2024
Kiy, R. T., Khoo, S. H., & Chadwick, A. E. (2024). Assessing the mitochondrial safety profile of the molnupiravir active metabolite, β-d-N4-hydroxycytidine (NHC), in the physiologically relevant HepaRG model.. Toxicology research, 13(1), tfae012. doi:10.1093/toxres/tfae012DOI: 10.1093/toxres/tfae012
Gardner, J., Hammond, S., Jensen, R., Gibson, A., Krantz, M. S., Ardern-Jones, M., . . . Naisbitt, D. J. (2024). Glycolysis: An early marker for vancomycin-specific T-cell activation.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 54(1), 21-33. doi:10.1111/cea.14423DOI: 10.1111/cea.14423
2023
Ball, A. L., Jolly, C. E., Lennon, M. G., Lyon, J. J., Alfirevic, A., & Chadwick, A. E. (2023). The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury. ELIFE, 12. doi:10.7554/eLife.78187DOI: 10.7554/eLife.78187
Bin Dayel, F. F., Alfirevic, A., & Chadwick, A. E. (2023). Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis. Biomedicines, 11(5), 1485. doi:10.3390/biomedicines11051485DOI: 10.3390/biomedicines11051485
4 Clinical consequences of drug-induced mitochondrial dysfunction (Chapter)
Jensen, R. L., Kiy, R. T., Bin Dayel, F. F., & Chadwick, A. E. (2023). 4 Clinical consequences of drug-induced mitochondrial dysfunction. In Mitochondrial Intoxication (pp. 77-100). Elsevier. doi:10.1016/b978-0-323-88462-4.00026-2DOI: 10.1016/b978-0-323-88462-4.00026-2
2022
Clinical consequences of drug-induced mitochondrial dysfunction (Chapter)
Jensen, R. L., Kiy, R. T., Bin Dayel, F. F., & Chadwick, A. E. (2023). Clinical consequences of drug-induced mitochondrial dysfunction. In Mitochondrial Intoxication (pp. 77-100). Elsevier. doi:10.1016/b978-0-323-88462-4.00026-2DOI: 10.1016/b978-0-323-88462-4.00026-2
Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. (Conference Paper)
Brennan, S., Esposito, S., Abdelaziz, M. I., Martin, C. A., Makwana, S., Sims, M. W., . . . Rainbow, R. D. (2022). Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 587-589). Retrieved from https://www.webofscience.com/
Brennan, S., Esposito, S., Abdelaziz, M. I. M., Martin, C. A. A., Makwana, S., Sims, M. W. W., . . . Rainbow, R. D. (2022). Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.997013DOI: 10.3389/fcvm.2022.997013
Investigating the ability of HepaRG cells to recapitulate antibiotic-induced mitochondrial dysfunction in order to elucidate hepatotoxicity mechanisms (Conference Paper)
Kiy, R., & Chadwick, A. (2022). Investigating the ability of HepaRG cells to recapitulate antibiotic-induced mitochondrial dysfunction in order to elucidate hepatotoxicity mechanisms. In TOXICOLOGY LETTERS Vol. 368 (pp. S171-S172). doi:10.1016/j.toxlet.2022.07.473DOI: 10.1016/j.toxlet.2022.07.473
Heaton, B. J., Jensen, R. L., Line, J., David, C. A. W., Brain, D. E., Chadwick, A. E., & Liptrott, N. J. (2022). Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1. BIOMEDICINE & PHARMACOTHERAPY, 150. doi:10.1016/j.biopha.2022.112999DOI: 10.1016/j.biopha.2022.112999
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational <i>in vitro</i> study (Preprint)
DOI: 10.1101/2022.03.21.485109
2021
Towards Elucidating the Mechanisms of Macrolide-Induced Liver Injury: Investigating the Role of the Mitochondria (Conference Paper)
Kiy, R., & Chadwick, A. (2021). Towards Elucidating the Mechanisms of Macrolide-Induced Liver Injury: Investigating the Role of the Mitochondria. In TOXICOLOGY LETTERS Vol. 350 (pp. S161). Retrieved from https://www.webofscience.com/
Jones, S. W., Ball, A. L., Chadwick, A. E., & Alfirevic, A. (n.d.). The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review. Frontiers in Genetics, 12. doi:10.3389/fgene.2021.698825DOI: 10.3389/fgene.2021.698825
Ball, A. L., Bloch, K. M., Rainbow, L., Liu, X., Kenny, J., Lyon, J. J., . . . Chadwick, A. E. (n.d.). Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers. Archives of Toxicology. doi:10.1007/s00204-021-02988-3DOI: 10.1007/s00204-021-02988-3
Jones, S. W., Penman, S. L., French, N. S., Park, B. K., & Chadwick, A. E. (2021). Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models. Toxicology in Vitro, 105096. doi:10.1016/j.tiv.2021.105096DOI: 10.1016/j.tiv.2021.105096
Determining individual variation of the mitotoxic potential of MCHr1 antagonist, AZD1979, in hepatic <i>in vitro</i> models (Conference Paper)
Jensen, R., Chadwick, A., Jolly, C., & Williams, D. (2021). Determining individual variation of the mitotoxic potential of MCHr1 antagonist, AZD1979, in hepatic <i>in vitro</i> models. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 394-395). Retrieved from https://www.webofscience.com/
