Professor Dean Naisbitt BSc, PhD

Senior Lecturer Pharmacology & Therapeutics

+44 (0)151 794 5346
Work email D.J.Naisbitt@liverpool.ac.uk

Publications

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2024

Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide (Journal article)

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830

DOI: 10.1111/all.15830

2023

What’s been Hapten-ing over the last 88 years? (Journal article)

Thomson, P., Hammond, S., Meng, X., & Naisbitt, D. J. (n.d.). What’s been Hapten-ing over the last 88 years?. Medicinal Chemistry Research. doi:10.1007/s00044-023-03091-1

DOI: 10.1007/s00044-023-03091-1

2022

Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications? (Journal article)

Hammond, S., Olsson-Brown, A., Grice, S., & Naisbitt, D. J. (2022). Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?. CLINICAL AND EXPERIMENTAL ALLERGY, 52(5), 600-603. doi:10.1111/cea.14134

DOI: 10.1111/cea.14134

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity (Journal article)

Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144

DOI: 10.1093/toxsci/kfab144

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01. (Journal article)

Gardner, J., Ogese, M., Betts, C. J., Pirmohamed, M., & Naisbitt, D. J. (2022). Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.. Chemical research in toxicology, 35(2), 199-202. doi:10.1021/acs.chemrestox.1c00425

DOI: 10.1021/acs.chemrestox.1c00425

2021

HLA Class-II. Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients (Journal article)

Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014

DOI: 10.1016/j.jid.2021.03.014

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction. (Journal article)

Jaruthamsophon, K., Thomson, P. J., Sukasem, C., Naisbitt, D. J., & Pirmohamed, M. (2021). HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.. Annual review of pharmacology and toxicology, 62, 509-529. doi:10.1146/annurev-pharmtox-052120-014115

DOI: 10.1146/annurev-pharmtox-052120-014115

Drug hapten-specific T-cell activation: Current status and unanswered questions (Journal article)

Adair, K., Meng, X., & Naisbitt, D. J. (2021). Drug hapten-specific T-cell activation: Current status and unanswered questions. PROTEOMICS, 21(17-18). doi:10.1002/pmic.202000267

DOI: 10.1002/pmic.202000267

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01 (Journal article)

Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084

DOI: 10.1093/toxsci/kfab084

Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions (Journal article)

Salinas-Jaramillo, O., Monroy-Arreola, A., Herrera-Norena, S., Guzman-Ortiz, A. L., Hernandez-Hernandez, A., Mendez-Flores, S., . . . Castrejon-Flores, J. L. (2021). Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. CHEMICAL RESEARCH IN TOXICOLOGY, 34(7), 1738-1748. doi:10.1021/acs.chemrestox.1c00047

DOI: 10.1021/acs.chemrestox.1c00047

Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat (Journal article)

Thomson, P. J., Kafu, L., Meng, X., Snoeys, J., De Bondt, A., De Maeyer, D., . . . Naisbitt, D. J. (2021). Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat. ALLERGY, 76(6), 1825-1835. doi:10.1111/all.14652

DOI: 10.1111/all.14652

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab (Journal article)

Hammond, S., Olsson-Brown, A., Gardner, J., Thomson, P., Ali, S. -E., Jolly, C., . . . Naisbitt, D. (2021). T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5). doi:10.1136/jitc-2021-002521

DOI: 10.1136/jitc-2021-002521

HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients (Journal article)

Satapornpong, P., Pratoomwun, J., Rerknimitr, P., Klaewsongkram, J., Nakkam, N., Rungrotmongkol, T., . . . Sukasem, C. (2021). HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.661135

DOI: 10.3389/fimmu.2021.661135

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01 (Journal article)

Pratoomwun, J., Thomson, P., Jaruthamsophon, K., Tiyasirichokchai, R., Jinda, P., Rerkpattanapipat, T., . . . Sukasem, C. (2021). Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.658593

DOI: 10.3389/fimmu.2021.658593

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs (Journal article)

Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530

DOI: 10.3389/fimmu.2021.630530

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses (Journal article)

Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3

DOI: 10.1038/s41467-021-21856-3

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol (Journal article)

Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317

DOI: 10.1136/bmjopen-2020-048317

Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4+ T lymphocytes (Journal article)

Roehmel, J. F., Ogese, M. O., Rohrbach, A., Mall, M. A., & Naisbitt, D. J. (2021). Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4+ T lymphocytes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 753-+. doi:10.1016/j.jaci.2020.05.041

DOI: 10.1016/j.jaci.2020.05.041

Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite (Journal article)

Hammond, S., Gibson, A., Jaruthamsophon, K., Roth, S., Mosedale, M., & Naisbitt, D. J. (2021). Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite. TOXICOLOGICAL SCIENCES, 179(1), 95-107. doi:10.1093/toxsci/kfaa157

DOI: 10.1093/toxsci/kfaa157

Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat (Journal article)

De Jonghe, S., Weinstock, D., Aligo, J., Washington, K., & Naisbitt, D. (2021). Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat. HEPATOLOGY, 73(1), 452-455. doi:10.1002/hep.31403

DOI: 10.1002/hep.31403

2020

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury (Journal article)

Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400

DOI: 10.1021/acs.chemrestox.0c00400

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury (Journal article)

Gibson, A., Hammond, S., Jaruthamsophon, K., Roth, S., Mosedale, M., & Naisbitt, D. J. (2020). Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(11), 2745-2748. doi:10.1021/acs.chemrestox.0c00328

DOI: 10.1021/acs.chemrestox.0c00328

Characterization of Clozapine-Responsive Human T Cells (Journal article)

Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646

DOI: 10.4049/jimmunol.2000646

HLA DaB115:01-DQB106:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)

Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128

DOI: 10.1093/toxsci/kfaa128

Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity (Journal article)

Ariza, A., Fernandez-Santamaria, R., Meng, X., Salas, M., Ogese, M. O., Tailor, A., . . . Naisbitt, D. J. (2020). Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity. ALLERGY, 75(10), 2562-2573. doi:10.1111/all.14298

DOI: 10.1111/all.14298

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124

DOI: 10.1093/toxsci/kfaa124

Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds. (Journal article)

Ogese, M. O., Watkinson, J., Lister, A., Faulkner, L., Gibson, A., Hillegas, A., . . . Naisbitt, D. J. (2020). Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.. Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 266-278. doi:10.1093/toxsci/kfaa034

DOI: 10.1093/toxsci/kfaa034

Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases (Journal article)

Vocanson, M., Naisbitt, D. J., & Nicolas, J. -F. (2020). Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1142-1144. doi:10.1016/j.jaci.2020.01.030

DOI: 10.1016/j.jaci.2020.01.030

Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions (Journal article)

