Photo of Prof Eithne Costello

Prof Eithne Costello B.Sc., Ph.D., SFHEA

Professor of Molecular Oncology Molecular and Clinical Cancer Medicine

    Publications

    2019

    Genetic variability of the ABCC2 gene and clinical outcomes in pancreatic cancer patients. (Journal article)

    Gentiluomo, M., Puchalt García, P., Galeotti, A. A., Talar-Wojnarowska, R., Tjaden, C., Tavano, F., . . . Campa, D. (2019). Genetic variability of the ABCC2 gene and clinical outcomes in pancreatic cancer patients.. Carcinogenesis, 40(4), 544-550. doi:10.1093/carcin/bgz006

    DOI: 10.1093/carcin/bgz006

    Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer. (Journal article)

    Sheel, A. R. G., Harrison, S., Sarantitis, I., Nicholson, J. A., Hanna, T., Grocock, C., . . . Collaborators, E. U. R. O. P. A. C. (2019). Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer. AMERICAN JOURNAL OF GASTROENTEROLOGY, 114(1), 155-164. doi:10.1038/s41395-018-0395-y

    DOI: 10.1038/s41395-018-0395-y

    2018

    S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes (Journal article)

    Nedjadi, T., Evans, A., Sheikh, A., Barerra, L., Al-Ghamdi, S., Oldfield, L., . . . Costello, E. (2018). S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes. BMC CANCER, 18. doi:10.1186/s12885-018-5161-4

    DOI: 10.1186/s12885-018-5161-4

    Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma (Journal article)

    Mahajan, U. M., Langhoff, E., Goni, E., Costello, E., Greenhalf, W., Halloran, C., . . . Mayerle, J. (2018). Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma. GASTROENTEROLOGY, 155(5), 1625-+. doi:10.1053/j.gastro.2018.08.009

    DOI: 10.1053/j.gastro.2018.08.009

    Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches (Journal article)

    Gomez-Rubio, P., Pinero, J., Molina-Montes, E., Gutierrez-Sacristan, A., Marquez, M., Rava, M., . . . Investigators, P. S. (2019). Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches. INTERNATIONAL JOURNAL OF CANCER, 144(7), 1540-1549. doi:10.1002/ijc.31866

    DOI: 10.1002/ijc.31866

    Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker. (Journal article)

    Martinez-Bosch, N., Barranco, L. E., Orozco, C. A., Moreno, M., Visa, L., Iglesias, M., . . . Navarro, P. (2018). Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.. Oncotarget, 9(68), 32984-32996. doi:10.18632/oncotarget.26034

    DOI: 10.18632/oncotarget.26034

    F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation (Journal article)

    Tanton, H., Voronina, S., Evans, A., Armstrong, J., Sutton, R., Criddle, D. N., . . . Tepikin, A. V. (2018). F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation. FRONTIERS IN PHYSIOLOGY, 9. doi:10.3389/fphys.2018.00833

    DOI: 10.3389/fphys.2018.00833

    Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

    Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625

    DOI: 10.18632/oncotarget.26625

    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

    Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497

    DOI: 10.18632/oncotarget.25497

    Therapeutic developments in pancreatic cancer: current and future perspectives (Journal article)

    Neoptolemos, J. P., Kleeff, J., Michl, P., Costello, E., Greenhalf, W., & Palmer, D. H. (2018). Therapeutic developments in pancreatic cancer: current and future perspectives. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 15(6), 332-347. doi:10.1038/s41575-018-0005-x

    DOI: 10.1038/s41575-018-0005-x

    The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. (Conference Paper)

    Abbruzzese, J. L., Andersen, D. K., Borrebaeck, C. A. K., Chari, S. T., Costello, E., Cruz-Monserrate, Z., . . . Powers, A. C. (2018). The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.. In Pancreas Vol. 47 (pp. 516-525). doi:10.1097/MPA.0000000000001037

    DOI: 10.1097/MPA.0000000000001037

    Development of Novel Diagnostic Pancreatic Tumor Biomarkers (Chapter)

    Oldfield, L., Rao, R., Barrera, L. N., & Costello, E. (2018). Development of Novel Diagnostic Pancreatic Tumor Biomarkers. In Pancreatic Cancer (pp. 1241-1272). Springer New York. doi:10.1007/978-1-4939-7193-0_86

    DOI: 10.1007/978-1-4939-7193-0_86

    Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer (Journal article)

    Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Can, E. S. G. P. (2018). Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer. BRITISH JOURNAL OF CANCER, 118(7), 947-954. doi:10.1038/s41416-018-0004-2

    DOI: 10.1038/s41416-018-0004-2

    Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy (Journal article)

    Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Canc, E. S. G. P. (2018). Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy. BRITISH JOURNAL OF CANCER, 118(8), 1084-1088. doi:10.1038/s41416-018-0005-1

    DOI: 10.1038/s41416-018-0005-1

    Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial (Journal article)

    Tatarian, T., Jiang, W., Leiby, B. E., Grigoli, A., Jimbo, M., Dabbish, N., . . . Brody, J. R. (2018). Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial. ANNALS OF SURGERY, 267(2), 364-369. doi:10.1097/SLA.0000000000002088

