Dr Pedro Perez-Mancera

Molecular & Clinical Cancer Medicine

    Publications

    2020

    Kras(P34R) and Kras(T58I) mutations induce distinct RASopathy phenotypes in mice (Journal article)

    Wong, J. C., Perez-Mancera, P. A., Huang, T. Q., Kim, J., Grego-Bessa, J., Alzamora, M. D. P., . . . Shannon, K. (2020). Kras(P34R) and Kras(T58I) mutations induce distinct RASopathy phenotypes in mice. JCI INSIGHT, 5(21). doi:10.1172/jci.insight.140495

    DOI: 10.1172/jci.insight.140495

    Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. (Journal article)

    Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2020). Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.. Cancer Research, 80(13), 2861-2873. doi:10.1158/0008-5472.can-19-3534

    DOI: 10.1158/0008-5472.can-19-3534

    A second site Kras(G12D) mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis. (Conference Paper)

    Wong, J. C., Perez-Mancera, P. A., Kim, J., Jen, K. -Y., Kogan, S. C., Firestone, A. J., . . . Shannon, K. (2020). A second site Kras(G12D) mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.. In MOLECULAR CANCER RESEARCH Vol. 18 (pp. 43). Retrieved from http://gateway.webofknowledge.com/

    A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma-Toward a Better Mimicry of the in vivo Tumor Microenvironment (Journal article)

    Gupta, P., Perez-Mancera, P. A., Kocher, H., Nisbet, A., Schettino, G., & Velliou, E. G. (2020). A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma-Toward a Better Mimicry of the in vivo Tumor Microenvironment. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8. doi:10.3389/fbioe.2020.00290

    DOI: 10.3389/fbioe.2020.00290

    2019

    Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model (Journal article)

    Gupta, P., Totti, S., Perez-Mancera, P. A., Dyke, E., Nisbet, A., Schettino, G., . . . Velliou, E. G. (2019). Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model. RSC ADVANCES, 9(71), 41649-41663. doi:10.1039/c9ra09123h

    DOI: 10.1039/c9ra09123h

    Tissue-Specific Oncogenic Activity of KRAS(A)(146)(T) (Journal article)

    Poulin, E. J., Bera, A. K., Lu, J., Lin, Y. -J., Strasser, S. D., Paulo, J. A., . . . Haigis, K. M. (2019). Tissue-Specific Oncogenic Activity of KRAS(A)(146)(T). CANCER DISCOVERY, 9(6), 738-755. doi:10.1158/2159-8290.CD-18-1220

    DOI: 10.1158/2159-8290.CD-18-1220

    Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer (Journal article)

    Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., . . . Tuveson, D. A. (2019). Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer. CANCER DISCOVERY, 9(9), 1268-1287. doi:10.1158/2159-8290.CD-18-1409

    DOI: 10.1158/2159-8290.CD-18-1409

    2018

    A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo (Journal article)

    Cassidy, L. D., Young, A. R. J., Perez-Mancera, P. A., Nimmervoll, B., Jaulim, A., Chen, H. -C., . . . Narita, M. (n.d.). A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo. Autophagy, 14(7), 1256-1266. doi:10.1080/15548627.2018.1458172

    DOI: 10.1080/15548627.2018.1458172

    Mouse Models of Pancreatic Exocrine Cancer (Chapter)

    Pérez-Mancera, P. A. (2018). Mouse Models of Pancreatic Exocrine Cancer. In Pancreatic Cancer (pp. 509-538). Springer New York. doi:10.1007/978-1-4939-7193-0_77

    DOI: 10.1007/978-1-4939-7193-0_77

    2017

    Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer (Journal article)

    Totti, S., Vernardis, S. I., Meira, L., Perez-Mancere, P. A., Costello, E., Greenhalf, W., . . . Velliou, E. G. (2017). Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. DRUG DISCOVERY TODAY, 22(4), 690-701. Retrieved from http://gateway.webofknowledge.com/

    2016

    Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors (Journal article)

    Ireland, L., Santos, A., Ahmed, M. S., Rainer, C., Nielsen, S. R., Quaranta, V., . . . Mielgo, A. (2016). Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. Cancer Research, 76(23), 6851-6863. doi:10.1158/0008-5472.CAN-16-1201

    DOI: 10.1158/0008-5472.CAN-16-1201

    2015

    Use of DNA transposons for functional genetic screens in mouse models of cancer (Journal article)

    Bermejo-Rodriguez, C., & Perez-Mancera, P. A. (2015). Use of DNA transposons for functional genetic screens in mouse models of cancer. CURRENT OPINION IN BIOTECHNOLOGY, 35, 103-110. doi:10.1016/j.copbio.2015.05.005

    DOI: 10.1016/j.copbio.2015.05.005

    Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 (Journal article)

    Kirschner, K., Samarajiwa, S. A., Cairns, J. M., Menon, S., Perez-Mancera, P. A., Tomimatsu, K., . . . Narita, M. (2015). Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53. PLOS GENETICS, 11(3). doi:10.1371/journal.pgen.1005053

    DOI: 10.1371/journal.pgen.1005053

    BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model (Journal article)

    Perna, D., Karreth, F. A., Rust, A. G., Perez-Mancera, P. A., Rashid, M., Iorio, F., . . . Adams, D. J. (2015). BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proceedings of the National Academy of Sciences of the United States of America, 112(6), E536-E545. doi:10.1073/pnas.1418163112

    DOI: 10.1073/pnas.1418163112

    2014

    STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma (Journal article)

    Evers, L., Perez-Mancera, P. A., Lenkiewicz, E., Tang, N., Aust, D., Knoesel, T., . . . Barrett, M. T. (2014). STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma. GENOME MEDICINE, 6. doi:10.1186/gm526

    DOI: 10.1186/gm526

    Cancer Cell Signaling (Chapter)

    Cancer Cell Signaling (n.d.). Apple Academic Press. doi:10.1201/b17138

    DOI: 10.1201/b17138

    Inside and out: the activities of senescence in cancer (Journal article)

    Perez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014). Inside and out: the activities of senescence in cancer. NATURE REVIEWS CANCER, 14(8), 547-558. doi:10.1038/nrc3773

    DOI: 10.1038/nrc3773