Dr John Jenkins PhD SFHEA

Senior Lecturer School of Medicine

Research

Research Interest 1

Colonic adenocarcinoma is considered to develop via the premalignant adenoma stage as a result of the accumulation of multiple genetic changes. Inactivation of the Adenomatous polyposis coli (Apc) gene is one of the first and most important genetic mutations. My research employs two complementary strategies to investigate the transcriptomic and proteomic consequences of short term Apc deletion in murine intestinal epithelium. Affymetrix cDNA micro-array analysis of transcriptomic changes: Protein profile analysis: iTRAQ multiplex LCMS/SM.

Research Grants

A pilot IBD biomarker study: analysis of serum levels of four proteins in IBD patients and healthy people

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

April 2015 - March 2016

Bench Fees for Shahram A I Ibrahim

KURDISTAN REGIONAL GOVERNMENT (IRAQ)

December 2010 - January 2014

Quantitative high-throughput proteomics for biomedical research.

MEDICAL RESEARCH COUNCIL

March 2005 - March 2008

Assessment of the abundance of potential biomarkers of colorectal neoplasia in human patients

CANCER RESEARCH UK (UK)

July 2010 - September 2011

Topoisomerase I interactions: exploiting the potential of new therapeutic targets.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

July 2003 - June 2005

Is the interaction between Topoisomerase II and PKC part of the Cellular Response Mechanism?

NORTH WEST CANCER RESEARCH FUND

October 2000 - September 2003

University of Liverpool Institutional Discipline Bridging.

MEDICAL RESEARCH COUNCIL

October 2003 - October 2006

Proteomic dissection of an early colon cancer model.

NORTH WEST CANCER RESEARCH FUND

July 2007 - June 2009

Research Collaborations

Hsp90 Research

Internal

Research on Hsp90 as a novel drug target