    DOI: 10.1097/SLA.0000000000002088

    Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives (Journal article)

    Molina-Montes, E., Gomez-Rubio, P., Marquez, M., Rava, M., Lohr, M., Michalski, C. W., . . . Investigators, P. S. (2018). Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47(2), 473-483. doi:10.1093/ije/dyx269

    DOI: 10.1093/ije/dyx269

    A metabolomics-based biomarker signature discriminates pancreatic cancer from chronic pancreatitis (Journal article)

    Costello, E. (2018). A metabolomics-based biomarker signature discriminates pancreatic cancer from chronic pancreatitis. GUT, 67(1), 2-+. doi:10.1136/gutjnl-2016-313665

    DOI: 10.1136/gutjnl-2016-313665

    2017

    Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer (Journal article)

    Bauer, A. S., Nazarov, P. V., Giese, N. A., Beghelli, S., Heller, A., Greenhalf, W., . . . Hoheisel, J. D. (2018). Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. INTERNATIONAL JOURNAL OF CANCER, 142(5), 1010-1021. doi:10.1002/ijc.31087

    DOI: 10.1002/ijc.31087

    Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium (Journal article)

    Campa, D., Obazee, O., Pastore, M., Panzuto, F., Lico, V., Greenhalf, W., . . . Canzian, F. (2017). Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 26(8), 1349-1351. doi:10.1158/1055-9965.EPI-17-0075

    DOI: 10.1158/1055-9965.EPI-17-0075

    A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk (Journal article)

    Gomez-Rubio, P., Rosato, V., Marquez, M., Bosetti, C., Molina-Montes, E., Rava, M., . . . Investigators, P. S. (2017). A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk. ANNALS OF ONCOLOGY, 28(7), 1618-1624. doi:10.1093/annonc/mdx167

    DOI: 10.1093/annonc/mdx167

    Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial (Journal article)

    Middleton, G., Palmer, D. H., Greenhalf, W., Ghaneh, P., Jackson, R., Cox, T., . . . Neoptolemos, J. P. (2017). Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. LANCET ONCOLOGY, 18(4), 486-499. doi:10.1016/S1470-2045(17)30084-0

    DOI: 10.1016/S1470-2045(17)30084-0

    Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer (Journal article)

    Totti, S., Vernardis, S. I., Meira, L., Perez-Mancere, P. A., Costello, E., Greenhalf, W., . . . Velliou, E. G. (2017). Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. DRUG DISCOVERY TODAY, 22(4), 690-701. Retrieved from http://gateway.webofknowledge.com/

    Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways (Journal article)

    Brandi, J., Dando, I., Dalla Pozza, E., Biondani, G., Jenkins, R., Elliott, V., . . . Palmieri, M. (2017). Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. JOURNAL OF PROTEOMICS, 150, 310-322. doi:10.1016/j.jprot.2016.10.002

    DOI: 10.1016/j.jprot.2016.10.002

    2016

    Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice (Journal article)

    Jandaghi, P., Najafabadi, H. S., Bauer, A. S., Papadakis, A. I., Fassan, M., Hall, A., . . . Hoheisel, J. D. (2016). Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice. GASTROENTEROLOGY, 151(6), 1218-1231. doi:10.1053/j.gastro.2016.08.040

    DOI: 10.1053/j.gastro.2016.08.040

    Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma (Journal article)

    Connor, A. A., Denroche, R. E., Jang, G. H., Timms, L., Kalimuthu, S. N., Selander, I., . . . Gallinger, S. (2017). Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma. JAMA ONCOLOGY, 3(6), 774-783. doi:10.1001/jamaoncol.2016.3916

    DOI: 10.1001/jamaoncol.2016.3916

    The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer (Journal article)

    Kleeff, J., Costello, E., Jackson, R., Halloran, C., Greenhalf, W., Ghaneh, P., . . . Canc, E. S. G. P. (2016). The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer. BRITISH JOURNAL OF CANCER, 115(7), 887-894. doi:10.1038/bjc.2016.277

    DOI: 10.1038/bjc.2016.277

    Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk (Journal article)

    Campa, D., Pastore, M., Gentiluomo, M., Talar-Wojnarowska, R., Kupcinskas, J., Malecka-Panas, E., . . . Canzian, F. (2016). Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. ONCOTARGET, 7(35), 57011-57020. doi:10.18632/oncotarget.10935

    DOI: 10.18632/oncotarget.10935

    Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 (Journal article)

    Zhang, M., Wang, Z., Obazee, O., Jia, J., Childs, E. J., Hoskins, J., . . . Amundadottir, L. T. (2016). Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21. ONCOTARGET, 7(41), 66328-66343. doi:10.18632/oncotarget.11041

    DOI: 10.18632/oncotarget.11041

    Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression (Journal article)

    Botla, S. K., Savant, S., Jandaghi, P., Bauer, A. S., Muecke, O., Moskalev, E. A., . . . Hoheisel, J. D. (2016). Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression. CANCER RESEARCH, 76(14), 4149-4159. doi:10.1158/0008-5472.CAN-15-0390

    DOI: 10.1158/0008-5472.CAN-15-0390

    GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer (Journal article)

