Where innovators meet
The Institute of Translational Medicine is a melting pot of exciting ideas and research collaborations that cross scientific boundaries.
Over 500 of our own researchers are joined in the institute by experts from top institutes, healthcare providers and bioscience organisations.
Liverpool’s large, complex hospital population provides fertile ground for clinical research and attracts some fine clinicians, many of whom collaborate with the institute.
Our facilities meanwhile are amongst the UK’s best and include a large array of mass spectrometers, as well as support from a thought-leading team of Biostatisticians.
As a well-funded, open-minded institute we’re always ready to explore potential research projects and collaborations with people and organisations. Contact us any time.
Finally, here are some examples of the groundbreaking basic science and life-changing therapies we’re involved in.
Antiretroviral drug-drug interaction research
Members of the Department of Pharmacology have developed a website (http://www.hiv-druginteractions.org/) and, most recently, an iPhone app that allows doctors to look up any drug used in the treatment of HIV and identify potentially harmful drug interactions.
Protecting patients from the side effects of drugs is an important part of the research in the Department of Pharmacology. Their research has revealed a genetic predisposition to serious adverse reactions from a drug used to treat epilepsy, carbamazepine (McCormack et al. (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 364, 1134-1143.) [http://www.ncbi.nlm.nih.gov/pubmed/21428769]. This has resulted in changes to drug labelling, clinical practice and guidelines and a reduction in adverse reactions.
New treatments for Crohn's disease (Rhodes, Campbell)
Researchers in the Department of Gastroenterology have demonstrated that certain bacteria, particularly E. Coli, are involved in the development of Crohn's disease, an inflammatory disease of the human bowel. In collaboration with a commercial partner (Provexis plc), they are investigating whether soluble dietary plant fibres, especially those obtained from plantains (green bananas), block the interactions between these bacteria and intestinal cells and are therefore useful for treating Crohn's disease.
Improving child birth
Members of the Department of Cellular and Molecular Physiology have worked closely with clinical groups at the Department of Women and Children’s Health to establish the new Centre for Better Births, which will integrate the latest findings from basic and clinical research to reduce risk during pregnancy and child-birth.
A new ‘moonlighting’ function for Clathrin (Royle)
Recent research has shown that in addition to its well-known role in membrane transport, clathrin can also stabilise microtubules within the mitotic spindle. This work has important implications for understanding how cells safeguard against chromosome mis-segregation, a key factor in both cancer and Down's syndrome.