Towards Elucidating the Mechanisms of Macrolide-Induced Liver Injury; Investigating the Role of the Mitochondria (Conference Paper)
Kiy, R., & Chadwick, A. (2021). Towards Elucidating the Mechanisms of Macrolide-Induced Liver Injury; Investigating the Role of the Mitochondria. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 396-397). Retrieved from https://www.webofscience.com/
2020
Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400DOI: 10.1021/acs.chemrestox.0c00400
Safety perspectives on presently considered drugs for the treatment of COVID‐19 (Journal article)
Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204DOI: 10.1111/bph.15204
Jolly, C. E., Douglas, O., Kamalian, L., Jenkins, R. E., Beckett, A. J., Penman, S. L., . . . Chadwick, A. E. (2020). The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.. Toxicology and applied pharmacology, 403, 115163. doi:10.1016/j.taap.2020.115163DOI: 10.1016/j.taap.2020.115163
Penman, S. L., Carter, A. S., & Chadwick, A. E. (n.d.). Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity. Biochemical Society Transactions. doi:10.1042/bst20190233DOI: 10.1042/bst20190233
Penman, S. L., Jensen, R. L., Kiy, R. T., & Chadwick, A. E. (2020). Anti-Cancer Drugs: The mitochondrial paradox. eLife, 9. doi:10.7554/elife.59140DOI: 10.7554/elife.59140
Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-xDOI: 10.1038/s41573-019-0048-x
2019
Penman, S. L., Sharma, P., Aerts, H., Park, B. K., Weaver, R. J., & Chadwick, A. E. (2019). Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells. TOXICOLOGY IN VITRO, 61. doi:10.1016/j.tiv.2019.104595DOI: 10.1016/j.tiv.2019.104595
Leedale, J., Colley, H. E., Gaskell, H., Williams, D. P., Bearon, R. N., Chadwick, A. E., . . . Webb, S. D. (2019). In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12, 100093. doi:10.1016/j.comtox.2019.100093DOI: 10.1016/j.comtox.2019.100093
Penman, S. L., Sharma, P., Park, B. K., Aerts, H., Weaver, R. J., & Chadwick, A. E. (2019). Elucidating the role of mitochondrial dysfunction in drug-induced intrahepatic cholestasis. In TOXICOLOGY LETTERS Vol. 314 (pp. S43-S44). Retrieved from https://www.webofscience.com/
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2019). Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.. Current protocols in toxicology, 80(01). doi:10.1002/cptx.76DOI: 10.1002/cptx.76
Kelly, R., Leedale, J. A., Calleja, D., Enoch, S., Harrell, A., Chadwick, A., & Webb, S. (2019). Modelling changes in glutathione homeostasis as a function of quinone redox metabolism. Scientific Reports, 9. doi:10.1038/s41598-019-42799-2DOI: 10.1038/s41598-019-42799-2
Thaventhiran, T., Wong, W., Alghanem, A. F., Alhumeed, N., Aljasir, M. A., Ramsey, S., . . . Sathish, J. G. (2019). CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.. Monoclonal antibodies in immunodiagnosis and immunotherapy, 38(2), 60-69. doi:10.1089/mab.2018.0042DOI: 10.1089/mab.2018.0042
2018
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2018). The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity. TOXICOLOGY IN VITRO, 53, 136-147. doi:10.1016/j.tiv.2018.08.001DOI: 10.1016/j.tiv.2018.08.001
Kelly, R. A., Leedale, J. A., Harrell, A., Beard, D. A., Randle, L. E., Chadwick, A. E., & Webb, S. D. (2018). Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13(11). doi:10.1371/journal.pone.0207803DOI: 10.1371/journal.pone.0207803
Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon bioenergetic function and susceptibility to hepatotoxicity (Journal article)
Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2018). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon bioenergetic function and susceptibility to hepatotoxicity. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1859, e113. doi:10.1016/j.bbabio.2018.09.334DOI: 10.1016/j.bbabio.2018.09.334
Evaluating Mitotoxicity as Either a Single or Multi‐Mechanistic Insult in the Context of Hepatotoxicity (Chapter)
Ball, A. L., Kamalian, L., Jolly, C. E., & Chadwick, A. E. (2018). Evaluating Mitotoxicity as Either a Single or Multi‐Mechanistic Insult in the Context of Hepatotoxicity. In Unknown Book (pp. 73-92). Wiley. doi:10.1002/9781119329725.ch6DOI: 10.1002/9781119329725.ch6
2017
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development (Chapter)
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4DOI: 10.1016/B978-0-12-409547-2.12384-4
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article)
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159DOI: 10.1038/ncomms15159
Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention (Journal article)
Yang, M., Chadwick, A., Dart, C., Kamishima, T., & Quayle, J. (2017). Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention. PLoS One, 12(5). doi:10.1371/journal.pone.0177951DOI: 10.1371/journal.pone.0177951
Sharkey, J., Starkey Lewis, P. J., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.. Cytotherapy, 19(4), 555-569. doi:10.1016/j.jcyt.2017.01.003DOI: 10.1016/j.jcyt.2017.01.003
Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-yDOI: 10.1007/s00204-016-1694-y
2016
Ball, A. L., Kamalian, L., Alfirevic, A., Chadwick, A. E., & Lyon, J. J. (2016). Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells. Toxicological Sciences, 153(02), 341-351. doi:10.1093/toxsci/kfw126DOI: 10.1093/toxsci/kfw126
2015
Kamalian, L., Chadwick, A., Bayliss, M., French, N., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.. Toxicology in Vitro, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011DOI: 10.1016/j.tiv.2015.02.011
2014
Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs (Conference Paper)
Firman, J., Cain, K., Park, B. K., MacFarlane, M., & Chadwick, A. (2014). Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs. In TOXICOLOGY LETTERS Vol. 229 (pp. S61-S62). doi:10.1016/j.toxlet.2014.06.247DOI: 10.1016/j.toxlet.2014.06.247
2013
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)
La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536DOI: 10.1002/cmdc.201200536
Inside Cover: Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013) (Journal article)
La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Inside Cover: Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013). ChemMedChem, 8(5), 674. doi:10.1002/cmdc.201390016DOI: 10.1002/cmdc.201390016
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)
La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. ChemMedChem, 8(5), 709-718.
2012
Copple, I. M., Mercer, A. E., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, B. K. (2012). Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18(7), 1045-1055. doi:10.2119/molmed.2012.00154DOI: 10.2119/molmed.2012.00154
Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials (Journal article)
Copple, I., Chadwick, A., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, K. (2012). Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. Molecular Medicine, 18, 1045-1055.
2011
Assessing the cytotoxic profile of novel endoperoxide derivatives (Conference Paper)
Firman, J. W., MacFarlane, M., Park, B. K., & Mercer, A. E. (2011). Assessing the cytotoxic profile of novel endoperoxide derivatives. In TOXICOLOGY Vol. 290 (pp. 138). doi:10.1016/j.tox.2011.09.065DOI: 10.1016/j.tox.2011.09.065
The elucidation of the mechanisms of bleomycin-induced cytotoxicity in alveolar type II cells <i>in</i> <i>vitro</i> (Conference Paper)
Jagota, B., Mercer, A. E., & Park, B. K. (2011). The elucidation of the mechanisms of bleomycin-induced cytotoxicity in alveolar type II cells <i>in</i> <i>vitro</i>. In TOXICOLOGY Vol. 290 (pp. 140). doi:10.1016/j.tox.2011.09.068DOI: 10.1016/j.tox.2011.09.068
The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations (Journal article)
Mercer, A. E., & Sallah, M. S. (2011). The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 7(4), 427-439. doi:10.1517/17425255.2011.557064DOI: 10.1517/17425255.2011.557064
The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)
Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(2), 987-996. doi:10.1074/jbc.M110.144188DOI: 10.1074/jbc.M110.144188
2010
Characterisation of bleomycin-induced cytotoxicity in mammalian alveolar type II cells (Conference Paper)
Anders, M. S., Mercer, A. E., & Park, B. K. (2010). Characterisation of bleomycin-induced cytotoxicity in mammalian alveolar type II cells. In TOXICOLOGY Vol. 278 (pp. 362). doi:10.1016/j.tox.2010.08.116DOI: 10.1016/j.tox.2010.08.116
The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials (Conference Paper)
Mercer, A. E., Copple, I. M., Maggs, J. L., & Park, B. K. (2010). The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials. In TOXICOLOGY Vol. 278 (pp. 358-359). doi:10.1016/j.tox.2010.08.110DOI: 10.1016/j.tox.2010.08.110
Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319dDOI: 10.1039/b924319d
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines (Journal article)
Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035DOI: 10.1016/j.bmc.2010.02.035
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. Organic and Biomolecular Chemistry, 8(9), 2068-2077.
