Photo of Dr Shankar Varadarajan

Dr Shankar Varadarajan BPharm, ME, PhD

Lecturer Molecular & Clinical Cancer Medicine

Publications

2021

STINGing Viral Tumors: What We Know from Head and Neck Cancers (Journal article)

Saulters, E., Woolley, J. F., Varadarajan, S., Jones, T. M., & Dahal, L. N. (2021). STINGing Viral Tumors: What We Know from Head and Neck Cancers. CANCER RESEARCH, 81(15), 3945-3952. doi:10.1158/0008-5472.CAN-21-0785

DOI: 10.1158/0008-5472.CAN-21-0785

2020

Resistance to venetoclax-induced apoptosis of CLL cells due to CD40 stimulation can be reversed by BCL-XL inhibition (Conference Paper)

Zhuang, J., Luckett, T., Cheng, X., Oates, M., Varadarajan, S., & Pettitt, A. (2020). Resistance to venetoclax-induced apoptosis of CLL cells due to CD40 stimulation can be reversed by BCL-XL inhibition. In LEUKEMIA & LYMPHOMA Vol. 61 (pp. 234-235). Retrieved from http://gateway.webofknowledge.com/

2019

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck (Journal article)

Carter, R. J., Milani, M., Butterworth, M., Alotibi, A., Harper, N., Yedida, G., . . . Varadarajan, S. (2019). Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death and Disease, 10(12). doi:10.1038/s41419-019-2150-8

DOI: 10.1038/s41419-019-2150-8

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. (Journal article)

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M., & Varadarajan, S. (2019). DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.. Cell death discovery, 5, 117. doi:10.1038/s41420-019-0199-x

DOI: 10.1038/s41420-019-0199-x

Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis (Journal article)

Yedida, G., Milani, M., Cohen, G. M., & Varadarajan, S. (2019). Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. CELL DEATH & DISEASE, 10. doi:10.1038/s41419-019-1759-y

DOI: 10.1038/s41419-019-1759-y

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L (Journal article)

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., . . . Varadarajan, S. (2019). BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L. CELL DEATH AND DIFFERENTIATION, 26(6), 1037-1047. doi:10.1038/s41418-018-0183-7

DOI: 10.1038/s41418-018-0183-7

Targeting Intermediary Metabolism Enhances The Efficacy Of BH3 Mimetic Therapy In Haematological Malignancies (Journal article)

Al-Zebeeby, A., Vogler, M., Milani, M., Richards, C., Alotibi, A., Greaves, G., . . . Varadarajan, S. (2019). Targeting Intermediary Metabolism Enhances The Efficacy Of BH3 Mimetic Therapy In Haematological Malignancies. Haematologica: the hematology journal, 104(5), 1016-1025. doi:10.3324/haematol.2018.204701

DOI: 10.3324/haematol.2018.204701

Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations (Journal article)

Henz, K., Al-Zebeeby, A., Basoglu, M., Fulda, S., Cohen, G. M., Varadarajan, S., & Vogler, M. (2019). Selective BH3-mimetics targeting BCL-2, BCL-X-L or MCL-1 induce severe mitochondrial perturbations. BIOLOGICAL CHEMISTRY, 400(2), 181-185. doi:10.1515/hsz-2018-0233

DOI: 10.1515/hsz-2018-0233

2018

ER shaping proteins regulate mitochondrial fission, outer membrane permeabilization and apoptosis (Journal article)

Milani, M., Cohen, G., & Varadarajan, S. (2018). ER shaping proteins regulate mitochondrial fission, outer membrane permeabilization and apoptosis. doi:10.1101/340448

DOI: 10.1101/340448

2017

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis (Journal article)

Milani, M., Byrne, D. P., Greaves, G., Butterworth, M., Cohen, G. M., Eyers, P. A., & Varadarajan, S. (2018). DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. Cell Death and Disease, 8. doi:10.1038/cddis.2016.485

DOI: 10.1038/cddis.2016.485

2016

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-X-L in chronic myeloid leukemia (Journal article)