    Martinelli, P., Pau, E. C. -D. S., Cox, T., Jr, S. B., Dusetti, N., Greenhalf, W., . . . Real, F. X. (2017). GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. GUT, 66(9), 1665-1676. doi:10.1136/gutjnl-2015-311256

    DOI: 10.1136/gutjnl-2015-311256

    Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia (Journal article)

    Demir, I. E., Tieftrunk, E., Schorn, S., Saricaoglu, O. C., Pfitzinger, P. L., Teller, S., . . . Ceyhan, G. O. (2016). Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia. GUT, 65(6), 1001-U148. doi:10.1136/gutjnl-2015-309784

    DOI: 10.1136/gutjnl-2015-309784

    miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer (Journal article)

    Muehlberg, L., Kuehnemuth, B., Costello, E., Shaw, V., Sipos, B., Huber, M., . . . Michl, P. (2016). miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer. ONCOIMMUNOLOGY, 5(6). doi:10.1080/2162402X.2016.1160181

    DOI: 10.1080/2162402X.2016.1160181

    Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma (Journal article)

    Middleton, G., Greenhalf, W., Costello, E., Shaw, V., Cox, T., Ghaneh, P., . . . Neoptolemos, J. P. (2016). Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma. BRITISH JOURNAL OF CANCER, 114(5), 510-518. doi:10.1038/bjc.2015.468

    DOI: 10.1038/bjc.2015.468

    Secretome protein signature of human pancreatic cancer stem-like cells (Journal article)

    Brandi, J., Dalla Pozza, E., Dando, I., Biondani, G., Robotti, E., Jenkins, R., . . . Cecconi, D. (2016). Secretome protein signature of human pancreatic cancer stem-like cells. JOURNAL OF PROTEOMICS, 136, 1-12. doi:10.1016/j.jprot.2016.01.017

    DOI: 10.1016/j.jprot.2016.01.017

    Choline Kinase Alpha (CHK alpha) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors (Journal article)

    Mazarico, J. M., Sanchez-Arevalo Lobo, V. J., Favicchio, R., Greenhalf, W., Costello, E., Carrillo-de Santa Pau, E., . . . Real, F. X. (2016). Choline Kinase Alpha (CHK alpha) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. MOLECULAR CANCER THERAPEUTICS, 15(2), 323-333. doi:10.1158/1535-7163.MCT-15-0214

    DOI: 10.1158/1535-7163.MCT-15-0214

    From mice to men: Murine models of colorectal cancer for use in translational research (Journal article)

    Evans, J. P., Sutton, P. A., Winiarski, B. K., Fenwick, S. W., Malik, H. Z., Vimalachandran, D., . . . Kitteringham, N. R. (2016). From mice to men: Murine models of colorectal cancer for use in translational research. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 98, 94-105. doi:10.1016/j.critrevonc.2015.10.009

    DOI: 10.1016/j.critrevonc.2015.10.009

    UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis (Journal article)

    Abu-Alainin, W., Gana, T., Liloglou, T., Olayanju, A., Barrera, L. N., Ferguson, R., . . . Costello, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. JOURNAL OF PATHOLOGY, 238(3), 423-433. doi:10.1002/path.4665

    DOI: 10.1002/path.4665

    2015

    Reduced risk of pancreatic cancer associated with asthma and nasal allergies (Journal article)

    Gomez-Rubio, P., Zock, J. -P., Rava, M., Marquez, M., Sharp, L., Hidalgo, M., . . . Investigators, P. S. (2017). Reduced risk of pancreatic cancer associated with asthma and nasal allergies. GUT, 66(2), 314-+. doi:10.1136/gutjnl-2015-310442

    DOI: 10.1136/gutjnl-2015-310442

    Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus (Journal article)

    Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., . . . Costello, E. (2016). Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus. CLINICAL CANCER RESEARCH, 22(7), 1734-1743. doi:10.1158/1078-0432.CCR-15-0879

    DOI: 10.1158/1078-0432.CCR-15-0879

    TERT gene harbors multiple variants associated with pancreatic cancer susceptibility (Journal article)

    Campa, D., Rizzato, C., Stolzenberg-Solomon, R., Pacetti, P., Vodicka, P., Cleary, S. P., . . . Canzian, F. (2015). TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. INTERNATIONAL JOURNAL OF CANCER, 137(9), 2175-2183. doi:10.1002/ijc.29590

    DOI: 10.1002/ijc.29590

    Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (Journal article)

    Radon, T. P., Massat, N. J., Jones, R., Alrawashdeh, W., Dumartin, L., Ennis, D., . . . Crnogorac-Jurcevic, T. (2015). Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma. CLINICAL CANCER RESEARCH, 21(15), 3512-3521. doi:10.1158/1078-0432.CCR-14-2467

    DOI: 10.1158/1078-0432.CCR-14-2467

    Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms (Journal article)

    Cioffi, M., Trabulo, S., Hidalgo, M., Costello, E., Greenhalf, W., Erkan, M., . . . Heeschen, C. (2015). Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms. CLINICAL CANCER RESEARCH, 21(10), 2325-2337. doi:10.1158/1078-0432.CCR-14-1399

