2023
Effectiveness of out-patient based acute heart failure care: a pilot randomised controlled trial. (Journal article)
Wong, K. Y. K., Hughes, D. A., Debski, M., Latt, N., Assaf, O., Abdelrahman, A., . . . Cleland, J. G. F. (2023). Effectiveness of out-patient based acute heart failure care: a pilot randomised controlled trial.. Acta cardiologica, 1-10. doi:10.1080/00015385.2023.2197834DOI: 10.1080/00015385.2023.2197834
Spanish translation of the ABC taxonomy for medication adherence (Journal article)
Garcia-Cardenas, V., Hughes, D., Aguilar-Palacio, I., Benrimoj, S. I., Rabanaque, M. J., Martinez-Martinez, F., & Malo, S. (2023). Spanish translation of the ABC taxonomy for medication adherence. Research in Social and Administrative Pharmacy, 19(9), 1292-1297. doi:10.1016/j.sapharm.2023.05.012DOI: 10.1016/j.sapharm.2023.05.012
A framework for understanding sources of bias in medication adherence research (Journal article)
Sinnappah, K. A. A., Hughes, D. A. A., Stocker, S. L. L., Vrijens, B., Aronson, J. K. K., & Wright, D. F. B. (2023). A framework for understanding sources of bias in medication adherence research. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15863DOI: 10.1111/bcp.15863
A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Journal article)
Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710DOI: 10.2196/46710
Medication adherence research comes of ageY (Journal article)
Wright, D. F. B., Sinnappah, K. A., & Hughes, D. A. (2023). Medication adherence research comes of ageY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 89(7), 1914-1917. doi:10.1111/bcp.15722DOI: 10.1111/bcp.15722
Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework (Journal article)
Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., & Wilson, I. B. (2023). Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 89(7), 1918-1927. doi:10.1111/bcp.15375DOI: 10.1111/bcp.15375
Gillespie, D., de Bruin, M., Hughes, D. A., Ma, R., Williams, A., Wood, F., . . . Hood, K. (2023). Between- and Within-Individual Sociodemographic and Psychological Determinants of PrEP Adherence Among Men Who have Sex with Men Prescribed a Daily PrEP Regimen in Wales.. AIDS and behavior, 27(5), 1564-1572. doi:10.1007/s10461-022-03890-4DOI: 10.1007/s10461-022-03890-4
Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2023). Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial (vol 19, 458, 2021). JOURNAL OF TRANSLATIONAL MEDICINE, 21(1). doi:10.1186/s12967-023-04131-5DOI: 10.1186/s12967-023-04131-5
Value of improving patient safety: health economic considerations for rapid response systems-a rapid review of the literature and expert round table (Journal article)
Subbe, C., Hughes, D. A., Lewis, S., Holmes, E. A., Kalkman, C., So, R., . . . Welch, J. (2023). Value of improving patient safety: health economic considerations for rapid response systems-a rapid review of the literature and expert round table. BMJ OPEN, 13(4). doi:10.1136/bmjopen-2022-065819DOI: 10.1136/bmjopen-2022-065819
Gebrehiwet, P., Meng, L., Rudnicki, S. A., Sarocco, P., Wei, J., Wolff, A. A., . . . Shefner, J. M. (2023). Health utilities and quality-adjusted life years for patients with amyotrophic lateral sclerosis receiving <i>reldesemtiv</i> or placebo in FORTITUDE-ALS.. Journal of medical economics, 26(1), 488-493. doi:10.1080/13696998.2023.2192588DOI: 10.1080/13696998.2023.2192588
Al-Najjar, N., Bray, L., Carter, B., Castle, A. P., Collingwood, A., Cook, G., . . . Pal, D. K. (2023). Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy. BMJ OPEN, 13(3). doi:10.1136/bmjopen-2022-065769DOI: 10.1136/bmjopen-2022-065769
A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint) (Preprint)
DOI: 10.2196/preprints.46710
Carter, B., Bray, L., al-Najjar, N., Piella, A. T., Tudur-Smith, C., Spowart, C., . . . Pal, D. (2023). The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial. TRIALS, 24(1). doi:10.1186/s13063-023-07091-9DOI: 10.1186/s13063-023-07091-9
Gillespie, D., Williams, A., Wood, F., Couzens, Z., Jones, A., Ma, R., . . . Hood, K. (2023). Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study. AIDS and Behavior. doi:10.1007/s10461-022-03967-0DOI: 10.1007/s10461-022-03967-0
2022
Hardy, W. A. S., & Hughes, D. A. (2022). Methods for Extrapolating Survival Analyses for the Economic Evaluation of Advanced Therapy Medicinal Products. HUMAN GENE THERAPY, 33(17-18), 845-856. doi:10.1089/hum.2022.056DOI: 10.1089/hum.2022.056
Sampson, C., Zamora, B., Watson, S., Cairns, J., Chalkidou, K., Cubi-Molla, P., . . . Towse, A. (2022). Supply-Side Cost-Effectiveness Thresholds: Questions for Evidence-Based Policy.. Applied health economics and health policy, 20(5), 651-667. doi:10.1007/s40258-022-00730-3DOI: 10.1007/s40258-022-00730-3
Marsden, J., Kelleher, M., Hoare, Z., Hughes, D., Bisla, J., Cape, A., . . . Mitcheson, L. (2022). Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone. TRIALS, 23(1). doi:10.1186/s13063-022-06595-0DOI: 10.1186/s13063-022-06595-0
Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals (Journal article)
Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals (2022). Pharmaceutical Journal. doi:10.1211/pj.2022.1.150934DOI: 10.1211/pj.2022.1.150934
Gillespie, D., Couzens, Z., de Bruin, M., Hughes, D. A., Jones, A., Ma, R., . . . Hood, K. (2022). PrEP Use, Sexual Behaviour, and PrEP Adherence Among Men who have Sex with Men Living in Wales Prior to and During the COVID-19 Pandemic.. AIDS and behavior, 26(8), 2746-2757. doi:10.1007/s10461-022-03618-4DOI: 10.1007/s10461-022-03618-4
Osanlou, R., Walker, L., Hughes, D. A., Burnside, G., & Pirmohamed, M. (2022). Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions. BMJ OPEN, 12(7). doi:10.1136/bmjopen-2021-055551DOI: 10.1136/bmjopen-2021-055551
Gillespie, D., Wood, F., Williams, A., Ma, R., de Bruin, M., Hughes, D. A., . . . Hood, K. (2022). Experiences of men who have sex with men when initiating, implementing and persisting with HIV pre-exposure prophylaxis. HEALTH EXPECTATIONS. doi:10.1111/hex.13446DOI: 10.1111/hex.13446
Sinnappah, K. A., Stocker, S. L., Chan, J. S., Hughes, D. A., & Wright, D. F. B. (2022). Clinical interventions to improve adherence to urate-lowering therapy in patients with gout: a systematic review.. The International journal of pharmacy practice, riac025. doi:10.1093/ijpp/riac025DOI: 10.1093/ijpp/riac025
Hughes, D. A., Bourke, S., Jones, A., Bhatt, R., Huda, S., Mutch, K., & Jacob, A. (2022). Health utilities and costs for neuromyelitis optica spectrum disorder. ORPHANET JOURNAL OF RARE DISEASES, 17(1). doi:10.1186/s13023-022-02310-zDOI: 10.1186/s13023-022-02310-z
Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug? (Journal article)
Culeddu, G., Su, L., Cheng, Y., Pereira, D. I. A., Payne, R. A., Powell, J. J., & Hughes, D. A. (2022). Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(3), 1347-1357. doi:10.1111/bcp.15078DOI: 10.1111/bcp.15078
Farmer, A., Jones, L., Newhouse, N., Kenning, C., Williams, N., Chi, Y., . . . French, D. (2022). Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial.. JMIR research protocols, 11(2), e32918. doi:10.2196/32918DOI: 10.2196/32918
Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations (Journal article)
Husereau, D., Drummond, M., Augustovski, F., De Bekker-Grob, E., Briggs, A. H., Carswell, C., . . . Staniszewska, S. (2022). Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations. CLINICAL THERAPEUTICS, 44(2), 158-168. doi:10.1016/j.clinthera.2022.01.011DOI: 10.1016/j.clinthera.2022.01.011
Hill-McManus, D., & Hughes, D. A. (2022). Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15183DOI: 10.1111/bcp.15183
2021
Hughes, D. A., Skiadas, K., Fitzsimmons, D., Anderson, P., & Heald, A. (2021). Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis. BMJ OPEN, 11(12). doi:10.1136/bmjopen-2021-051702DOI: 10.1136/bmjopen-2021-051702
Carter, B., Zenasni, Z., Moat, S. J., Hudson, P. R., Russell, I. T., & McCaddon, A. (2021). Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial. JOURNAL OF NUTRITION, 151(12), 3738-3745. doi:10.1093/jn/nxab280DOI: 10.1093/jn/nxab280
Heald, A. H., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., . . . Hughes, D. A. (2021). Is there a role for natural desiccated thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a consecutive case series. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 75(12). doi:10.1111/ijcp.14967DOI: 10.1111/ijcp.14967
Magavern, E. F., Daly, A. K., Gilchrist, A., & Hughes, D. A. (2021). Pharmacogenomics spotlight commentary: From the United Kingdom to global populations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4546-4548. doi:10.1111/bcp.14917DOI: 10.1111/bcp.14917
Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2021). Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial. JOURNAL OF TRANSLATIONAL MEDICINE, 19(1). doi:10.1186/s12967-021-03128-2DOI: 10.1186/s12967-021-03128-2
Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series (Journal article)
Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., . . . Hughes, D. (2021). Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series. doi:10.22541/au.163251250.02145771/v1DOI: 10.22541/au.163251250.02145771/v1
johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2021). Mechanistically Informed Non-invasive Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: a Randomised Double-blind Sham-controlled Trial.. doi:10.21203/rs.3.rs-809958/v1DOI: 10.21203/rs.3.rs-809958/v1
Powell, G. A., Bonnett, L. J., Smith, C. T., Hughes, D. A., Williamson, P. R., & Marson, A. G. (2021). Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods. TRIALS, 22(1). doi:10.1186/s13063-021-05294-6DOI: 10.1186/s13063-021-05294-6
Hill-McManus, D., Marshall, S., Liu, J., Willke, R. J., & Hughes, D. A. (2021). Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development. CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(1), 49-63. doi:10.1002/cpt.2051DOI: 10.1002/cpt.2051
Lloyd-Williams, H., & Hughes, D. A. (2021). A systematic review of economic evaluations of advanced therapy medicinal products. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2428-2443. doi:10.1111/bcp.14275DOI: 10.1111/bcp.14275
Managing access to advanced therapy medicinal products: Challenges for NHS Wales (Journal article)
Champion, A. R., Lewis, S., Davies, S., & Hughes, D. A. (2021). Managing access to advanced therapy medicinal products: Challenges for NHS Wales. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2444-2449. doi:10.1111/bcp.14286DOI: 10.1111/bcp.14286
TEOS: A framework for constructing operational definitions of medication adherence based on Timelines-Events-Objectives-Sources (Journal article)
Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., & Wilson, I. B. (2021). TEOS: A framework for constructing operational definitions of medication adherence based on Timelines-Events-Objectives-Sources. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2521-2533. doi:10.1111/bcp.14659DOI: 10.1111/bcp.14659
McCarroll, Z., Townson, J., Pickles, T., Gregory, J. W., Playle, R., Robling, M., & Hughes, D. A. (2021). Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial. BMJ OPEN, 11(5). doi:10.1136/bmjopen-2020-043523DOI: 10.1136/bmjopen-2020-043523
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation. LANCET RHEUMATOLOGY, 3(5), E347-E356. doi:10.1016/S2665-9913(21)00036-9DOI: 10.1016/S2665-9913(21)00036-9
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). MEDICINA-LITHUANIA, 57(4). doi:10.3390/medicina57040388DOI: 10.3390/medicina57040388
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. (2021). The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. LANCET, 397(10282), 1363-1374. Retrieved from https://www.webofscience.com/
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. (2021). The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. LANCET, 397(10282), 1375-1386. Retrieved from https://www.webofscience.com/
Thorn, J. C., Davies, C. F., Brookes, S. T., Noble, S. M., Dritsaki, M., Gray, E., . . . Hollingworth, W. (2020). Content of Health Economics Analysis Plans (HEAPs) for Trial-Based Economic Evaluations: Expert Delphi Consensus Survey. VALUE IN HEALTH, 24(4), 539-547. doi:10.1016/j.jval.2020.10.002DOI: 10.1016/j.jval.2020.10.002
Brogan, P. A., Arch, B., Hickey, H., Anton, J., Iglesias, E., Baildam, E., . . . Eleftheriou, D. (2021). Mycophenolate mofetil versus cyclophosphamide for remission induction in childhood polyarteritis nodosa: An open label, randomised, Bayesian, non-inferiority trial.. Arthritis & rheumatology (Hoboken, N.J.). doi:10.1002/art.41730DOI: 10.1002/art.41730
Gillespie, D., Knapper, C., Hughes, D., Couzens, Z., Wood, F., de Bruin, M., . . . Hood, K. (2021). Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales. SEXUALLY TRANSMITTED INFECTIONS, 97(2), 85-87. doi:10.1136/sextrans-2020-054598DOI: 10.1136/sextrans-2020-054598
Cullinan, J., Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE). MEDICINA-LITHUANIA, 57(3). doi:10.3390/medicina57030208DOI: 10.3390/medicina57030208
Cividini, S., Sinha, I., Donegan, S., Maden, M., Culeddu, G., Rose, K., . . . Tudur Smith, C. (2021). EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD). BMJ Open, 11(2), e040528. doi:10.1136/bmjopen-2020-040528DOI: 10.1136/bmjopen-2020-040528
Acceptability of generic versus innovator oral medicines: not only a matter of taste (Journal article)
Tuleu, C., Hughes, D. A., Clapham, D., Vallet, T., & Ruiz, F. (2020). Acceptability of generic versus innovator oral medicines: not only a matter of taste. DRUG DISCOVERY TODAY, 26(2), 329-343. doi:10.1016/j.drudis.2020.11.008DOI: 10.1016/j.drudis.2020.11.008
Albassam, A., & Hughes, D. A. (2021). What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 77(2), 251-260. doi:10.1007/s00228-020-03003-xDOI: 10.1007/s00228-020-03003-x
Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., . . . Day, S. (2021). Utilising benefit-risk assessments within clinical trials-a protocol for the BRAINS project. TRIALS, 22(1). doi:10.1186/s13063-021-05022-0DOI: 10.1186/s13063-021-05022-0
Utilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project (Journal article)
Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., . . . Day, S. (2021). Utilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project. doi:10.21203/rs.3.rs-22996/v3DOI: 10.21203/rs.3.rs-22996/v3
Hill-McManus, D., & Hughes, D. A. (2021). Combining Model-Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 10(1), 75-83. doi:10.1002/psp4.12579DOI: 10.1002/psp4.12579
Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. M. (2021). Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs Introduction. HEALTH TECHNOLOGY ASSESSMENT, 25(75), 1-+. doi:10.3310/hta25750DOI: 10.3310/hta25750
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.. Health Technology Assessment, 25(24), 1-86. doi:10.3310/hta25240DOI: 10.3310/hta25240
Patient and public engagement in medication adherence research (Conference Paper)
Holmes, E. A. F., Gillespie, D., & Hughes, D. A. (2021). Patient and public engagement in medication adherence research. In INTERNATIONAL JOURNAL OF CLINICAL PHARMACY Vol. 43 (pp. 305). Retrieved from https://www.webofscience.com/
Lewis, R. A., Hughes, D., Sutton, A. J., & Wilkinson, C. (2021). Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions. PHARMACOECONOMICS, 39(1), 25-61. doi:10.1007/s40273-020-00980-wDOI: 10.1007/s40273-020-00980-w
2020
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE). MEDICINA-LITHUANIA, 57(1). doi:10.3390/medicina57010007DOI: 10.3390/medicina57010007
Impact of Relaxing Covid-19 Social Distancing Measures on Rural North Wales: A Simulation Analysis (Journal article)
Hughes, R. P., & Hughes, D. A. (2020). Impact of Relaxing Covid-19 Social Distancing Measures on Rural North Wales: A Simulation Analysis. FRONTIERS IN PUBLIC HEALTH, 8. doi:10.3389/fpubh.2020.562473DOI: 10.3389/fpubh.2020.562473
A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE) (Journal article)
Pheby, D., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2020). A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). doi:10.20944/preprints202011.0735.v1DOI: 10.20944/preprints202011.0735.v1
Hughes, D. A. (2020). Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam. BRITISH JOURNAL OF PHARMACOLOGY, 177(21), 4975-4989. doi:10.1111/bph.15101DOI: 10.1111/bph.15101
Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority (Journal article)
Heald, A., Livingston, M., & Hughes, D. (2020). Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 128(9), 596-598. doi:10.1055/a-1062-6167DOI: 10.1055/a-1062-6167
Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II). (Journal article)
Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P. E. M., . . . Marson, A. G. (2020). Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).. BMJ open, 10(8), e040635. doi:10.1136/bmjopen-2020-040635DOI: 10.1136/bmjopen-2020-040635
Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT (Journal article)
Poolman, M., Roberts, J., Wright, S., Hendry, A., Goulden, N., Holmes, E. A. F., . . . Wilkinson, C. (2020). Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(25), 1-+. doi:10.3310/hta24250DOI: 10.3310/hta24250
TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources (Journal article)
Dima, A., Allemann, S., Dunbar-Jacob, J., Hughes, D., Vrijens, B., & Wilson, I. (2020). TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources. doi:10.31234/osf.io/2ndmqDOI: 10.31234/osf.io/2ndmq
Seizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controlled pilot trial (Journal article)
Noble, A., Snape, D., Nevitt, S., Holmes, E. A. F., Morgan, M., Tudur Smith, C., . . . Marson, A. G. (2020). Seizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controlled pilot trial. BMJ Open, 10(4). doi:10.1136/bmjopen-2019-035516DOI: 10.1136/bmjopen-2019-035516
Noble, A., Nevitt, S., Holmes, E., Ridsdale, L., Morgan, M., Tudur-Smith, C., . . . Snape, D. (2020). Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT.
