1994 intake

Guy Bate

Bate, G.W., Varro, A., Dimaline, R., Dockray, G.J. (1996) Control of preprogastrin messenger RNA translation by gastric acid in the rat Gastroenterology 111: 1224-1229.

Varro, A., Dockray, G.J., Bate, G.W., Higham, A., Armitage, E., Thompson, D.G. (1997) Gastrin biosynthesis in the antrum of pernicious anaemia patients. Gastroenterology 112, 733-741.

Macro, J.A., Bate, G.W., Varro, A., Vaillant, C., Seidah, N., Dimaline, R., Dockray, G.J. (1997) Regulation by gastric acid of the processing of progastrin-derived peptides in rat antral mucosa. J. Physiol. 502, 409-419.

Hussain,I, Bate,G.W, Henry,J, Djali,P, Dimaline,R, Dockray,G.J, Varro,A (1999) : Modulation of gastrin processing by vesicular monoamine transporter type 1 (VMAT1) in rat gastrin cells. J.Physiol. London, 517, 495-505.

Luke Chamberlain

Chamberlain, L.H., Roth, D., Morgan, A., Burgoyne, R.D. (1995) Distinct effects of a-SNAP, 14-3-3 proteins and calmodulin on priming and triggering of regulated exocytosis. J. Cell Biol. 130: 1063-1071.

Burgoyne, R.D., Morgan, A., Barnard, R.J.O., Chamberlain, L.H., Glenn, D.E., Kibble, A.V. (1996). SNAPs and SNAREs in exocytosis in chromaffin cells. Biochem. Soc. Trans. 24: 653-657.

Chamberlain, L.H., Burgoyne, R.D. (1996) Identification of a novel cysteine string protein variant and expression of cysteine string proteins in non-neuronal cells. J. Biol. Chem. 271: 7320-7323.

Chamberlain, L.H., Henry, J., Burgoyne, R.D. (1996) Cysteine string proteins are associated with chromaffin granules. J. Biol. Chem. 271: 19514-19517.

Chamberlain, L.H., Burgoyne, R.D. (1997) Activation of the ATPase activity of heat shock proteins Hsc70/Hsp70 by cysteine-string proteins. Biochem. J. 322, 853-858.

Chamberlain, L.H., Burgoyne, R.D. (1997) The molecular chaperone function of the secretory vesicle cysteine string proteins. J. Biol. Chem. 272, 31420-31426.

Chamberlain, L.H., Burgoyne, R.D. (1998) The cysteine-string domain of the secretory vesicle cysteine-string protein is required for membrane targeting. Biochem. J. 335: 205-209.

Zhang, H., Kelley, W.L., Chamberlain, L.H., Burgoyne, R.D. Wollheim, C.B., Lang, J. (1998) Cysteine-string protein regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Letters 437: 267-272.

Chamberlain, L.H., Burgoyne, R.D. (1998) Cysteine-string protein functions directly in regulated exocytosis. Mol. Biol. Cell 9: 2259-2267.

Zhang,H, Kelley,W.L, Chamberlain,L.H, Burgoyne,R.D, Lang,J.C (1999) Mutational analysis of cysteine-string protein function in insulin exocytosis. J.Cell Science, 112,1345-1351.

Chamberlain, L.H. Burgoyne,R.D. (2000) Cysteine-string protein: the chaperone at the synapse. J. Neurochem. 74, 1781-1789.

Evans, G.J.O., Wilkinson, M.C., Graham, M.E., Turner, K.M., Chamberlain, L.H., Burgoyne, R.D. and Morgan, A. (2002) Phosphorylation of cysteine string protein by PKA: implications for the modulation of exocytosis. J. Biol. Chem. 276, 47877-47885.

Peter Djali

Djali, P.K., Dimaline, R., Dockray, G.J. (1998) Novel form of non - L-aromatic amino acid decarboxylase mRNA in rat antral mucosa. Exp. Physiol. 83: 617-627.

Hussain,I, Bate,G.W, Henry,J, Djali,P, Dimaline,R, Dockray,G.J, Varro,A (1999) : Modulation of gastrin processing by vesicular monoamine transporter type 1 (VMAT1) in rat gastrin cells. J.Physiol. London, 517, 495-505.

Daphne Glenn

Glenn, D.E., Burgoyne, R.D. (1996) Botulinum neurotoxin light chains inhibit both Ca2+-induced and GTP analogue-induced catecholamine release from permeabilised adrenal chromaffin cells. FEBS Letters. 386: 137-140.

Burgoyne, R.D., Morgan, A., Barnard, R.J.O., Chamberlain, L.H., Glenn, D.E., Kibble, A.V. (1996). SNAPs and SNAREs in exocytosis in chromaffin cells. Biochem. Soc. Trans. 24: 653-657.

Glenn, D.E., Thomas, G.M.H., O’Sullivan, A.J., Burgoyne, R.D. (1998) Examination of the role of ADP-ribosylation factor and phospholipase D activation in regulated exocytosis in chromaffin and PC12 cells. J. Neurochem. 71, 2023-2033.

Matthew Lancaster

Diaz, M.E., Cook, S.J., Chamunorwa, J.P., Trafford, A.W., Lancaster, M., O’Neill, S.C., Eisner, D.A. (1996) Variability of spontaneous Ca release between different rat ventricular myocytes is correlated with Na/Ca exchange and intracellular Na concentration. Circ. Res. 78: 857-862.

Cook, S.J., Chamunorwa, J.P., Lancaster, M.K., O’Neill, S.C. (1997) Regional differences in rest effects on contraction: the role of sodium regulation and action potential configuration. Pflügers Archiv. 433: 515-522.

Lancaster, M.K., Cook, S.J. (1997) The effects of levosimendan on [Ca2+]i in guinea-pig isolated ventricular myocytes. Eur. J. Pharmacol. 339: 97-100.

Lancaster, M.K., Bennett, D.L., Cook, S.J., O'Neill, S.C. (2000) Na/K pump alpha subunit expression in rabbit ventricle and regional variations of intracellular sodium regulation. Pflügers Arch. 440: 735-739.

1995 intake

Colin Blackmore

Bishop, L., Dimaline, R., Blackmore, C., Deavall, D., Dockray, G.J., Varro, A. (1998). Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation. Gastroenterology 115: 1154-1162.

Higham, A.D, Bishop, L.A, Dimaline, R, Blackmore, C.G, Dobbins, A.C, Varro, A, Thompson, D.G, Dockray, G.J (1999) Mutations of Regl alpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology 116, 1310-1318.

Blackmore, C.D., Varro,A., Dimaline, R., Bishop,L., Gallacher,D.V., Dockray,G.J.(2000) Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage. J.Physiol. 531, 605-617.

Naomi Buttell

Naderali, E.K., Buttell, N., Taggart, M.J., Bullock, A.J., Eisner, D.A., Wray, S. (1997) The role of the sarcolemmal Ca-ATPase in the pH transients associated with contraction in rat smooth muscle. J. Physiol. 505, 329-336.

Bullock, A.J., Duquette, R.A., Buttell, N., Wray,S. (1998) Developmental changes in intracellular pH buffering power in smooth muscle. Pflügers Archiv. 435, 575-577.

Larcombe-McDouall,J, Buttell,N, Harrison,N, Wray,S (1999) In vivo pH and metabolite changes during a single contraction in rat uterine smooth muscle. J. Physiol. 518, 783-790.

