2024
O241: A multi-omic systematic review of metabolites involved in predicting of the response to neoadjuvant therapy in locally advanced rectal cancer (Journal article)
Kler, A., Fok, M., Grundy, G., Sciacovelli, M., Dunn, W., & Vimalchandran, D. (2024). O241: A multi-omic systematic review of metabolites involved in predicting of the response to neoadjuvant therapy in locally advanced rectal cancer. British Journal of Surgery, 111(Supplement_2). doi:10.1093/bjs/znae046.020DOI: 10.1093/bjs/znae046.020
Saleh, H., Liloglou, T., Rigden, D. J., Parsons, J. L., & Grundy, G. J. (2024). KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein-Protein Interactions to Promote Cancer Cell Survival.. Journal of molecular biology, 436(4), 168434. doi:10.1016/j.jmb.2023.168434DOI: 10.1016/j.jmb.2023.168434
2023
Hill, R. M., Fok, M., Grundy, G., Parsons, J. L., & Rocha, S. (2023). The role of autophagy in hypoxia-induced radioresistance.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 189, 109951. doi:10.1016/j.radonc.2023.109951DOI: 10.1016/j.radonc.2023.109951
Fok, M., Hill, R., Fowler, H., Clifford, R., Kler, A., Uzzi-Daniel, J., . . . Vimalachandran, D. (2023). Enhancing radiotherapy outcomes in rectal cancer: A systematic review of targeting hypoxia-induced radioresistance. Clinical and Translational Radiation Oncology, 44, 100695. doi:10.1016/j.ctro.2023.100695DOI: 10.1016/j.ctro.2023.100695
2022
Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma. (Journal article)
Zhou, C., Fabbrizi, M. R., Hughes, J. R., Grundy, G. J., & Parsons, J. L. (2022). Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma.. Frontiers in oncology, 12, 940377. doi:10.3389/fonc.2022.940377DOI: 10.3389/fonc.2022.940377
The Base Excision Repair (BER) Pathway (Chapter)
Parsons, J. L., & Grundy, G. J. (2023). The Base Excision Repair (BER) Pathway. In Encyclopedia of Cell Biology (pp. 541-551). Elsevier. doi:10.1016/b978-0-12-821618-7.00100-0DOI: 10.1016/b978-0-12-821618-7.00100-0
2020
Grundy, G. J., & Parsons, J. L. (2020). Base excision repair and its implications to cancer therapy. GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR, 64(5), 831-843. doi:10.1042/EBC20200013DOI: 10.1042/EBC20200013
2017
Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process (Journal article)
Rulten, S. L., & Grundy, G. J. (2017). Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process. BIOESSAYS, 39(3). doi:10.1002/bies.201600209DOI: 10.1002/bies.201600209
2016
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B<SUP>Glu2</SUP> (Journal article)
Grundy, G. J., Polo, L. M., Zeng, Z., Rulten, S. L., Hoch, N. C., Paomephan, P., . . . Caldecott, K. W. (2016). PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B<SUP>Glu2</SUP>. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12404DOI: 10.1038/ncomms12404
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins (Journal article)
Grundy, G. J., Rulten, S. L., Arribas-Bosacoma, R., Davidson, K., Kozik, Z., Oliver, A. W., . . . Caldecott, K. W. (2016). The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms11242DOI: 10.1038/ncomms11242
2014
One ring to bring them all-The role of Ku in mammalian non-homologous end joining (Journal article)
Grundy, G. J., Moulding, H. A., Caldecott, K. W., & Rulten, S. L. (2014). One ring to bring them all-The role of Ku in mammalian non-homologous end joining. DNA REPAIR, 17, 30-38. doi:10.1016/j.dnarep.2014.02.019DOI: 10.1016/j.dnarep.2014.02.019
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage (Journal article)
Rulten, S. L., Rotheray, A., Green, R. L., Grundy, G. J., Moore, D. A. Q., Gomez-Herreros, F., . . . Caldecott, K. W. (2014). PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. NUCLEIC ACIDS RESEARCH, 42(1), 307-314. doi:10.1093/nar/gkt835DOI: 10.1093/nar/gkt835
2013
APLF promotes the assembly and activity of non-homologous end joining protein complexes (Journal article)
Grundy, G. J., Rulten, S. L., Zeng, Z., Arribas-Bosacoma, R., Iles, N., Manley, K., . . . Caldecott, K. W. (2013). APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO JOURNAL, 32(1), 112-125. doi:10.1038/emboj.2012.304DOI: 10.1038/emboj.2012.304
2010
Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination (Journal article)
Grundy, G. J., Yang, W., & Gellert, M. (2010). Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(52), 22487-22492. doi:10.1073/pnas.1014958107DOI: 10.1073/pnas.1014958107
2009
Initial Stages of V(D)J Recombination: The Organization of RAG1/2 and RSS DNA in the Postcleavage Complex (Journal article)
Grundy, G. J., Ramon-Maiques, S., Dimitriadis, E. K., Kotova, S., Biertuempfel, C., Heymann, J. B., . . . Yang, W. (2009). Initial Stages of V(D)J Recombination: The Organization of RAG1/2 and RSS DNA in the Postcleavage Complex. MOLECULAR CELL, 35(2), 217-227. doi:10.1016/j.molcel.2009.06.022DOI: 10.1016/j.molcel.2009.06.022
2008
An Activation-Induced Cytidine Deaminase-Independent Mechanism of Secondary V<sub>H</sub> Gene Rearrangement in Preimmune Human B Cells (Journal article)
Longo, N. S., Grundy, G. J., Lee, J., Gellert, M., & Lipsky, P. E. (2008). An Activation-Induced Cytidine Deaminase-Independent Mechanism of Secondary V<sub>H</sub> Gene Rearrangement in Preimmune Human B Cells. JOURNAL OF IMMUNOLOGY, 181(11), 7825-7834. doi:10.4049/jimmunol.181.11.7825DOI: 10.4049/jimmunol.181.11.7825
2007
Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells (Journal article)
McCloskey, N., Hunt, J., Beavil, R. L., Jutton, M. R., Grundy, G. J., Girardi, E., . . . Gould, H. J. (2007). Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(33), 24083-24091. doi:10.1074/jbc.M703195200DOI: 10.1074/jbc.M703195200
Requirements for DNA hairpin formation by RAG1/2 (Journal article)
Grundy, G. J., Hesse, J. E., & Gellert, M. (2007). Requirements for DNA hairpin formation by RAG1/2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(9), 3078-3083. doi:10.1073/pnas.0611293104DOI: 10.1073/pnas.0611293104
2006
Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-α:: A potential role in systemic lupus erythematosus (Journal article)
Asokan, R., Hua, J., Young, K. A., Gould, H. J., Hannan, J. P., Kraus, D. M., . . . Holers, V. M. (2006). Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-α:: A potential role in systemic lupus erythematosus. JOURNAL OF IMMUNOLOGY, 177(1), 383-394. doi:10.4049/jimmunol.177.1.383DOI: 10.4049/jimmunol.177.1.383
2005
The structure of human CD23 and its interactions with IgE and CD21 (Journal article)
Hibbert, R. G., Teriete, P., Grundy, G. J., Beavil, R. L., Reljic, R., Holers, V. M., . . . McDonnell, J. M. (2005). The structure of human CD23 and its interactions with IgE and CD21. JOURNAL OF EXPERIMENTAL MEDICINE, 202(6), 751-760. doi:10.1084/jem.20050811DOI: 10.1084/jem.20050811
