MRes in Biological and Biomedical Sciences projects 26/27

If you’re looking to move into a career in science, whether in academia, industry, or biomedicine research, the Biological and Biomedical Sciences MRes will enable you to develop advanced knowledge, skills, and understanding of biological and biomedical sciences. A year-long research project, under the supervision of an expert tutor, forms the central part of the course. Selecting the right project is a key decision and we’ll help you choose a topic relevant to your interests and career plans.

Project title		Supervisor
Assessing the effects of the ultra‑long‑acting antiretroviral lenacapavir on placental biology using human trophoblast organoids	Laboratory	Adeniyi Olagunju
Trimester‑resolved steady‑state pharmacokinetics of ultra long-acting lenacapavir using pregnancy PBPK modelling	Laboratory	Adeniyi Olagunju
The role of Liprin-α1 in pancreatic cancer progression	Laboratory	Paul Atherton
Investigating the role of calmodulin in cardiac arrhythmia	Laboratory	Nordine Helassa
Investigating mechanisms controlling cellular responses to low oxygen (Hypoxia) and inflammation	Laboratory	Sonia Rocha
Development of Bioinstrumentation for Point-of-Care Devices for Dementia Screening	Laboratory	Sanjiv Sharma
Development of Artificial Intelligence Tools for Clinical Decision Support in Alzheimer’s Disease	Laboratory	Sanjiv Sharma
Applying Deep Learning-based methods for protein structure prediction	Desk	Dan Rigden
From rupture to repair: a microscopy assay of lysosomal membrane damage responses and potential recovery kinetics	Laboratory	Massimiliano Stagi
Microscopy-based analysis of lysosomal membrane damage and recovery	Laboratory	Massimiliano Stagi
Development of Novel Nanomaterial-Based Synthetic Antibodies for Dementia Diagnostics	Laboratory	Sanjiv Sharma
Regulation Of Atrial Ip₃ Pathways By Pde8: Uncovering Mechanisms Of Intracellular Signalling	Laboratory	Rebecca Burton
Lysosomal Calcium Signalling in the Ageing Heart	Laboratory	Rebecca Burton
Why do cancers cells re-express meiotic SYCP1 protein?	Laboratory	Urszula McClurg
From Meiosis to Medicine: Targeting Hidden Germline Antigens for Next-Generation Liver Cancer Immunotherapy	Laboratory	Urszula McClurg
Brain imaging in epilepsy disorders	Desk	Simon Keller
Two Kinases, One Pathway? Investigating IKKα and IKKβ in Non-Canonical NF-κB Signalling	Laboratory	Niall Kenneth
Defining Polarity Regulators as Determinants of Transformation and Therapy Response in Pancreatic Cancer	Laboratory	Pedro Perez-Mancera
3D Printing for Personalised Medicine: Development of Customised Drug Delivery Systems	Laboratory	Sheng Qi
Development of Long-Acting Injectable Systems for Sustained Drug Delivery	Laboratory	Sheng Qi
Investigating the role of gut microbiome-derived functional amyloids in neurodegenerative diseases	Laboratory	Jill Madine
Investigating how the malignant cells of chronic lymphocytic leukaemia and other cancers adapt to loss of the short arm of chromosome 17	Laboratory	Mark Glenn
Assessment of matrix metalloproteinase inhibitors as putative treatments for immune-mediated skin conditioNS	Laboratory	Dan Carr
CENPA supply chain management and its influence on the epigenetic landscape	Laboratory	Colin Hammond
Developing a novel technology to track the deposition and localisation of individual histones on chromatin	Laboratory	Colin Hammond
Understanding how histone mRNAs are handled during biosynthesis	Laboratory	Colin Hammond
Application of structure based drug discovery for treatment of Amyotrophic lateral sclerosis (ALS)	Laboratory	Svetlana Antonyuk
Modelling the Ageing Human Heart in a Dish: Mechanisms and Therapeutic Targets	Laboratory	Parveen Sharma
Investigating the Dual Cardioprotective and Antitumour Effects of SGLT2 Inhibitors in Immune Checkpoint Inhibitor Therapy	Laboratory	Parveen Sharma
Fibroblast–immune cell metabolic interactions in squamous cell carcinoma	Laboratory	Timothy Budden
Understanding chronic lymphocytic leukemia (CLL) through genome-scale metabolic modelling	Desk	Francesco Del Carratore
Modelling growth dynamics of bacterial consortia (microbiomes)	Desk	Francesco Del Carratore
Metabolomics investigation of bacterial response to antibiotics	Laboratory	Howbeer Muhamad Ali
Triggering the production of novel antimicrobials through microbial interaction	Laboratory	Howbeer Muhamad Ali
Understanding the impact of chromosome 17p loss in chronic lymphocytic leukaemia	Laboratory	Joseph Slupsky
Functional and comparative genomics of the regulation of Crassulacean acid metabolism by the circadian clock	Laboratory	James Hartwell
Advanced Bio-Imaging of Polymeric Microneedle Systems-Tissue Interactions for Controlled Drug Delivery	Laboratory	Wing Man Lau
Designing Controlled Multi-Drug Delivery Platforms for Complex Therapies	Laboratory	Wing Man Lau
Analysing the microcephaly-related neurodevelopmental phenotype of Trappc9 mutations	Laboratory	Antonius Plagge
