Neuronal Signalling group

About

The Neuronal Signalling Group comprising Jeff Barclay, Bob Burgoyne, Lee Haynes and Alan Morgan is based in the Department of Cellular and Molecular Physiology. Our research interests cover various aspects of neuronal function including neurotransmitter release, neuronal calcium signals and sensors and the role of chaperone proteins in ageing, neurodegeneration and protection from stressful challenge.

Our research interests cover various aspects of neuronal function including neurotransmitter release, neuronal calcium signals and sensors and the role of chaperone proteins in ageing, neurodegeneration and protection from stressful challenge.

Our experimental approaches involve biochemical, behavioural, electrophysiological, molecular and structural techniques applied to mammalian cell systems and also to the model organism Caenorhabdities elegans. The use of the C. elegans worm allows us to genetically dissect pathways involved in neurotransmission and neuroprotection. We complement these studies with work at the level of the individual protein and also by studying conserved mechanisms in the yeast Saccharomyces cerevisiae.

We collaborate with other members of the Institute of Translational Medicine, with members of the Institute of Integrative Biology in Liverpool and with other UK Universities. Recent international collaborations have involved groups in Germany, Slovenia, Ukraine and the USA.

A major ambition of our research is to develop fundamental model systems that can be used for initial stages of drug discovery.