Madelaine Craske

Craske,M., Takeo,T., Gerasimenko,O., Vaillant,C., Torok,K., Petersen,O., Tepikin,A.V. (1999) Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with nucleus as an integator. Proc. Natl. Acad. Sci. 96, 4426-4431.

Takeo, T., M. Craske, M. Ashby, P.Belan, O. Gerasimenko, J. Gerasimenko, O.H. Petersen, A.V. Tepikin. (2000) Calcium and calmodulin signalling in pancreatic acinar cells. In Calcium Signaling, NATO Science Series, Life and Behaviour Sciences, V. 331: 183 - 189.

Ashby, M.C., Craske, M., Park, K.P., Gerasimenko, O.V., Burgoyne, R.D., Petersen, O.H. & Tepikin, A.V. (2002) Localised Ca2+ uncaging reveals polarized distribution of Ca2+ sensitive Ca2+ release sites: mechanisms of unidirectional Ca2+ waves. J. Cell Biol. 158, 283-292.

Catherine Overend

Overend, C.L., Eisner, D.A., O’Neill, S.C. (1997). The effect of tetracaine on spontaneous Ca release and sacroplasmic reticulum content in rat ventricular myocytes. J. Physiol., 471-479.

Eisner, D.A., Trafford, A.W., Diaz, M.E., Overend, C.L., O’Neill, S.C. (1998) The control of Ca release from the cardiac sarcoplasmic reticulum, regulation versus autoregulation. Cardio. Res. 38: 589-604.

Overend, C.L., O’Neill, S.C., Eisner, D.A. (1998) The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca2+ content and membrane current in isolated rat ventricular myocytes. J. Physiol. 507: 759-769.

Overend,C.L., Eisner, D.A. & O'Neill, S.C. (2001). Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition. Circ. Res. 88 181-187.

Kate Turner

Turner,K.M., Burgoyne,R.D., Morgan,A. (1999) Protein phosphorylation and the regulation of synaptic membrane traffic. Trends Neurosci. 22, 459-464.

Evans, G.J.O., Wilkinson, M.C., Graham, M.E., Turner, K.M., Chamberlain, L.H., Burgoyne, R.D. and Morgan, A. (2002) Phosphorylation of cysteine string protein by PKA: implications for the modulation of exocytosis. J. Biol. Chem. 276, 47877-47885.

1996 intake

Damian Deavall

Bishop, L., Dimaline, R., Blackmore, C., Deavall, D., Dockray, G.J., Varro, A. (1998). Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation. Gastroenterology 115: 1154-1162.

Watson,F, Deavall,D.G, Macro,J.A, Kiernan,R, Dimaline,R (1999) Transcriptional activation of vesicular monoamine transporter 2 in the pre-B cell line Ea3.123. Biochem. J. 337, 193-199.

Murai, A, Noble, PJ, Deavall, DG, Dockray, GJ (2000) Control of c-fos expression in STC-1 cells by peptidomimetic stimuli. Eur. J. Pharmacol. 394: 27-34.

Deavall,D.G., Raychowdury,R., Dockray,G.J., Dimaline,R. (2000) Control of CCK gene expression by PACAP in STC-1. Am J. Physiol., 279, G605-G612.

Watson, F., Kiernan, R.S., Deavall, D.G., Varro, A. Dimaline, R.D. (2001) Transcriptional activation of the rat vesicular monoamine transporter 2 promoter in gastric epithelial cells: Regulation by gastrin J. Biol. Chem. 276 7661-7671.

Richard Fisher

Fisher, R.J., Burgoyne, R.D. (1999) The effect of transfection with botulinum neurotoxin C1 light chain on exocytosis measured in cell populations and by a single cell amperometry in PC12 cells. Pflügers Arch. Eur.J. Physiol. 437, 754-762.

Graham, M.E.., Fisher,R.J. & Burgoyne,R.D. (2000) Measurement of exocytosis by amperometry in adrenal chromaffin cells: effects of clostridial neurotoxins and activation of protein kinase C on fusion pore kinetics. Biochimie 82: 469-479.

Fisher, R.J., Pevsner, J. & Burgoyne R.D. (2001) Control of fusion pore dynamics during exocytosis by munc18. Science 291 875-878.

Burgoyne,R.D., Fisher, R.J., Graham, M.E., Haynes, L.P. & Morgan, A. (2001) Control of membrane fusion dynamics during regulated exocytosis. Biochem. Soc. Trans. 29, 467-472.

Burgoyne, R.D., Fisher, R.J. & Graham, M.E. (2001) Regulation of kiss-and-run exocytosis. Trends Cell Biol. 11, 404-405.

Lee Haynes

Haynes, L.P., Barnard, R.J.O., Morgan, A. Burgoyne, R.D. (1998) Stimulation of NSF ATPase activity during t-SNARE priming. FEBS Letters 436, 1-5.

Haynes,L.P., Morgan,A., Burgoyne,R.D. (1999) nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules. Biochem. J. 342, 707-714.

Haynes, L.P., Evans. G.J.O., Morgan, A. & Burgoyne, R.D. (2001) A direct inhibitory role for the Rab3 specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. J Biol. Chem. 276 9726-9732.

Burgoyne,R.D., Fisher, R.J., Graham, M.E., Haynes, L.P. & Morgan, A. (2001) Control of membrane fusion dynamics during regulated exocytosis. Biochem. Soc. Trans. 29, 467-472.

Ian Mills

Jones, A.T., Mills, I.G., Scheidig, A.J., Alexandrov, K., Clague, M.J. (1998) Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Mol. Biol. Cell. 9: 323-332.

Mills, I.G., Jones, A.T., Clague, M.J. (1998) Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Current Biology 8: 881-884.

Mills,I.G., Jones,A.T. Clague,M.J. (1999) Regulation of endosome fusion. Mol. Membran. Biol. 16, 73-79.

Clague,M.J, Jones,A.T, Mills,IG, Walker,D.M, Urbe,S (1999) Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. Biochem. Soc. Trans. . 27, 662-666.

Urbé S, Mills IG, Stenmark H, Kitamura N, Clague MJ (2000) Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. Mol. Cell. Biol. 20, 7685-7692.

Mills,I.G., Urbé,S. and Clague,M.J. (2001) Relationships between EEA1 binding partners and their role in endosome fusion. J. Cell Sci., 114, 1959-1965

Gillian Sibbring

Trafford, AW, Diaz, ME, Sibbring, GC, Eisner, DA (2000) Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes. J. Physiol. 522: 259-270.

Trafford, A.W., Sibbring, G.C., Díaz, M.E. & Eisner, D.A. (2000). The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes. Cell Calcium 28, 267-274.

1997 intake

Mark Cuff

Cuff, M., Lambert, D, Shirazi-Beechey, S. (2002) Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J. Physiol. 539, 361-371.

Cuff, M., Shirazi-Beechey, S. (2002) The human monocarboxylate transporter, MCT1: Genomic organisation and promoter analysis.. Biochem and Biophys. Re. Comm. 292, 1048-1056.

Cuff MA & Shirazi-Beechey SP (2004). The importance of butyrate transport to the regulation of gene expression in the colonic epithelium. Invited review; Biochem Soc Trans 32, 1100-1102.

Cuff M, Dyer J, Jones M, & Shirazi-Beechey SP (2005). The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. Gastroenterology 128, 676-686.

