The LBIH Biobank is an exciting new venture, created to help SMEs access high quality biosamples and data. The LBIH Biobank has been jointly funded by the University of Liverpool and the European Regional Development Fund (ERDF).
Based in the University of Liverpool, the LBIH Biobank has benefited by amalgamation with the Liverpool Tissue Bank (LTB). The LTB was one of the oldest tissue banks in the country and was established in 1993 from a charitable donation by the Candis Club, the charitable arm of Candis Magazine.
The LBIH Biobank collects biological samples (tissue and blood) from patients undergoing surgery, or biopsy procedure, for the treatment and diagnosis of a wide variety of medical conditions. These samples are banked to provide an invaluable resource for research groups investigating the molecular mechanisms involved in a range of medical conditions with the aim of devising new treatments and therapies. On average, the LBIH Biobank consents and collects biological samples (e.g. primary and metastatic tumours; blood) from over 800 patients per year.
As well as access to biosamples, the LBIH Biobank also provides SMEs and researchers with access to a range of histology based services. For more information, please click here to navigate to our Services section.
The LBIH Biobank also has available a number of Tissue Microarrays, which have been constructed from paraffin wax embedded tissue. Cores of tissue from multiple blocks from different cases can be placed onto a single recipient block to allow for the rapid staining of multiple cases. This provides an essential tool that can be utilised in a high throughput manner.
Aims of the Liverpool Bio-Innovation Hub (LBIH) Biobank
The primary aim of the LBIH Biobank is to promote collaboration and avoid wasteful competition in the use of limited and precious resources.
By collecting and storing tissue the LBIH Biobank is providing the foundation for:
- Research into the molecular mechanisms involved in disease development and its response to possible resistance to treatment
- The discovery and validation of new targets and biomarkers for detection, diagnosis, treatment stratification and development.
The LBIH Biobank will endeavour to make biosamples available to researchers provided that:
- the stated research objectives have been approved by the LBIH Biobank Governance Board
- the proposed research is covered by the scope of the donor consent covering the uses of biosamples
- the research is sufficiently funded and otherwise resourced
- the necessary biosamples can be sourced and supplied
- the research project is supported by the institution or organisation in which it will take place
- the researcher's organisation enters into a contract that governs the transfer and use of biosamples supplied
- the project is deemed to be of high priority in situations where there is competition for access to limited resources.
The LBIH Biobank is a member of the Confederation of Cancer Biobanks (CCB), an organisation whose members consist of a number of tissue and biobanks working together to promote transfer of knowledge between banks.
The use of human tissues for research purposes is tightly regulated by both national and local policies and procedures to which the LBIH Biobank strictly adheres to.
The LBIH Biobank is licensed by the Human Tissue Authority (HTA) and the collection and storage of biosamples has been ethically approved by the North West 5 Research Ethics Committee. The LBIH Biobank has Research Tissue Bank status with generic approval status for projects receiving material.
Each NHS Trust involved in the collection has approved the biobank locally. The University of Liverpool acts as the custodian of the donated data and samples. Issues such as consent, confidentiality and security of the data are guided by the Royal Liverpool and Broadgreen University Hospitals Trust and University of Liverpool research and ethics governance framework. These are informed in accordance to national policies and procedures and under conditions of the HTA licence.
Applicable regulation in the UK includes: