Photo of Prof Jerry Turnbull

Prof Jerry Turnbull BSc (Hons), PhD FRSB FRSC

Johnston Professor of Biochemistry Biochemistry & Systems Biology

    Research

    Chemical biology, Glycomics and Translational Applications of Heparan Sulphates in Health and Disease

    Chemical biology and glycomics of heparan sulphates (a specialized class of multi-functional glycoproteins) in the nervous system in development and disease, with applications for translational drug discovery. Current topics include: 1. dynamic HS biosynthesis and functions; 2. role of heparan sulphate in stem cell biology; 3. development of innovative technologies for “glycomics” studies on HS structure-activity relationships - saccharide libraries (natural, semi-synthetic and synthetic glycans and mime tics), mass spec sequencing, glycooarrays; 4. the role of HS in neural & neurodegenerative diseases including Alzheimers disease and Kallmanns syndrome; 5. translational studies on drug discovery and biotechnology applications of HS compounds and mimetics in Alzheimers disease, cancer and spinal cord repair. Multi-disciplinary experimental approaches are used including biochemistry (protein expression, carbohydrate analysis), molecular biology (gene cloning & expression, RNA interference), cell biology (cell culture, immunofluorescence) and chemistry (semi-synthetic and synthetic carbohydrates).

    Research Group Membership

    Research Grants

    Analysis of Mucin Interactions

    UNILEVER PLC (UK)

    October 2017 - December 2017

    Heparan mimetics as a novel therapeutic for multiple sclerosis

    THE MULTIPLE SCLEROSIS SOCIETY OF GREAT BRITAIN AND NORTHERN IRELAND (UK)

    April 2017 - March 2019

    Polysaccharide analysis

    SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CHINA)

    November 2016 - March 2017

    Model for Alzheimer's disease

    VICTORIA LINK LIMITED (VICLINK) (NEW ZEALAND)

    April 2016 - July 2016

    Exploring glycosidic neo-epitopes of degenerative granules in aged mice: implications for ageing and dementia -GLYCONEOBRAIN

    EUROPEAN COMMISSION

    September 2017 - August 2019

    Inhibition of beta-secretase

    ALZHEIMER'S RESEARCH (UK)

    November 2015 - August 2016

    Prodromal inhibitiond of beta-secretase by synthetic heparins

    ALZHEIMERS SOCIETY (UK)

    June 2016 - December 2021

    Enzymatic heparin production

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2015 - October 2016

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    Sparking Impact

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    June 2013 - July 2014

    Interaction of heparan sulfate with the protease beta-secretase: a novel mechanism for regulation of APP processing.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2004 - December 2007

    Extracellular Modulation of Multiprotein Signalling Complexes: Molecular Regulation of FGFR Signalling by Anosmin & Heparan Sulphate Proteoglycans

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2008 - December 2010

    Evaluation of optimised heparins as novel therapeutics for alzheimers disease.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2006 - August 2007

    China-UK Partnership to Develop Biotechnology Applications of Novel Heparinoids and Sulfated Polysaccharides

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2013 - November 2017

    Novel oligosaccharide inhibitors of the Alzheimer's beta-secretase enzyme

    SOCIETY OF BIOLOGY (UK)

    June 2014 - July 2014

    Heparinoid Beta-secretase Inhibitors with Novel Mode of Action: Pilot Development of Leads

    ALZHEIMER'S RESEARCH (UK)

    November 2012 - December 2013

    Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria

    WELLCOME TRUST (UK)

    October 2010 - September 2011

    Identifying intestinal receptors for Crohn's Escherichia coli

    NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)

    June 2013 - January 2015

    Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2004 - January 2007

    Exploiting heparan sulfates for directed neural differentiation of stem cells.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2003 - March 2006

    CASE studentship: Controlling stem cells with heparan sulfate analogues and polymer scaffolds

    SPHERITECH LTD (UK)

    September 2009 - September 2012

    The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2013 - August 2013

    Adel Alghamdi - bench fees

    ROYAL EMBASSY OF SAUDI ARABIA

    November 2014 - October 2015

    “Manipulation of heparan sulphate proteoglycans as a strategy for promoting brain repair"

    WELLCOME TRUST (UK)

    October 2008 - September 2011

    Enhancing the propagation of ES cells by regulation of visceral endoderm differentiation.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2004 - September 2007

    Chemical intervention in heparan sulphate-dependent growth factor signalling systems using engineered heparin saccharides.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2006 - March 2009

    Basic technology: glycochips-strategies for high-throughput analysis of the glycome.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    January 2009 - April 2011

    Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy. EU - PROPOSAL NUMBER 036097-2 KIDSTEM

    EUROPEAN COMMISSION

    September 2006 - August 2010

    Novel strategies for promoting CNS repair through manipulation of FGF signalling and heparan sulphate proteoglycans

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2013 - May 2015

    Preclinical studies of novel heparan mimetics for prevention and treatment of TSE (HMS AS ANTI PRION DRUGS).

    EUROPEAN COMMISSION

    October 2003 - September 2004

    Shotgun Functional Glycomics of Heparan Sulphate Saccharides: Generating Diverse Libraries to Decode Biological Selectivity

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    April 2011 - September 2014

    Isolating a heparin-derived sequence to activate endogenous Dnase I agreement

    CYSTIC FIBROSIS TRUST (UK)

    October 2005 - September 2006

    Molecular function in post-genome biology (MOLFUN).

    EUROPEAN COMMISSION

    October 2006 - September 2010

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    Heparan sulphates as dynamic cell regulators: structure, biosynthesis and mechanisms of action of the neural heparanome.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - September 2006

    The potential role of soluble plantain fibre and its components in preventing colonisation and invasion of the intestinal mucosa by S.Typhimurium.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2009 - December 2012

    Microarray Bioassays for Functional Glycome Screening

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2009 - September 2010

    Heparan sulfate and Alzheimer's Disease: Modulation of β-secretase Processing of Amyloid Precursor Protein by Oligosaccharide Inhibitors

    WELLCOME TRUST (UK)

    June 2006 - July 2006

    Altered Heparan Sulfate in Ageing and Dementia: a Potential Axis for Dysregulation of BACE-1 in Alzheimers Disease

    ALZHEIMER'S RESEARCH (UK)

    October 2013 - September 2016

    CIC biomaGUNE studentship

    CIC BIOMAGUNE (SPAIN)

    January 2012 - December 2015

    Research Collaborations

    Dr Ed Yates

    Project: Novel activities of modified heparins and drug discovery applications
    Internal

    Collaborations on chemically modified heparins

    Dr Dada Pisconti

    Project: Muscle stem cell proteoglycans
    Internal

    Studies on role of HS in muscle stem cell phenotype