    DOI: 10.1158/1078-0432.CCR-14-1399

    Pancreatic Mass in a Young CFTR Carrier With a Heterozygous p.R117H CFTR Gene Mutation and Homozygous 7T (Journal article)

    Hanna, T., Abdul-Rahman, Z., Greenhalf, W., Costello, E., & Neoptolemos, J. P. (2015). Pancreatic Mass in a Young CFTR Carrier With a Heterozygous p.R117H CFTR Gene Mutation and Homozygous 7T. PANCREAS, 44(2), 343-345. doi:10.1097/MPA.0000000000000244

    DOI: 10.1097/MPA.0000000000000244

    Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection (Journal article)

    O'Brien, D. P., Sandanayake, N. S., Jenkinson, C., Gentry-Maharaj, A., Apostolidou, S., Fourkala, E. -O., . . . Timms, J. F. (2015). Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection. CLINICAL CANCER RESEARCH, 21(3), 622-631. doi:10.1158/1078-0432.CCR-14-0365

    DOI: 10.1158/1078-0432.CCR-14-0365

    Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer (Journal article)

    Jenkinson, C., Elliott, V., Menon, U., Apostolidou, S., Fourkala, O. E., Gentry-Maharaj, A., . . . Costello, E. (2015). Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer. JOURNAL OF PROTEOMICS, 113, 400-402. doi:10.1016/j.jprot.2014.10.001

    DOI: 10.1016/j.jprot.2014.10.001

    Biomarkers for early diagnosis of pancreatic cancer (Journal article)

    Jenkinson, C., Earl, J., Ghaneh, P., Halloran, C., Carrato, A., Greenhalf, W., . . . Costello, E. (2015). Biomarkers for early diagnosis of pancreatic cancer. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9(3), 305-315. doi:10.1586/17474124.2015.965145

    DOI: 10.1586/17474124.2015.965145

    2014

    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer (Journal article)

    Wolpin, B. M., Rizzato, C., Kraft, P., Kooperberg, C., Petersen, G. M., Wang, Z., . . . Amundadottir, L. T. (2014). Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. NATURE GENETICS, 46(9), 994-+. doi:10.1038/ng.3052

    DOI: 10.1038/ng.3052

    Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial (Journal article)

    Middleton, G., Silcocks, P., Cox, T., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. LANCET ONCOLOGY, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0

    DOI: 10.1016/S1470-2045(14)70236-0

    Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial (Journal article)

    Greenhalf, W., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., Lamb, R. F., . . . Canc, E. S. G. P. (2014). Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 106(1). doi:10.1093/jnci/djt347

    DOI: 10.1093/jnci/djt347

    Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease (Journal article)

    Shaw, V. E., Lane, B., Jenkinson, C., Cox, T., Greenhalf, W., Halloran, C. M., . . . Costello, E. (2014). Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease. MOLECULAR CANCER, 13. doi:10.1186/1476-4598-13-114

    DOI: 10.1186/1476-4598-13-114

    Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease. (Journal article)

    Shaw, V. E., Lane, B., Jenkinson, C., Cox, T., Greenhalf, W., Halloran, C. M., . . . Costello, E. (2014). Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease.. Molecular cancer, 13, 114. doi:10.1186/1476-4598-13-114

    DOI: 10.1186/1476-4598-13-114

    2013

    EU Pancreas: An Integrated European Platform for Pancreas Cancer Research - from Basic Science to Clinical and Public Health Interventions for a Rare Disease (Journal article)

    Milne, R., La Vecchia, C., Van Steen, K., Hahn, S., Buchholz, M., Costello, E., . . . Participants, C. O. S. T. A. B. (2013). EU Pancreas: An Integrated European Platform for Pancreas Cancer Research - from Basic Science to Clinical and Public Health Interventions for a Rare Disease. PUBLIC HEALTH GENOMICS, 16(6), 305-312. doi:10.1159/000355937

    DOI: 10.1159/000355937

    Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium (Journal article)

    Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., . . . Canzian, F. (2013). Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Digestive and Liver Disease, 45(2), 95-99. doi:10.1016/j.dld.2012.09.014

    DOI: 10.1016/j.dld.2012.09.014

    Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations (Journal article)

    Campa, D., Rizzato, C., Bauer, A. S., Werner, J., Capurso, G., Costello, E., . . . Canzian, F. (2013). Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 22(2), 320-323. doi:10.1158/1055-9965.EPI-12-1182

    DOI: 10.1158/1055-9965.EPI-12-1182

    Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival (Journal article)

    Rachakonda, P. S., Bauer, A. S., Xie, H., Campa, D., Rizzato, C., Canzian, F., . . . Kumar, R. (2013). Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival. PLOS ONE, 8(4). doi:10.1371/journal.pone.0060870

    DOI: 10.1371/journal.pone.0060870

    Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival (Journal article)

    Rachakonda, P. S., Bauer, A. S., Xie, H., Campa, D., Rizzato, C., Canzian, F., . . . Kumar, R. (n.d.). Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival. PLoS ONE, 8(4), e60870. doi:10.1371/journal.pone.0060870

    DOI: 10.1371/journal.pone.0060870

    The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer (Journal article)