Naisbitt, D. J., Olsson-Brown, A., Gibson, A., Meng, X., Ogese, M. O., Tailor, A., & Thomson, P. (2020). Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions. ALLERGY, 75(4), 781-797. doi:10.1111/all.14127

DOI: 10.1111/all.14127

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation (Journal article)

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., . . . Naisbitt, D. J. (2020). Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation. ALLERGY, 75(3), 636-647. doi:10.1111/all.14057

DOI: 10.1111/all.14057

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models (Journal article)

Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x

DOI: 10.1038/s41573-019-0048-x

T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity (Journal article)

Hammond, S., Thomson, P. J., Ogese, M. O., & Naisbitt, D. J. (2020). T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 77-94. doi:10.1021/acs.chemrestox.9b00327

DOI: 10.1021/acs.chemrestox.9b00327

2019

Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701

DOI: 10.1002/hep.30701

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article)

Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282

DOI: 10.1021/acs.chemrestox.9b00282

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01 (Journal article)

Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769

DOI: 10.1111/all.13769

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers (Journal article)

Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007

DOI: 10.1093/toxsci/kfz007

Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions (Conference Paper)

Ariza, A., Isabel Montanez, M., Ogese, M. O., Tailor, A., Fernandez, T. D., Torres, M. J., & Naisbitt, D. J. (2019). Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 143 (pp. AB184). doi:10.1016/j.jaci.2018.12.563

DOI: 10.1016/j.jaci.2018.12.563

A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin (Conference Paper)

Diacono, D., Mwenechanya, J., Mayell, S. J., & Naisbitt, D. J. (2019). A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin. In CLINICAL AND EXPERIMENTAL ALLERGY Vol. 49 (pp. 1674-1675). Retrieved from https://www.webofscience.com/

Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions (Conference Paper)

Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/

Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions (Conference Paper)

Ariza Veguillas, A., Salas, M., Ogese, M. O., Montanez, M. I., Fernandez, T., Mayorga, C., . . . Naisbitt, D. J. (2019). Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions. In ALLERGY Vol. 74 (pp. 84-85). Retrieved from https://www.webofscience.com/

2018

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)

Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163

DOI: 10.1021/acs.chemrestox.8b00163

The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash. (Journal article)

Sharma, A., Saito, Y., Hung, S. -I., Naisbitt, D., Uetrecht, J., & Bussiere, J. (2018). The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.. Journal of immunotoxicology, 1-12. doi:10.1080/1547691x.2018.1514444

DOI: 10.1080/1547691x.2018.1514444

Immune drug-induced liver disease and drugs (Journal article)

Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006

DOI: 10.1016/j.cotox.2017.12.006

Mechanisms leading to T-cell activation in drug hypersensitivity (Journal article)

Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458

DOI: 10.1097/ACI.0000000000000458

Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4(+) T-Cells from Hypersensitive Patients (Journal article)

Monroy-Arreola, A., Duran-Figueroa, N. V., Mendez-Flores, S., Dominguez-Cherit, J., Watkinson, J., Badillo-Corona, J. A., . . . Castrejon-Flores, J. L. (2018). Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4+ T-Cells from Hypersensitive Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 31(6), 454-461. doi:10.1021/acs.chemrestox.7b00330

DOI: 10.1021/acs.chemrestox.7b00330

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)

Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

DOI: 10.1021/acs.chemrestox.8b00030

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions (Journal article)

Sullivan, A., Watkinson, J., Waddington, J., Park, B. K., & Naisbitt, D. J. (2018). Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(3), 261-274. doi:10.1080/17425255.2018.1441285

DOI: 10.1080/17425255.2018.1441285

Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020

DOI: 10.4049/jimmunol.1800020

The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

DOI: 10.4049/jimmunol.1800019

Immune Mechanisms in Drug-Induced Liver Injury (Chapter)

Jaeschke, H., & Naisbitt, D. J. (2018). Immune Mechanisms in Drug-Induced Liver Injury. In DRUG-INDUCED LIVER TOXICITY (pp. 511-531). doi:10.1007/978-1-4939-7677-5_25

DOI: 10.1007/978-1-4939-7677-5_25

State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop (Journal article)

van Vliet, E., Kuehnl, J., Goebel, C., Martinozzi-Teissier, S., Alepee, N., Ashikaga, T., . . . Petersohn, D. (n.d.). State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(2), 179-192. doi:10.14573/altex.1709011

DOI: 10.14573/altex.1709011

β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells (Journal article)

sullivan, A., Wang, E., Farrell, J., Whitaker, P., Faulkner, L., Peckham, D., . . . Naisbitt, D. (2018). β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells. Journal of Allergy and Clinical Immunology, 141(01), 235-249.E8. doi:10.1016/j.jaci.2017.01.020

DOI: 10.1016/j.jaci.2017.01.020

2017

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291

DOI: 10.1021/acs.chemrestox.7b00291

Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors (Journal article)

Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263

DOI: 10.1021/acs.chemrestox.7b00263

Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts (Journal article)

Park, B. K., & Naisbitt, D. (n.d.). Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts. Chemical Research in Toxicology.

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029

DOI: 10.4049/jimmunol.1602029

Identification of drug- and drug-metabolite immune responses originating from both naïve and memory T-cells. (Journal article)

Gibson, A., Faulkner, L., Wood, S., Park, B. K., & Naisbitt, D. J. (2017). Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 578-+. doi:10.1016/j.jaci.2016.11.032

DOI: 10.1016/j.jaci.2016.11.032

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells (Journal article)

Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069

DOI: 10.1093/toxsci/kfx069

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development (Chapter)

Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4

DOI: 10.1016/B978-0-12-409547-2.12384-4

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. (Journal article)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209

DOI: 10.4049/jimmunol.1700209

Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity (Journal article)

Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087

DOI: 10.1111/all.13087

Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity (Conference Paper)

Yip, V., Zhang, E., Clarke, K., Francis, B., Rainbow, L., Falciani, F., . . . Pirmohamed, M. (2017). Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity. In LANCET Vol. 389 (pp. 104). Retrieved from https://www.webofscience.com/

Trimethoprim-induced aseptic meningism (Journal article)

Lochlainn, M. N., Gooi, H. C., Ogese, M. O., Naisbitt, D. J., & Jafar-Mohammadi, B. (2017). Trimethoprim-induced aseptic meningism. BRITISH JOURNAL OF HOSPITAL MEDICINE, 78(2), 108-109. doi:10.12968/hmed.2017.78.2.108

DOI: 10.12968/hmed.2017.78.2.108

Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury (Journal article)

Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218

DOI: 10.1093/toxsci/kfw218

Drug-specific CD4+ T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome (Journal article)