Investigating a newly identified cause of headaches, migraines and epilepsy	Laboratory	Benjamin Goult
Collagen Remodelling by Senescent CAFs in Oral Squamous Cell Carcinoma ECM	Laboratory	Keith Hunter
Genomic variation underpinning aging and neurodegenerative disease	Laboratory	Ben Middlehurst
Epigenetic control of ‘jumping genes’ and neuroinflammation in neurodegenerative disease	Laboratory	Ben Middlehurst
Unlocking the Sulfur Code: How the Glutathione Pathway Controls Supersulfide Levels in Eukaryotic Cells	Laboratory	Paraskevi Kritsiligkou
The role of oxidative damage in neurodegeneration: Engineering Targeted Biosensors to Map Oxidation at Cell Adhesion Sites	Laboratory	Paraskevi Kritsiligkou
Infrared “ECM fingerprinting” to quantify stromal remodelling across head & neck cancer	Laboratory	Amy Harding
Investigating how the ubiquitin E3 ligase DTX3L regulates endocytic trafficking and signalling of cell surface receptors	Laboratory	Sylvie Urbe
Supramolecular Organisation of Morphogen Signal	Laboratory	Marisa Merino
When Tumours Break the Rules: Death-Mediated Scaling in Human Cancer	Laboratory	Marisa Merino
Characterising Novel Small Molecule Therapeutics for Mast Cell Activation	Laboratory	Nicola Darling
Signalling in Allergy and Beyond: Decoding Mast Cell Activation Pathways	Laboratory	Nicola Darling
Targeting Bacterial Kinases: A Novel Strategy Against Antimicrobial Resistance	Laboratory	Dominic Byrne
Development of AI approaches for assessing the function of protein variants in plants	Desk	Andy Jones
Using AI for uncovering hidden protein function in pathogens	Desk	Andy Jones
Assessing non-enzymatic post translational modifications in blood and urien samples for improved kidney omics	Laboratory	Andy Chetwynd
Developing a benchtop model system for the investigation of brain tumour growth and drug responses	Laboratory	Rasheed Zakaria
Exploring what modality is best for pre-operative speech mapping in humans	Desk	Rasheed Zakaria
Molecular mechanisms of the biogenesis and life cycle of bacterial organelles for pathogenesis	Laboratory	Luning Liu
Bioengineering and Reprogramming of self-assembling protein organelles	Laboratory	Luning Liu
Understanding evolution and dissemination of plasmid-borne antimicrobial resistance	Laboratory	Yu Wan
Biomarker profiling of clinical and preclinical models to investigate drug-induced toxicity	Laboratory	Sudeep Pushpakom
Investigating the effect of antipsychotics on mitochondrial bioenergetics	Laboratory	Sudeep Pushpakom
Analysis of the vascular protective effect of statins	Laboratory	Mike Cross
The role of liver endothelial cells in methotrexate-induced liver toxicity	Laboratory	Mike Cross
Mechanisms of protein kinase fibrillogenesis	Laboratory	Pat Eyers
Neglected signalling pathways in PTEN driven cancers- a new route to therapy?	Laboratory	Laura Swan
Lysosomal damage from environmental microplastics	Laboratory	Laura Swan
Multi-modal imaging technologies to assess cancer treatment response	Laboratory	Harish Poptani
Multi-modal imaging technologies to assess orphogen gradients and organ development	Laboratory	Harish Poptani
Multi-modal imaging technologies to assess the heart-brain axis	Laboratory	Harish Poptani
Molecular Imaging of human cancer models	Laboratory	Harish Poptani
High resolution MRI and CT for measuring organ development in a drosophila model	Laboratory	Harish Poptani
High resolution MRI to characterise tumour organoids	Laboratory	Harish Poptani
Modulation of a blood-brain barrier model to enhance biological relevance	Laboratory	David Dickens
Inhibition of LAT1 transporter as a novel treatment for glioblastoma	Laboratory	David Dickens
Investigating the role of hepatic stellate cells in a human 3D in vitro model for the study of liver fibrosis therapy	Laboratory	Ian Copple
Structure, activity and interactions of dietary phenols and their derivatives	Laboratory	Edwin Yates
Investigating the role of hepatic stellate cells in a human 3D in vitro model for the study of liver fibrosis therapy	Laboratory	Ian Copple
How cancer survives stress: the hidden role of RNA in treatment	Laboratory	Aditi Kanhere
Reading RNA signals: early detection and prognosis of drug treatment	Laboratory	Aditi Kanhere
Mapping the DNMT1 interactome: new insights into gene regulation and cancer	Laboratory	Aditi Kanhere
A new enzymatic activity of a Parkinson's related gene	Laboratory	Laura Swan
Building a molecular signature of lysosomal damage resistance	Laboratory	Laura Swan
How do autism mutations disrupt brain signalling? Molecular mechanisms of SHANK3 function	Laboratory	Igor Barsukov
Switch adhesion on and off: how cells control interactions with the extracellular matrix	Laboratory	Igor Barsukov
Structural and functional investigation of A. baumannii virulence factors	Laboratory	Chris Harding
Evaluating off-target mitochondrial dysfunction of novel compounds in early-stage drug discovery	Laboratory	Amy Chadwick
Decoding tumour microenvironment crosstalk in cancer invasion and metastasis	Laboratory	Mark Morgan