Clinical Trials Research Centre (Clinical Trials Unit)

Portfolio

Clinical Trial of Investigational Medicinal Products (CTIMP)

Study Topic Population Design Website
TORPEDO-CF Pseudomonas Eradication Paediatric - Cystic Fibrosis RCT Visit Website
SYCAMORE Adalumimab in paediatric uveitis secondary to juvenile idiopathic arthritis Paediatric - Arthritis RCT Visit Website
MYPAN Mycophenolate mofetil versus cyclophosphamide for  polyarteritis nodosa Paediatric - Polyarteritis RCT Visit Website
HUMOX Humidified oxygen versus standard oxygen therapy Paediatric - Asthma Pilot  
SANAD-II Standard and New Anti-epileptic Drugs Adult/Paediatric - Epilepsy RCT Visit Website
TAILOR TelmisArtan and InsuLin Resistance in HIV Adults - HIV RCT Visit Website
ECLIPSE Emergency treatment with LevetIracetam or Phenytoin in Status Epilepticus Paediatric RCT Visit Website
OVERT Botulinum toxin-A versus extended release tolterodine in the management of idiopathic overactive bladder in children: A randomised controlled trial Paediatric RCT  
PROTEKT Phase IIa, Randomised, Controlled, OpenLabel Trial of Rosuvastatin for the Prevention of AminoglycosideInduced Kidney Toxicity in Children with Cystic Fibrosis Paediatric RCT Visit Website
TREAT Assessing the efficacy and safety of methotrexate vs ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema in children Taskforce (TREAT) randomised controlled trial Paediatric RCT Visit Website
APTITUDE APTITUDE A phase II trial of Tocilizumab in anti-TNF refractory patients with JIA associated uveitis Paediatric RCT Visit Website
DEX ENCEPH COrticosteroids in Herpes SImplex Virus Encephalitis Adult/Paediatric   Visit Website
RAPID Phase IIb, randomised, double-blind placebo- controlled, multi-centre trial of infliximab with transcriptomic biomarker and mechanism evaluation in patients with acute pancreatitis Adult (18-85) Randomised, double-blind, placebo-controlled, multicentre trial, employing and adaptive design with two interim analyses Visit Website
PIROUETTE A double-blind randomised controlled trial of Pirfenidone in patients with heart failure and preserved ejection fraction Adults – heart failure RCT Visit Website
CHERRY Feasibility Study on the effects of L-Citrulline on uteroplacental and Cardiovascular function in hypertensive pregnant women Pregnant Women Double-blinded, randomised- controlled feasibility study  

Non -CTIMP Clinical Trials

Study Topic Population Design Website
SAFE Seizure first aid training for epilepsy (pilot) Epilepsy Pilot Visit Website
EDIBLE Epilepsy - Strategies to improve diagnosis, prevention and treatment Paediatric - Epilepsy   Visit Website
ISDR Screening for diabetic retinopathy  Adults - Diabetes RCT visit website
DENTALRECUR Primary care service to reduce the re-occurrence of childhood dental caries Adult / Paediatric - Dental RCT Visit Website
ENCEPH Encephalitis  -implementation of guidelines Adult / Paediatric - Encephalitis Cohort and Cluster RCT Visit Website
SLUMBRS Sleep position in cleft babies (SLUMBERS) feasibility Paediatric RCT  
ACORN Improving oral health in cleft lip and/or palate: A health promotion Paediatric Health Promotion  
REACT An online randomised controlled trial to evaluate the clinical and cost effectiveness of the Relatives Education And Coping Toolkit (REACT) Adult RCT Visit Website
FOUNDATION Feasibility study of a trial of bilateral cochlear implantation in adults Adults with profound deafness Feasibility Study Visit Website
NAMASTE The Namaste Care intervention to improve the quality of dying for people with advanced dementia living in care homes: A realist review and feasibility study for cluster randomised controlled trial Adults with advanced dementia Feasibility study for a cluster randomised controlled trial Visit Website

Surgical Clinical Trials  (Including devices)

Study Topic Population Design Website
TOPS-CP Timing of Primary Surgery for Cleft Palate Paediatric - Cleft Palate RCT Visit Website
BASICS Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts Paediatric - Hydrocephalus RCT visit website
NERVES Transforaminal epidural steroid injection to surgical microdiscectomy for the treatment of acute lumbar radicular pain Adult RCT Visit Website

Devices Clinical Trials

Study Topic Population Design Website
PREVAIL Preventing Infection using Antibiotic Impregnated Long Lines Paediatric Open two-arm, multi-centre RCT visit website 

Research Methodology

Study Topic Population Design Website
EPIC Optimise methods for involving patient and public representatives in clinical trials:  a systematic investigation of a cohort of Health Technology Assessment funded clinical trials PPI Cohort Visit Website

Other Research Designs

Study Topic Population Design Website
  ReaDySpeech for people with dysarthria after stroke: a feasibility study. ADD   Feasibility  
  Core outcome set for anal cancer studies ADD   Core Outcome Set  
  Neighbourhoods and Dementia ADD   Core Outcome Set  
IVIS Impact of Visual Impairment after Stroke (IVIS) Vision   Visit Website
ROAM Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial (The ROAM trial) Adult (16+) Open two-arm, multi-centre RCT Visit Website
BOSS British Orthopaedic Surgery and Surveillance Study Paediatric Prospective Cohort Study Visit Website
NOVEMBR Non-invasive ventilation in the management of children with bronchiolitis: A feasibility study Paediatric- bronchiolitis Feasibility, Delphi Visit Website

Contact:

Jo Gardner
Administrator
Clinical Trials Research Centre
University of Liverpool

Telephone: 0151 795 8751
Facsimile: 0151 795 8770

Email: jogard@liverpool.ac.uk

Postal address:

Institute of Child Health
Alder Hey Children's Hospital
Eaton Road, Liverpool
L12 2AP