Cuff MA, & Shirazi-Beechey SP (2005). The Human Monocarboxylate Transporter MCT1: Gene Structure and Regulation. Am J Physiol Gastrointest Liver Physiol 289, G977.

Daly K, Cuff MA, Fung F, & Shirazi-Beechey SP (2005). The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis. Invited Review, Biochem Soc Trans 33, 733-735.

Alex Harmer

Smith, PM, Harmer, AR, Letcher, AJ, Irvine, RF (2000) The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells Biochem. J. 347: 77-82.

Harmer,A.R., Gallacher,D.V. and Smith, P.M. (2001) Role of Ins(1,4,5)P3, cADP-ribose and nicotinic acid-adenine dinucleotide phosphate in Ca2+ signalling in mouse submandibular acinar cells. Biochem. J., 353, 555-560.

Dawson, L.J., Field, E.A., Harmer, A.R. and Smith, P.M. (2001) Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjogren's syndrome. Clinical Exp. Immunol. 124, 480-485.

Harmer, A.R., Gallacher, D.V., Smith PM. (2002) Correlations between the functional integrity of the endoplasmic reticulum and polarized Ca2+ signalling in mouse lacrimal acinar cells: a role for inositol 1,3,4,5-tetrakisphosphate. Biochem J. 367, 137-43.

Harmer, A.R., Smith, P.M, and Gallacher, D.V. (2005) Local and global calcium signals and fluid and electrolyte secretion in mouse submandibular acinar cells. Am J Physiol Gastrointest Liver Physiol 288 G118-24

Zara Khan

Khan Z.E., Wang T.C., Cui G., Chi A.L., Dimaline R. (2003) Transcriptional Regulation of the Human Trefoil Factor, TFF1, by Gastrin. Gastroenterology 125, 510-521

Alex Laude

Steel, G.J., Laude, A.J., Boojawan, A., Harvey, D.J. and Morgan, A. (1999) Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: Implications for the molecular mechanism of membrane fusion. Biochemistry 38, 7764-7772.

Hocine Mankouri

Mankouri HW and Morgan A (2001) The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors. Mech. Ageing Dev. 122, 1107-1120.

Mankouri, H., Craig, T.J. & Morgan, A. (2002) SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. Nucleic Acids Res. 30, 1103-1113.

1998 intake

Michael Ashby

Ashby M.C. Tepikin A.V. (2000) ER calcium and the functions of intracellular organelles. Seminars in cell and developmental biology 12 11-17.

Takeo, T., M. Craske, M. Ashby, P.Belan, O. Gerasimenko, J. Gerasimenko, O.H. Petersen, A.V. Tepikin. (2000) Calcium and calmodulin signalling in pancreatic acinar cells. In Calcium Signaling, NATO Science Series, Life and Behaviour Sciences, V. 331: 183 - 189.

Park, M.K., Ashby, M.C., Erdemli, G., Petersen, O.H. and Tepikin, A.V. (2001). Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport. EMBO J. 20, 1863-1874.

O'Callaghan, D.W., Ivings, L., Weiss, J.L., Ashby, M.C., Tepikin, A.V., Burgoyne, R.D. (2002) Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+- signal transduction. J. Biol. Chem. 277,14227-14237

Ashby, M.C., Craske, M., Park, K.P., Gerasimenko, O.V., Burgoyne, R.D., Petersen, O.H. & Tepikin, A.V. (2002) Localised Ca2+ uncaging reveals polarized distribution of Ca2+ sensitive Ca2+ release sites: mechanisms of unidirectional Ca2+ waves. J. Cell Biol. 158, 283-292.

Ashby, M.C. & Tepikin, A.V. (2002) Polarized calcium and calmodulin signaling in secretory epithelia. Physiol. Rev. 82, 701-734.

Ashby, M.C., Petersen, O.H. and Tepikin, A.V. (2003) Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochem. J. 369, 441-445.

Ashby, M.C., Camello-Almaraz, C., Gerasimenko, O.V., Petersen, O.H. and Tepikin, A.V. (2003) Long-distance communication between muscarinic receptors and Ca2+-release channels revealed by carbachol uncaging in cell-attached patch pipette. J. Biol. Chem. 278, 20860-20864.

Dolman, N.J., Ashby, M.C., Park, M.K., Petersen, O.H. and Tepikin, A.V. (2005) Subcellular Compertmentalization of Calcium Signalling. In Methods in Calcium Signalling Research book published by CRC Press. (Ed. by J.W.Putney).

Dean Hammond

Hammond,D.E., Urbé,S., Vande Woude,G.F. and Clague,M.J. (2001) Down-regulation of MET, the receptor for hepatocyte growth factor. Oncogene, 20, 2761-2770.

Hammond,D.E., Carter,S. McCullough,J., Urbé,S. Vande Woude,G.F. and Clague, M.J. (2003) Endosomal dynamics determine Met signalling. Mol. Biol. Cell 14, 1346-1354.

Hammond,D.E., Carter,S. and Clague,M.J. (2004) Met receptor dynamics and signalling. Current Topics in Microbiology and Immunology, 286, 21-44.

Lenka Ivings

O'Callaghan, D.W., Ivings, L., Weiss, J.L., Ashby, M.C., Tepikin, A.V., Burgoyne, R.D. (2002) Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+- signal transduction. J. Biol. Chem. 277,14227-14237

Ivings,L., Pennington, S.R., Jenkins,R., Weiss, J.L. & Burgoyne, R.D. (2002) Identification of calcium-dependent binding partners for the neuronal calcium sensor protein neurocalcin d: interaction with actin, clathrin and tubulin. Biochem, J. 363, 599-608.

Rebecca Longbottom

Longbottom, ER, Luckas, MJ, Kupittayanant, S, Badrick, E, Shmigol, T, Wray, S (2000) The effects of inhibiting myosin light chain kinase on contraction and calcium signalling in human and rat myometrium. Pflügers Arch. 440: 315-321.

Voronina, S., Longbottom, R., Sutton, R., Petersen, O.H. & Tepikin, A. (2002) Bile acids induce calcium signals in mouse pancreatic acinar cells. Implications for bile-induced pancreatic pathology. J. Physiol. 540, 49-55.

Barrow SL, Voronina SG, da Silva Xavier G, Chvanov MA, Longbottom RE, Gerasimenko OV, Petersen OH, Rutter GA, Tepikin AV. (2008) ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Arch. 455, 1025-39.

Donna Walker

Clague,M.J, Jones,A.T, Mills,IG, Walker,D.M, Urbe,S (1999) Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. Biochem. Soc. Trans. . 27, 662-666.

Negretti, N, Perez, MR, Walker, D., O'Neill, SC (2000) Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. J. Physiol. 523: 367-375.

Walker, D.M., Urbé, S.,Dove, S.K., Tenza, D., Raposo, G.and Clague, M.J. (2001) Characterisation of MTMR3: an Inositol lipid 3-phosphatase with novel substrate specificity. Current Biol. 11, 1600-1605.

1999 intake

Deborah Archer

Weiss,J.L., Archer, D.A., Burgoyne, R.D. (2000) NCS-1/frequenin functions in an autocrine pathway regulating Ca2+ channels in bovine adrenal chromaffin cells. J. Biol. Chem. 275, 40082-40087.

