, J. R. (2020). A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-70191-yDOI: 10.1038/s41598-020-70191-y
Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R. A., Duckworth, A., Slupsky, J. R., . . . Coupland, S. E. (2020). Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.. The Journal of Pathology, 250(4), 420-439. doi:10.1002/path.5384DOI: 10.1002/path.5384
2019
Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells (Preprint)
DOI: 10.1101/841312
POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES (Conference Paper)
Till, K. J., Gallardo Zapata, J., Marks, T., Weaver, D. T., Pachter, J. A., Abdullah, M., . . . Slupsky, J. R. (2019). POTENTIAL THERAPEUTIC ADVANTAGE FOR DUVELISIB IN MANTLE CELL LYMPHOMA: PI3Kδ AND OVEREXPRESSED PI3Kγ IN LYMPHOMA CELLS HAVE SPECIALIZED FUNCTIONAL ROLES. In Hematological Oncology Vol. 37 (pp. 511-512). Wiley. doi:10.1002/hon.194_2631DOI: 10.1002/hon.194_2631
Duckworth, A. D., Gherardini, P. F., Sykorova, M., Yasin, F., Nolan, G. P., Slupsky, J. R., & Kalakonda, N. (2019). Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry. Nature Protocols, 14(03), 901-920. doi:10.1038/s41596-018-0120-8DOI: 10.1038/s41596-018-0120-8
2018
Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9 (Conference Paper)
Maerken, M., MacEwan, D., Harper, N., Slupsky, J. R., & Linley, A. (2018). Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-113804DOI: 10.1182/blood-2018-99-113804
Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291DOI: 10.1158/0008-5472.CAN-17-2291
2017
Till, K. J., Allen, J. C., Talab, F., Lin, K., Allsup, D., Cawkwell, L., . . . Slupsky, J. R. (2017). Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17021-wDOI: 10.1038/s41598-017-17021-w
Al-Sanabra, O., Duckworth, A. D., Glenn, M. A., Brown, B. R., Angelillo, P., Lee, K., . . . Slupsky, J. R. (2017). Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells. Scientific Reports, 7. doi:10.1038/srep43228DOI: 10.1038/srep43228
2016
Allen, J. C., Talab, F., & Slupsky, J. R. (2016). Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?. International journal of hematologic oncology, 5(1), 37-53. doi:10.2217/ijh-2016-0003DOI: 10.2217/ijh-2016-0003
UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis (Journal article)
Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665DOI: 10.1002/path.4665
2015
Farahani, M., Rubbi, C., Liu, L., Slupsky, J. R., & Kalakonda, N. (2015). CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p. PLOS ONE, 10(10). doi:10.1371/journal.pone.0141429DOI: 10.1371/journal.pone.0141429
Till, K., Pettitt, A., & Slupsky, J. (n.d.). Expression of functional sphingosine-1 phosphate receptor-1is reduced by B cell receptor signaling and increased byinhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukaemia cells. The Journal of Immunology, 194. doi:10.4049/jimmunol.1402304DOI: 10.4049/jimmunol.1402304
Middle, S., Coupland, S. E., Taktak, A., Kidgell, V., Slupsky, J. R., Pettitt, A. R., & Till, K. J. (2015). Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1phosphate receptors and integrins. EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 4. doi:10.1186/s40164-015-0004-3DOI: 10.1186/s40164-015-0004-3
Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587. (Journal article)
Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587. (2015). Blood, 125(12), 2008. doi:10.1182/blood-2015-02-627679DOI: 10.1182/blood-2015-02-627679
Till, K. J., Pettitt, A., & Slupsky, J. (2015). Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells. Journal of Immunology, 194(5), 2439-2446. doi:10.4049/jimmunol.1402304DOI: 10.4049/jimmunol.1402304
Enhancing BCR signals at the cell membrane (Journal article)
Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane. BLOOD, 125(4), 586-587. doi:10.1182/blood-2014-11-611756DOI: 10.1182/blood-2014-11-611756
Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015) (Journal article)
Slupsky, J. R. (2015). Enhancing BCR signals at the cell membrane (vol 125, pg 586, 2015). BLOOD, 125(12), 2008. Retrieved from https://www.webofscience.com/
Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis (Conference Paper)
Tarafdar, A., Vukovik, M., Cosimo, E., Dunn, K., Slupsky, J. R., & Michie, A. M. (2015). Subversion of PKCα signalling in B cell progenitors results in an upregulation of PKCβII expression and leukaemogenesis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 73). Retrieved from https://www.webofscience.com/
2014
Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy. (Journal article)
Duckworth, A., Glenn, M., Slupsky, J. R., Packham, G., & Kalakonda, N. (2014). Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.. Blood, 123(21), 3277-3285. doi:10.1182/blood-2013-11-539049DOI: 10.1182/blood-2013-11-539049
Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.DOI: 10.1371/journal.pone.0095892.
