Image of APT team




  • William Hope and Shampa Das are both presenting at British Society for Antimicrobial Chemotherapy (BSAC) conference -‘Meeting the Challenges of Gram-Negative Infection Management’ on 19th November in London William on ‘PK-PD challenges for Gram-negative infections’ and Shampa ‘Advances in betalactamase inhibition in difficult to treat infections’.

  • Kat Stott one of our clinical PhD fellows, returns to Liverpool this month from Malawi. Kat has had a very successful 2 years in Malawi recruiting patients with cryptococcal meningitis to a pharmacokinetic-pharmacodynamic (PK-PD) substudy of the Ambition-cm trial (ISRCTN72509687).  Ambition-cm examines whether a novel drug regimen for cryptococcal meningitis may be non-inferior to standard of care.  Together with the local study team, Kat has successfully reached her recruitment target of 65 patients.  Samples are awaiting shipment back to the University of Liverpool for PK analysis and whole genome sequencing, and to Duke University in North Carolina for pathogen phenotyping and transcriptomic analysis.  Further samples will stay in Malawi and undergo immunological analyses at the Malawi-Liverpool Wellcome Trust Clinical Research Programme, to examine the impact of host immunity on PD outcomes.