    Thornton, M., Aslam, M. A., Tweedle, E. M., Ang, C., Campbell, F., Jackson, R., . . . Boyd, M. T. (2013). The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. INTERNATIONAL JOURNAL OF CANCER, 133(6), 1408-1418. doi:10.1002/ijc.28137

    DOI: 10.1002/ijc.28137

    The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer (Journal article)

    Thornton, M., Aslam, M. A., Tweedle, E. M., Ang, C., Campbell, F., Jackson, R., . . . Boyd, M. T. (2013). The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. International Journal of Cancer, 133(6), 1408-1418. doi:10.1002/ijc.28137

    DOI: 10.1002/ijc.28137

    cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC (Journal article)

    Burdyga, A., Conant, A., Haynes, L., Zhang, J., Jalink, K., Sutton, R., . . . Tepikin, A. (2013). cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1833(12), 2664-2672. doi:10.1016/j.bbamcr.2013.06.011

    DOI: 10.1016/j.bbamcr.2013.06.011

    iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

    Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. BRITISH JOURNAL OF CANCER, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

    DOI: 10.1038/bjc.2013.150

    iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance (Journal article)

    Tonack, S., Jenkinson, C., Cox, T., Elliott, V., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2013). iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance. British Journal of Cancer, 108(9), 1846-1853. doi:10.1038/bjc.2013.150

    DOI: 10.1038/bjc.2013.150

    2012

    The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion (Journal article)

    Evans, A., & Costello, E. (2012). The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. FRONTIERS IN PHYSIOLOGY, 3. doi:10.3389/fphys.2012.00270

    DOI: 10.3389/fphys.2012.00270

    Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue (Journal article)

    Bauer, A. S., Keller, A., Costello, E., Greenhalf, W., Bier, M., Borries, A., . . . Hoheisel, J. D. (2012). Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue. PLOS ONE, 7(4). doi:10.1371/journal.pone.0034151

    DOI: 10.1371/journal.pone.0034151

    Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium (Journal article)

    Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., . . . Canzian, F. (2013). Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. DIGESTIVE AND LIVER DISEASE, 45(2), 95-99. doi:10.1016/j.dld.2012.09.014

    DOI: 10.1016/j.dld.2012.09.014

    Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer (Journal article)

    Sykes, P. D., Neoptolemos, J. P., Costello, E., & Halloran, C. M. (2012). Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 6(3), 343-356. doi:10.1586/EGH.12.13

    DOI: 10.1586/EGH.12.13

    New biomarkers and targets in pancreatic cancer and their application to treatment (Journal article)

    Costello, E., Greenhalf, W., & Neoptolemos, J. P. (2012). New biomarkers and targets in pancreatic cancer and their application to treatment. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 9(8), 435-444. doi:10.1038/nrgastro.2012.119

    DOI: 10.1038/nrgastro.2012.119

    Pancreatic Cancer Biomarker Panel (Patent)

    Costello-Goldring, E. (2012). Pancreatic Cancer Biomarker Panel.

    2011

    PANCREATIC CANCER IN 2010 New insights for early intervention and detection (Journal article)

    Costello, E., & Neoptolemos, J. P. (2011). PANCREATIC CANCER IN 2010 New insights for early intervention and detection. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 8(2), 71-73. doi:10.1038/nrgastro.2010.214

    DOI: 10.1038/nrgastro.2010.214

    Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury (Journal article)

    Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538

    DOI: 10.1002/hep.24538

    Circulating microRNAs as potential markers of human drug-induced liver injury (Journal article)

    Starkey Lewis, P. J., Dear, J., Platt, V., Simpson, K. J., Craig, D. G., Antoine, D. J., . . . Park, B. K. (2011). Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology.

    Circulating microRNAs as potential markers of human drug-induced liver injury (Journal article)

    Lewis Starkey, P. J., Dear, J., Platt, V., Simpson, K. J., Craig, D. G., Antoine, D. J., . . . Park, B. K. (2011). Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology, 1767-1776.

    Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction (Journal article)

    Tonack, S., Jenkinson, C., Elliot, V., Dajani, K., Jenkins, R. E., Kitteringham, N. R., . . . Costello, E. (2011). Combined LC-MS/MS and iTRAQ analysis of serum and pancreatic juice for the detection of biomarkers for pancreatic cancer: Influence of biliary obstruction. Pancreas, 40, 1358.

    Enhancing the translation of cancer biomarkers (Journal article)

    Costello, E., & Neoptolemos, J. (2011). Enhancing the translation of cancer biomarkers. BRITISH JOURNAL OF SURGERY, 98(8), 1039-1040. doi:10.1002/bjs.7556

    DOI: 10.1002/bjs.7556

    Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer (Journal article)

    Olariu, C. I., Yiu, H. H. P., Bouffier, L., Nedjadi, T., Costello, E., Williams, S. R., . . . Rosseinsky, M. J. (2011). Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer. JOURNAL OF MATERIALS CHEMISTRY, 21(34), 12650-12659. doi:10.1039/c1jm11370d

    DOI: 10.1039/c1jm11370d

    Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer (Journal article)

    Olariu, C. I., Yiu, H. H. P., Bouffier, L., Nedjadi, T., Costello, E., Williams, S. R., . . . Rosseinsky, M. J. (2011). Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer. J. Mater. Chem.

    Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10, 37.

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. MOLECULAR CANCER, 10. doi:10.1186/1476-4598-10-37

    DOI: 10.1186/1476-4598-10-37

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10(1), 37. doi:10.1186/1476-4598-10-37

    DOI: 10.1186/1476-4598-10-37

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.. Mol Cancer, 10(1), 37.

    Pancreatic Cancer Susceptibility Loci and Their Role in Survival (Journal article)

    Rizzato, C., Campa, D., Giese, N., Werner, J., Rachakonda, P. S., Kumar, R., . . . Canzian, F. (2011). Pancreatic Cancer Susceptibility Loci and Their Role in Survival. PLOS ONE, 6(11). doi:10.1371/journal.pone.0027921

    DOI: 10.1371/journal.pone.0027921

    Pancreatic cancer in 2010 (Journal article)

    Costello, E., & Neoptolemos, J. P. (2011). Pancreatic cancer in 2010. Nat Rev Gastroenterol Hepatol., 8(2), 71-73.

    Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression (Journal article)

    Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947

    DOI: 10.3748/wjg.v17.i15.1947

    2010

    Analysis of serum proteins by LC-MS/MS. (Journal article)

    Tonack, S., Neoptolemos, J. P., & Costello, E. (2010). Analysis of serum proteins by LC-MS/MS.. Methods in molecular biology (Clifton, N.J.), 658, 281-291. doi:10.1007/978-1-60761-780-8_17

    DOI: 10.1007/978-1-60761-780-8_17

    Proteomic Analysis of Blood and Pancreatic Juice (Chapter)

    Aspinall-O’Dea, M., Neoptolemos, J., & Costello, E. (2010). Proteomic Analysis of Blood and Pancreatic Juice. In Drug Discovery in Pancreatic Cancer (pp. 223-241). Springer New York. doi:10.1007/978-1-4419-1160-5_12

    DOI: 10.1007/978-1-4419-1160-5_12

    Multifunctional nanoparticles for healthcare applications (Journal article)

    Olariu, C. I., Yiu, H. P. P., Bouffier, L., Nedjadi, T., Costello, E., Halloran, C. M., & Rosseinsky, M. J. (2010). Multifunctional nanoparticles for healthcare applications. European Cells and Materials, 20(SUPPL.3), 192.

    Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (Journal article)

    Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92

    DOI: 10.1586/ERV.10.92

    Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies (Journal article)

    Schroeder, C., Jacob, A., Tonack, S., Radon, T. P., Sill, M., Zucknick, M., . . . Hoheisel, J. D. (2010). Dual-color Proteomic Profiling of Complex Samples with a Microarray of 810 Cancer-related Antibodies. MOLECULAR & CELLULAR PROTEOMICS, 9(6), 1271-1280. doi:10.1074/mcp.M900419-MCP200

    DOI: 10.1074/mcp.M900419-MCP200

    Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies (Journal article)

    Schröder, C., Jacob, A., Tonack, S., Radon, T. P., Sill, M., Zucknick, M., . . . Hoheisel, J. D. (2010). Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies. Molecular and Cellular Proteomics, 9(6), 1501-1510.

    Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer (Journal article)

    Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626

    DOI: 10.1136/gut.2009.196626

    Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells (Journal article)

    Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. CARCINOGENESIS, 31(9), 1541-1551. doi:10.1093/carcin/bgq137

    DOI: 10.1093/carcin/bgq137

    2009

    A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ (Journal article)

    Tonack, S., Aspinall-O'Dea, M., Jenkins, R. E., Elliot, V., Murray, S., Lane, C. S., . . . Costello, E. (2009). A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ. JOURNAL OF PROTEOMICS, 73(2), 352-356. doi:10.1016/j.jprot.2009.07.009

    DOI: 10.1016/j.jprot.2009.07.009

    S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility (Journal article)

    Nedjadi, T., Kitteringham, N., Campbell, F., Jenkins, R. E., Park, B. K., Navarro, P., . . . Costello, E. (2009). S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. BRITISH JOURNAL OF CANCER, 101(7), 1145-1154. doi:10.1038/sj.bjc.6605289

    DOI: 10.1038/sj.bjc.6605289

    Molecular Biological Understanding of Development of Pancreatic Cancer (Chapter)

    Costello, E. (n.d.). Molecular Biological Understanding of Development of Pancreatic Cancer. In The Pancreas (pp. 583-590). Blackwell Publishing Ltd.. doi:10.1002/9781444300123.ch58

    DOI: 10.1002/9781444300123.ch58

    Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer (Journal article)

    Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., . . . Costello, E. (2009). Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer. JOURNAL OF PROTEOME RESEARCH, 8(1), 142-148. doi:10.1021/pr800451h

    DOI: 10.1021/pr800451h

    Pancreatic Cancer: Proteomic Approaches to a Challenging Disease (Journal article)

    Tonack, S., Aspinall-O'Dea, M., Neoptolemos, J. P., & Costello, E. (2009). Pancreatic Cancer: Proteomic Approaches to a Challenging Disease. PANCREATOLOGY, 9(5), 567-576. doi:10.1159/000212083