Slupsky, J. R. (2014). Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?. Scientifica, 2014, 208928. doi:10.1155/2014/208928DOI: 10.1155/2014/208928
Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach? (Journal article)
E. Clapham, C., R. Pettitt, A., & R. Slupsky, J. (n.d.). Targeting Cell Metabolism In Chronic Lymphocytic Leukaemia (CLL); A Viable Therapeutic Approach?. Journal of Hematology And Oncology Research, 1(1), 7-23. doi:10.14302/issn.2372-6601.jhor-13-346DOI: 10.14302/issn.2372-6601.jhor-13-346
2013
LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells (Journal article)
Talab, F., Allen, J. C., Thompson, V., Lin, K., & Slupsky, J. R. (2013). LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells. MOLECULAR CANCER RESEARCH, 11(5), 541-554. doi:10.1158/1541-7786.MCR-12-0415-TDOI: 10.1158/1541-7786.MCR-12-0415-T
Differential induction of PRDM1 in chronic lymphocytic leukaemia (Conference Paper)
Duckworth, A. D., Glenn, M. A., Venkateswarlu, P., Slupsky, J. R., Cawley, J. C., & Kalakonda, N. (2013). Differential induction of PRDM1 in chronic lymphocytic leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 45). Retrieved from https://www.webofscience.com/
Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells (Conference Paper)
Clapham, C. E., Slupsky, J. R., & Pettitt, A. R. (2013). Expression of monocarboxylate transporters-1 and-4 in circulating and CD40L-stimulated chronic lymphocytic leukaemia (CLL) cells. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 42). Retrieved from https://www.webofscience.com/
High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis (Conference Paper)
Allen, J. C., Talab, F., Thompson, V., Lin, K., Packham, G., & Slupsky, J. R. (2013). High LCK expression in the malignant cells of chronic lymphocytic leukaemia is a marker of good disease prognosis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 47). Retrieved from https://www.webofscience.com/
Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells (Journal article)
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2013). Lck is an important mediator of BCR-induced signalling in chronic lymphocytic leukaemia cells. BRITISH JOURNAL OF HAEMATOLOGY, 161, 19. Retrieved from https://www.webofscience.com/
Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF (Journal article)
McNamara, P. S., Fonceca, A. M., Howarth, D., Correia, J. B., Slupsky, J. R., Trinick, R. E., . . . Flanagan, B. F. (2013). Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF. THORAX, 68(1), 76-81. doi:10.1136/thoraxjnl-2012-202288DOI: 10.1136/thoraxjnl-2012-202288
2012
Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak (Journal article)
Melarangi, T., Zhuang, J., Lin, K., Rockliffe, N., Bosanquet, A. G., Oates, M., . . . Pettitt, A. R. (2012). Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak. CELL DEATH & DISEASE, 3. doi:10.1038/cddis.2012.102DOI: 10.1038/cddis.2012.102
Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia (Chapter)
Allen, J. C., & Slupsky, J. R. (2012). Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia. In P. Oppezzo (Ed.), Chronic Lymphocytic Leukemia (pp. 153-178). Rijeka, Croatia: InTech.
2011
Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression (Journal article)
Lucas, C. M., Harris, R. J., Giannoudis, A., Copland, M., Slupsky, J. R., & Clark, R. E. (2011). Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. BLOOD, 117(24), 6660-6668. doi:10.1182/blood-2010-08-304477DOI: 10.1182/blood-2010-08-304477
c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells (Journal article)
Allen, J. C., Talab, F., Zuzel, M., Lin, K., & Slupsky, J. R. (2011). c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells. BLOOD, 117(8), 2414-2422. doi:10.1182/blood-2010-08-301176DOI: 10.1182/blood-2010-08-301176
2010
Mechanisms of monoclonal antibody-induced platelet activation. (Journal article)
Slupsky, J. R. (2010). Mechanisms of monoclonal antibody-induced platelet activation..
Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells (Journal article)
Abrams, S. T., Brown, B. R. B., Zuzel, M., & Slupsky, J. R. (2010). Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells. BLOOD, 115(22), 4447-4454. doi:10.1182/blood-2009-06-229872DOI: 10.1182/blood-2009-06-229872
Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells (Conference Paper)
Talab, F., Thompson, V., Allen, J. C., Lin, K., & Slupsky, J. R. (2010). Characterisation of B Cell Receptor-Induced NF-KB Activation In Chronic Lymphocytic Leukaemia Cells. In BLOOD Vol. 116 (pp. 169-170). Retrieved from https://www.webofscience.com/
2007
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII (Journal article)
Abrams, S. T., Lakum, T., Lin, K., Jones, G. M., Treweeke, A. T., Farahani, M., . . . Slupsky, J. R. (2007). B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII. BLOOD, 109(3), 1193-1201. doi:10.1182/blood-2006-03-012021DOI: 10.1182/blood-2006-03-012021
Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia (Journal article)
Slupsky, J. R., Kamiguti, A. S., Harris, R. J., Cawley, J. C., & Zuzel, M. (2007). Central role of protein kinase Cε in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia. AMERICAN JOURNAL OF PATHOLOGY, 170(2), 745-754. doi:10.2353/ajpath.2007.060557DOI: 10.2353/ajpath.2007.060557
2006
c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications (Journal article)
Lin, K., Glenn, M. A., Harris, R. J., Duckworth, A. D., Dennett, S., Cawley, J. C., . . . Slupsky, J. R. (2006). c-Abl expression in chronic lymphocytic leukemia cells: Clinical and therapeutic implications. CANCER RESEARCH, 66(15), 7801-7809. doi:10.1158/0008-5472.CAN-05-3901DOI: 10.1158/0008-5472.CAN-05-3901
2005
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia (Journal article)
Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. JOURNAL OF IMMUNOLOGY, 175(12), 8424-8430. doi:10.4049/jimmunol.175.12.8424DOI: 10.4049/jimmunol.175.12.8424
B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia (Journal article)
Allsup, D. J., Kamiguti, A. S., Lin, K., Sherrington, P. D., Matrai, Z., Slupsky, J. R., . . . Zuzel, N. (2005). B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. CANCER RESEARCH, 65(16), 7328-7337. doi:10.1158/0008-5472.CAN-03-1563DOI: 10.1158/0008-5472.CAN-03-1563
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia (Journal article)
Kamiguti, A. S., Serrander, L., Lin, K., Harris, R. J., Cawley, J. C., Allsup, D. J., . . . Zuzel, M. (2005). Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol., 175(12), 8424-8430. Retrieved from http://www.jimmunol.org/cgi/content/full/175/12/8424
Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB (Conference Paper)
Lin, K., Harris, R. J., Dennett, S., Cawley, J. C., Zuzel, M., & Slupsky, J. R. (2005). Over-expression of c-Abl in CLL cells is associated with advanced disease, and contributes to CLL-cell survival through activation of NF-kB. In BLOOD Vol. 106 (pp. 348A). Retrieved from https://www.webofscience.com/
2004
Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells (Conference Paper)
Syrovets, T., Colognato, R., Slupsky, J. R., & Simmet, T. (2004). Function and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. In FASEB JOURNAL Vol. 18 (pp. C301). Retrieved from https://www.webofscience.com/
2003
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells (Journal article)
Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., Syrovets, T., & Simmet, T. (2003). Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. BLOOD, 102(7), 2645-2652. doi:10.1182/blood-2002-08-2497DOI: 10.1182/blood-2002-08-2497
The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL) (Journal article)
Aziz, K. A., Till, K. J., Chen, H. J., Slupsky, J. R., Campbell, F., Cawley, J. C., & Zuzel, M. (2003). The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL). BLOOD, 102(3), 1051-1056. doi:10.1182/blood-2002-12-3737DOI: 10.1182/blood-2002-12-3737
Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways (Journal article)
Kamiguti, A. S., Harris, R. J., Slupsky, J. R., Baker, P. K., Cawley, J. C., & Zuzel, M. (2003). Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. ONCOGENE, 22(15), 2272-2284. doi:10.1038/sj.onc.1206398DOI: 10.1038/sj.onc.1206398
Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias. (Chapter)
Kamiguti, A. S., Slupsky, J. R., & Zuzel, M. (2003). Malignant cell signalling in chronic lymphocytic and hairy-cell leukaemias.. In S. G. Pandalai (Ed.), Recent Research Developments in Haematology (Vol. 1, pp. 81-101). Trivandrum: Transworld Research Network.
