Some of our current work and applications include:
Epilepsy
- The identification of preoperative imaging biomarkers of postoperative seizure outcome in patients with refractory focal epilepsy.
- The development and application of network imaging approaches to identify novel prognostic markers of anti-epileptic drug treatment outcome in newly diagnosed epilepsy.
- The use of quantitative neuroimaging to understand cognitive dysfunction in focal epilepsy.
- The prediction of epilepsy from a first seizure using MRI, electrophysiological and biological approaches.
- The development of MRI analysis tools for the automated detection of epileptogenic lesions causing seizures.
- The application of novel MRI techniques to differentiate intra-axonal and extra-axonal changes in epilepsy.
- Understanding brain structural and functional connectivity alterations in genetic generalised epilepsy.
Movement disorders
- The identification of architectural pathways affected in the early stages of Parkinson’s disease
- Predicting deep brain stimulation treatment outcomes in movement disorders
- Neuroimaging-genomic studies in Parkinson’s disease
- Understanding of the relationships between brain alterations, inter-individual symptomatology and cognitive decline in movement disorders
- Understanding the mechanisms and predicting treatment outcomes in cervical dystonia.
Neurodegeneration
- Imaging biomarkers in Alzheimer’s disease
- Understanding central and peripheral neurodegeneration in prediabetes and early Type 2 diabetes
- Understanding how brain injury can lead to dementia.
Infectious diseases
- Neuroimaging studies in patients with post-acute COVID-19
- Determining the relationship between neuropsychological impairment and brain damage in encephalitis
- The development of quantitative neuroimaging markers of drug treatment outcome in herpes simplex encephalitis and autoimmune encephalitis
- Quantitative neuroimaging in Neurocysticercosis and the identification of clinical and imaging factors associated with the presentation of intractable seizures.
Pain
- Neuroimaging studies in patients with chronic post-stroke pain
- Using lesion mapping, connectomics and fMRI to predict the development of pain following a stroke
- Predicting transcranial magnetic stimulation treatment outcomes in post-stroke pain
- Understanding the role of the primary somatosensory cortex in normal and pathological pain.
Anatomical basis of language lateralisation
- Studying the relationship between cerebral structural asymmetry and language lateralisation in healthy people
- Identifying structural and functional brain connectivity markers of language lateralisation
- Determining the effects of reorganised language and cognitive functioning in neurological disorders.
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