Photo of Dr Gareth Wright

Dr Gareth Wright BSc (Hons) MSc PhD

Post-doctoral research associate Biochemistry & Systems Biology

Publications

2020

Molecular and pharmacological chaperones for SOD1 (Journal article)

Wright, G. S. A. (2020). Molecular and pharmacological chaperones for SOD1. BIOCHEMICAL SOCIETY TRANSACTIONS, 48(4), 1795-1806. doi:10.1042/BST20200318

DOI: 10.1042/BST20200318

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases (Journal article)

Wright, G. S. A., Watanabe, T. F., Amporndanai, K., Plotkin, S. S., Cashman, N. R., Antonyuk, S. V., & Hasnain, S. S. (2020). Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases. iScience, 23(6). doi:10.1016/j.isci.2020.101159

DOI: 10.1016/j.isci.2020.101159

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy (Journal article)

Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3

DOI: 10.1038/s42003-020-0826-3

2019

The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis. (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2019). The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis.. Quarterly reviews of biophysics, 52, e12. doi:10.1017/s003358351900012x

DOI: 10.1017/s003358351900012x

Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis. (Journal article)

Manjula, R., Unni, S., Wright, G. S. A., Bharath M M, S., & Padmanabhan, B. (2019). Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.. Journal of biomolecular structure & dynamics, 37(15), 3936-3946. doi:10.1080/07391102.2018.1531787

DOI: 10.1080/07391102.2018.1531787

Crystal Structure of the Japanese Encephalitis Virus Capsid Protein (Journal article)

Poonsiri, T., Wright, G., Solomon, T., & Antonyuk, S. V. (2019). Crystal Structure of the Japanese Encephalitis VirusCapsid Protein. Viruses, 11(7). doi:10.3390/v11070623

DOI: 10.3390/v11070623

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis (Journal article)

Hedison, T. M., Shenoy, R. T., Iorgu, A. I., Heyes, D. J., Fisher, K., Wright, G. S. A., . . . Scrutton, N. S. (2019). Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis. ACS Catalysis, 9(7), 6087-6099. doi:10.1021/acscatal.9b01266

DOI: 10.1021/acscatal.9b01266

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM (Journal article)

Chiduza, G. N., Johnson, R. M., Wright, G. S. A., Antonyuk, S. V., Muench, S. P., & Hasnain, S. S. (2019). LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, 660-669. doi:10.1107/S2059798319009094

DOI: 10.1107/S2059798319009094

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS (Journal article)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2019). Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. PLOS BIOLOGY, 17(2). doi:10.1371/journal.pbio.3000141

DOI: 10.1371/journal.pbio.3000141

2018

Activation of superoxide dismutase-1 by its copper chaperone is orchestrated by a single methyl group (Conference Paper)

Wright, G., Sala, F., Antonyuk, S., Garratt, R., & Hasnain, S. (2018). Activation of superoxide dismutase-1 by its copper chaperone is orchestrated by a single methyl group. In FEBS OPEN BIO Vol. 8 (pp. 37). Retrieved from http://gateway.webofknowledge.com/

Structural studies of human superoxide dismutase (SOD1) with its metallochaperone (Conference Paper)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2018). Structural studies of human superoxide dismutase (SOD1) with its metallochaperone. In FEBS OPEN BIO Vol. 8 (pp. 432-433). Retrieved from http://gateway.webofknowledge.com/

Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation (Journal article)

Manjula, R., Wright, G. S. A., Strange, R. W., & Padmanabhan, B. (2018). Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation. FEBS LETTERS, 592(10), 1725-1737. doi:10.1002/1873-3468.13055

DOI: 10.1002/1873-3468.13055

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (Journal article)

Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x

DOI: 10.1038/s41467-018-04114-x

Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system (Journal article)

Wright, G. S. A., Saeki, A., Hikima, T., Nishizono, Y., Hisano, T., Kamaya, M., . . . Sawai, H. (2018). Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system. SCIENCE SIGNALING, 11(525). doi:10.1126/scisignal.aaq0825

DOI: 10.1126/scisignal.aaq0825

Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus (Journal article)

Poonsiri, T., Wright, G. S. A., Diamond, M. S., Turtle, L., Solomon, T., & Antonyuk, S. V. (2018). Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus. Journal of Virology, 92(7). doi:10.1128/jvi.01868-17

DOI: 10.1128/jvi.01868-17

2017

INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS (Conference Paper)