Archer, D.A., Graham, M.E., Burgoyne, R.D. (2002) Complexin regulates the closure of the fusion pore during regulated exocytosis. J. Biol. Chem. 277, 18249-18252.

Varro A, Hemers E, Archer D, Pagliocca A, Haigh C, Ahmed S, Dimaline R, Dockray GJ. (2002) Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Gastroenterology 123, 271-80.

Rickman, C, Archer, D.A., Meunier, F.A., Craxton, M., Fukuda, M., Burgoyne, R.D. & Davletov, B. (2004) Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J. Biol. Chem. 279, 12574-12579.

Rickman, C., Jiménez, J.L., Graham,M.E., Archer, D.A., Soloviev, M., Burgoyne, R.D, & Davletov, B. (2006) Conserved pre-fusion protein assembly in regulated exocytosis. Mol Biol. Cell 17, 283-194.

Dermott O'Callaghan

Graham, M. E., O'Callaghan, D. W., McMahon, H. T., Burgoyne, R. D. (2002) Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc. Natl. Acad. Sci. USA 99, 7124-7129.

O'Callaghan, D.W., Ivings, L., Weiss, J.L., Ashby, M.C., Tepikin, A.V., Burgoyne, R.D. (2002) Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+- signal transduction. J. Biol. Chem. 277,14227-14237

O’Callaghan, D.W., Hasdemir, B., Leighton, M. & Burgoyne, R.D. (2003) Residues within the myristoylation motif determine intracellular targeting of the neuronal Ca2+ sensor protein KChIP1 to post-ER transport vesicles and traffic of Kv4 K+ channels. J. Cell Sci. 116, 4833-4845.

O’Callaghan, D.W. & Burgoyne, R.D. (2003) Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins. Biochem. Soc. Trans. 31, 963-965.

O’Callaghan, D.W. Tepikin, A.V. & Burgoyne, R.D.(2003) Dynamics and calcium-sensitivity of the calcium-myristoyl switch protein hippocalcin in living cells. J Cell Biol. 163, 715-721.

O'Callaghan, D.W., & Burgoyne, R.D (2004) Identification of residues that determine the absence of a Ca2+/myristoyl switch in Neuronal Calcium Sensor-1. J. Biol. Chem. 279, 14347-14354.

Burgoyne,R.D., O'Callaghan, D.W., Hasdemir, B., Haynes, L.P., Tepikin, A. (2004) Neuronal calcium sensor proteins: multitalented regulators of neuronal function. Trends Neurosci. 27, 203-209.

Felicity Ashcroft

Pagliocca A, Wroblewski LE, Ashcroft FJ, Noble PJ, Dockray GJ, Varro A. (2002) Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. Am J Physiol. 283, G292-299.

Ashcroft FJ, Varro A, Dimaline R, Dockray GJ. (2004) Control of Reg-1 expression by gastrin: role of RhoA and a C-rich promoter element. Biochem. J. 381 397-403.

Adelina Pagliocca

Pagliocca A, Wroblewski LE, Ashcroft FJ, Noble PJ, Dockray GJ, Varro A. (2002) Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. Am J Physiol. 283, G292-299.

Varro A, Hemers E, Archer D, Pagliocca A, Haigh C, Ahmed S, Dimaline R, Dockray GJ. (2002) Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Gastroenterology 123, 271-80.

Wroblewski, L.E., Noble, P-J.M., Pagliocca, A., Pritchard, D.M.. Hart, C.A. Campbell, F., Dodson, A.R., Dockray, G.J. and Varro, A. (2003) Stimulation of matrix metalloproteinase-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J. Cell Sci. 116, 3017-3026.

2000 intake

Stephanie Carter

Hammond,D.E., Carter,S. McCullough,J., Urbé,S. Vande Woude,G.F. and Clague, M.J. (2003) Endosomal dynamics determine Met signalling. Mol. Biol. Cell 14, 1346-1354.

Carter S, Urbé S, Clague MJ. (2004) The met receptor degradation pathway: requirement for Lys48-linkedpolyubiquitin independent of proteasome activity. J. Biol. Chem. 279 52835-9.

Hammond,D.E., Carter,S. and Clague,M.J. (2004) Met receptor dynamics and signalling. Current Topics in Microbiology and Immunology, 286, 21-44.

Tim Craig

Mankouri, H., Craig, T.J. & Morgan, A. (2002) SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. Nucleic Acids Res. 30, 1103-1113.

Barclay,J.W.*, Craig,T.J.*, Fisher,R.J., Ciufo,L.F., Evans,G.J.O. Morgan, A. and Burgoyne, R.D. (2003) Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. J Biol. Chem. 278, 10538-10545 
(* equal first authors)

Craig, T.J, Evans, G.J.O, and Morgan, A. (2003) Physiological regulation of Munc18/nSec1 phosphorylation on serine-313. J Neurochem 86 1450-1457.

Craig, T.J., Ciufo, L.F., Morgan, A. (2004) A protein-protein binding assay using coated microtitre plates: Increased throughput, reproducibility and speed compared to bead based assays. J. Biochem. Biophys. Meth. 60 49-60.

Barclay, J.W., Aldea, M. Craig, T.J., Morgan,A & Burgoyne, R,D, (2004) Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5. J. Biol. Chem. 279 41495-41503.

Morgan, A., Burgoyne, R.D., Barclay, J.W., Craig, T.J., Prescott, G.R., Ciufo, L.F., Evans, G.J.O. and Graham, M.E. (2005) Regulation of exocytosis by protein kinase C. Biochem. Soc. Trans. 33, 1341-1344

Yang, Y., Craig T.J., Ciufo, L.F., Takahashi, M., Morgan, A. and Gillis, K.D. (2007) Phosphomimetic mutation of Ser187 of SNAP-25 increases both syntaxin binding and a highly Ca2+ sensitive component of exocytosis. J. Gen. Physiol. 129, 233-44.

Nick Dolman

Dolman NJ, Tepikin AV, Petersen OH (2003). Generation and modulation of cytosolic Ca2+ signals in pancreatic acinar cells: techniques and mechanisms. Biochem Soc Trans. 31, 947-949.

Gerasimenko, J.V., Maruyama,Y. Yano, K., Dolman, N.J., Tepikin, A.V. Petersen, O.H. and Gerasimenko, O.V. (2003) NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J. Cell Biol. 163,271-282.

Johnson PR, Dolman NJ, Pope M, Vaillant C, Petersen OH, Tepikin AV, Erdemli G. (2003). Non-uniform distribution of mitochondria in pancreatic acinar cells. Cell and Tissue Research 313 37-45.

Dolman, N.J., Gerasimenko, J.V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H., and Tepikin, A. V. (2005) Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. J. Biol Chem., 280 15794-9.

Dolman, N.J., Ashby, M.C., Park, M.K., Petersen, O.H. and Tepikin, A.V. (2005) Subcellular Compertmentalization of Calcium Signalling. In Methods in Calcium Signalling Research book published by CRC Press. (Ed. by J.W.Putney).

Barrow, S. L., Sherwood, M. W., Dolman, N.J, Gerasimenko, O. V., Voronina, S. G. and Tepikin, A.V. (2006). Movement of calcium signals and calcium binding proteins – firewalls, traps and tunnels. Biochemical Society Transactions (in press).

Dolman NJ, Tepikin AV. (2006) Calcium gradients and the Golgi. Cell Calcium 40, 505-12.