2002
Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion (Journal article)
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-α involves induction of apoptosis through autocrine TNF-α and protection by adhesion. BLOOD, 100(2), 647-653. doi:10.1182/blood.V100.2.647DOI: 10.1182/blood.V100.2.647
Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells (Conference Paper)
Colognato, R., Slupsky, J. R., Jendrach, M., Syrovets, T., & Simmet, T. (2002). Characterization of protease-activated receptor expression in human peripheral monocytes and antigen presenting cells. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 365 (pp. R76). Retrieved from https://www.webofscience.com/
Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion (Journal article)
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion. Blood, 100(2), 647-653.
Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion. (Conference Paper)
Baker, P. K., Pettitt, A. R., Slupsky, J. R., Chen, H. J., Glenn, M. A., Zuzel, M., & Cawley, J. C. (2002). Response of hairy cells to α-IFN involves induction of apoptosis through autocrine TNF-α and protection by adhesion.. In BLOOD Vol. 100 (pp. 596A). Retrieved from https://www.webofscience.com/
2001
Active Ras induces heterodimerization of cRaf and BRaf (Journal article)
Weber, C. K., Slupsky, J. R., Kalmes, H. A., & Rapp, U. R. (2001). Active Ras induces heterodimerization of cRaf and BRaf. CANCER RESEARCH, 61(9), 3595-3598. Retrieved from https://www.webofscience.com/
Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines (Conference Paper)
Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., & Simmet, T. (2001). Regulation of protease-activated receptor-1 and-2 expression on antigen presenting cells by cytokines. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 363 (pp. R82). Retrieved from https://www.webofscience.com/
2000
Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα (Journal article)
Syrovets, T., Büchele, B., Gedig, E., Slupsky, J. R., & Simmet, T. (2000). Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIα. MOLECULAR PHARMACOLOGY, 58(1), 71-81. doi:10.1124/mol.58.1.71DOI: 10.1124/mol.58.1.71
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes (Journal article)
Weber, C. K., Slupsky, J. R., Herrmann, C., Schuler, M., Rapp, U. R., & Block, C. (2000). Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes. ONCOGENE, 19(2), 169-176. doi:10.1038/sj.onc.1203261DOI: 10.1038/sj.onc.1203261
1999
Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling (Journal article)
Slupsky, J. R., Quitterer, U., Weber, C. K., Gierschik, P., Lohse, M. J., & Rapp, U. R. (1999). Binding of Gβγ subunits to cRaf1 downregulates G-protein-coupled receptor signalling. CURRENT BIOLOGY, 9(17), 971-974. doi:10.1016/S0960-9822(99)80426-6DOI: 10.1016/S0960-9822(99)80426-6
1998
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells (Journal article)
Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., Müller-Berghaus, G., & Kroczek, R. A. (1998). CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. NATURE, 391(6667), 591-594. doi:10.1038/35393DOI: 10.1038/35393
Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40 (Journal article)
Slupsky, J. R., Kalbas, M., Willuweit, A., Henn, V., Kroczek, R. A., & Müller-Berghaus, G. (1998). Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40. THROMBOSIS AND HAEMOSTASIS, 80(6), 1008-1014. Retrieved from https://www.webofscience.com/
1997
The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals (Journal article)
Slupsky, J. R., Kamiguti, A. S., Rhodes, N. P., Cawley, J. C., Shaw, A. R. E., & Zuzel, M. (1997). The platelet antigens CD9, CD42 and integrin alpha(IIb)beta(IIIa) can be topographically associated and transduce functionally similar signals. EUROPEAN JOURNAL OF BIOCHEMISTRY, 244(1), 168-175. doi:10.1111/j.1432-1033.1997.00168.xDOI: 10.1111/j.1432-1033.1997.00168.x
Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation (Journal article)
Slupsky, J. R., Cawley, J. C., Kaplan, C., & Zuzel, M. (1997). Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation. BRITISH JOURNAL OF HAEMATOLOGY, 96(2), 275-286. doi:10.1046/j.1365-2141.1997.d01-2011.xDOI: 10.1046/j.1365-2141.1997.d01-2011.x
TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells (Conference Paper)
Henn, V., Slupsky, J. R., Grafe, M., Muller-Berghaus, G., & Kroczek, R. A. (1997). TRAP (CD40 ligand) on activated platelets triggers a pro-inflammatory reaction of endothelial cells. In Immunobiology Vol. 197 (pp. 305).