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2020). The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE). HEALTHCARE, 8(2). doi:10.3390/healthcare8020088DOI: 10.3390/healthcare8020088
Medication adherence-Key considerations for clinical pharmacologists (Journal article)
Hughes, D. A. (2020). Medication adherence-Key considerations for clinical pharmacologists. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 86(4), 628-629. doi:10.1111/bcp.14228DOI: 10.1111/bcp.14228
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., . . . Gamble, C. (2020). Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(17), 1-+. doi:10.3310/hta24170DOI: 10.3310/hta24170
The New and Non-Transparent Cancer Drugs Fund (Journal article)
Wood, E. M., & Hughes, D. A. (2020). The New and Non-Transparent Cancer Drugs Fund. PHARMACOECONOMICS, 38(1), 1-4. doi:10.1007/s40273-019-00871-9DOI: 10.1007/s40273-019-00871-9
2019
Farmer, A., Allen, J., Bartlett, K., Bower, P., Chi, Y., French, D., . . . SuMMiT-D Collaborative Group. (2019). Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol.. BMJ open, 9(12), e033504. doi:10.1136/bmjopen-2019-033504DOI: 10.1136/bmjopen-2019-033504
Catt, H., Bodger, K., Kirkham, J. J., & Hughes, D. A. (2019). Value Assessment and Quantitative Benefit-Risk Modelling of Biosimilar Infliximab for Crohn's Disease. PHARMACOECONOMICS, 37(12), 1509-1523. doi:10.1007/s40273-019-00826-0DOI: 10.1007/s40273-019-00826-0
Developing patient-centred, feasible alternative care for adult emergency department users with epilepsy: protocol for the mixed-methods observational 'Collaborate' project (Journal article)
Noble, A. J., Mathieson, A., Ridsdale, L., Holmes, E. A., Morgan, M., McKinlay, A., . . . Marson, A. G. (2019). Developing patient-centred, feasible alternative care for adult emergency department users with epilepsy: protocol for the mixed-methods observational 'Collaborate' project. BMJ OPEN, 9(11). doi:10.1136/bmjopen-2019-031696DOI: 10.1136/bmjopen-2019-031696
Health Utilities and Costs for Motor Neurone Disease (Journal article)
Moore, A., Young, C. A., & Hughes, D. A. (2019). Health Utilities and Costs for Motor Neurone Disease. VALUE IN HEALTH, 22(11), 1257-1265. doi:10.1016/j.jval.2019.05.011DOI: 10.1016/j.jval.2019.05.011
Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Nonadherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers (Journal article)
Alshreef, A., Latimer, N., Tappenden, P., Wong, R., Hughes, D., Fotheringham, J., & Dixon, S. (2019). Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Nonadherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers. MEDICAL DECISION MAKING, 39(8), 910-925. doi:10.1177/0272989X19881654DOI: 10.1177/0272989X19881654
Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation (Journal article)
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., . . . Gamble, C. (2019). Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation. Lancet, 394(10208), 1530-1539. doi:10.1016/S0140-6736(19)31603-4DOI: 10.1016/S0140-6736(19)31603-4
Medicines Shortages in the United Kingdom (Journal article)
Hughes, D. A. (2019). Medicines Shortages in the United Kingdom. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(4), 712. doi:10.1002/cpt.1495DOI: 10.1002/cpt.1495
Holmes, E. A. F., & Hughes, D. A. (2019). Challenges for Economic Evaluation of Health Care Strategies to Contain Antimicrobial Resistance. ANTIBIOTICS-BASEL, 8(4). doi:10.3390/antibiotics8040166DOI: 10.3390/antibiotics8040166
McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., . . . O'Brien, S. J. (2019). A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System. JMIR RESEARCH PROTOCOLS, 8(9). doi:10.2196/13941DOI: 10.2196/13941
Johnson, D., Hughes, D., Pirmohamed, M., & Jorgensen, A. (2019). Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials. JOURNAL OF PERSONALIZED MEDICINE, 9(3). doi:10.3390/jpm9030042DOI: 10.3390/jpm9030042
Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout (Journal article)
Hill-McManus, D., Marshall, S., Soto, E., & Hughes, D. A. (2019). Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(3), 652-660. doi:10.1002/cpt.1454DOI: 10.1002/cpt.1454
Pharmacists must embrace pharmacogenetic services before other professions beat them to it (Journal article)
Pharmacists must embrace pharmacogenetic services before other professions beat them to it (2019). Pharmaceutical Journal. doi:10.1211/pj.2019.20206906DOI: 10.1211/pj.2019.20206906
Ring, A., Jacoby, A., Baker, G., Holmes, E., Hughes, D., Kierans, C., & Marson, A. (2019). What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK. EPILEPSY & BEHAVIOR, 95, 181-191. doi:10.1016/j.yebeh.2019.03.033DOI: 10.1016/j.yebeh.2019.03.033
Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2019). Cost‐Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework. Clinical pharmacology and therapeutics, 105(6), 1429-1438. doi:10.1002/cpt.1312DOI: 10.1002/cpt.1312
Crudgington, H., Rogers, M., Bray, L., Carter, B., Currier, J., Dunkley, C., . . . Morris, C. (2019). Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus. EPILEPSIA, 60(5), 857-871. doi:10.1111/epi.14735DOI: 10.1111/epi.14735
Improving Medication Adherence Research Reporting European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline (Journal article)
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. B., & Vrijens, B. (2019). Improving Medication Adherence Research Reporting European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline. JOURNAL OF CARDIOVASCULAR NURSING, 34(3), 199-200. doi:10.1097/JCN.0000000000000572DOI: 10.1097/JCN.0000000000000572
Blair, J. C., Mckay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Investigators, S. C. I. P. I. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation. BMJ: British Medical Journal, 365. doi:10.1136/bmj.l1226DOI: 10.1136/bmj.l1226
Blair, J. C., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . SCIPI investigators. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.. BMJ (Clinical research ed.), 365, l1226. doi:10.1136/bmj.l1226DOI: 10.1136/bmj.l1226
Ramanan, A. V., Dick, A. D., Jones, A. P., Hughes, D. A., McKay, A., Rosala-Halas, A., . . . Grp, S. Y. C. A. M. O. R. E. S. (2019). Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT. HEALTH TECHNOLOGY ASSESSMENT, 23(15), 1-139. doi:10.3310/hta23150DOI: 10.3310/hta23150
Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE) (Journal article)
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. B., & Vrijens, B. (2019). Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE). EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, 18(4), 258-259. doi:10.1177/1474515119830298DOI: 10.1177/1474515119830298
Systematic Review: Outcomes and Adverse Events From Randomised Trials in Crohn's Disease (Journal article)
Catt, H., Hughes, D., Kirkham, J., & Bodger, K. (2019). Systematic Review: Outcomes and Adverse Events From Randomised Trials in Crohn's Disease. Alimentary Pharmacology and Therapeutics, 49(8), 978-996. doi:10.1111/apt.15174DOI: 10.1111/apt.15174
McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., . . . O’Brien, S. J. (2019). A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System (Preprint). doi:10.2196/preprints.13941DOI: 10.2196/preprints.13941
Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., . . . Ramanan, A. V. (2019). Cost-Effectiveness Analysis of Adalimumab for the Treatment of Uveitis Associated with Juvenile Idiopathic Arthritis. Ophthalmology, 126(3), 415-424. doi:10.1016/j.ophtha.2018.09.043DOI: 10.1016/j.ophtha.2018.09.043
Holmes, E. A. F., Plumpton, C., Baker, G. A., Jacoby, A., Ring, A., Williamson, P., . . . Hughes, D. A. (2019). Patient-Focused Drug Development Methods for Benefit-Risk Assessments: A Case Study Using a Discrete Choice Experiment for Antiepileptic Drugs. CLINICAL PHARMACOLOGY & THERAPEUTICS, 105(3), 672-683. doi:10.1002/cpt.1231DOI: 10.1002/cpt.1231
Reply. (Journal article)
Hughes, D. A., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W., & Ramanan, A. V. (2019). Reply.. Ophthalmology, 126(3), e24-e25. doi:10.1016/j.ophtha.2018.12.005DOI: 10.1016/j.ophtha.2018.12.005
Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., . . . Wilkinson, C. (2019). CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial. TRIALS, 20. doi:10.1186/s13063-019-3179-9DOI: 10.1186/s13063-019-3179-9
CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial (Journal article)
Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., . . . Wilkinson, C. (2019). CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial. doi:10.21203/rs.2.122/v2DOI: 10.21203/rs.2.122/v2
Community views on factors affecting medicines resource allocation: cross-sectional survey of 3080 adults in Australia (Journal article)
Chim, L., Salkeld, G., Kelly, P. J., Lipworth, W., Hughes, D. A., & Stockler, M. R. (2019). Community views on factors affecting medicines resource allocation: cross-sectional survey of 3080 adults in Australia. AUSTRALIAN HEALTH REVIEW, 43(3), 254-260. doi:10.1071/AH16209DOI: 10.1071/AH16209
Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis REPLY (Journal article)
Hughes, D. A., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W., & Ramanan, A. V. (2019). Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis REPLY. OPHTHALMOLOGY, 126(3), E24-E25. doi:10.1016/j.ophtha.2018.12.005DOI: 10.1016/j.ophtha.2018.12.005
2018
Holmes, E. A. F., Harris, S. D., Hughes, A., Craine, N., & Hughes, D. A. (2018). Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care. ANTIBIOTICS-BASEL, 7(4). doi:10.3390/antibiotics7040106DOI: 10.3390/antibiotics7040106
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model (Journal article)
Hill-McManus, D., Marshall, S., Soto, E., Lane, S., & Hughes, D. (2018). Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model. VALUE IN HEALTH, 21(12), 1373-1381. doi:10.1016/j.jval.2018.06.002DOI: 10.1016/j.jval.2018.06.002
Moore, A., Young, C. A., & Hughes, D. A. (2018). Mapping ALSFRS-R and ALSUI to EQ-5D in Patients with Motor Neuron Disease. VALUE IN HEALTH, 21(11), 1322-1329. doi:10.1016/j.jval.2018.05.005DOI: 10.1016/j.jval.2018.05.005
Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma (Journal article)
Jenkinson, M. D., Weber, D. C., Haylock, B. J., Sherratt, F. C., Young, B., Weller, M., . . . Gamble, C. (2018). Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma. JOURNAL OF NEUROSURGERY, 129(4), 1104-1105. doi:10.3171/2018.6.JNS181418DOI: 10.3171/2018.6.JNS181418
QUANTITATIVE BENEFIT-RISK MODELLING OF BIOSIMILARS: A CASE STUDY OF INFLIXIMAB IN CROHN'S DISEASE. (Conference Paper)
Catt, H., Bodger, K., Kirkham, J., & Hughes, D. A. (2018). QUANTITATIVE BENEFIT-RISK MODELLING OF BIOSIMILARS: A CASE STUDY OF INFLIXIMAB IN CROHN'S DISEASE.. In VALUE IN HEALTH Vol. 21 (pp. S380). doi:10.1016/j.jval.2018.09.2262DOI: 10.1016/j.jval.2018.09.2262
Wilby, M. J., Hopkins, C., Bedson, E., Howlin, S., Burnside, G., Conroy, E. J., . . . Williamson, P. (2018). Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial. TRIALS, 19. doi:10.1186/s13063-018-2677-5DOI: 10.1186/s13063-018-2677-5
Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. A., & Jadhav, P. R. (2018). Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(5), 450-460. doi:10.1111/cts.12559DOI: 10.1111/cts.12559
Blair, J., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Gamble, C. (2018). Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technology Assessment, 22(42). doi:10.3310/hta22420DOI: 10.3310/hta22420
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., . . . Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). TRIALS, 19. doi:10.1186/s13063-018-2801-6DOI: 10.1186/s13063-018-2801-6
ESPACOMP Medication Adherence Reporting Guideline (EMERGE) (Journal article)
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Helmy, R., Hughes, D. A., Wilson, I. B., & Vrijens, B. (2018). ESPACOMP Medication Adherence Reporting Guideline (EMERGE). ANNALS OF INTERNAL MEDICINE, 169(1), 30-+. doi:10.7326/M18-0543DOI: 10.7326/M18-0543
Thorn, J. C., Brookes, S. T., Ridyard, C., Riley, R., Hughes, D. A., Wordsworth, S., . . . Hollingworth, W. (2018). Core Items for a Standardized Resource Use Measure: Expert Delphi Consensus Survey. VALUE IN HEALTH, 21(6), 640-649. doi:10.1016/j.jval.2017.06.011DOI: 10.1016/j.jval.2017.06.011
Economics of Pharmacogenetic-Guided Treatments: Underwhelming or Overstated? (Journal article)
Hughes, D. A. (2018). Economics of Pharmacogenetic-Guided Treatments: Underwhelming or Overstated?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(5), 749-751. doi:10.1002/cpt.1030DOI: 10.1002/cpt.1030
Varnava, A., Bracchi, R., Samuels, K., Hughes, D. A., & Routledge, P. A. (2018). New Medicines in Wales: The All Wales Medicines Strategy Group (AWMSG) Appraisal Process and Outcomes. PHARMACOECONOMICS, 36(5), 613-624. doi:10.1007/s40273-018-0632-7DOI: 10.1007/s40273-018-0632-7
Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods (Journal article)
Bourke, S. M., Plumpton, C. O., & Hughes, D. A. (2018). Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods. VALUE IN HEALTH, 21(5), 538-546. doi:10.1016/j.jval.2017.12.026DOI: 10.1016/j.jval.2017.12.026
Seizure First Aid Training for People with Epilepsy who Attend Emergency Departments and Their Family and Friends: Results from a Pilot Randomised Controlled Trial (Conference Paper)
Snape, D., Nevitt, S., Tudur-Smith, C., Goodacre, S., Hughes, D. A., Morgan, M., . . . Noble, A. J. (2018). Seizure First Aid Training for People with Epilepsy who Attend Emergency Departments and Their Family and Friends: Results from a Pilot Randomised Controlled Trial. In EPILEPSIA Vol. 59 (pp. S140). Retrieved from https://www.webofscience.com/
Rare disease prevention and treatment: the need for a level playing field (Journal article)
Hughes, D. A., & Plumpton, C. O. (2018). Rare disease prevention and treatment: the need for a level playing field. PHARMACOGENOMICS, 19(3), 243-247. doi:10.2217/pgs-2017-0300DOI: 10.2217/pgs-2017-0300
Access to High-Cost Medicines in Wales (Chapter)
Varnava, A., Rind, S., Bracchi, R., Samuels, K., Routledge, P. A., & Hughes, D. A. (2018). Access to High-Cost Medicines in Wales. In Equitable Access to High-Cost Pharmaceuticals (pp. 199-213). Elsevier. doi:10.1016/b978-0-12-811945-7.00013-0DOI: 10.1016/b978-0-12-811945-7.00013-0
Hill-McManus, D., Soto, E., Marshall, S., Lane, S., & Hughes, D. (2018). Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 84(1), 142-152. doi:10.1111/bcp.13427DOI: 10.1111/bcp.13427
Impact of the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales (Journal article)
Alam, M. F., Cohen, D., Dunstan, F., Hughes, D., & Routledge, P. (2018). Impact of the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales. HEALTH ECONOMICS, 27(1), 236-243. doi:10.1002/hec.3530DOI: 10.1002/hec.3530
2017
Economic Impact of Emergency Visits due to Drug-Related Morbidity on a Brazilian Hospital. (Journal article)
Freitas, G. R. M. D., Tramontina, M. Y., Balbinotto, G., Hughes, D. A., & Heineck, I. (2017). Economic Impact of Emergency Visits due to Drug-Related Morbidity on a Brazilian Hospital.. Value in health regional issues, 14, 1-8. doi:10.1016/j.vhri.2017.03.003DOI: 10.1016/j.vhri.2017.03.003
Morris, C., Dunkley, C., Gibbon, F. M., Currier, J., Roberts, D., Rogers, M., . . . Pal, D. K. (2017). Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set. TRIALS, 18. doi:10.1186/s13063-017-2323-7DOI: 10.1186/s13063-017-2323-7
Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2017). COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS. In VALUE IN HEALTH Vol. 20 (pp. A753). doi:10.1016/j.jval.2017.08.2111DOI: 10.1016/j.jval.2017.08.2111
Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford, England), 56(10), 1729-1739. doi:10.1093/rheumatology/kex253DOI: 10.1093/rheumatology/kex253
Hagemi, A., Plumpton, C., & Hughes, D. A. (2017). Renal transplant patients' preference for the supply and delivery of immunosuppressants in Wales: a discrete choice experiment. BMC NEPHROLOGY, 18. doi:10.1186/s12882-017-0720-5DOI: 10.1186/s12882-017-0720-5
CONTINUOUS SUBCUTANEOUS INFUSION VERSUS MULTIPLE DOSE INJECTION OF INSULIN FOR NEWLY-DIAGNOSED T1D PAEDIATRIC PATIENTS: A COST UTILITY ANALYSIS (Conference Paper)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). CONTINUOUS SUBCUTANEOUS INFUSION VERSUS MULTIPLE DOSE INJECTION OF INSULIN FOR NEWLY-DIAGNOSED T1D PAEDIATRIC PATIENTS: A COST UTILITY ANALYSIS. In VALUE IN HEALTH Vol. 20 (pp. A582). doi:10.1016/j.jval.2017.08.1042DOI: 10.1016/j.jval.2017.08.1042
Cost-effectiveness of HLA-B*15:02 screening in Malaysia (Journal article)
Plumpton, C., & Hughes, D. (2017). Cost-effectiveness of HLA-B*15:02 screening in Malaysia. BRITISH JOURNAL OF DERMATOLOGY, 177(4), 904-905. doi:10.1111/bjd.15832DOI: 10.1111/bjd.15832
PATTERNS IN WORKING DAYS LOST BY PARENTS OF CHILDREN NEWLY DIAGNOSED WITH TYPE 1 DIABETES (T1D) (Conference Paper)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). PATTERNS IN WORKING DAYS LOST BY PARENTS OF CHILDREN NEWLY DIAGNOSED WITH TYPE 1 DIABETES (T1D). In VALUE IN HEALTH Vol. 20 (pp. A590). doi:10.1016/j.jval.2017.08.1086DOI: 10.1016/j.jval.2017.08.1086
PUMP-DOWNLOADED INSULIN USAGE FOR THE FIRST 12 MONTHS IN A COHORT OF CHILDREN NEWLY-DIAGNOSED WITH TYPE 1 DIABETES (T1D) (Conference Paper)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). PUMP-DOWNLOADED INSULIN USAGE FOR THE FIRST 12 MONTHS IN A COHORT OF CHILDREN NEWLY-DIAGNOSED WITH TYPE 1 DIABETES (T1D). In VALUE IN HEALTH Vol. 20 (pp. A481-A482). doi:10.1016/j.jval.2017.08.470DOI: 10.1016/j.jval.2017.08.470
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., . . . Wilkinson, C. (2017). Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica. HEALTH TECHNOLOGY ASSESSMENT, 21(60), 1-+. doi:10.3310/hta21600DOI: 10.3310/hta21600
USE OF THE IMS CORE DIABETES MODEL (CDM) IN A LONG-TERM PROJECTED HEALTH ECONOMIC COMPARISON OF CSII AND MDI TREATMENTS OF TYPE 1 DIABETES (T1D) IN A NEWLY-DIAGNOSED POPULATION OF PAEDIATRIC PATIENTS (Conference Paper)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). USE OF THE IMS CORE DIABETES MODEL (CDM) IN A LONG-TERM PROJECTED HEALTH ECONOMIC COMPARISON OF CSII AND MDI TREATMENTS OF TYPE 1 DIABETES (T1D) IN A NEWLY-DIAGNOSED POPULATION OF PAEDIATRIC PATIENTS. In VALUE IN HEALTH Vol. 20 (pp. A580). doi:10.1016/j.jval.2017.08.1029DOI: 10.1016/j.jval.2017.08.1029
Ridyard, C. H., Plumpton, C. O., Gilbert, R. E., & Hughes, D. A. (2017). Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00644DOI: 10.3389/fphar.2017.00644
Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access (Journal article)
Powell, G., Bonnett, L., Tudur-Smith, C., Hughes, D., Marson, A., & Williamson, P. (2017). Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access. TRIALS, 18. Retrieved from http://gateway.webofknowledge.com/
Ramanan, A. V., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., . . . Grp, S. Y. C. A. M. O. R. E. S. (2017). Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis. New England Journal of Medicine, 376(17), 1637-1646. doi:10.1056/NEJMoa1614160DOI: 10.1056/NEJMoa1614160
Prayle, A. P., Cox, T., Smith, S. J., Rycroft-Malone, J., Thomas, K. S., Hughes, D. A., & Smyth, A. R. (2018). Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review. THORAX, 73(7), 670-673. doi:10.1136/thoraxjnl-2016-208790DOI: 10.1136/thoraxjnl-2016-208790
Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D. (Journal article)
Mulhern, B., Pink, J., Rowen, D., Borghs, S., Butt, T., Hughes, D., . . . Brazier, J. (2017). Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D.. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 20(4), 687-693. doi:10.1016/j.jval.2016.03.1860DOI: 10.1016/j.jval.2016.03.1860
Economic Studies in Motor Neurone Disease: A Systematic Methodological Review (Journal article)
Moore, A., Young, C. A., & Hughes, D. A. (2017). Economic Studies in Motor Neurone Disease: A Systematic Methodological Review. PHARMACOECONOMICS, 35(4), 397-413. doi:10.1007/s40273-016-0478-9DOI: 10.1007/s40273-016-0478-9
P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update (Journal article)
Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Bulbeck, H., Farrell, M., . . . Weber, D. (2017). P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update. Neuro-oncology, 19(Suppl 3), iii97.
Chim, L., Salkeld, G., Kelly, P., Lipworth, W., Hughes, D. A., & Stockler, M. R. (2017). Societal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia. PLOS ONE, 12(3). doi:10.1371/journal.pone.0172971DOI: 10.1371/journal.pone.0172971
Helmy, R., Zullig, L. L., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., Wilson, I. B., & De Geest, S. (2017). ESPACOMP Medication Adherence Reporting Guidelines (EMERGE): a reactive-Delphi study protocol. BMJ OPEN, 7(2). doi:10.1136/bmjopen-2016-013496DOI: 10.1136/bmjopen-2016-013496
Affordable orphan drugs: a role for not-for-profit organizations (Journal article)
Davies, E. H., Fulton, E., Brook, D., & Hughes, D. A. (2017). Affordable orphan drugs: a role for not-for-profit organizations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 83(7), 1595-1601. doi:10.1111/bcp.13240DOI: 10.1111/bcp.13240
Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D (Journal article)
Mulhern, B., Pink, J., Rowen, D., Borghs, S., Butt, T., Hughes, D., . . . Brazier, J. (2017). Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D. VALUE IN HEALTH, 20(4), 687-693. doi:10.1016/j.jval.2016.03.1860DOI: 10.1016/j.jval.2016.03.1860
Holmes, E., Marson, A. G., & Hughes, D. A. (2017). Patient preferences for outcomes in clinical trials: implications for medicines optimization. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/
2016
Johnson, S., Goebel, A., Richey, R., Holmes, E., & Hughes, D. (2016). A randomised, patient-assessor blinded, sham-controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial. TRIALS, 17. doi:10.1186/s13063-016-1709-2DOI: 10.1186/s13063-016-1709-2
Poletti-Hughes, J., & Hughes, D. (2016). How pharmaceutical companies profit from drugs for rare diseases.
How pharmaceutical companies profit from drugs for rare diseases. The Conversation (Media)
Poletti-Hughes, J., & Hughes, D. (2016). How pharmaceutical companies profit from drugs for rare diseases. The Conversation.
