Professor Dean Naisbitt BSc, PhD
Senior Lecturer Pharmacology & Therapeutics
- +44 (0)151 794 5346
- Work email D.J.Naisbitt@liverpool.ac.uk
- About
- Research
- Publications
- Teaching
Research
Research Interest 1
The major aim of my research is exploration of the chemical and cellular basis of hypersensitivity reactions to drugs and chemicals. More specifically, these studies attempt to relate drug metabolism and covalent binding of chemicals to protein to the basic immunology and functioning of immune cells. These studies provide further insight into the critical question of how low molecular weight chemicals cause serious tissue injury in man.
• My research group has published 65 full research articles and/or reviews in internationally recognised journals.
Specific projects
1. Investigation of the phenotype, specificity and cytokine profile of drug-specific T-cell lines and clones from hypersensitive patients
2. Characterization of the role of metabolism in drug hypersensitivity reactions
3. In vitro induction of drug-specific T-cell responses using blood from drug-naïve human donors
4. Investigation of the chemical and cellular basis of contact sensitisation mediated by exposure to hair dyes
5. Investigation of the molecular and chemical basis of differential (Th1, Th2 and Th0) drug-specific lymphocyte activation
6. Transcriptional profiling of T-cell clones from hypersensitive patients
7. Exploration of the interaction of drug & chemical haptens with protein
8. Evaluation of the T-cell stimulatory capacity of peptide vaccines in patients with pancreatic cancer
9. Investigation of the immunological mechanisms of drug-induced allergic events in patients with cystic fibrosis
10. Development of an animal model of drug-induced allergic disease
Research Grants
Bench Fees for Luis Castrejon.
CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA (MEXICO)
February 2008 - January 2010
Definition of chemical and immunological signals associated with the development of contact dermatitis.
BRITISH SKIN FOUNDATION (UK)
January 2006 - December 2008
Signalling and function of immunomodulatory biologics
REPUBLIC OF IRAQ MINISTRY OF EDUCATION
October 2014 - September 2017
Quantitative high-throughput proteomics for biomedical research.
MEDICAL RESEARCH COUNCIL
March 2005 - March 2008
Bridging and accelerating the translation of novel scientific findings for health and wealth gain
MEDICAL RESEARCH COUNCIL
March 2014 - August 2015
Chic-FILI—Definition of the chemical and immunological characteristics of flucloxacillin-induced liver injury
EUROPEAN COMMISSION
September 2012 - August 2013
The immunological response consequences of metabolic drug activation by dendritic cells.
WELLCOME TRUST (UK)
April 2006 - April 2009
A prospective investigation of drug-specific B-cell responses in allergic patients with cystic fibrosis
UNIVERSITY OF ILORIN (NIGERIA)
December 2011 - November 2014
Molecular basis of T-cell triggering in patients with drug allergy
THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)
October 2012 - September 2016
Development of an in vivo mouse model to study the role of metabolism in drug-induced cutaneous hypersensitivity reactions
ASTRAZENECA LIMITED (UK)
October 2009 - September 2013
A prospective investigation of β-lactam allergy in patients with cystic fibrosis to define drug immunogenicity
CYSTIC FIBROSIS TRUST (UK)
December 2011 - August 2016
Development of an in vivo model of drug-induced cutaneous toxicity.
WELLCOME TRUST (UK)
July 2001 - September 2001
The role of drug-specific T-cells in allergic reactions to drugs
ROYAL EMBASSY OF SAUDI ARABIA
October 2011 - September 2014
Mechanistic basis of dapsone hypersensitivity
ROYAL EMBASSY OF SAUDI ARABIA
July 2014 - June 2017
The Chemical and Cellular Basis of Drug Hypersensitivity.
WELLCOME TRUST (UK)
January 2000 - January 2004
The role of peripheral and liver-associated T lymphocytes in pathogenesis of alcholic liver disease.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
May 2004 - October 2005
Research Collaborations
Andrea Cavani
External: University of Rome
Characterization of skin resident T-cells
Stefan Martin
External: University of Frankfurt (Germany)
Development of in vitro T-cell priming assays
Dr Daniel Peckham
External: The University of Leeds
Immune mechanisms of drug allergy in patients with cystic fibrosis
Werner Pichler
External: Aachen University
T-cell projects
L Trepanier
External: University of Wisconsin
T-cell experiments in experimental models
JF Nicolas
External: ADER Fez
Developing models of drug allergy