Barrow SL, Sherwood MW, Dolman NJ, Gerasimenko OV, Voronina SG, Tepikin AV. (2006) Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels. Biochem Soc Trans. 34, 381-4.

Voronina S, Sherwood M, Barrow S, Dolman N, Conant A, Tepikin A. (2009) Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage.
Acta Physiol (Oxf). 195, 161-9.

Haynes, L.P., Sherwood, M.W., Dolman, N.J. & Burgoyne , R.D. (2007) Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III. Traffic 8, 1080-1092.

Elaine Hemmers

Varro A, Hemers E, Archer D, Pagliocca A, Haigh C, Ahmed S, Dimaline R, Dockray GJ. (2002) Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Gastroenterology 123, 271-80.

Hemers,E., Duval,C., McCaig,C., Handley,M., Dockray, G.J., Varro,A., (2005) Insulin-like growth factor binding protein-5 (IGFBP-5) is a target of matrix metalloproteinase-7 (MMP-7): implications for epithelial-mesenchymal signalling. Cancer Research, 65 7363-7369

2001 intake

Burcu Hasdemir

O’Callaghan, D.W.*, Hasdemir, B.*, Leighton, M. & Burgoyne, R.D. (2003) Residues within the myristoylation motif determine intracellular targeting of the neuronal Ca2+ sensor protein KChIP1 to post-ER transport vesicles and traffic of Kv4 K+ channels. J. Cell Sci. 116, 4833-4845. 
(* equal first authors)

Burgoyne,R.D., O'Callaghan, D.W., Hasdemir, B., Haynes, L.P., Tepikin, A. (2004) Neuronal calcium sensor proteins: multitalented regulators of neuronal function. Trends Neurosci. 27, 203-209.

Hasdemir, B., Fitzgerald, D.J., Prior, I.A., Tepikin, A.V. & Burgoyne, R.D (2005) Traffic of Kv4 K+channels mediated by KChIP1 is via a novel post-ER vesicular pathway. J .Cell Biol. 171, 459-469

Hasdemir, B. Tepikin, A & Burgoyne R.D. (2006) Imaging calcium and calcium-binding proteins. Methods Express: Cell Imaging , Stephens, D (ed.) Scion, Oxford pp 143-164

Dawson LJ., Stanbury J., Venn N., Hasdimir B., Rogers SN., and Smith PM (2006) Antimuscarinic antibodies in primary Sjögrens syndrome Reversibly Inhibit the Mechanism of Fluid Secretion by Human Submandibular Salivary Acinar Cells. Arthritis and Rheumatism.In Press

Rachel Floyd

Floyd R, Mobasheri A, Martin-Vasallo P, Wray S.(2003) Na,K-ATPase isoforms in pregnant and nonpregnant rat uterus. Ann N Y Acad Sci. 986, 614-616.

Floyd R, Wray S. (2007). Calcium transporters and signalling in smooth muscles. Cell Calcium. Oct-Nov;42(4-5):467-76

Noble K, Floyd R, Shmygol A, Shmygol A, Mobasheri A. & Wray S. (2010)Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Cell Calcium :47(1):47-54

Floyd, R.V, Wray S, Martin-Vasallo P, and Mobasheri A (2010). Differential cellular expression of FXYD1 and FXYD2 proteins in normal human tissues: a study using high density human tissue microarrays. Ann Anat. Feb 20;192(1):7-16.

Floyd, R.V., Wray, S., Quenby, S., Vasallo-Martin, P., Mobasheri, A. (2010) Expression and Distribution of Na, K-ATPase Isoforms in the Human Uterus. Reprod Sci Apr:17(4):366-76.

John McCullough

Hammond,D.E., Carter,S. McCullough,J., Urbé,S. Vande Woude,G.F. and Clague, M.J. (2003) Endosomal dynamics determine Met signalling. Mol. Biol. Cell 14, 1346-1354.

McCullough J, Clague MJ, Urbé S. (2004) AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol. 166 487-92.

McCullough J., Row P.E., Lorenzo, O. Doherty M., Beynon R., Clague M.J., Urbé S. (2006) Activation of the endosome associated deubiquitinating enzyme AMSH by STAM, a component of the multivesicular body pathway, Current Biology 16, 160-165.

McCullough,J., Clague,M.J. and Urbé,S. (2006) Ubiquitin and protein sorting to the lysosome. vol 3. Protein Degradation (Wiley-VCH) eds. Mayer,R.J. Ciechanover,A., Rechsteiner, M.

Row, P.E., Prior, I.A., McCullough, J., Clague, M.J. and Urbé, S. (2006) The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin and receptor dynamics, J. Biol. Chem. 281, 12618-12624.

Urbé,S., McCullough,J., Row,P.E., Welchman,R. and Clague,M.J. (2006) Control of growth factor receptor dynamics by reversible ubiquitination. Biochem Soc. Trans. 34, 754-756.

Kojiro Yano

Gerasimenko, J.V., Maruyama,Y. Yano, K., Dolman, N.J., Tepikin, A.V. Petersen, O.H. and Gerasimenko, O.V. (2003) NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J. Cell Biol. 163,271-282.

Yano K, Petersen OH, Tepikin AV. (2004) Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochem J. 383 353-60.

Nicole Gennet

Gennet, N., Herden, C., Bubb, V. J., Quinn, J. P. and Kipar, A. (2008) Expression of activity-dependent neuroprotective protein in the brain of adult rats. Histology and histopathology, 23, 309-317

2002 intake

Eleanor Spencer

Spencer, E. M., Chandler, K. E., Haddley, K. et al. (2006) Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models. Neurobiology of Disease, 24, 41-52.

Haddley, K., Spencer, E. M., Vasiliou, S. A., Howard, M., Thippeswamy, T., Bubb, V. J. and Quinn, J. P. (2011) Lithium chloride regulation of the substance P encoding preprotachykinin a, Tac1 gene in rat hippocampal primary cells. J Mol Neurosci, 45, 94-100.

Dan Fitzgerald

Dawson LJ, Allison HE, Stanbury J, Fitzgerald D, Smith PM. (2004) Putative anti-muscarinic antibodies cannot be detected in patients with primary Sjogren's syndrome using conventional immunological approaches. Rheumatology 43,1488-95.

Hasdemir, B., Fitzgerald, D.J., Prior, I.A., Tepikin, A.V. & Burgoyne, R.D (2005) Traffic of Kv4 K+channels mediated by KChIP1 is via a novel post-ER vesicular pathway. J .Cell Biol. 171, 459-469

Haynes, L.P.*, Fitzgerald, D.J.*, Wareing, B., O’Callaghan, D.W., Morgan, A. & Burgoyne,R.D. (2006) Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin d. Proteomics in press (* equal first authors)

Fitzgerald, D.J., Burgoyne, R.D. & Haynes, L.P. (2008) Neuronal calcium sensor proteins are unable to modulate NFAT activation in mammalian cells. Biochim Biophys Acta 1780, 240–248.

Markova,O.,Fitzgerald, D., Stepanyuk, A., Dovgan, A., Cherkas, V., Tepikin, A. Burgoyne, R.D. & Belan, P. (2008) Hippocalcin signalling via site specific translocation in hippocampal neurons. Neurosci Lett. 442, 152-157.