    DOI: 10.1159/000212083

    2008

    New treatment options for advanced pancreatic cancer. (Journal article)

    Middleton, G., Ghaneh, P., Costello, E., Greenhalf, W., & Neoptolemos, J. P. (2008). New treatment options for advanced pancreatic cancer.. Expert review of gastroenterology & hepatology, 2(5), 673-696. doi:10.1586/17474124.2.5.673

    DOI: 10.1586/17474124.2.5.673

    Biology and management of pancreatic cancer. (Journal article)

    Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2008). Biology and management of pancreatic cancer.. Postgraduate medical journal, 84(995), 478-497. doi:10.1136/gut.2006.103333

    DOI: 10.1136/gut.2006.103333

    2007

    Both HIV- and EIAV-based lentiviral vectors mediate gene delivery to pancreatic cancer cells and human pancreatic primary patient xenografts (Journal article)

    Saraga, G., Mafficini, A., Ghaneh, P., Sorio, C., & Costello, E. (2007). Both HIV- and EIAV-based lentiviral vectors mediate gene delivery to pancreatic cancer cells and human pancreatic primary patient xenografts. CANCER GENE THERAPY, 14(9), 781-790. doi:10.1038/sj.cgt.7701066

    DOI: 10.1038/sj.cgt.7701066

    The pancreatic cancer proteome - recent advances and future promise (Journal article)

    Aspinall-O'Dea, M., & Costello, E. (2007). The pancreatic cancer proteome - recent advances and future promise. PROTEOMICS CLINICAL APPLICATIONS, 1(9), 1066-1079. doi:10.1002/prca.200700144

    DOI: 10.1002/prca.200700144

    Biology and management of pancreatic cancer (Journal article)

    Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2007). Biology and management of pancreatic cancer. GUT, 56(8), 1134-1152. doi:10.1136/gut.2006.103333

    DOI: 10.1136/gut.2006.103333

    The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells (Journal article)

    Sheikh, A. A., Vimalachandran, D., Thompson, C. C., Jenkins, R. E., Nedjadi, T., Shekouh, A., . . . Costello, E. (2007). The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. PROTEOMICS, 7(11), 1929-1940. doi:10.1002/pmic.200700072

    DOI: 10.1002/pmic.200700072

    2006

    Molecular-biological understanding of the development of pancreatic cancer (Chapter)

    Costello, E. (2006). Molecular-biological understanding of the development of pancreatic cancer. In H. Beger, M. Büchler, & R. Kozarek (Eds.), The Pancreas: A Clinical and Surgical Text, 2e (pp. 6). Oxford: Blackwell Publishing Ltd.

    Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility (Journal article)

    Thompson, C. C., Ashcroft, F. J., Patel, S., Saraga, G., Vimalachandran, D., Prime, W., . . . Costello, E. (2007). Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. GUT, 56(1), 95-106. doi:10.1136/gut.2005.083691

    DOI: 10.1136/gut.2005.083691

    Tetracycline-inducible pancreatic cancer cell lines (Journal article)

    Patel, S. I., Bier, M., Goldring, C. E. P., Hillen, W., & Costello, E. (2006). Tetracycline-inducible pancreatic cancer cell lines. PANCREAS, 4(33), 489.

    The expression of S100A8 in tumour-associated monocytes is associated with the Smad4 status of pancreatic and colorectal cancer (Journal article)

    Sheikh, A. A., Vimalachandran, D., Tweedle, E. M., Prime, W., Campbell, F., Dodson, A., . . . Costello, E. (2006). The expression of S100A8 in tumour-associated monocytes is associated with the Smad4 status of pancreatic and colorectal cancer. Pancreas, 4(33), 506.

    2005

    High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients (Journal article)

    Vimalachandran, D., Greenhalf, W., Thompson, C., Luttges, J., Prime, W., Campbell, F., . . . Costello, E. (2005). High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. CANCER RESEARCH, 65(8), 3218-3225. doi:10.1158/0008-5472.CAN-04-4311

    DOI: 10.1158/0008-5472.CAN-04-4311

    Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma (Journal article)

    Crnogorac-Jurcevic, T., Gangeswaran, R., Bhakta, V., Capurso, G., Lattimore, S., Akada, M., . . . Lemoine, N. R. (2005). Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. GASTROENTEROLOGY, 129(5), 1454-1463. doi:10.1053/j.gastro.2005.08.012

    DOI: 10.1053/j.gastro.2005.08.012

    Proteomic analysis of pancreas samples using two-dimensional electrophoresis combined with mass spectrometry (Chapter)

    Shore, S., Vimalachandran, D., Neoptolemos, J. P., & Costello, E. (2005). Proteomic analysis of pancreas samples using two-dimensional electrophoresis combined with mass spectrometry. In T. M. Gress, J. P. Neoptoelmos, & N. R. Lemoine (Eds.), Exocrine pancreas cancer (pp. 244-253). Hannover: Felsenstein CCCP.