Verhoef, T. I., Redekop, W. K., Langenskiold, S., Kamali, F., Wadelius, M., Burnside, G., . . . Pirmohamed, M. (2016). Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden. PHARMACOGENOMICS JOURNAL, 16(5), 478-484. doi:10.1038/tpj.2016.41DOI: 10.1038/tpj.2016.41
Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study (Journal article)
Hughes, D. A., & Poletti-Hughes, J. (2016). Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study. PLOS ONE, 11(10). doi:10.1371/journal.pone.0164681DOI: 10.1371/journal.pone.0164681
A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions (Journal article)
Plumpton, C. O., Roberts, D., Pirmohamed, M., & Hughes, D. A. (2016). A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions. PHARMACOECONOMICS, 34(8), 771-793. doi:10.1007/s40273-016-0397-9DOI: 10.1007/s40273-016-0397-9
A Systematic Review of Patients' Perspectives on the Subcutaneous Route of Medication Administration (Journal article)
Ridyard, C. H., Dawoud, D. M. M., Tuersley, L. V., & Hughes, D. A. (2016). A Systematic Review of Patients' Perspectives on the Subcutaneous Route of Medication Administration. PATIENT-PATIENT CENTERED OUTCOMES RESEARCH, 9(4), 281-292. doi:10.1007/s40271-015-0160-xDOI: 10.1007/s40271-015-0160-x
Prof. John Urquhart Obituary (Journal article)
Breckenridge, A., & Hughes, D. (2016). Prof. John Urquhart Obituary. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 82(2), 573. doi:10.1111/bcp.12974DOI: 10.1111/bcp.12974
Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches (Journal article)
Hughes, D., Charles, J., Dawoud, D., Edwards, R. T., Holmes, E., Jones, C., . . . Yeo, S. T. (2016). Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. PHARMACOECONOMICS, 34(5), 447-461. doi:10.1007/s40273-015-0371-yDOI: 10.1007/s40273-015-0371-y
Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., . . . Investigators, C. A. T. C. H. T. (2016). Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial. The Lancet, 387(10029), 1732-1742. doi:10.1016/S0140-6736(16)00340-8DOI: 10.1016/S0140-6736(16)00340-8
Opportunity costs and local health service spending decisions: a qualitative study from Wales (Journal article)
Schaffer, S. K., Sussex, J., Hughes, D., & Devlin, N. (2016). Opportunity costs and local health service spending decisions: a qualitative study from Wales. BMC HEALTH SERVICES RESEARCH, 16. doi:10.1186/s12913-016-1354-1DOI: 10.1186/s12913-016-1354-1
Harron, K., Mok, Q., Dwan, K., Ridyard, C. H., Moitt, T., Millar, M., . . . Gilbert, R. E. (2016). CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children. HEALTH TECHNOLOGY ASSESSMENT, 20(18), 1-+. doi:10.3310/hta20180DOI: 10.3310/hta20180
Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England (Journal article)
Harron, K., Mok, Q., Hughes, D., Muller-Pebody, B., Parslow, R., Ramnarayan, P., & Gilbert, R. (2016). Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England. PLOS ONE, 11(3). doi:10.1371/journal.pone.0151348DOI: 10.1371/journal.pone.0151348
Plumpton, C. O., Morris, T., Hughes, D. A., & White, I. R. (2016). Multiple imputation of multiple multi-item scales when a full imputation model is infeasible.. BMC research notes, 9, 45. doi:10.1186/s13104-016-1853-5DOI: 10.1186/s13104-016-1853-5
What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients (Journal article)
Holmes, E. A. F., Morrison, V. L., & Hughes, D. A. (2016). What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 82(2), 522-531. doi:10.1111/bcp.12971DOI: 10.1111/bcp.12971
2015
HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE (Journal article)
Nakamura, C. A., Roberts, P., Beadsworth, M., O'Brien, S., Pirmohamed, M., Hughes, D., & Miyajima, F. (2015). HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE. VALUE IN HEALTH, 18(7), A582. doi:10.1016/j.jval.2015.09.1947DOI: 10.1016/j.jval.2015.09.1947
Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., . . . Weber, D. C. (2015). The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial. TRIALS, 16. doi:10.1186/s13063-015-1040-3DOI: 10.1186/s13063-015-1040-3
IDENTIFICATION OF ITEMS FORA STANDARDISED RESOURCE-USE MEASURE: REVIEW OF CURRENT INSTRUMENTS (Journal article)
Thorn, J. C., Ridyard, C. H., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., . . . Hollingworth, W. (2015). IDENTIFICATION OF ITEMS FORA STANDARDISED RESOURCE-USE MEASURE: REVIEW OF CURRENT INSTRUMENTS. VALUE IN HEALTH, 18(7), A688. doi:10.1016/j.jval.2015.09.2549DOI: 10.1016/j.jval.2015.09.2549
Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery (Journal article)
Powell, G., Holmes, E. A. F., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., . . . Hughes, D. A. (2015). Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(5), 1149-1159. doi:10.1111/bcp.12715DOI: 10.1111/bcp.12715
Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions (Journal article)
Roberts, E., Dawoud, D. M., Hughes, D. A., & Cefai, C. (2015). Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions. INTERNATIONAL JOURNAL OF PHARMACY PRACTICE, 23(5), 333-339. doi:10.1111/ijpp.12173DOI: 10.1111/ijpp.12173
Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group (Journal article)
Richter, T., Nestler-Parr, S., Babela, R., Khan, Z. M., Tesoro, T., Molsen, E., & Hughes, D. A. (2015). Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group. VALUE IN HEALTH, 18(6), 906-914. doi:10.1016/j.jval.2015.05.008DOI: 10.1016/j.jval.2015.05.008
Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke (Journal article)
Kilarski, L. L., Rutten-Jacobs, L. C. A., Bevan, S., Baker, R., Hassan, A., Hughes, D. A., & Markus, H. S. (2015). Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke. PLOS ONE, 10(8). doi:10.1371/journal.pone.0136352DOI: 10.1371/journal.pone.0136352
Noble, A. J., Marson, A. G., Tudur-Smith, C., Morgan, M., Hughes, D. A., Goodacre, S., & Ridsdale, L. (2015). 'Seizure First Aid Training' for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial. BMJ OPEN, 5(7). doi:10.1136/bmjopen-2015-009040DOI: 10.1136/bmjopen-2015-009040
Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria (Journal article)
Loetsch, F., Auer-Hackenberg, L., Groger, M., Rehman, K., Morrison, V., Holmes, E., . . . Ramharter, M. (2015). Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria. WIENER KLINISCHE WOCHENSCHRIFT, 127(9-10), 379-384. doi:10.1007/s00508-015-0782-yDOI: 10.1007/s00508-015-0782-y
GOVERNMENT UNDERMINING OF NICE NICE recommendations: why no disinvestment recommendations to offset investment decisions? (Journal article)
Hughes, D. A., Wood, E. M., & Tuersley, L. (2015). GOVERNMENT UNDERMINING OF NICE NICE recommendations: why no disinvestment recommendations to offset investment decisions?. BMJ-BRITISH MEDICAL JOURNAL, 350. doi:10.1136/bmj.h2656DOI: 10.1136/bmj.h2656
Blair, J., Gregory, J. W., Hughes, D., Ridyard, C. H., Gamble, C., Mckay, A., . . . Peak, M. (2015). Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections. TRIALS, 16. doi:10.1186/s13063-015-0658-5DOI: 10.1186/s13063-015-0658-5
Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios (Journal article)
Parham, P. E., & Hughes, D. A. (2015). Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 370(1665). doi:10.1098/rstb.2013.0557DOI: 10.1098/rstb.2013.0557
Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy (Journal article)
Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937DOI: 10.1111/epi.12937
Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence (Journal article)
Plumpton, C. O., Brown, I., Reuber, M., Marson, A. G., & Hughes, D. A. (2015). Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence. EPILEPSY & BEHAVIOR, 45, 180-186. doi:10.1016/j.yebeh.2015.01.035DOI: 10.1016/j.yebeh.2015.01.035
Predictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey (Journal article)
Morrison, V. L., Holmes, E. A. F., Parveen, S., Plumpton, C. O., Clyne, W., De Geest, S., . . . Hughes, D. A. (2015). Predictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey. VALUE IN HEALTH, 18(2), 206-216. doi:10.1016/j.jval.2014.12.013DOI: 10.1016/j.jval.2014.12.013
TAXONOMY FOR METHODS OF RESOURCE USE MEASUREMENT (Journal article)
Ridyard, C. H., & Hughes, D. A. (2015). TAXONOMY FOR METHODS OF RESOURCE USE MEASUREMENT. HEALTH ECONOMICS, 24(3), 372-378. doi:10.1002/hec.3029DOI: 10.1002/hec.3029
Identification of items for a standardised resource-use measure: review of current instruments (Journal article)
Thorn, J., Ridyard, C., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., . . . Hollingworth, W. (2015). Identification of items for a standardised resource-use measure: review of current instruments. TRIALS, 16. doi:10.1186/1745-6215-16-S2-O26DOI: 10.1186/1745-6215-16-S2-O26
The trials and tribulations of accessing data from routine sources (Conference Paper)
Powell, G., Marson, T., Hughes, D., Williamson, P., & Tudur-Smith, C. (2015). The trials and tribulations of accessing data from routine sources. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P225DOI: 10.1186/1745-6215-16-S2-P225
2014
Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity (Journal article)
Sutton, S., Kinmonth, A. -L., Hardeman, W., Hughes, D., Boase, S., Prevost, A. T., . . . Farmer, A. (2014). Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity. ANNALS OF BEHAVIORAL MEDICINE, 48(3), 293-299. doi:10.1007/s12160-014-9595-xDOI: 10.1007/s12160-014-9595-x
Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research (Journal article)
Holmes, E. A. F., Hughes, D. A., & Morrison, V. L. (2014). Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research. VALUE IN HEALTH, 17(8), 863-876. doi:10.1016/j.jval.2014.08.2671DOI: 10.1016/j.jval.2014.08.2671
OPPORTUNITY COSTS OF IMPLEMENTING NICE DECISIONS IN NHS WALES (Journal article)
Schaffer, K. S., Sussex, J., Hughes, D., & Devlin, N. (2014). OPPORTUNITY COSTS OF IMPLEMENTING NICE DECISIONS IN NHS WALES. VALUE IN HEALTH, 17(7), A422. doi:10.1016/j.jval.2014.08.1043DOI: 10.1016/j.jval.2014.08.1043
Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Williams, N. (2014). Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.. Health Technology Assessment, 18(48). doi:10.3310/hta18480DOI: 10.3310/hta18480
Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation (Journal article)
Pink, J., Pirmohamed, M., Lane, S., & Hughes, D. A. (2014). Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation. Clinical Pharmacology and Therapeutics, 95(2), 199-207. doi:10.1038/clpt.2013.190DOI: 10.1038/clpt.2013.190
A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis (Journal article)
Ramanan, A. V., Dick, A. D., McKay, A., Jones, A., Williamson, P., Compeyrot-Lacassagne, S., . . . Beresford, M. W. (2015). A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis. ARTHRITIS & RHEUMATOLOGY, 67. Retrieved from https://www.webofscience.com/
A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial) (Journal article)
Ramanan, A. V., Dick, A. D., Benton, D., Compeyrot-Lacassagne, S., Dawoud, D., Hardwick, B., . . . The SYCAMORE Trial Management Group. (2014). A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial). Trials, 15. doi:10.1186/1745-6215-15-14DOI: 10.1186/1745-6215-15-14
The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol (Journal article)
Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. TRIALS, 15. doi:10.1186/1745-6215-15-4DOI: 10.1186/1745-6215-15-4
Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population (Journal article)