1996
GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases (Journal article)
Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTP gamma S-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not via tyrosine kinases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 220(3), 484-490. doi:10.1006/bbrc.1996.0431DOI: 10.1006/bbrc.1996.0431
GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases (Journal article)
Lowe, G. M., Slupsky, J. R., Galvani, D. W., & Edwards, S. W. (1996). GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases. Biochemical and Biophysical Research Communications, 220(3), 484-490. doi:10.1006/bbrc.1996.0431DOI: 10.1006/bbrc.1996.0431
CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets. (Conference Paper)
Shaw, A. R. E., Seehafer, J. G., & Slupsky, J. R. (1996). CD9 associates with CD36 to form novel high density molecular aggregates in collagen stimulated human platelets.. In BLOOD Vol. 88 (pp. 95). Retrieved from https://www.webofscience.com/
1995
CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals. (Conference Paper)
Slupsky, J. R., Shaw, R. E., & Zuzel, M. (1995). CD9, 41 & 42 on platelets can be topographically associated and transduce functionally similar signals.. In BLOOD Vol. 86 (pp. 2196). Retrieved from https://www.webofscience.com/
ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB (Conference Paper)
SLUPSKY, J. R., KROPP, B., & POTZSCH, B. (1995). ENDOTHELIAL-CELLS EXPRESS A FUNCTIONALLY IDENTICAL BUT IMMUNOLOGICALLY DIFFERENT VARIANT OF PLATELET GLYCOPROTEIN-IB. In THROMBOSIS AND HAEMOSTASIS Vol. 73 (pp. 909). Retrieved from https://www.webofscience.com/
1994
PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA (Journal article)
KAMIGUTI, A. S., SLUPSKY, J. R., ZUZEL, M., & HAY, C. R. M. (1994). PROPERTIES OF FIBRINOGEN CLEAVED BY JARARHAGIN, A METALLOPROTEINASE FROM THE VENOM OF BOTHROPS-JARARACA. THROMBOSIS AND HAEMOSTASIS, 72(2), 244-249. Retrieved from https://www.webofscience.com/
1993
C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA (Journal article)
TILL, K. J., LOPEZ, A., SLUPSKY, J., & CAWLEY, J. C. (1993). C-FMS PROTEIN EXPRESSION BY B-CELLS, WITH PARTICULAR REFERENCE TO THE HAIRY-CELLS OF HAIRY-CELL LEUKEMIA. BRITISH JOURNAL OF HAEMATOLOGY, 83(2), 223-231. doi:10.1111/j.1365-2141.1993.tb08276.xDOI: 10.1111/j.1365-2141.1993.tb08276.x
THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS (Journal article)
SLUPSKY, J. R., DUGGANKEEN, M., BOOTH, L. A., KARPAS, A., RHODES, E. G. H., CAWLEY, J. C., & ZUZEL, M. (1993). THE PEANUT-AGGLUTININ (PNA)-BINDING SURFACE COMPONENTS OF MALIGNANT PLASMA-CELLS. BRITISH JOURNAL OF HAEMATOLOGY, 83(4), 567-573. doi:10.1111/j.1365-2141.1993.tb04692.xDOI: 10.1111/j.1365-2141.1993.tb04692.x
1992
ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES (Journal article)
SLUPSKY, J. R., CAWLEY, J. C., GRIFFITH, L. S., SHAW, A. R. E., & ZUZEL, M. (1992). ROLE OF FC-GAMMA-RII IN PLATELET ACTIVATION BY MONOCLONAL-ANTIBODIES. JOURNAL OF IMMUNOLOGY, 148(10), 3189-3194. Retrieved from https://www.webofscience.com/