    Trials of gene therapy for pancreatic carcinoma (Journal article)

    Halloran, C. M., Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2005). Trials of gene therapy for pancreatic carcinoma. Current Gastroenterology Reports, 7(3), 165-169. doi:10.1007/s11894-005-0028-7

    DOI: 10.1007/s11894-005-0028-7

    Trials of gene therapy for pancreatic carcinoma. (Journal article)

    Halloran, C. M., Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2005). Trials of gene therapy for pancreatic carcinoma.. Current gastroenterology reports, 7(3), 165-169. doi:10.1007/s11894-005-0028-7

    DOI: 10.1007/s11894-005-0028-7

    2004

    5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16(INK4A) greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells (Journal article)

    Halloran, C. M., Ghaneh, P., Shore, S., Greenhalf, W., Zumstein, L., Wilson, D., . . . Costello, E. (2004). 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16(INK4A) greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. JOURNAL OF GENE MEDICINE, 6(5), 514-525. doi:10.1002/jgm.540

    DOI: 10.1002/jgm.540

    Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis (Journal article)

    Missiaglia, E., Blaveri, E., Terris, B., Wang, Y. H., Costello, E., Neoptolemos, J. P., . . . Lemoine, N. R. (2004). Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. INTERNATIONAL JOURNAL OF CANCER, 112(1), 100-112. doi:10.1002/ijc.20376

    DOI: 10.1002/ijc.20376

    Genetics and prevention of pancreatic cancer. (Journal article)

    Vimalachandran, D., Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2004). Genetics and prevention of pancreatic cancer.. Cancer control : journal of the Moffitt Cancer Center, 11(1), 6-14. doi:10.1177/107327480401100102

    DOI: 10.1177/107327480401100102

    Proteomic technologies and their application to pancreatic cancer (Journal article)

    Vimalachandran, D., & Costello, E. (2004). Proteomic technologies and their application to pancreatic cancer. EXPERT REVIEW OF PROTEOMICS, 1(4), 493-501. doi:10.1586/14789450.1.4.493

    DOI: 10.1586/14789450.1.4.493

    2003

    Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma (Journal article)

    Shekouh, A. R., Thompson, C. C., Prime, W., Campbell, F., Hamlett, J., Herrington, C. S., . . . Costello, E. (2003). Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. PROTEOMICS, 3(10), 1988-2001. doi:10.1002/pmic.200300466

    DOI: 10.1002/pmic.200300466

    Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent (Journal article)

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    MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. (Journal article)

    Bhatia, M., Brady, M., Kang, Y. K., Costello, E., Newton, D. J., Christmas, S. E., . . . Slavin, J. (2002). MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation.. American journal of physiology. Gastrointestinal and liver physiology, 282(1), G77-G85. doi:10.1152/ajpgi.00031.2002

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    2001

    Stable transduction with lentiviral vectors and amplification of immature hematopoietic progenitors from cord blood of preterm human fetuses (Journal article)

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    Fetal hematopoietic stem cells: In vitro expansion and transduction using lentiviral vectors (Journal article)

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    2000

    Gene transfer into stimulated and unstimulated T lymphocytes by HIV-1-derived lentiviral vectors (Journal article)

    Costello, E., Munoz, M., Buetti, E., Meylan, P. R. A., Diggelmann, H., & Thali, M. (2000). Gene transfer into stimulated and unstimulated T lymphocytes by HIV-1-derived lentiviral vectors. GENE THERAPY, 7(7), 596-604. doi:10.1038/sj.gt.3301135

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    Gene therapy for pancreatic cancer - current and prospective strategies (Journal article)

    Halloran, C. M., Ghaneh, P., Neoptolemos, J. P., & Costello, E. (2000). Gene therapy for pancreatic cancer - current and prospective strategies. SURGICAL ONCOLOGY-OXFORD, 9(4), 181-191. doi:10.1016/S0960-7404(01)00011-1

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    1997

    The minute virus of mice (MVM) nonstructural protein NS1 induces nicking of MVM DNA at a unique site of the right-end telomere in both hairpin and duplex conformations in vitro (Journal article)

    Willwand, K., Baldauf, A. Q., Deleu, L., Mumtsidu, E., Costello, E., Beard, P., & Rommelaere, J. (1997). The minute virus of mice (MVM) nonstructural protein NS1 induces nicking of MVM DNA at a unique site of the right-end telomere in both hairpin and duplex conformations in vitro. JOURNAL OF GENERAL VIROLOGY, 78, 2647-2655. doi:10.1099/0022-1317-78-10-2647

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    High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression (Journal article)

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    1995

    THE MISMATCHED NUCLEOTIDES IN THE 5'-TERMINAL HAIRPIN OF MINUTE VIRUS OF MICE ARE REQUIRED FOR EFFICIENT VIRAL-DNA REPLICATION (Journal article)

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    1994

    PROTEIN KINASE-A AND AP-1 (C-FOS/JUND) ARE INDUCED DURING APOPTOSIS OF MOUSE MAMMARY EPITHELIAL-CELLS (Journal article)

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    1992

    OVEREXPRESSION OF MOS, RAS, SRC, AND FOS INHIBITS MOUSE MAMMARY EPITHELIAL-CELL DIFFERENTIATION (Journal article)

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