Mulhern, B., Rowen, D., Snape, D., Jacoby, A., Marson, T., Hughes, D., . . . Brazier, J. (2014). Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population. EPILEPSY & BEHAVIOR, 36, 12-17. doi:10.1016/j.yebeh.2014.04.011DOI: 10.1016/j.yebeh.2014.04.011
2013
ANTIEPILEPTIC DRUGS New advice on switching antiepileptic drugs might be a false economy (Journal article)
Holmes, E., Plumpton, C., Duerden, M., Marson, T., & Hughes, D. (2013). ANTIEPILEPTIC DRUGS New advice on switching antiepileptic drugs might be a false economy. BMJ-BRITISH MEDICAL JOURNAL, 347. doi:10.1136/bmj.f7471DOI: 10.1136/bmj.f7471
Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group (Journal article)
Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P., & Cowell, W. (2013). Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group. OSTEOPOROSIS INTERNATIONAL, 24(12), 2907-2918. doi:10.1007/s00198-013-2364-zDOI: 10.1007/s00198-013-2364-z
Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation (Journal article)
Pink, J., Pirmohamed, M., & Hughes, D. A. (2013). Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(2), 269-276. doi:10.1038/clpt.2013.83DOI: 10.1038/clpt.2013.83
SOCIETAL VIEWS ON NICE, CANCER DRUGS FUND AND VALUE-BASED PRICING CRITERIA FOR PRIORITISING MEDICINES: A CROSS-SECTIONAL SURVEY OF 4118 ADULTS IN GREAT BRITAIN (Journal article)
Linley, W. G., & Hughes, D. A. (2013). SOCIETAL VIEWS ON NICE, CANCER DRUGS FUND AND VALUE-BASED PRICING CRITERIA FOR PRIORITISING MEDICINES: A CROSS-SECTIONAL SURVEY OF 4118 ADULTS IN GREAT BRITAIN. HEALTH ECONOMICS, 22(8), 948-964. doi:10.1002/hec.2872DOI: 10.1002/hec.2872
Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group (Journal article)
Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A., & Grubisic, M. (2013). Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group. VALUE IN HEALTH, 16(5), 863-871. doi:10.1016/j.jval.2013.03.1631DOI: 10.1016/j.jval.2013.03.1631
Resource-use measurement based on patient recall: issues and challenges for economic evaluation. (Journal article)
Thorn, J. C., Coast, J., Cohen, D., Hollingworth, W., Knapp, M., Noble, S. M., . . . Hughes, D. (2013). Resource-use measurement based on patient recall: issues and challenges for economic evaluation.. Applied health economics and health policy, 11(3), 155-161. doi:10.1007/s40258-013-0022-4DOI: 10.1007/s40258-013-0022-4
Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis (Journal article)
Demonceau, J., Ruppar, T., Kristanto, P., Hughes, D. A., Fargher, E., Kardas, P., . . . Vrijens, B. (2013). Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis. DRUGS, 73(6), 545-562. doi:10.1007/s40265-013-0041-3DOI: 10.1007/s40265-013-0041-3
Decision-Makers' Preferences for Approving New Medicines in Wales: A Discrete-Choice Experiment with Assessment of External Validity (Journal article)
Linley, W. G., & Hughes, D. A. (2013). Decision-Makers' Preferences for Approving New Medicines in Wales: A Discrete-Choice Experiment with Assessment of External Validity. PHARMACOECONOMICS, 31(4), 345-355. doi:10.1007/s40273-013-0030-0DOI: 10.1007/s40273-013-0030-0
Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)
Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199DOI: 10.2217/PGS.12.199
Pharmacogenetic tests: the need for a level playing field (Journal article)
Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921DOI: 10.1038/nrd3921
Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation (Journal article)
Ridyard, C., & Hughes, D. (2013). Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation. Trials, 14(Suppl 1), O22. doi:10.1186/1745-6215-14-s1-o22DOI: 10.1186/1745-6215-14-s1-o22
Using discrete choice experiments to define patient preferences for outcomes in trials (Journal article)
Fargher, E., Hughes, D., Ring, A., Jacoby, A., Rawnsley, M., & Marson, A. (2013). Using discrete choice experiments to define patient preferences for outcomes in trials. Trials, 14(Suppl 1), O33. doi:10.1186/1745-6215-14-s1-o33DOI: 10.1186/1745-6215-14-s1-o33
2012
Challenges in the Development and Reimbursement of Personalized Medicine-Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group (Journal article)
Faulkner, E., Annemans, L., Garrison, L., Helfand, M., Holtorf, A. -P., Hornberger, J., . . . Watkins, J. (2012). Challenges in the Development and Reimbursement of Personalized Medicine-Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group. VALUE IN HEALTH, 15(8), 1162-1171. doi:10.1016/j.jval.2012.05.006DOI: 10.1016/j.jval.2012.05.006
Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs (Journal article)
Verhoef, T. I., Redekop, W. K., van Schie, R. M. F., Bayat, S., Daly, A. K., Geitona, M., . . . Maitland-van der Zee, A. -H. (2012). Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. PHARMACOGENOMICS, 13(12), 1405-1417. doi:10.2217/PGS.12.124DOI: 10.2217/PGS.12.124
Reimbursement Decisions of the All Wales Medicines Strategy Group Influence of Policy and Clinical and Economic Factors (Journal article)
Linley, W. G., & Hughes, D. A. (2012). Reimbursement Decisions of the All Wales Medicines Strategy Group Influence of Policy and Clinical and Economic Factors. PHARMACOECONOMICS, 30(9), 779-794. doi:10.2165/11591530-000000000-00000DOI: 10.2165/11591530-000000000-00000
Harron, K., Lee, T., Ball, T., Mok, Q., Gamble, C., Macrae, D., & Gilbert, R. (2012). Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041791DOI: 10.1371/journal.pone.0041791
Development of a Database of Instruments for Resource-Use Measurement: Purpose, Feasibility, and Design (Journal article)
Ridyard, C. H., & Hughes, D. A. (2012). Development of a Database of Instruments for Resource-Use Measurement: Purpose, Feasibility, and Design. VALUE IN HEALTH, 15(5), 650-655. doi:10.1016/j.jval.2012.03.004DOI: 10.1016/j.jval.2012.03.004
Pharmacoeconomics (Journal article)
Hughes, D. A. (2012). Pharmacoeconomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(6), 968-972. doi:10.1111/j.1365-2125.2012.04247.xDOI: 10.1111/j.1365-2125.2012.04247.x
A Risk-Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention (Journal article)
Guzauskas, G. F., Hughes, D. A., Bradley, S. M., & Veenstra, D. L. (2012). A Risk-Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(5), 829-837. doi:10.1038/clpt.2011.303DOI: 10.1038/clpt.2011.303
A new taxonomy for describing and defining adherence to medications (Journal article)
Vrijens, B., De Geest, S., Hughes, D. A., Przemyslaw, K., Demonceau, J., Ruppar, T., . . . Urquhart, J. (2012). A new taxonomy for describing and defining adherence to medications. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(5), 691-705. doi:10.1111/j.1365-2125.2012.04167.xDOI: 10.1111/j.1365-2125.2012.04167.x
The development of a QALY measure for epilepsy: NEWQOL-6D (Journal article)
Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D., . . . Brazier, J. E. (2012). The development of a QALY measure for epilepsy: NEWQOL-6D. EPILEPSY & BEHAVIOR, 24(1), 36-43. doi:10.1016/j.yebeh.2012.02.025DOI: 10.1016/j.yebeh.2012.02.025
Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma (Journal article)
Pink, J., Lane, S., & Hughes, D. A. (2012). Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma. PHARMACOECONOMICS, 30(5), 413-429. doi:10.2165/11591540-000000000-00000DOI: 10.2165/11591540-000000000-00000
An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes (Journal article)
Farmer, A., Hardeman, W., Hughes, D., Prevost, A. T., Kim, Y., Craven, A., . . . Kinmonth, A. -L. (2012). An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes. BMC FAMILY PRACTICE, 13. doi:10.1186/1471-2296-13-30DOI: 10.1186/1471-2296-13-30
Defining rewardable innovation in drug therapy (Journal article)
Aronson, J. K., Ferner, R. E., & Hughes, D. A. (2012). Defining rewardable innovation in drug therapy. NATURE REVIEWS DRUG DISCOVERY, 11(4), 253-254. doi:10.1038/nrd3715DOI: 10.1038/nrd3715
The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors (Journal article)
Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.xDOI: 10.1111/j.1365-2125.2011.04051.x
2011
DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib (Journal article)
Hughes, D. A., Pink, J., Lane, S., & Pirmohamed, M. (2011). DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib. BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d7718DOI: 10.1136/bmj.d7718
PHARMACEUTICAL INNOVATION: DEFINITION, AND MECHANISMS FOR REWARD (Conference Paper)
Hughes, D. (2011). PHARMACEUTICAL INNOVATION: DEFINITION, AND MECHANISMS FOR REWARD. In VALUE IN HEALTH Vol. 14 (pp. A363). doi:10.1016/j.jval.2011.08.713DOI: 10.1016/j.jval.2011.08.713
Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses (Journal article)
Pink, J., Lane, S., Pirmohamed, M., & Hughes, D. A. (2011). Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses. BMJ-BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d6333DOI: 10.1136/bmj.d6333
Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units (Journal article)
Harron, K., Ramachandra, G., Mok, Q., & Gilbert, R. (2011). Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units. INTENSIVE CARE MEDICINE, 37(10), 1641-1647. doi:10.1007/s00134-011-2343-9DOI: 10.1007/s00134-011-2343-9
Ring-fencing a budget for cancer drugs: is it fair? (Journal article)
Graham, J., Cassidy, J., Hughes, D., & Duerden, M. (2011). Ring-fencing a budget for cancer drugs: is it fair?. The journal of the Royal College of Physicians of Edinburgh, 41(3), 224-228. doi:10.4997/jrcpe.2011.310DOI: 10.4997/jrcpe.2011.310
Value-Based Pricing Incentive for Innovation or Zero Net Benefit? (Journal article)
Hughes, D. A. (2011). Value-Based Pricing Incentive for Innovation or Zero Net Benefit?. PHARMACOECONOMICS, 29(9), 731-735. doi:10.2165/11592570-000000000-00000DOI: 10.2165/11592570-000000000-00000
Generic substitution: authors' response (Journal article)
Hughes, D. A., & Duerden, M. G. (2011). Generic substitution: authors' response. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 71(6), 968. doi:10.1111/j.1365-2125.2010.03878.xDOI: 10.1111/j.1365-2125.2010.03878.x
MOST EFFECTIVE ADHERENCE-ENHANCING INTERVENTIONS FOR OSTEOPOROSIS MEDICATIONS (Conference Paper)
Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F., Linck, P., & Cowell, W. (2011). MOST EFFECTIVE ADHERENCE-ENHANCING INTERVENTIONS FOR OSTEOPOROSIS MEDICATIONS. In VALUE IN HEALTH Vol. 14 (pp. A130). doi:10.1016/j.jval.2011.02.724DOI: 10.1016/j.jval.2011.02.724
HTAs and rare diseases: How to assess their cost-effectiveness (Journal article)
Phillips, C. J., & Hughes, D. A. (2011). HTAs and rare diseases: How to assess their cost-effectiveness. Pharmaceuticals, Policy and Law, 13(3,4), 161-165. doi:10.3233/ppl-2011-0321DOI: 10.3233/ppl-2011-0321
Interventions To Improve Patients Compliance with Lipid Lowering Medications: A Systematic Review of the Literature (Conference Paper)
Zuluaga, A., Salas, M., Gwadry-Sridhar, F. H., Manias, E., & Hughes, D. A. (2011). Interventions To Improve Patients Compliance with Lipid Lowering Medications: A Systematic Review of the Literature. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 20 (pp. S356). Retrieved from https://www.webofscience.com/
Letters: Involving colleagues can be challenging (Journal article)
Fargher, E., & Hughes, D. (2011). Letters: Involving colleagues can be challenging. Pharmaceutical Journal, 286(7647), 404.