2009
Mechanism-based bioanalysis and biomarkers for hepatic chemical stress (Journal article)
Antoine, D. J., Mercer, A. E., Williams, D. P., & Park, B. K. (2009). Mechanism-based bioanalysis and biomarkers for hepatic chemical stress. XENOBIOTICA, 39(8), 565-577. doi:10.1080/00498250903046993DOI: 10.1080/00498250903046993
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis (Journal article)
Mercer, A. E., Regan, S. L., Hirst, C. M., Graham, E. E., Antoine, D. J., Benson, C. A., . . . Park, B. K. (2009). Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 239(3), 297-305. doi:10.1016/j.taap.2009.05.027DOI: 10.1016/j.taap.2009.05.027
Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Antitumour and antimalarial activity of artemisinin–acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J. I., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells (Journal article)
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017DOI: 10.1016/j.bmc.2008.12.017
The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials (Journal article)
Mercer, A. E. (2009). The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 12(1), 125-132. Retrieved from https://www.webofscience.com/
2007
Biochemical and toxicological consequences of methapyrilene bioactivation (Conference Paper)
Hirst, C., Dalton-Brown, E., Regan, S., Benson, C., Mercer, A., Carr, D., . . . Park, K. (2007). Biochemical and toxicological consequences of methapyrilene bioactivation. In TOXICOLOGY Vol. 240 (pp. 154-155). doi:10.1016/j.tox.2007.06.076DOI: 10.1016/j.tox.2007.06.076
Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs (Journal article)
Stocks, P. A., Bray, P. G., Barton, V. E., Al‐Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie, 119(33), 6394-6399. doi:10.1002/ange.200604697DOI: 10.1002/ange.200604697
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs (Journal article)
Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(33), 6278-6283. doi:10.1002/anie.200604697DOI: 10.1002/anie.200604697
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds (Journal article)
Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2007). Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9372-9382. doi:10.1074/jbc.M610375200DOI: 10.1074/jbc.M610375200
2006
Anticancer activity of artemisinin-derived trioxanes (Journal article)
Posner, G. H., D'Angelo, J., O'Neill, P. M., & Mercer, A. (2006). Anticancer activity of artemisinin-derived trioxanes. EXPERT OPINION ON THERAPEUTIC PATENTS, 16(12), 1665-1672. doi:10.1517/13543776.16.12.1665DOI: 10.1517/13543776.16.12.1665
Evidence for carbon-centred radical involvement in the induction of apoptotic cell death by artemisinin compounds (Journal article)
Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2006). Evidence for carbon-centred radical involvement in the induction of apoptotic cell death by artemisinin compounds. DRUG METABOLISM REVIEWS, 38, 171. Retrieved from https://www.webofscience.com/
Evidence for carbon-centred radical involvement in the induction of apoptotic cell death by artemisinin compounds (Conference Paper)
Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2006). Evidence for carbon-centred radical involvement in the induction of apoptotic cell death by artemisinin compounds. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 34-35). Retrieved from https://www.webofscience.com/
2005
Biochemical aspects of the toxicity of endoperoxides (Conference Paper)
Mercer, A. E., O'Neil, P. M., Williams, D. P., & Park, B. K. (2005). Biochemical aspects of the toxicity of endoperoxides. In TOXICOLOGY Vol. 213 (pp. 258-259). Retrieved from https://www.webofscience.com/
Biochemical aspects of the toxicity of endoperoxides. (Journal article)
Mercer, A. E., O'Neill, P. M., Williams, D. P., & Park, B. K. (2005). Biochemical aspects of the toxicity of endoperoxides.. Toxicology, 3(213), 258-259.
The Chemical and Molecular Basis of Endoperoxide-Mediated Cell Death in Human Cell Lines (Thesis / Dissertation)
Mercer, A. E. (2005). The Chemical and Molecular Basis of Endoperoxide-Mediated Cell Death in Human Cell Lines. (PhD Thesis, The University of Liverpool).
2004
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin (Journal article)
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974cDOI: 10.1021/jm030974c
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin (Journal article)
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974cDOI: 10.1021/jm030974c