Ye, Y. -M., Hur, G. -Y., Kim, S. -H., Ban, G. -Y., Jee, Y. -K., Naisbitt, D. J., . . . Kim, S. -H. (2017). Drug-specific CD4+ T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome. BRITISH JOURNAL OF DERMATOLOGY, 176(2), 378-386. doi:10.1111/bjd.14839

DOI: 10.1111/bjd.14839

Human leukocyte antigen and idiosyncratic adverse drug reactions (Journal article)

Usui, T., & Naisbitt, D. J. (2017). Human leukocyte antigen and idiosyncratic adverse drug reactions. DRUG METABOLISM AND PHARMACOKINETICS, 32(1), 21-30. doi:10.1016/j.dmpk.2016.11.003

DOI: 10.1016/j.dmpk.2016.11.003

Immunological Mechanisms of Drug Hypersensitivity (Journal article)

Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103

DOI: 10.2174/1381612822666161003115103

New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

DOI: 10.1021/acs.chemrestox.6b00333

Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test (Conference Paper)

Poyner, E., Naisbitt, D. J., Farrell, J., Nagarajan, S., Ellis, R., & Fatah, S. (2017). Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test. In BRITISH JOURNAL OF DERMATOLOGY Vol. 177 (pp. 27). Retrieved from https://www.webofscience.com/

2016

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury (Journal article)

Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400

DOI: 10.1021/acs.chemrestox.6b00400

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. (Journal article)

Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177

DOI: 10.1093/toxsci/kfw177

Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury (Journal article)

Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393

DOI: 10.1021/acs.chemrestox.6b00393

Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis (Journal article)

Spriggs, S., Sheffield, D., Olayanju, A., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2016). Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis. TOXICOLOGICAL SCIENCES, 154(1), 5-15. doi:10.1093/toxsci/kfw140

DOI: 10.1093/toxsci/kfw140

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients (Journal article)

Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253

DOI: 10.1021/acs.chemrestox.6b00253

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury (Journal article)

Kim, S. -H., & Naisbitt, D. J. (2016). Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 8(1), 3-11. doi:10.4168/aair.2016.8.1.3

DOI: 10.4168/aair.2016.8.1.3

2015

The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury (Journal article)

Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015). The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury. HUMAN & EXPERIMENTAL TOXICOLOGY, 34(12), 1310-1317. doi:10.1177/0960327115606529

DOI: 10.1177/0960327115606529

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation (Journal article)

Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867

DOI: 10.1097/QAD.0000000000000867

Cutaneous immunopathology of long-standing complex regional pain syndrome (Journal article)

Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D., Moots, R., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. European Journal of Pain, 19(10), 1516-1526. doi:10.1002/ejp.685

DOI: 10.1002/ejp.685

In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base (Journal article)

Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294

DOI: 10.1021/acs.chemrestox.5b00294

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury (Journal article)

Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury. Hepatology, 62(3), 887-899. doi:10.1002/hep.27912

DOI: 10.1002/hep.27912

Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin (Journal article)

Jacquoilleot, S., Sheffield, D., Olayanju, A., Sison-Young, R., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2015). Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin. TOXICOLOGY LETTERS, 237(1), 11-20. doi:10.1016/j.toxlet.2015.05.016

DOI: 10.1016/j.toxlet.2015.05.016

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)

Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

DOI: 10.1111/cea.12546

Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036

DOI: 10.1016/j.jaci.2015.02.036

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy (Conference Paper)

Wheatley, L. M., Plaut, M., Schwaninger, J. M., Banerji, A., Castells, M., Finkelman, F. D., . . . Trepanier, L. A. (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 136 (pp. 262-+). doi:10.1016/j.jaci.2015.05.027

DOI: 10.1016/j.jaci.2015.05.027

Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model (Journal article)

Nattrass, R., Faulkner, L., Vocanson, M., Antoine, D., Kipar, A., Kenna, G., . . . Naisbitt, D. (2015). Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model. Toxicological Sciences, 146(1), 146-156. doi:10.1093/toxsci/kfv077

DOI: 10.1093/toxsci/kfv077

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity (Journal article)

Duran-Figueroa, N., Badillo-Corona, J. A., Naisbitt, D. J., & Castrejon-Flores, J. L. (2015). Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity. TOXICOLOGY RESEARCH, 4(4), 777-795. doi:10.1039/c4tx00238e

DOI: 10.1039/c4tx00238e

Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function (Journal article)

Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2015). Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function. Journal of Immunology, 192(06), 2611-2621. doi:10.4049/jimmunol.1302720

DOI: 10.4049/jimmunol.1302720

Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions? (Journal article)

Sullivan, A., Gibson, A., Park, B. K., & Naisbitt, D. J. (2015). Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 11(3), 357-368. doi:10.1517/17425255.2015.992780

DOI: 10.1517/17425255.2015.992780

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)

Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k

DOI: 10.1021/tx500285k

Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase (Journal article)

Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k

DOI: 10.1021/tx500458k

CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17 (Conference Paper)

Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from https://www.webofscience.com/

Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)

Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from https://www.webofscience.com/

2014

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial (Journal article)

Middleton, G., Silcocks, P., Cox, T. F., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. P. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0

DOI: 10.1016/S1470-2045(14)70236-0

Abacavir forms novel cross-linking abacavir protein adducts in patients (Journal article)

Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p

DOI: 10.1021/tx400406p

HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient (Journal article)

Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w

DOI: 10.1021/tx400460w

In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs (Journal article)

Naisbitt, D. J., Nattrass, R. G., & Ogese, M. O. (2014). In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 34(3), 691-+. doi:10.1016/j.iac.2014.04.009

DOI: 10.1016/j.iac.2014.04.009

T cell responses to drugs and drug metabolites. (Journal article)

Earnshaw, C. J., Pecaric-Petkovic, T., Park, B. K., & Naisbitt, D. J. (2014). T cell responses to drugs and drug metabolites.. Experientia supplementum (2012), 104, 137-163. doi:10.1007/978-3-0348-0726-5_10

DOI: 10.1007/978-3-0348-0726-5_10

The importance of hapten - protein complex formation in the development of drug allergy (Journal article)

Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078

DOI: 10.1097/ACI.0000000000000078

2013

The Generation, Detection, and Effects of Reactive Drug Metabolites (Journal article)

Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273

DOI: 10.1002/med.21273

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement (Journal article)

Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

DOI: 10.1016/j.clim.2013.05.008

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (Journal article)

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., . . . Hengstler, J. G. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. ARCHIVES OF TOXICOLOGY, 87(8), 1315-1530. doi:10.1007/s00204-013-1078-5

DOI: 10.1007/s00204-013-1078-5

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)

Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v

DOI: 10.1021/tx400041v

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI: 10.1021/tx400124m

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

DOI: 10.1021/tx400060p

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

DOI: 10.1021/tx4000107

Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)

Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

DOI: 10.1038/nrd3974

Human Leukocyte Antigen (HLA)-B☆57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B☆57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

DOI: 10.1002/hep.26077

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI: 10.1016/j.jaci.2013.02.045

Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis (Conference Paper)

Amali, M., Sullivan, A., Yaseen, F. S., Farrell, J., Faulkner, L., Whitaker, P., . . . Naisbitt, D. J. (2013). Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 140 (pp. 192). Retrieved from https://www.webofscience.com/

Definition of the mechanistic basis immunological drug reactions using human cells (Conference Paper)

Naisbitt, D. J. (2013). Definition of the mechanistic basis immunological drug reactions using human cells. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 246. Retrieved from https://www.webofscience.com/

Idiosyncratic Adverse Drug Reactions: Current Concepts (Journal article)

Uetrecht, J., & Naisbitt, D. J. (2013). Idiosyncratic Adverse Drug Reactions: Current Concepts. PHARMACOLOGICAL REVIEWS, 65(2), 779-808. doi:10.1124/pr.113.007450

DOI: 10.1124/pr.113.007450

Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function (Conference Paper)

Ogese, M. O., Gibson, A., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. (2013). Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function. In IMMUNOLOGY Vol. 140 (pp. 206). Retrieved from https://www.webofscience.com/

2012

Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity (Journal article)

Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146

DOI: 10.2217/PGS.12.146

IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers (Journal article)

Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350s

DOI: 10.1021/tx300350s

Nonimmediate β-lactam reactions in patients with cystic fibrosis (Journal article)

Whitaker, P., Naisbitt, D., & Peckham, D. (2012). Nonimmediate β-lactam reactions in patients with cystic fibrosis. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 12(4), 369-375. doi:10.1097/ACI.0b013e328355b849

DOI: 10.1097/ACI.0b013e328355b849

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)

Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

DOI: 10.1186/gm350

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI: 10.1124/jpet.111.190900

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs (Journal article)

Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs. TOXICOLOGICAL SCIENCES, 127(1), 150-158. doi:10.1093/toxsci/kfs080

DOI: 10.1093/toxsci/kfs080

Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta (Conference Paper)

Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from https://www.webofscience.com/

Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis (Journal article)

Yaseen, F., Monshi, M., Farrell, J., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis. J Allergy Clin Immunol.

Characterization of B-cell resposnes in piperacillin allergic and tolerant patients (Journal article)

Sullivan, A., Amali, M., Faulkner, L., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterization of B-cell resposnes in piperacillin allergic and tolerant patients. Allergy.

Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients. (Journal article)

El-Ghaiesh, S., Monshi, M., Whitaker, P., Meng, X., Jenkins, R., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.. J Pharmacol Exp Ther, 341, 597-610.

Clinical picture of drug hypersensitivity reactions (Journal article)

Bell, C., Naisbitt, D. J., & Park, B. K. (2012). Clinical picture of drug hypersensitivity reactions. ALTA.

Development of in vitro assays to characterize primary T cell responses to drugs (Journal article)

Faulkner, J., Martinsson, K., Castelazo, A. S., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). Development of in vitro assays to characterize primary T cell responses to drugs. Toxicological Sciences, 127, 150-158.

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers (Journal article)

Kiorpelidou, E., Foster, B., Naisbitt, D. J., & Park, B. K. (2012). IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers. Che Res Toxicol.

Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells. (Journal article)

Daubner, B., Groux-Keller, M., Hausmann, O., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells.. Allergy, 187, 1398-1405.

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells (Journal article)

Daubner, B., Groux-Keller, M., Hausmann, O. V., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. ALLERGY, 67(1), 58-66. doi:10.1111/j.1398-9995.2011.02720.x

DOI: 10.1111/j.1398-9995.2011.02720.x

Perspectives to predict idiosyncratic drug-induced liver injury in vitro. (Journal article)

Gibson, A., Eakins, R., Goldring, C. E. P., Naisbitt, D. J., Rowe, C., & Park, B. K. (2012). Perspectives to predict idiosyncratic drug-induced liver injury in vitro.. Drug Metabolism Reviews.

T-cell responses to drugs and drug metabolites (Chapter)

Earnshaw, C., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to drugs and drug metabolites. In S. F. Martin (Ed.), T Lymphocytes as Tools in Chemical and Drug Allergy (pp. 180-193). San Fransisco: Springer.

T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity (Journal article)

Nattrass, R., Jenkins, R., Faulkner, L., Yaseen, F., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity. Tox Sci.

T-cell responses to halogenated carbamazepine (Journal article)

Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to halogenated carbamazepine. Chem Res Toxicol.

The generation, detection and effects of reactive drug metabolites. Med Res Reviews. (Journal article)

Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., Srivastava, A., . . . Stachulski, A. V. (2012). The generation, detection and effects of reactive drug metabolites. Med Res Reviews.. Med Res Reviews.

The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming (Journal article)

Gibson, A., Faulkner, L., Park, B. K., & Naisbitt, D. J. (2012). The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming. Tox Sci.

2011

Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions (Journal article)

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057

DOI: 10.1016/j.tox.2011.09.057

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI: 10.1124/jpet.111.183871

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI: 10.1124/jpet.111.183871

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis (Journal article)

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI: 10.4049/jimmunol.1100647

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity (Journal article)

Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011

DOI: 10.1016/j.cbi.2010.09.011

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256

DOI: 10.1021/tx2001256

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis (Journal article)

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. Journal of Allergy and Clinical Immunology, 127(6), 1543-1551.e3. doi:10.1016/j.jaci.2010.12.1119

DOI: 10.1016/j.jaci.2010.12.1119

Managing the challenge of chemically reactive metabolites in drug development (Journal article)

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. NATURE REVIEWS DRUG DISCOVERY, 10(4), 292-306. doi:10.1038/nrd3408

DOI: 10.1038/nrd3408

Multiple drug hypersensitivity: role of T regulatory cells (Conference Paper)

Daubner, B., Groux-Keller, M., Kawabata, T., Naisbitt, D. J., Park, K. B., Thomas, W., . . . Pichler, W. J. (2011). Multiple drug hypersensitivity: role of T regulatory cells. In JOURNAL OF IMMUNOLOGY Vol. 186. Retrieved from https://www.webofscience.com/

Immune pathomechanism of drug hypersensitivity reactions (Journal article)

Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(3), S74-S81. doi:10.1016/j.jaci.2010.11.048

DOI: 10.1016/j.jaci.2010.11.048

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031

DOI: 10.1016/j.jaci.2011.04.031

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.. J Allergy Clin Immunol., 128, 680-683.