MOST EFFECTIVE INTERVENTIONS TO IMPROVE PATIENT COMPLIANCE WITH OSTEOPOROSIS MEDICATIONS (Conference Paper)
Hiligsmann, M., Salas, M., Hughes, D., Manias, E., Gwadry-Sridhar, F., Linck, P., & Cowell, W. (2011). MOST EFFECTIVE INTERVENTIONS TO IMPROVE PATIENT COMPLIANCE WITH OSTEOPOROSIS MEDICATIONS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. 335). Retrieved from https://www.webofscience.com/
PHARMACOECONOMIC ASPECTS OF RATIONAL MEDICINES USE (Conference Paper)
Hughes, D. (2011). PHARMACOECONOMIC ASPECTS OF RATIONAL MEDICINES USE. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 109 (pp. 49). Retrieved from https://www.webofscience.com/
Where is the evidence? (Journal article)
Hughes, D. A. (2011). Where is the evidence?. Pharmaceutical Journal, 286(7634-7635), 9.
2010
The problem of orphan drugs (Journal article)
Ferner, R. E., & Hughes, D. A. (2010). The problem of orphan drugs. BRITISH MEDICAL JOURNAL, 341. doi:10.1136/bmj.c6456DOI: 10.1136/bmj.c6456
Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay. (Journal article)
Groves, S., Cohen, D., Alam, M. F., Dunstan, F. D. J., Routledge, P. A., Hughes, D. A., & Myles, S. (2010). Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay.. The International journal of pharmacy practice, 18(6), 332-340. doi:10.1111/j.2042-7174.2010.00063.xDOI: 10.1111/j.2042-7174.2010.00063.x
ABOLITION OF PRESCRIPTION CO-PAYMENTS IN WALES: AN OBSERVATIONAL STUDY ON DISPENSING RATES (Conference Paper)
Cohen, D., Alam, F., Dunstan, F., Myles, S., Hughes, D., & Routledge, P. (2010). ABOLITION OF PRESCRIPTION CO-PAYMENTS IN WALES: AN OBSERVATIONAL STUDY ON DISPENSING RATES. In JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Vol. 64 (pp. A25). doi:10.1136/jech.2010.120956.62DOI: 10.1136/jech.2010.120956.62
From NCE to NICE: the role of pharmacoeconomics (Journal article)
Hughes, D. A. (2010). From NCE to NICE: the role of pharmacoeconomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(3), 317-319. doi:10.1111/j.1365-2125.2010.03708.xDOI: 10.1111/j.1365-2125.2010.03708.x
Generic and therapeutic substitutions in the UK: are they a good thing? (Journal article)
Duerden, M. G., & Hughes, D. A. (2010). Generic and therapeutic substitutions in the UK: are they a good thing?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(3), 335-341. doi:10.1111/j.1365-2125.2010.03718.xDOI: 10.1111/j.1365-2125.2010.03718.x
Is exercise effective in promoting mental well-being in older age? A systematic review (Journal article)
Windle, G., Hughes, D., Linck, P., Russell, I., & Woods, B. (2010). Is exercise effective in promoting mental well-being in older age? A systematic review. AGING & MENTAL HEALTH, 14(6), 652-669. doi:10.1080/13607861003713232DOI: 10.1080/13607861003713232
A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives (Journal article)
Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., . . . Zee, A. -H. M. -V. D. (2010). A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. PHARMACOGENOMICS, 11(7), 989-1002. doi:10.2217/PGS.10.74DOI: 10.2217/PGS.10.74
A BENEFIT-RISK ASSESSMENT OF USING CYP2C19 GENOTYPE INFORMATION TO GUIDE ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME (Conference Paper)
Guzauskas, G. F., Veenstra, D., & Hughes, D. (2010). A BENEFIT-RISK ASSESSMENT OF USING CYP2C19 GENOTYPE INFORMATION TO GUIDE ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME. In VALUE IN HEALTH Vol. 13 (pp. A152-A153). doi:10.1016/S1098-3015(10)72741-8DOI: 10.1016/S1098-3015(10)72741-8
INTERVENTIONS TO IMPROVE COMPLIANCE WITH LIPID LOWERING MEDICATIONS: A SYSTEMATIC REVIEW OF THE LITERATURE (Conference Paper)
Zuluaga, A., Salas, M., Gwadry-Sridhar, F., Manias, E., & Hughes, D. (2010). INTERVENTIONS TO IMPROVE COMPLIANCE WITH LIPID LOWERING MEDICATIONS: A SYSTEMATIC REVIEW OF THE LITERATURE. In VALUE IN HEALTH Vol. 13 (pp. A168). doi:10.1016/S1098-3015(10)72819-9DOI: 10.1016/S1098-3015(10)72819-9
TRENDS IN THE PRESCRIBING OF CONVENTIONAL ANTIRHEUMATIC THERAPY AMONG CANADIANS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE COHORT STUDY (Conference Paper)
Gomez-Galicia, D. L., Kezouh, A., Salas, M., Gwadry-Sridhar, F., Manias, E., Reyes-Esparza, J. A., & Hughes, D. (2010). TRENDS IN THE PRESCRIBING OF CONVENTIONAL ANTIRHEUMATIC THERAPY AMONG CANADIANS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE COHORT STUDY. In VALUE IN HEALTH Vol. 13 (pp. A131). doi:10.1016/S1098-3015(10)72635-8DOI: 10.1016/S1098-3015(10)72635-8
New drugs for old: Disinvestment and NICE (Journal article)
Hughes, D., & Ferner, R. (2010). New drugs for old: Disinvestment and NICE. BMJ (Online), 340(7748), 690-692.
Biosimilars: Evidential Standards for Health Technology Assessment (Journal article)
Hughes, D. A. (2010). Biosimilars: Evidential Standards for Health Technology Assessment. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(3), 257-261. doi:10.1038/clpt.2009.112DOI: 10.1038/clpt.2009.112
New drugs for old: disinvestment and NICE (Journal article)
Hughes, D. A., & Ferner, R. E. (2010). New drugs for old: disinvestment and NICE. BMJ-BRITISH MEDICAL JOURNAL, 340. doi:10.1136/bmj.c572DOI: 10.1136/bmj.c572
NICE and new: Appraising innovation (Journal article)
Ferner, R., Hughes, D. A., & Aronson, J. (2010). NICE and new: Appraising innovation. BMJ (Online), 340(7740), 245-247.