Dovgan, A.V., Cherkas, V.P., Stepanyuk, A.R., Fitzgerald, D.J,. Haynes,L.P., Tepikin, A.V., Burgoyne,R.D. & Belan, P.V. (2010) Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons. Eur J Neurosci. 32, 247-358.

Mark Sherwood

J. V. Gerasimenko, M Sherwood, A. V. Tepikin, O. H. Petersen and O. V. Gerasimenko. (2006) NAADP, cADPR or IP3 release Ca2+ from both the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci., in press.

Barrow SL, Sherwood MW, Dolman NJ, Gerasimenko OV, Voronina SG, Tepikin AV. (2006) Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels. Biochem Soc Trans. 34, 381-4.

Gerasimenko JV, Sherwood M, Tepikin AV, Petersen OH, Gerasimenko OV. (2006) NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J Cell Sci. 119, 226-38.

Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH, Tepikin AV. (2007)Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci USA. 104, 5674-9.

Voronina SG, Sherwood MW, Gerasimenko OV, Petersen OH, Tepikin AV. (2007) Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. Am J Physiol Gastrointest Liver Physiol. 293, G1333-8.

Murphy JA, Criddle DN, Sherwood M, Chvanov M, Mukherjee R, McLaughlin E, Booth D, Gerasimenko JV, Raraty MG, Ghaneh P, Neoptolemos JP, Gerasimenko OV, Tepikin AV, Green GM, Reeve JR Jr, Petersen OH, Sutton R. (2008) Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.
Gastroenterology 135, 632-41.

Voronina S, Sherwood M, Barrow S, Dolman N, Conant A, Tepikin A. (2009) Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage.
Acta Physiol (Oxf). 195, 161-9.

Haynes, L.P., Sherwood, M.W., Dolman, N.J. & Burgoyne , R.D. (2007) Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III. Traffic 8, 1080-1092.

2003 intake

Louise Ashurst

M. Ocejo-Garcia, T.A.S. Baokbah, H.L. Ashurst, D. Cowlishaw, I. Soomro, J. M. Coulson & P. J. Woll. (2005) Roles for USF-2 in lung cancer proliferation and bronchial carcinogenesis. J Pathol. 206,151-159

Ashurst HL, Varro A, Dimaline R.(2008) Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo.Exp Physiol. 93(2):223-36.

Catlow K, Ashurst HL, Varro A, Dimaline R. (2007) Identification of a gastrin response element in the vesicular monoamine transporter type 2 promoter and requirement of 20 S proteasome subunits for transcriptional activity. J Biol Chem. 282(23):17069-77.

Cedric Duval

Hemers,E., Duval,C., McCaig,C., Handley,M., Dockray, G.J., Varro,A., (2005) Insulin-like growth factor binding protein-5 (IGFBP-5) is a target of matrix metalloproteinase-7 (MMP-7): implications for epithelial-mesenchymal signalling. Cancer Research, 65 7363-7369

Gerald Prescott

Morgan, A., Burgoyne, R.D., Barclay, J.W., Craig, T.J., Prescott, G.R., Ciufo, L.F., Evans, G.J.O. and Graham, M.E. (2005) Regulation of exocytosis by protein kinase C. Biochem. Soc. Trans. 33, 1341-1344

Evans, G.J.O.*, Barclay, J.W.*, Prescott, G.R.*, Jo, S.-R., Burgoyne, R.D. Birnbaum, M.J., Morgan, A. (2006) Protein kinase B/AKT is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. J. Biol. Chem. 281, 1564-1572 
(* equal first authors)

Prescott GR, Jenkins RE, Walsh CM, Morgan A. (2008) Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding. Biochem Biophys Res Commun. 377, 809-14.

Graham ME, Prescott GR, Johnson JR, Jones M, Walmesley A, Haynes LP, Morgan A, Burgoyne RD, Barclay JW. (2011) Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis. PLoS One. 6:e17999

Neil Venn

Dawson LJ., Stanbury J., Venn N., Hasdimir B., Rogers SN., and Smith PM (2006) Antimuscarinic antibodies in primary Sjögrens syndrome Reversibly Inhibit the Mechanism of Fluid Secretion by Human Submandibular Salivary Acinar Cells. Arthritis and Rheumatism vol In Press Updated January 2006

Venn N, Haynes LP, Burgoyne RD. (2008) Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells. Biochem J. 413, 71-80.

2004 intake

Richard Buus

Buus, R., Faronato, M. Hammond, D.E., Urbé,S. and Clague,M.J. (2009) Deubiquitinase Activities Required for Hepatocyte Growth Factor-Induced Scattering of Epithelial Cells. Current Biology, 19, 1463-1466.

Liu, H., Buus, R., Clague,M.J., Urbé,S. (2009) Regulation of ErbB-2 status by the proteasomal DUB POH1. PLOS One 4(5):e5544.

Jane De Lartigue (Jane Whittingham)

de Lartigue, J., Polson, H., Feldmann, M., Shokat, K., Tooze, S.A., Urbé,S. and Clague,M.J. (2009) PIKfyve regulation of endosome-linked pathways. Traffic, 10, 883-893.

Polson, H.E.J., de Lartigue, J., Rigden,D.J., Reedijk,M., Urbé,S., Clague,M.J. and Tooze,S.A. (2010) Mammalian Atg18 (WIPI2) localises to omegasome-anchored isolation membranes and positively regulates LC3 lipidation. Autophagy, 6, 506-522.

Clague,M.J., Urbé,S. and de Lartigue, J. (2009) Phosphoinositides and the endocytic pathway. Experimental Cell Research 9, 1627-1631.

Carol Roberts

Mpofu CM, Campbell BJ, Subramanian S, Marshall-Clarke S, Hart CA, Cross A, Roberts CL, McGoldrick A, Edwards SW, Rhodes JM. (2007) Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease. Gastroenterology 133, 1487-98.

Subramanian S, Roberts CL, Hart CA, Martin HM, Edwards SW, Rhodes JM, Campbell BJ (2008) Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics.
Antimicrob Agents Chemother. 52 427-34.

Subramanian S, Rhodes JM, Hart CA, Tam B, Roberts CL, Smith SL, Corkill JE, Winstanley C, Virji M, Campbell BJ. (2008) Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine. Inflamm Bowel Dis. 14, 162-75.

Roberts CL, Keita AV, Duncan SH, O'Kennedy N, Söderholm JD, Rhodes JM, Campbell BJ (2010). Translocation of Crohn's disease E. coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 59: 1331-1339.

Fahad Ali

Haddley K, Vasiliou AS, Ali FR, Paredes UM, Bubb VJ, Quinn JP. (2008) Molecular genetics of monoamine transporters: relevance to brain disorders. Neurochem Res. 33, 652-67.

Ali, F. R., Haddley, K. and Quinn, J. P. (2010a) Assessing the impact of genetic variation on transcriptional regulation in vitro. Methods in molecular biology (Clifton, N.J), 628, 195-214.

Ali, F. R., Vasiliou, S. A., Haddley, K., Paredes, U. M., Roberts, J. C., Miyajima, F., Klenova, E., Bubb, V. J. and Quinn, J. P. (2010) Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. Journal of neurochemistry, 112, 296-306.

Vasiliou, S. A., Ali, F. R., Haddley, K., Cardoso, M. C., Bubb, V. J. and Quinn, J. P. (2012) The SLC6A4 VNTR genotype determines transcription factor binding and epigenetic variation of this gene in response to cocaine in vitro. Addict Biol, 17, 156-170.