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. (Journal article)

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis (Journal article)

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1543-U348. doi:10.1016/j.jaci.2010.12.1119

DOI: 10.1016/j.jaci.2010.12.1119

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. (Journal article)

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.. The Journal of allergy and clinical immunology, 127(6), 1543-51.e3. doi:10.1016/j.jaci.2010.12.1119

DOI: 10.1016/j.jaci.2010.12.1119

Immune pathomechanism of drug hypersensitivity reactions (Journal article)

Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. Journal of Allergy and Clinical Immunology, 127(S3), S74-S81.

Managing the challenge of chemically reactive metabolites in drug development. (Journal article)

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nat Rev Drug Discov., 10, 292-306.

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. (Journal article)

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.. J Immunol., 187, 200-211.

rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.. Chem Res Toxicol., 24, 791-793.

2010

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism (Journal article)

Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889

DOI: 10.4049/jimmunol.1000889

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (Journal article)

Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92

DOI: 10.1586/ERV.10.92

Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis (Journal article)

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 23(6), 1009-1011. doi:10.1021/tx100151v

DOI: 10.1021/tx100151v

Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein (Journal article)

Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

DOI: 10.1038/jid.2009.271

Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives (Journal article)

Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b

DOI: 10.1021/tx900329b

ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS? (Conference Paper)

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Park, B. K., & Naisbitt, D. J. (2010). ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/

AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS (Conference Paper)

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Peckham, B. K., & Naisbitt, D. J. (2010). AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/

Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis (Conference Paper)

El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from https://www.webofscience.com/

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. (Journal article)

Shaw, V., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.. Expert Reviews in Vaccines, 9, 1007-1016.

DRUG HYPERSENSITIVITY (Chapter)

Naisbitt, D. J., Park, B. K., & Demoly, P. (2010). DRUG HYPERSENSITIVITY. In S. Holgate (Ed.), Allergy (pp. 200). London: Elsveier.

Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism (Conference Paper)

Kiorpelidou, E., Foster, B. J., Goldring, C., Naisbitt, D. J., & Park, K. (2010). Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism. In IMMUNOLOGY Vol. 131 (pp. 171-172). Retrieved from https://www.webofscience.com/

Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism (Journal article)

Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism. Journal of Immunology, 185, 6448-6460. doi:10.4049/jimmunol.1000889

DOI: 10.4049/jimmunol.1000889

Drug immunogenicity and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism (Conference Paper)

Elsheikh, A., Lavergne, S., Castrejon, J., Sathish, J., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Drug immunogenicity and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism. In IMMUNOLOGY Vol. 131 (pp. 145). Retrieved from https://www.webofscience.com/

Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis (Journal article)

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. Chemical Research in Toxicology, 23, 1009-1011.

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis (Journal article)

Elsheikh, A., Monshi, M., Castrejon, J., Lavergne, S., Whitaker, P., Pichler, W. J., . . . Naisbitt, D. J. (2010). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis. IMMUNOLOGY, 131, 145-146. Retrieved from https://www.webofscience.com/

Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions (Conference Paper)

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from https://www.webofscience.com/

Involvement of drug-specific CD4+ and CD8+ T-cells in trimethoprim-mediated hepatitis (Conference Paper)

El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4+ and CD8+ T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from https://www.webofscience.com/

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI: 10.1038/jid.2009.187

Stimulation of human T cells with sulfonamides and sulfonamide metabolites (Journal article)

Castrejon, J. L., Berry, N., El-Ghaiesh, S., Gerber, B., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), 411-418. doi:10.1016/j.jaci.2009.10.031

DOI: 10.1016/j.jaci.2009.10.031

Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis (Conference Paper)

Elsheikh, A., Callan, H., Monshi, M., Lavergne, S., Castrejon, J., El-Ghaiesh, S., . . . Naisbitt, D. J. (2010). Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from https://www.webofscience.com/

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays (Journal article)

Martin, S. F., Esser, P. R., Schmucker, S., Dietz, L., Naisbitt, D. J., Park, B. K., . . . Sallusto, F. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(24), 4171-4184. doi:10.1007/s00018-010-0495-3

DOI: 10.1007/s00018-010-0495-3

TeloVac trial translational studies: investigation of the immune response to GV1001 (Conference Paper)

Shaw, V., Naisbitt, D., Costello, E., Farrell, J., Park, B. K., Neoptolemos, J., & Middleton, G. (2010). TeloVac trial translational studies: investigation of the immune response to GV1001. In IMMUNOLOGY Vol. 131 (pp. 164). Retrieved from https://www.webofscience.com/

2009

"Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells (Journal article)

Lavergne, S. N., Wang, H., Callan, H. E., Park, B. K., & Naisbitt, D. J. (2009). "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(2), 372-381. doi:10.1124/jpet.109.155374

DOI: 10.1124/jpet.109.155374

The role of metabolism in T-cell mediated drug hypersensitivity reactions (Journal article)

Naisbitt, D. (2009). The role of metabolism in T-cell mediated drug hypersensitivity reactions. TOXICOLOGY LETTERS, 189, S170-S171. doi:10.1016/j.toxlet.2009.06.698

DOI: 10.1016/j.toxlet.2009.06.698

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 (Journal article)

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI: 10.1016/j.taap.2009.05.001

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 (Journal article)

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI: 10.1016/j.taap.2009.05.001

Involvement of drug-specific CD4+ and CD8+ T-cells in trimethoprim-mediated hepatitis (Conference Paper)

El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4+ and CD8+ T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010

DOI: 10.1016/j.tox.2009.04.010

A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine (Journal article)

Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r

DOI: 10.1021/tx900095r

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation (Journal article)

Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r

DOI: 10.1021/tx900034r

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse (Journal article)

Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008

DOI: 10.1016/j.toxlet.2008.12.008

A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells (Conference Paper)

Lavergne, S. N., Wang, H., Park, B. K., & Naisbitt, D. J. (2009). A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 293-294). Retrieved from https://www.webofscience.com/

Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse. (Journal article)

Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.. Toxicol Lett., 185(153-15).

Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity (Conference Paper)

Elsheikh, A., Lavergne, S. N., Sathish, J., Park, B. K., & Naisbitt, D. J. (2009). Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 287-288). Retrieved from https://www.webofscience.com/

Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients (Conference Paper)

Lavergne, S. N., Wang, H., Castrejon, J. L., Park, B. K., & Naisbitt, D. J. (2009). Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 279). Retrieved from https://www.webofscience.com/

Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals (Conference Paper)

Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from https://www.webofscience.com/

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1 (Conference Paper)

Megherbi, R., Kiorpelidou, E., Foster, B., Farrell, J., Rowe, C., Naisbitt, D. J., . . . Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 292-293). Retrieved from https://www.webofscience.com/

Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites (Conference Paper)

Casterjon, J. L., Jenkinson, C., Gerber, B. O., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2009). Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 289-290). Retrieved from https://www.webofscience.com/

Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes (Conference Paper)

Elsheikh, A., Castrejon, J. L., Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2009). Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288). Retrieved from https://www.webofscience.com/

The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability (Conference Paper)

Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Naisbitt, D. J., & Park, B. K. (2009). The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288-289). Retrieved from https://www.webofscience.com/

2008

Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites (Journal article)

Sanderson, J. P., Hollis, F. J., Maggs, J. L., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2008). Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites. DRUG METABOLISM AND DISPOSITION, 36(12), 2424-2428. doi:10.1124/dmd.108.021246

DOI: 10.1124/dmd.108.021246

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity (Journal article)

Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2008). The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 8(4), 299-307. doi:10.1097/ACI.0b013e3283079c64

DOI: 10.1097/ACI.0b013e3283079c64

Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites (Journal article)

Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from https://www.webofscience.com/

p-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye (Conference Paper)

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Pirmohamed, M., . . . Naisbitt, D. J. (2008). p-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 984). Retrieved from https://www.webofscience.com/

A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-S-transferase Pi (Conference Paper)

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Naisbitt, D. J., & Park, B. K. (2008). A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-S-transferase Pi. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 996-997). Retrieved from https://www.webofscience.com/

Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base (Journal article)

Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071

DOI: 10.1038/sj.jid.5701071

Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with p-phenylenediamine and Bandrowski's base (Conference Paper)

Coulter, E. M., Pease, C. K., White, A., Lockley, D., Basketter, D., Williams, D. P., . . . Naisbitt, D. J. (2008). Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with p-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 982-984). Retrieved from https://www.webofscience.com/

Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2 (Conference Paper)

Yeang, H. X. A., Naisbitt, D. J., Park, K., & Sathish, J. G. (2008). Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2. In IMMUNOLOGY Vol. 125 (pp. 140-141). Retrieved from https://www.webofscience.com/

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base (Conference Paper)

Farrell, J., Jenkinson, C., Coulter, E., Park, B. K., & Naisbitt, D. J. (2008). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1000-1001). Retrieved from https://www.webofscience.com/

2007

Drugs as Haptens, Antigens, and Immunogens (Chapter)

Park, B. K., Sanderson, J. P., & Naisbitt, D. J. (2007). Drugs as Haptens, Antigens, and Immunogens. In Drug Hypersensitivity (pp. 55-65). KARGER. doi:10.1159/000104189

DOI: 10.1159/000104189

Drug hypersensitivity reactions in patients with HIV disease. (Journal article)

Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395

DOI: 10.1586/1744666x.3.3.395

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542.

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

DOI: 10.4049/jimmunol.178.9.5533

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazopine hypersensitivity (Journal article)

Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617

DOI: 10.1016/j.jaci.2006.12.617

Immunological principles of T-cell-mediated adverse drug reactions in skin (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI: 10.1517/14740338.6.2.109

Immunological principles of T-cell-mediated adverse drug reactions in skin (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. Expert Opinion on Drug Safety, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI: 10.1517/14740338.6.2.109

Activation of human dendritic cells by p-phenylenediamine (Journal article)

Coulter, E. M., Farrell, J., Mathews, K. L., Maggs, J. L., Pease, C. K., Lockley, D. J., . . . Naisbitt, D. J. (2007). Activation of human dendritic cells by p-phenylenediamine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2), 885-892. doi:10.1124/jpet.106.113803

DOI: 10.1124/jpet.106.113803

Investigation of the immunogenicity of diclofenac and diclofenac metabolites (Journal article)

Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014

DOI: 10.1016/j.toxlet.2006.10.014

Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base (Journal article)

Coulter, E. M., Jenkinson, C., Wu, Y., Pease, C. K., Basketter, D. A., Friedmann, P. S., . . . Naisbitt, D. J. (2007). Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base. J Invest Dermatol.

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

2006

The 2nd International Drug Hypersensitivity Meeting (Journal article)

Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729

DOI: 10.1517/14740338.5.5.729

The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK. (Journal article)

Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK.. Expert opinion on drug safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729

DOI: 10.1517/14740338.5.5.729

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan (Journal article)

Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.x

DOI: 10.1111/j.1365-2133.2006.07338.x

Activation of T cells by carbamazepine and carbamazepine metabolites (Journal article)

Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005

DOI: 10.1016/j.jaci.2006.03.005

Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis (Journal article)

Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from https://www.webofscience.com/

Role of bioactivation in drug-induced hypersensitivity reactions (Journal article)

Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). Role of bioactivation in drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E55-E64. doi:10.1208/aapsj080107

DOI: 10.1208/aapsj080107

Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients (Conference Paper)

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2006). Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 632). Retrieved from https://www.webofscience.com/

Chemical and molecular investigation of hazard associated with drug bioactivation (Conference Paper)

Drummond, N. S., Gardner, I., Jones, R., Wood, T., Naisbitt, D. J., Owen, A., . . . Park, B. K. (2006). Chemical and molecular investigation of hazard associated with drug bioactivation. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 180-181). Retrieved from https://www.webofscience.com/

Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity (Conference Paper)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 645). Retrieved from https://www.webofscience.com/

Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers (Conference Paper)

Coulter, E. M., Wu, Y., Farrell, J., Pease, C. K., Lockley, D. J., Basketter, D. A., . . . Naisbitt, D. J. (2006). Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 639). Retrieved from https://www.webofscience.com/

Drug Hypersnesitivity Meeting, Liverpool, 2006 (Conference Paper)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.

Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity (Conference Paper)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 182-183). Retrieved from https://www.webofscience.com/

The role of covalent binding in drug hypersensitivity (Chapter)

Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). The role of covalent binding in drug hypersensitivity. In W. J. Pichler (Ed.), Drug Hypersensitivity (pp. 460). Basel: Karger.

The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool (Journal article)

Alfirevic, A., & Naisbitt, D. J. (2006). The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool. Expert Opinion in Drug Safety, 5(5), 729-734.