Sawai, H., Wright, G. S. A., Saeki, A., Hikima, T., Yamamoto, M., Antonyuk, S., . . . Shiro, Y. (2017). INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS. In AMERICAN JOURNAL OF HEMATOLOGY Vol. 92 (pp. E463). Retrieved from http://gateway.webofknowledge.com/

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580

DOI: 10.1038/srep43580

2016

A faulty interaction between SOD1 and hCCS in neurodegenerative disease (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2016). A faulty interaction between SOD1 and hCCS in neurodegenerative disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27691

DOI: 10.1038/srep27691

2015

Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism (Journal article)

Hughes, A. J., Rudd, T. R., Wright, G. S. A., Fernig, D. G., Siligardi, G., & Yates, E. A. (2015). Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism. ANALYTICAL METHODS, 7(5), 1667-1671. doi:10.1039/c4ay02618g

DOI: 10.1039/c4ay02618g

2014

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (Journal article)

Austin, J. A., Wright, G. S. A., Watanabe, S., Grossmann, J. G., Antonyuk, S. V., Yamanaka, K., & Hasnain. (2014). Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the National Academy of Sciences of the United States of America, 111(11), 4309-4314. doi:10.1073/pnas.1317317111

DOI: 10.1073/pnas.1317317111

2013

Ligand binding and aggregation of pathogenic SOD1 (Journal article)

Wright, G. S. A., Antonyuk, S. V., Kershaw, N. M., Strange, R. W., & Hasnain, S. S. (2013). Ligand binding and aggregation of pathogenic SOD1. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms2750

DOI: 10.1038/ncomms2750

The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation (Journal article)

Wright, G. S. A., Lee, H. C., Schulze-Briese, C., Grossmann, J. G., Strange, R. W., & Hasnain, S. S. (2013). The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation. JOURNAL OF SYNCHROTRON RADIATION, 20, 383-385. doi:10.1107/S0909049513001866

DOI: 10.1107/S0909049513001866

X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)

Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from http://gateway.webofknowledge.com/

2012

Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii (Journal article)

Han, C., Wright, G. S. A., Fisher, K., Rigby, S. E. J., Eady, R. R., & Hasnain, S. S. (2012). Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii. BIOCHEMICAL JOURNAL, 444, 219-226. doi:10.1042/BJ20111623

DOI: 10.1042/BJ20111623

2011

The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies (Journal article)

Wright, G. S. A., Hasnain, S. S., & Grossmann, J. G. (2011). The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies. BIOCHEMICAL JOURNAL, 439, 39-44. doi:10.1042/BJ20110948

DOI: 10.1042/BJ20110948

2008

A high-throughput assay of membrane protein stability (Journal article)

Postis, V. L. G., Deacon, S. E., Roach, P. C. J., Wright, G. S. A., Xia, X., Ingram, J. C., . . . Baldwin, S. A. (2008). A high-throughput assay of membrane protein stability. MOLECULAR MEMBRANE BIOLOGY, 25(8), 617-624. doi:10.1080/09687680802530469

DOI: 10.1080/09687680802530469

Investigation of the structure and function of a Shewanella oneidensis arsenical-resistance family transporter (Journal article)

Xia, X., Postis, V. L. G., Rahman, M., Wright, G. S. A., Roach, P. C. J., Deacon, S. E., . . . Baldwin, S. A. (2008). Investigation of the structure and function of a Shewanella oneidensis arsenical-resistance family transporter. MOLECULAR MEMBRANE BIOLOGY, 25(8), 691-705. doi:10.1080/09687680802535930

DOI: 10.1080/09687680802535930

Large-scale preparation of bacterial cell membranes by tangential flow filtration (Journal article)

Roach, P. C. J., Postis, V. L. G., Deacon, S. E., Wright, G. S. A., Ingram, J. C., Xia, X., . . . Baldwin, S. A. (2008). Large-scale preparation of bacterial cell membranes by tangential flow filtration. MOLECULAR MEMBRANE BIOLOGY, 25(8), 609-616. doi:10.1080/09687680802530451

DOI: 10.1080/09687680802530451

Reliable scale-up of membrane protein over-expression by bacterial auto-induction: From microwell plates to pilot scale fermentations (Journal article)

Deacon, S. E., Roach, P. C. J., Postis, V. L. G., Wright, G. S. A., Xia, X., Phillips, S. E. V., . . . Baldwin, S. A. (2008). Reliable scale-up of membrane protein over-expression by bacterial auto-induction: From microwell plates to pilot scale fermentations. MOLECULAR MEMBRANE BIOLOGY, 25(8), 588-598. doi:10.1080/09687680802511774

DOI: 10.1080/09687680802511774