1991
PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL (Journal article)
GRIFFITH, L., SLUPSKY, J., SEEHAFER, J., BOSHKOV, L., & SHAW, A. R. E. (1991). PLATELET ACTIVATION BY IMMOBILIZED MONOCLONAL-ANTIBODY - EVIDENCE FOR A CD9 PROXIMAL SIGNAL. BLOOD, 78(7), 1753-1759. Retrieved from https://www.webofscience.com/
1990
MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS (Journal article)
SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1990). MYRISTIC ACID IS INCORPORATED INTO THE 2 ACYLATABLE DOMAINS OF THE FUNCTIONAL GLYCOPROTEIN CD9 IN ESTER, BUT NOT IN AMIDE BONDS. BIOCHIMICA ET BIOPHYSICA ACTA, 1039(2), 218-226. doi:10.1016/0167-4838(90)90189-MDOI: 10.1016/0167-4838(90)90189-M
ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM (Journal article)
MASELLISSMITH, A., JENSEN, G. S., SEEHAFER, J. G., SLUPSKY, J. R., & SHAW, A. R. E. (1990). ANTI-CD9 MONOCLONAL-ANTIBODIES INDUCE HOMOTYPIC ADHESION OF PRE-B CELL-LINES BY A NOVEL MECHANISM. JOURNAL OF IMMUNOLOGY, 144(5), 1607-1613. Retrieved from https://www.webofscience.com/
1989
EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX (Journal article)
SLUPSKY, J. R., SEEHAFER, J. G., TANG, S. C., MASELLISSMITH, A., & SHAW, A. R. E. (1989). EVIDENCE THAT MONOCLONAL-ANTIBODIES AGAINST CD9 ANTIGEN INDUCE SPECIFIC ASSOCIATION BETWEEN CD9 AND THE PLATELET GLYCOPROTEIN-IIB-GLYCOPROTEIN-IIIA COMPLEX. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(21), 12289-12293. Retrieved from https://www.webofscience.com/
MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA (Journal article)
VISSER, L., SHAW, A., SLUPSKY, J., VOS, H., & POPPEMA, S. (1989). MONOCLONAL-ANTIBODIES REACTIVE WITH HAIRY-CELL LEUKEMIA. BLOOD, 74(1), 320-325. Retrieved from https://www.webofscience.com/
1988
THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19 (Journal article)
SEEHAFER, J. G., TANG, S. C., SLUPSKY, J. R., & SHAW, A. R. E. (1988). THE FUNCTIONAL GLYCOPROTEIN-CD9 IS VARIABLY ACYLATED - LOCALIZATION OF THE VARIABLY ACYLATED REGION TO A MEMBRANE-ASSOCIATED PEPTIDE CONTAINING THE BINDING-SITE FOR THE AGONISTIC MONOCLONAL-ANTIBODY 50H.19. BIOCHIMICA ET BIOPHYSICA ACTA, 957(3), 399-410. doi:10.1016/0167-4838(88)90231-2DOI: 10.1016/0167-4838(88)90231-2
THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET (Journal article)
SEEHAFER, J. G., SLUPSKY, J. R., TANG, S. C., & SHAW, A. R. E. (1988). THE FUNCTIONAL CELL-SURFACE GLYCOPROTEIN CD9 IS DISTINGUISHED BY BEING THE MAJOR FATTY-ACID ACYLATED AND A MAJOR IODINATED CELL-SURFACE COMPONENT OF THE HUMAN-PLATELET. BIOCHIMICA ET BIOPHYSICA ACTA, 952(1), 92-100. doi:10.1016/0167-4838(88)90105-7DOI: 10.1016/0167-4838(88)90105-7
1987
CHARACTERIZATION OF CARDIAC CALSEQUESTRIN (Journal article)
SLUPSKY, J. R., OHNISHI, M., CARPENTER, M. R., & REITHMEIER, R. A. F. (1987). CHARACTERIZATION OF CARDIAC CALSEQUESTRIN. BIOCHEMISTRY, 26(20), 6539-6544. doi:10.1021/bi00394a038DOI: 10.1021/bi00394a038
