Dr John Green BSc MBChB DM FRCPE FRCP

Honorary Sen Lec (Clin,Hcc) Molecular & Clinical Cancer Medicine

    Research

    Systematic reviews of therapeutic interventions for advanced cancers

    Cochrane systematic reviews
    1. Chemoradiation for locally advanced cervical cancer
    2. Pemetrexed in combination with cisplatin in advanced mesothelioma
    3. First line therapy for EGFR mutated non-small cell lung cancer

    Phase 1 and 2 studies of novel anticancer agents

    Phase 1b/11 study of APR-246 in combination with chemotherapy in platinum sensitive relapsed high grade serous ovarian cancer

    This novel agent has 2 anticancer actions - firstly it reverses the unfolding of the tumour suppressor p53 and secondly it reduces glutathione levels and inhibits thioredoxin reductase. Both mechanisms may be relevant to targeting tumours with p53 alterations, detected in over 50% of human cancers, by promoting apoptosis. Secondly enhancing sensitivity to cytotoxic agents including cisplatin and radiation by altering the REDOX status of the cell.

    Targeting invasion in ovarian cancer

    Collaboration with Dr Daimark Bennett in Life Sciences in translation of invasion model systems based on the Drosophila ovary and cell line systems

    Research Grants

    Molecular markers of prognosis in ovarian cancer though analysis of the EORTC/NCRI randomised phase III study of platinum/taxane chemotherapy ± erlotinib.

    CANCER RESEARCH UK (UK)

    April 2007 - September 2010

    Ovplex

    HEALTHLINX LIMITED (AUSTRALIA)

    July 2010 - March 2012

    OVO7.

    CANCER RESEARCH UK (UK)

    January 2006 - June 2010

    Dr S L Lim Fellowship.

    CLATTERBRIDGE CANCER RESEARCH

    February 2006 - January 2007

    Randomised Phase III Trial of Paclitaxel plus Carboplatin Therapy versus Irinotecan plus Cisplatin therapy as a First Line Chemotherapy for Clear Cell Carcinoma of the Ovary

    CANCER RESEARCH UK (UK)

    January 2010 - December 2012

    To investigate the diagnostic and prognostic utility of MIPs in endometrial cancer

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    September 2012 - September 2016

    Translational research in clear cell cancer of the ovary: CCC-1TRANS

    CANCER RESEARCH UK (UK)

    January 2010 - December 2013

    The role and regulation of TOR signalling networks in ovarian cancer metastasis

    NORTH WEST CANCER RESEARCH FUND

    January 2013 - June 2015

    Research Collaborations

    Prof D Fernig

    Internal

    Translational studies in ovarian cancer related to clinical trial

    Professor H Rees

    Internal

    Collaboration on serum proteomics project in ovarian cancer