Genetic Variation. Springer Publishing. Edited by M. Barnes. (2010). Assessing the Impact of Genetic Variation on Transcriptional Regulation In Vitro. F.R. Ali, Kate Haddley and John P. Quinn

2005 intake

Hannah Stevens

Stevens, H. C., Fiskerstrand, C., Bubb, V. J., Dalziel, R. and Quinn, J. P. (2009) A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts. FEBS letters, 583, 3335-3338.

Stevens, H. C., Cham, K. S., Hughes, D. J., Sun, R., Sample, J. T., Bubb, V. J., Stewart, J. P. and Quinn, J. P. (2012) CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements. Virus Genes.

Sebastian Hayes

Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, Clague MJ, Sanderson CM, Urbé S. (2007) The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem. 282, 30929-37.

Urbé S., Liu H., Hayes S., Rigden D., Eccles R.L., Heride C. and Clague M.J. (2012) Systematic survey of deubiquitinase localisation identifies USP21 as a regulator of centrosome and microtubule associated functions. Molecular Biology of the Cell, 23, 1095-1013.

Rigden D.J., Liu H., Hayes S.D. Urbé S. and Clague M.J. (2009) Bioinformatic discovery of novel human MIT domains. FEBS Lett. 583, 872-878.

Hayes S., Liu H., MacDonald E., Sanderson C.M., Coulson J.M., Clague M.J., Urbé S. Direct and indirect control of MAPK pathway associated components, BRAP/IMP and CRAF, by the deubiquitylating enzyme USP15. Journal of Biological Chemistry in press.

Feldman M., Abrami L., Kunz B., Hayes S., Urbé S., van der Goot G.F. The ER Deubiquitinase USP19 controls cellular levels of the Wnt signaling co-receptor LRP6. Under review

Sarah Flowerdew

Gerasimenko JV, Flowerdew SE, Voronina SG, Sukhomlin TK, Tepikin AV, Petersen OH, Gerasimenko OV. (2006) Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. J Biol Chem. 281, 40154-63.

Flowerdew SE, Burgoyne RD. (2009) A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. Biochem J. In press

Michelle Riesen

Boyd A, Ciufo LF, Barclay JW, Graham ME, Haynes LP, Doherty MK, Riesen M, Burgoyne RD, Morgan A. (2008) A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins. Genetics 180, 165-78.

Riesen M, Morgan A. (2009) Calorie restriction reduces rDNA recombination independently of rDNA silencing.Aging Cell8, 624-32.

Herbert AP, Riesen M, Bloxam L, Kosmidou E, Wareing BM, Johnson JR, Phelan MM, Pennington SR, Lian LY, Morgan A. (2012) NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. PLoS One 7:e41975.

Riesen M, Morgan A. (2009) Calorie restriction reduces rDNA recombination independently of rDNA silencing. Aging Cell. 8:624-32.

2006 intake

Jonathan Woodsmith

Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH, Tepikin AV. (2007)Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci USA. 104, 5674-9.

Ciara Walsh

Chvanov M, Walsh CM, Haynes LP, Voronina SG, Lur G, Gerasimenko OV, Barraclough R, Rudland PS, Petersen OH, Burgoyne RD, Tepikin AV. (2008) ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Arch. 457, 505-17.

Prescott GR, Jenkins RE, Walsh CM, Morgan A. (2008) Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding. Biochem Biophys Res Commun. 377, 809-14.

Walsh, C.M., Chvanov, M., Haynes, L.P., Petersen, O.H., Tepikin, A.V. & Burgoyne, R.D. (2009) Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem. J. 425, 159-168.

Walsh C, Barrow S, Voronina S, Chvanov M, Petersen OH, Tepikin A. (2009) Modulation of calcium signalling by mitochondria. Biochim Biophys Acta. 1787, 1374-82.

Walsh, C.M., Doherty, M.K., Tepikin, A.V. & Burgoyne, R.D. (2010) Evidence for an interaction between Golli and Stim1 in store-operated calcium entry. Biochem. J. 430, 453-460.

Gyorgy Lur

Chvanov M, Walsh CM, Haynes LP, Voronina SG, Lur G, Gerasimenko OV, Barraclough R, Rudland PS, Petersen OH, Burgoyne RD, Tepikin AV. (2008) ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Arch. 457, 505-17.

Chvanov M, Walsh CM, Haynes LP, Voronina SG, Lur G, Gerasimenko OV, Barraclough R, Rudland PS, Petersen OH, Burgoyne RD, Tepikin AV. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP.Pflugers Arch. 2008 Nov;457(2):505-17. doi: 10.1007/s00424-008-0529-y. Epub 2008 Jun 10.

Gerasimenko JV, Lur G, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Gerasimenko OV, Petersen OH.Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10758-63. doi: 10.1073/pnas.0904818106. Epub 2009 Jun 15.

Lur G, Haynes LP, Prior IA, Gerasimenko OV, Feske S, Petersen OH, Burgoyne RD, Tepikin AV. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors.Curr Biol.Oct 13;19(19):1648-53.

de Lartigue G, Lur G, Dimaline R, Varro A, Raybould H, Dockray GJ. EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.Endocrinology. 2010 Aug;151(8):3589-99. doi: 10.1210/en.2010-0106. Epub 2010 Jun 9.

Gerasimenko JV, Lur G, Ferdek P, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Petersen OH, Gerasimenko OV. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5873-8. doi: 10.1073/pnas.1016534108. Epub 2011 Mar 21.

Lur G, Sherwood MW, Ebisui E, Haynes L, Feske S, Sutton R, Burgoyne RD, Mikoshiba K, Petersen OH, Tepikin AV. InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochem J. 2011 Jun 1;436(2):231-9. doi: 10.1042/BJ20110083.

Dingsdale H, Voronina S, Haynes L, Tepikin A, Lur G. Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells.Biochem Soc Trans. 2012 Feb;40(1):108-11. doi: 10.1042/BST20110639. Review.

Hayley Dingsdale, Lee Haynes, Gyorgy Lur and Alexei Tepikin. (2011).The role of ER and ER junctions with the plasma membrane in the regulation of SOCE. Store-operated Ca2+ Entry (SOCE) Pathways. pp137-151. Published by Springer. Edited by Groschner, Graier and Romanin.

Hayley Dingsdale, Lee P Haynes, Alexei Tepikin and Gyorgy Lur. (2011) Visualising the endoplasmic reticulum and its contacts with other organelles in live acinar cells. The Pancreapeadia. Exocrine Pancreas Knowledge Base. MPublishing (University of Michigan) Edited by John Williams.

Chris Thorne

Baumgartner HK, Gerasimenko JV, Thorne C, Ashurst LH, Barrow SL, Chvanov MA, Gillies S, Criddle DN, Tepikin AV, Petersen OH, Sutton R, Watson AJ, Gerasimenko OV. (2007) Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am J Physiol Gastrointest Liver Physiol. 293, G296-307

Thorne,C., Eccles, R.L., Coulson,J.M., Urbé,S. and Clague,M.J. (2011) Isoform specific localisation of the deubiquitinase USP33 to the Golgi Apparatus. Traffic 12, 1563-1574

2007 intake

Sarah Arrowsmith

Arrowsmith S, Robinson H, Noble K, Turton P, and Wray S (2012); What do we know about what happens to myometrial function as women age? (J Muscle Res Cell Motil, 33, Page 209-217.)