2005

Errata (Journal article)

Errata (n.d.). International Journal of Clinical Practice, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729a.x

DOI: 10.1111/j.1368-5031.2005.00729a.x

Investigation of toxic metabolites during drug development. (Journal article)

Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029

DOI: 10.1016/j.taap.2005.02.029

Carbamazepine-induced acute liver failure as part of the DRESS syndrome (Journal article)

Syn, W. K., Naisbitt, D. J., Holt, A. P., Pirmohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(8), 988-991. doi:10.1111/j.1368-5031.2005.00550.x

DOI: 10.1111/j.1368-5031.2005.00550.x

Characterization of the T-cell response in a patient with phenindione hypersensitivity (Journal article)

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758

DOI: 10.1124/jpet.105.083758

Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization (Journal article)

Hopkins, J. E., Naisbitt, D. J., Kitteringham, N. R., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization. CHEMICAL RESEARCH IN TOXICOLOGY, 18(2), 375-381. doi:10.1021/tx049688+

DOI: 10.1021/tx049688+

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells (Journal article)

Hopkins, J. E., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells. TOXICOLOGY, 206(2), 221-231. doi:10.1016/j.tox.2004.08.010

DOI: 10.1016/j.tox.2004.08.010

Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005) (Journal article)

Sun, W. K., Naisbitt, D. J., Holt, A. P., Primohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005). INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729.x

DOI: 10.1111/j.1368-5031.2005.00729.x

Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding (Conference Paper)

Pease, C. K. S., Divkovic, M., Payne, O., Vassallo, J. D., Coulter, E., Naisbitt, D. J., . . . Basketter, D. A. (2005). Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding. In TOXICOLOGY LETTERS Vol. 158 (pp. S222-S223). Retrieved from https://www.webofscience.com/

Drug presentation to T cells (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011

DOI: 10.1016/j.jaci.2005.01.011

Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis (Journal article)

Drummond, N. S., Vilar, J., Naisbitt, D. J., Hanson, A., Park, B. K., & Pirmohamed, M. (2005). Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 635-636. Retrieved from https://www.webofscience.com/

G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity (Journal article)

Alfirevic, A., Naisbitt, D. J., Wu, Y., Farrell, J., Park, B. K., & Pirmohamed, M. (2005). G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 645. Retrieved from https://www.webofscience.com/

2004

A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals (Journal article)

Engler, O. B., Strasser, I., Naisbitt, D. J., Cerny, A., & Pichler, W. J. (2004). A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. TOXICOLOGY, 197(1), 47-56. doi:10.1016/j.tox.2003.12.008

DOI: 10.1016/j.tox.2003.12.008

Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests (Journal article)

Naisbitt, D. J. (2004). Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests. TOXICOLOGY, 194(3), 179-196. doi:10.1016/j.tox.2003.09.004

DOI: 10.1016/j.tox.2003.09.004

Characterization of T-cell responses in phenindione hypersensitivity (Conference Paper)

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Park, B. K., & Pirmohamed, M. (2004). Characterization of T-cell responses in phenindione hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 675). Retrieved from https://www.webofscience.com/

Characterization of drug-specific CD4+ T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity (Conference Paper)

Farrell, J., Gibney, C. A., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Characterization of drug-specific CD4+ T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 690). Retrieved from https://www.webofscience.com/

Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay (Conference Paper)

Farrell, J., Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2004). Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay. In TOXICOLOGY Vol. 194 (pp. 255-256). Retrieved from https://www.webofscience.com/

Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests (Conference Paper)

Naisbitt, D. J. (2004). Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests. In TOXICOLOGY Vol. 194 (pp. 211-212). Retrieved from https://www.webofscience.com/

Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications (Conference Paper)

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 683). Retrieved from https://www.webofscience.com/

T-cell recognition of carbamazepine and carbamazepine metabolites (Journal article)

Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/

2003

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans (Journal article)

Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112

DOI: 10.1124/jpet.103.050112

Characterization of drug-specific T cells in lamotrigine hypersensitivity (Journal article)

Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507

DOI: 10.1067/mai.2003.1507

Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones (Journal article)

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732

DOI: 10.1124/mol.63.3.732

Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation in vitro (Conference Paper)

Dodd, C. C., Naisbitt, D. J., Vilar, F. J., Gordon, S. F., Maggs, J. L., Park, B. K., & Pirmohamed, M. (2003). Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation in vitro. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 421). Retrieved from https://www.webofscience.com/

Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man (Journal article)

Farrell, J., Naisbitt, D. J., Depta, J. P. H., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2003). Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man. TOXICOLOGY, 192(1), 83-84. Retrieved from https://www.webofscience.com/

Characterization of lamotrigine-specific T cells from hypersensitive patients. (Conference Paper)

Naisbitt, D. J., Farrell, J., Hopkins, J. E., Wong, G., Pichler, W. J., Pirmohamed, M., & Park, K. (2003). Characterization of lamotrigine-specific T cells from hypersensitive patients.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 52). Retrieved from https://www.webofscience.com/

Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals (Conference Paper)

Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, B. K. (2003). Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 444). Retrieved from https://www.webofscience.com/

Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones (Conference Paper)

Naisbitt, D. J., Farrell, J., Wong, G., Dodd, C. C., Hopkins, J. E., Depta, J. P. H., . . . Park, B. K. (2003). Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones. In TOXICOLOGY Vol. 192 (pp. 82-83). Retrieved from https://www.webofscience.com/

Immunopharmacology of hypersensitivity reactions to drugs (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9

DOI: 10.1007/s11882-003-0006-9

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system. (Journal article)

Vilar, F. J., Naisbitt, D. J., Park, B. K., & Pirmohamed, M. (2003). Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.. Journal of HIV therapy, 8(2), 42-47.

The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse in vivo (Conference Paper)

Kenny, J. R., Naisbitt, D. J., Stachulski, A. W., Hopkins, J. E., Dearman, R. J., Kimber, I., . . . Park, B. K. (2003). The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse in vivo. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 435). Retrieved from https://www.webofscience.com/

The relationship between cellular disposition and cytokine polarization for simple haptens. (Conference Paper)

Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, K. (2003). The relationship between cellular disposition and cytokine polarization for simple haptens.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 54). Retrieved from https://www.webofscience.com/

2002

The danger hypothesis - potential role in idiosyncratic drug reactions (Journal article)

Pirmohamed, M., Naisbitt, D. J., Gordon, F., & Park, B. K. (2002). The danger hypothesis - potential role in idiosyncratic drug reactions. TOXICOLOGY, 181, 55-63. doi:10.1016/S0300-483X(02)00255-X

DOI: 10.1016/S0300-483X(02)00255-X

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation (Journal article)

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628

DOI: 10.1124/mol.62.3.628

Are chemically reactive metabolites responsible for adverse reactions to drugs? (Journal article)

Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423

DOI: 10.2174/1389200023337423

Toxicophores: Groups and metabolic routes associated with increased safety risk (Journal article)

Williams, D. P., & Naisbitt, D. J. (2002). Toxicophores: Groups and metabolic routes associated with increased safety risk. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 5(1), 104-115. Retrieved from https://www.webofscience.com/

Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells (Conference Paper)

Naisbitt, D. J., Depta, J., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 443P). Retrieved from https://www.webofscience.com/

Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones (Conference Paper)