Lucas, C. M., Milani, M., Butterworth, M., Carmell, N., Scott, L. J., Clark, R. E., . . . Varadarajan, S. (2016). High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-X-L in chronic myeloid leukemia. LEUKEMIA, 30(6), 1273-1281. doi:10.1038/leu.2016.42

DOI: 10.1038/leu.2016.42

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells (Journal article)

Butterworth, M., Pettitt, A., Varadarajan, S., & Cohen, G. M. (2016). BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells. BRITISH JOURNAL OF CANCER, 114(6), 638-641. doi:10.1038/bjc.2016.49

DOI: 10.1038/bjc.2016.49

2015

The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration (Journal article)

Varadarajan, S., Breda, C., Smalley, J., Butterworth, M., Farrow, S., Giorgini, F., & Cohen, G. (2015). The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death and Differentiation, 22(8), 1388-1396. doi:10.1038/cdd.2015.1

DOI: 10.1038/cdd.2015.1

Maritoclax and Dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner (Journal article)

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H. -G., & Cohen, G. (2015). Maritoclax and Dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner. Oncotarget, 6, 12668-12681. doi:10.18632/oncotarget.3706

DOI: 10.18632/oncotarget.3706

2013

Evaluation and critical assessment of putative MCL-1 inhibitors (Journal article)

Varadarajan, S., Vogler, M., Butterworth, M., Dinsdale, D., Walensky, L. D., & Cohen, G. M. (2013). Evaluation and critical assessment of putative MCL-1 inhibitors. CELL DEATH AND DIFFERENTIATION, 20(11), 1475-1484. doi:10.1038/cdd.2013.79

DOI: 10.1038/cdd.2013.79

The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export (Journal article)

Lu, L., Hannoush, R. N., Goess, B. C., Varadarajan, S., Shair, M. D., & Kirchhausen, T. (2013). The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. MOLECULAR BIOLOGY OF THE CELL, 24(7), 1020-1029. doi:10.1091/mbc.E12-08-0575

DOI: 10.1091/mbc.E12-08-0575

Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis (Journal article)

Varadarajan, S., Tanaka, K., Smalley, J. L., Bampton, E. T. W., Pellecchia, M., Dinsdale, D., . . . Cohen, G. M. (2013). Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis. PLOS ONE, 8(2). doi:10.1371/journal.pone.0056603

DOI: 10.1371/journal.pone.0056603

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis (Journal article)

Varadarajan, S., Butterworth, M., Wei, J., Pellecchia, M., Dinsdale, D., & Cohen, G. M. (2013). Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis. NEOPLASIA, 15(5), 568-+. doi:10.1593/neo.13230

DOI: 10.1593/neo.13230

2012

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum (Journal article)

Varadarajan, S., Bampton, E. T. W., Smalley, J. L., Tanaka, K., Caves, R. E., Butterworth, M., . . . Cohen, G. M. (2012). A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. CELL DEATH AND DIFFERENTIATION, 19(12), 1896-1907. doi:10.1038/cdd.2012.108

DOI: 10.1038/cdd.2012.108

2010

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1 (Journal article)

Son, J. K., Varadarajan, S., & Bratton, S. B. (2010). TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. CELL DEATH AND DIFFERENTIATION, 17(8), 1288-1301. doi:10.1038/cdd.2010.9

DOI: 10.1038/cdd.2010.9

2007

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease (Journal article)

Challa, M., Malladi, S., Pellock, B. J., Dresnek, D., Varadarajan, S., Yin, Y. W., . . . Bratton, S. B. (2007). Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO JOURNAL, 26(13), 3144-3156. doi:10.1038/sj.emboj.7601745

DOI: 10.1038/sj.emboj.7601745

2003

Bacterial glycoproteins: Functions, biosynthesis and applications (Journal article)

Upreti, R. K., Kumar, M., & Shankar, V. (2003). Bacterial glycoproteins: Functions, biosynthesis and applications. PROTEOMICS, 3(4), 363-379. doi:10.1002/pmic.200390052

DOI: 10.1002/pmic.200390052