Arrowsmith S, Quenby S, Weeks A, Burdyga T, Wray S (2012); Poor Spontaneous and Oxytocin-Stimulated Contractility in Human Myometrium from Postdates Pregnancies. PLoS ONE 7(5): e36787. Epub May 2012

Arrowsmith S, Wray S and Quenby S (2011); Maternal obesity and labour complications following induction of labour in prolonged pregnancy. BJOG 118, 578-88.

Arrowsmith S, Kendrick A and Wray S (2010); Drugs acting on the pregnant uterus. Obstetrics, Gynaecology and Reproductive Medicine 20, 241-247.

Hannah McCue

McCue, H., BURGOYNE, R.D. & HAYNES, L.P. (2009) Membrane targeting of the EF-hand containing calcium sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun. 380, 825-831.

McCue, H.V., Haynes, L.P. & Burgoyne, R.D. (2010) Bioinformatic analysis of CaBP/calneuron proteins reveals a family of highly conserved vertebrate Ca2+-binding proteins. BMC Research Notes 3,118.

McCue, H.V., Haynes, L.P. & Burgoyne, R.D. The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harbor Perspectives in Biology, a004085 (2010)

McCue, H.V., BURGOYNE, R.D. & HAYNES, L.P. (2011) Determination of the membrane topology of the small EF-hand Ca2+-sensing proteins CaBP7 and CaBP8. PLoS ONE 6(3): e17853

Lian, L.-Y., Pandalaneni, S., Patel, P., McCue, H.V., Haynes, L.P. & Burgoyne, R.D. (2011) Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1. PLoS ONE 6(11): e277779

Haynes, L.P., McCue, H.V. & Burgoyne, R.D. (2012) Evolution and functional diversity of the Calcium Binding Proteins (CaBPs). Front. Mol. Neurosci. 5:9.

McCue, H.V., Patel, P., Herbert, A.P., Lian, L.Y., Burgoyne, R.D., Haynes, L.P. (2012) Solution NMR structure of the Ca2+-bound N-terminal domain of Calcium Binding Protein 7 (CaBP7): a regulator of Golgi trafficking. J Biol Chem in press.

Hannah V. McCue, Joanna D. Wardyn, Robert D. Burgoyne and Lee P. Haynes (2012) Generation and characterisation of a lysosomally targeted, genetically encoded, Ca2+-sensor. Biochem. J. In press.

Pawel Ferdek

Ferdek PE, Gerasimenko JV, Peng S, Tepikin AV, Petersen OH, Gerasimenko OV. (2012). A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr Biol. Jul 10;22(13):1241-6.

Gerasimenko JV, Lur G, Ferdek P, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Petersen OH, Gerasimenko OV. (2011). Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+release through IP3 receptors. Proc Natl Acad Sci U S A. Apr 5;108(14):5873-8.

Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R, Watson AJ, Gerasimenko OV (2009). Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem. Jul 31;284(31):20796-803.

Johnson, J.R., Ferdek, P., Lian, L-Y, Barclay, J.W., Burgoyne, R.D. & Morgan, A. (2009) Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans. Biochem. J. 418, 73-80.

Daniel Booth

Cheeseman, L.P., Booth, D.G., Hood, F.E., Prior, I.A. & Royle, S.J. (2011) Aurora A kinase activity is required for localisation of TACC3/ch-TOG/clathrin inter-microtubule bridges. Commun. Integr. Biol., 4: 409-12.

Booth, D.G., Hood, F.E., Prior, I.A. & Royle, S.J. (2011) A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J., 30: 906-19.

2008 intake

Hayley Dingsdale

Dingsdale H, Voronina S, Haynes L, Tepikin A, Lur G. Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells. Biochem Soc Trans. 2012 Feb;40(1):108-11. doi: 10.1042/BST20110639. Review.

Dingsdale H, Okeke E, Awais M, Haynes LP, Criddle DN, Sutton R, Tepikin AV.Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.Biochem J. 2013 Jan 16. [Epub ahead of print]

Hayley Dingsdale, Lee Haynes, Gyorgy Lur and Alexei Tepikin. (2011).The role of ER and ER junctions with the plasma membrane in the regulation of SOCE. Store-operated Ca2+ Entry (SOCE) Pathways. pp137-151. Published by Springer. Edited by Groschner, Graier and Romanin.

Hayley Dingsdale, Lee P Haynes, Alexei Tepikin and Gyorgy Lur. (2011) Visualising the endoplasmic reticulum and its contacts with other organelles in live acinar cells. The Pancreapeadia. Exocrine Pancreas Knowledge Base. MPublishing (University of Michigan) Edited by John Williams.

Amanda Heath

Al-Qahtani S, Heath A, Quenby S, Dawood F, Floyd R, Burdyga T and Wray S (2011) Diabetes is associated with impairment of uterine contractility and high caesarean section rate. Diabetologia: 55, 489-498.

Hayley Robinson

Robinson, H. & Wray, S. (2012) A new slow releasing, H2S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium. PLoS One, 2012;7(9):e46278. doi: 10.1371/journal.pone.0046278.

2009 intake

Leanne Bloxom

Herbert AP, Riesen M, Bloxam L, Kosmidou E, Wareing BM, Johnson JR, Phelan MM, Pennington SR, Lian LY, Morgan A. (2012) NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. PLoS One 7:e41975.

Liam Cheeseman

Cheeseman LP, Booth DG, Hood FE, Prior IA and Royle SJ (2011) Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges. Communicative & Integrative Biology 4, 409-412.

Booth DG*, Cheeseman LP*, Prior IA and Royle SJ (2013) Studying kinetochore-fiber ultrastructure using correlative light-electron microscopy. Methods in Cell Biology – Microtubules in vitro 115, 327-342

* = These authors contributed equally to this work

Cheeseman LP, Harry EF, McAinsh AD, Prior IA and Royle SJ (2013) Specific removal of TACC3–ch-TOG–clathrin at metaphase deregulates kinetochore fiber tension. Journal of Cell Science 126, 2102-2113.

2010 intake

Anna Newlaczyl

Newlaczyl AU, Yu LG. Galectin-3--a jack-of-all-trades in cancer. Cancer Lett. 2011 Dec 27;313(2):123-8. doi: 10.1016/j.canlet.2011.09.003. Epub 2011 Sep 17. Review.

Krechowec SO, Burton KL, Newlaczyl AU, Nunn N, Vlatković N, Plagge A. Ostnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice. PLoS One. 2012;7(1):e29753. doi: 10.1371/journal.pone.0029753. Epub 2012 Jan 11.

Emmanuel Okeke

Fielding AB, Willox AK, Okeke E, Royle SJ. Clathrin-mediated endocytosis is inhibited during mitosis.Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6572-7. doi: 10.1073/pnas.1117401109. Epub 2012 Apr 9.

Dingsdale H, Okeke E, Awais M, Haynes LP, Criddle DN, Sutton R, Tepikin AV.Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.Biochem J. 2013 Jan 16. [Epub ahead of print]

2011 intake

Joanna Wardyn

Hannah V. McCue, Joanna D. Wardyn, Robert D. Burgoyne and Lee P. Haynes (2012) Generation and characterisation of a lysosomally targeted, genetically encoded, Ca2+-sensor. Biochem. J. In press.