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 418P-419P). Retrieved from https://www.webofscience.com/

Cellular and molecular pathophysiology of cutaneous drug reactions. (Journal article)

Pichler, W. J., Yawalkar, N., Britschgi, M., Depta, J., Strasser, I., Schmid, S., . . . Naisbitt, D. (2002). Cellular and molecular pathophysiology of cutaneous drug reactions.. American journal of clinical dermatology, 3(4), 229-238. doi:10.2165/00128071-200203040-00001

DOI: 10.2165/00128071-200203040-00001

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation (Journal article)

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation. Mol. Pharmacol., 62(3), 628-637. Retrieved from http://molpharm.aspetjournals.org/cgi/reprint/62/3/628?ck=nck

Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression (Conference Paper)

Hopkins, J., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2002). Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression. In TOXICOLOGY Vol. 178 (pp. 41-42). Retrieved from https://www.webofscience.com/

MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat (Conference Paper)

Farrell, J., Gordon, S. F., Naisbitt, D. J., Gallimore, A., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 442P). Retrieved from https://www.webofscience.com/

2001

Metabolic activation in drug allergies (Journal article)

Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., & Pirmohamed, M. (2001). Metabolic activation in drug allergies. TOXICOLOGY, 158(1-2), 11-23. doi:10.1016/S0300-483X(00)00397-8

DOI: 10.1016/S0300-483X(00)00397-8

Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo (Journal article)

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001). Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo. BRITISH JOURNAL OF PHARMACOLOGY, 133(2), 295-305. doi:10.1038/sj.bjp.0704074

DOI: 10.1038/sj.bjp.0704074

Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells (Journal article)

Burkhart, C., Von Greyerz, S., Depta, J. P. H., Naisbitt, D. J., Britschgi, M., Park, K. B., & Pichler, W. J. (2001). Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells. BRITISH JOURNAL OF PHARMACOLOGY, 132(3), 623-630. doi:10.1038/sj.bjp.0703845

DOI: 10.1038/sj.bjp.0703845

Reactive metabolites and their role in drug reactions (Journal article)

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from https://www.webofscience.com/

The danger hypothesis: inflammation and idiosyncratic toxicity (Conference Paper)

Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2001). The danger hypothesis: inflammation and idiosyncratic toxicity. In TOXICOLOGY Vol. 164 (pp. 5). Retrieved from https://www.webofscience.com/

2000

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection (Journal article)

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(18), 1929-1938. doi:10.1089/088922200750054657

DOI: 10.1089/088922200750054657

Metabolism of lamotrigine to a reactive arene oxide intermediate (Journal article)

Maggs, J. L., Naisbitt, D. J., Tettey, J. N. A., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(11), 1075-1081. doi:10.1021/tx0000825

DOI: 10.1021/tx0000825

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine (Journal article)

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207

DOI: 10.1124/mol.58.1.207

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals (Journal article)

Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647

DOI: 10.4049/jimmunol.164.12.6647

Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment (Journal article)

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., & Park, B. K. (2000). Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment. DRUG SAFETY, 23(6), 483-507. doi:10.2165/00002018-200023060-00002

DOI: 10.2165/00002018-200023060-00002

Metabolism of lamotrigine to a reactive arene oxide intermediate (Journal article)

Maggs, J. L., Naisbitt, D. J., Tetty, J. N., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. Chemical Research in Toxicology, 11(11), 1075-1081.

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. (Journal article)

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.. AIDS research and human retroviruses, 16(18), 1926-1938.

1999

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity (Journal article)

Naisbitt, D. J., Hough, S. J., Gill, H. J., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1999). Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. BRITISH JOURNAL OF PHARMACOLOGY, 126(6), 1393-1407. doi:10.1038/sj.bjp.0702453

DOI: 10.1038/sj.bjp.0702453

1998

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs (Journal article)

Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k

DOI: 10.1021/tx980148k

1997

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis (Journal article)

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from https://www.webofscience.com/

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat (Journal article)

Gill, H. J., Hough, S. J., Naisbitt, D. J., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1997). The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 282(2), 795-801. Retrieved from https://www.webofscience.com/

Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design (Journal article)

Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/

1996

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity. (Journal article)

Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0

DOI: 10.1016/S0960-894X(96)00260-0

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component (Journal article)

Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345

DOI: 10.1128/AAC.40.10.2345

Publications

2024

Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide (Journal article)

2023

What’s been Hapten-ing over the last 88 years? (Journal article)

2022

Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications? (Journal article)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity (Journal article)

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01. (Journal article)

2021

HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients (Journal article)

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction. (Journal article)

Drug hapten-specific T-cell activation: Current status and unanswered questions (Journal article)

Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01 (Journal article)

Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions (Journal article)

Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat (Journal article)

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab (Journal article)

<i>HLA-B*13:01</i> Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients (Journal article)

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing <i>HLA-B*13:01</i> (Journal article)

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs (Journal article)

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses (Journal article)

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol (Journal article)

Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4<SUP>+</SUP> T lymphocytes (Journal article)

Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite (Journal article)

Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat (Journal article)

2020

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury (Journal article)

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury (Journal article)

Characterization of Clozapine-Responsive Human T Cells (Journal article)

HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)

Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity (Journal article)

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds. (Journal article)

Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases (Journal article)

Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions (Journal article)

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation (Journal article)

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models (Journal article)

T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity (Journal article)

2019

Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article)

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01 (Journal article)

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers (Journal article)

Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions (Conference Paper)

A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin (Conference Paper)

Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions (Conference Paper)

Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions (Conference Paper)

2018

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)

The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash. (Journal article)

Immune drug-induced liver disease and drugs (Journal article)

Mechanisms leading to T-cell activation in drug hypersensitivity (Journal article)

Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4(+) T-Cells from Hypersensitive Patients (Journal article)

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions (Journal article)

Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)

The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)

Immune Mechanisms in Drug-Induced Liver Injury (Chapter)

State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop (Journal article)

β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells (Journal article)

2017

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors (Journal article)

Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts (Journal article)

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)

Identification of drug- and drug-metabolite immune responses originating from both naïve and memory T-cells. (Journal article)

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells (Journal article)

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development (Chapter)

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. (Journal article)

Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity (Journal article)

Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity (Conference Paper)

Trimethoprim-induced aseptic meningism (Journal article)

Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury (Journal article)

Drug-specific CD4<SUP>+</SUP> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome (Journal article)

Human leukocyte antigen and idiosyncratic adverse drug reactions (Journal article)

Immunological Mechanisms of Drug Hypersensitivity (Journal article)

New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test (Conference Paper)

2016

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury (Journal article)

HLA DaB115:01-DQB106:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)