NICE and new: appraising innovation (Journal article)
Ferner, R. E., Hughes, D. A., & Aronson, J. K. (2010). NICE and new: appraising innovation. BMJ-BRITISH MEDICAL JOURNAL, 340. doi:10.1136/bmj.b5493DOI: 10.1136/bmj.b5493
A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action (Journal article)
Hughes, D. A., & Aronson, J. K. (2010). A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action. JOURNAL OF CLINICAL PHARMACOLOGY, 50(1), 17-26. doi:10.1177/0091270008329555DOI: 10.1177/0091270008329555
Abolition of Prescription Copayments in Wales: An Observational Study on Dispensing Rates (Journal article)
Cohen, D., Alam, M. F., Dunstan, F. D. J., Myles, S., Hughes, D. A., & Routledge, P. A. (2010). Abolition of Prescription Copayments in Wales: An Observational Study on Dispensing Rates. VALUE IN HEALTH, 13(5), 675-680. doi:10.1111/j.1524-4733.2010.00717.xDOI: 10.1111/j.1524-4733.2010.00717.x
Methods for the Collection of Resource Use Data within Clinical Trials: A Systematic Review of Studies Funded by the UK Health Technology Assessment Program (Journal article)
Ridyard, C. H., & Hughes, D. A. (2010). Methods for the Collection of Resource Use Data within Clinical Trials: A Systematic Review of Studies Funded by the UK Health Technology Assessment Program. VALUE IN HEALTH, 13(8), 867-872. doi:10.1111/j.1524-4733.2010.00788.xDOI: 10.1111/j.1524-4733.2010.00788.x
2009
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)
Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5DOI: 10.1097/FPC.0b013e3283317ab5
Estimating Drug Costs in Economic Evaluations in Ireland and the UK An Analysis of Practice and Research Recommendations (Journal article)
Hughes, D. A., Tilson, L., & Drummond, M. (2009). Estimating Drug Costs in Economic Evaluations in Ireland and the UK An Analysis of Practice and Research Recommendations. PHARMACOECONOMICS, 27(8), 635-643. doi:10.2165/10899570-000000000-00000DOI: 10.2165/10899570-000000000-00000
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi (Journal article)
Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2009). Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. MALARIA JOURNAL, 8. doi:10.1186/1475-2875-8-204DOI: 10.1186/1475-2875-8-204
Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis (Journal article)
Sorensen, S. V., Baker, T., Fleurence, R., Dixon, J., Roberts, C., Haider, S., & Hughes, D. (2009). Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 13(8), 945-954. Retrieved from https://www.webofscience.com/
Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data (Journal article)
Bodger, K., Kikuchi, T., & Hughes, D. (2009). Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(3), 265-274. doi:10.1111/j.1365-2036.2009.04033.xDOI: 10.1111/j.1365-2036.2009.04033.x
Follow-up of cancer in primary care versus secondary care: systematic review (Journal article)
Lewis, R. A., Neal, R. D., Williams, N. H., France, B., Hendry, M., Russell, D., . . . Wilkinson, C. (2009). Follow-up of cancer in primary care versus secondary care: systematic review. BRITISH JOURNAL OF GENERAL PRACTICE, 59(564), 525-532. doi:10.3399/bjgp09X453567DOI: 10.3399/bjgp09X453567
Patients' and healthcare professionals' views of cancer follow-up: systematic review (Journal article)
Lewis, R. A., Neal, R. D., Hendry, M., France, B., Williams, N. H., Russell, D., . . . Wilkinson, C. (2009). Patients' and healthcare professionals' views of cancer follow-up: systematic review. BRITISH JOURNAL OF GENERAL PRACTICE, 59(564), 533-540. doi:10.3399/bjgp09X453576DOI: 10.3399/bjgp09X453576
ABOLITION OF PRESCRIPTION CO-PAYMENTS: AN ANALYSIS OF ITEMS DISPENSED IN WALES (Conference Paper)
Hughes, D. A., Alam, F. M., Cohen, D., Dunstan, F., Groves, S., & Routledge, P. A. (2009). ABOLITION OF PRESCRIPTION CO-PAYMENTS: AN ANALYSIS OF ITEMS DISPENSED IN WALES. In VALUE IN HEALTH Vol. 12 (pp. A80). doi:10.1016/S1098-3015(10)73460-4DOI: 10.1016/S1098-3015(10)73460-4
ECONOMIC EVALUATION OF INFLIXIMAB AND ADALIMUMAB FOR CROHN'S DISEASE (Conference Paper)
Hughes, D. A., Kikuchi, T., & Bodger, K. (2009). ECONOMIC EVALUATION OF INFLIXIMAB AND ADALIMUMAB FOR CROHN'S DISEASE. In VALUE IN HEALTH Vol. 12 (pp. A59). doi:10.1016/S1098-3015(10)73358-1DOI: 10.1016/S1098-3015(10)73358-1
ESTIMATING DRUG COSTS IN ECONOMIC EVALUATIONS IN IRELAND AND THE UK: AN ANALYSIS OF PRACTICE AND RESEARCH RECOMMENDATIONS (Conference Paper)
Hughes, D. A., Tilson, L., & Drummond, M. F. (2009). ESTIMATING DRUG COSTS IN ECONOMIC EVALUATIONS IN IRELAND AND THE UK: AN ANALYSIS OF PRACTICE AND RESEARCH RECOMMENDATIONS. In VALUE IN HEALTH Vol. 12 (pp. A6-A7). doi:10.1016/S1098-3015(10)73093-XDOI: 10.1016/S1098-3015(10)73093-X
IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS (Journal article)
Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3DOI: 10.1016/S1098-3015(10)73081-3
Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244x-9-14DOI: 10.1186/1471-244x-9-14
Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review (Journal article)
Lewis, R., Neal, R. D., Williams, N. H., France, B., Wilkinson, C., Hendry, M., . . . Weller, D. (2009). Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review. JOURNAL OF ADVANCED NURSING, 65(4), 706-723. doi:10.1111/j.1365-2648.2008.04927.xDOI: 10.1111/j.1365-2648.2008.04927.x
A Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs (Journal article)
Gwadry-Sridhar, F. H., Manias, E., Zhang, Y., Roy, A., Yu-Isenberg, K., Hughes, D. A., & Nichol, M. B. (2009). A Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs. CLINICAL THERAPEUTICS, 31(2), 421-435. doi:10.1016/j.clinthera.2009.02.021DOI: 10.1016/j.clinthera.2009.02.021
A SYSTEMATIC REVIEW AND EMPIRICAL ANALYSIS OF THE RELATION BETWEEN DOSE AND DURATION OF DRUG ACTION (Conference Paper)
Hughes, D. A., & Aronson, J. K. (2009). A SYSTEMATIC REVIEW AND EMPIRICAL ANALYSIS OF THE RELATION BETWEEN DOSE AND DURATION OF DRUG ACTION. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 32). Retrieved from https://www.webofscience.com/
Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC psychiatry, 9, 14.
Costs of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature (Journal article)
Salas, M., Hughes, D., Zuluaga, A., Vardeva, K., & Lebmeier, M. (2009). Costs of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature. VALUE IN HEALTH, 12(6), 915-922. doi:10.1111/j.1524-4733.2009.00539.xDOI: 10.1111/j.1524-4733.2009.00539.x
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008) (Journal article)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008). BMC PSYCHIATRY, 9. doi:10.1186/1471-244X-9-14DOI: 10.1186/1471-244X-9-14
IMPACT OF THE ABOLITION OF THE PRESCRIPTION CHARGE IN WALES (Conference Paper)
Hughes, D., Alam, F., Cohen, D., Dunstan, F., Groves, S., & Routledge, P. (2009). IMPACT OF THE ABOLITION OF THE PRESCRIPTION CHARGE IN WALES. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 94). Retrieved from https://www.webofscience.com/
Pharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees (Journal article)
Hughes, D., & Reynolds, D. J. M. (2009). Pharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees. CLINICAL MEDICINE, 9(5), 490-492. doi:10.7861/clinmedicine.9-5-490DOI: 10.7861/clinmedicine.9-5-490
2008
NHS and charitable funding for children and young people with cancer in England and Wales (Journal article)
Linck, P., Tunnage, B., Hughes, D. A., & Edwards, R. T. (2008). NHS and charitable funding for children and young people with cancer in England and Wales. JOURNAL OF CHILD HEALTH CARE, 12(2), 156-168. doi:10.1177/1367493508090173DOI: 10.1177/1367493508090173
METHODOLOGICAL ISSUES IN THE LITERATURE ON COSTS OF NON-COMPLIANCE IN CHRONIC DISEASES (Conference Paper)
Salas, M., Zuluaga, A., Hughes, D., Cowell, W., Lebmeier, M., Vardeva, K., . . . Shinogle, J. (2008). METHODOLOGICAL ISSUES IN THE LITERATURE ON COSTS OF NON-COMPLIANCE IN CHRONIC DISEASES. In VALUE IN HEALTH Vol. 11 (pp. A571-A572). doi:10.1016/S1098-3015(10)66879-9DOI: 10.1016/S1098-3015(10)66879-9
Medicines concordance and game theory (Journal article)
Hughes, D. (2008). Medicines concordance and game theory. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 66(4), 577. doi:10.1111/j.1365-2125.2008.03260.xDOI: 10.1111/j.1365-2125.2008.03260.x
Costs of chiral switching (Journal article)
Hughes, D. A. (2008). Costs of chiral switching. Pharmaceutical Journal, 281(7516), 213.
Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens (Journal article)
Hughes, D. A. (2008). Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 871-878. doi:10.1111/j.1365-2125.2008.03124.xDOI: 10.1111/j.1365-2125.2008.03124.x
Costs of non-compliance with antipsychotic medications among patients with schizophrenia (Conference Paper)
Salas, M., Zuluaga, A., Hughes, D., Lebmeier, M., Vardeva, K., Pisu, M., & Shinogle, J. (2008). Costs of non-compliance with antipsychotic medications among patients with schizophrenia. In VALUE IN HEALTH Vol. 11 (pp. A125). doi:10.1016/S1098-3015(10)70399-5DOI: 10.1016/S1098-3015(10)70399-5
Effects of the abolition of prescription charges in Wales: A preliminary analysis (Journal article)
Cohen, D., Alam, M. F., Hughes, D., Dunstan, F., & Routledge, P. (2008). Effects of the abolition of prescription charges in Wales: A preliminary analysis. International Journal of Pharmacy Practice, 16(SUPPL. 1).
A global survey of antibiotic leftovers in the outpatient setting (vol 30, pg 530, 2007) (Journal article)
Kardas, P., Pechere, J. -C., Hughes, D. A., & Cornaglia, G. (2008). A global survey of antibiotic leftovers in the outpatient setting (vol 30, pg 530, 2007). INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 31(2), 188. doi:10.1016/j.ijantimicag.2007.11.002DOI: 10.1016/j.ijantimicag.2007.11.002
A SYSTEMATIC REVIEW OF THE EFFECTIVENESS OF PUBLIC HEALTH INTERVENTIONS AIMED AT PROMOTING MENTAL WELL-BEING IN OLDER PEOPLE (Conference Paper)
Windle, G., Russell, I., Linck, P., Woods, R., & Hughes, D. (2008). A SYSTEMATIC REVIEW OF THE EFFECTIVENESS OF PUBLIC HEALTH INTERVENTIONS AIMED AT PROMOTING MENTAL WELL-BEING IN OLDER PEOPLE. In GERONTOLOGIST Vol. 48 (pp. 740). Retrieved from https://www.webofscience.com/
Statistical comments are unfounded (Journal article)
Hughes, D., Cowell, W., Koncz, T., & Cramer, J. (2008). Statistical comments are unfounded. VALUE IN HEALTH, 11(2), 346. doi:10.1111/j.1524-4733.2008.00317.xDOI: 10.1111/j.1524-4733.2008.00317.x
The cost-effectiveness of biological therapies for Crohn's disease: Markov cohort analyses incorporating UK patient-level cost data (Conference Paper)
Bodger, K., Kikuchi, T., & Hughes, D. A. (2008). The cost-effectiveness of biological therapies for Crohn's disease: Markov cohort analyses incorporating UK patient-level cost data. In GASTROENTEROLOGY Vol. 134 (pp. A139-A140). Retrieved from https://www.webofscience.com/
The cost-effectiveness of biological therapies for crohn's disease: markov cohort analyses incorporating uk patient-level cost data (Journal article)
Bodger, K., Kikuchi, T., & Hughes, D. A. (2008). The cost-effectiveness of biological therapies for crohn's disease: markov cohort analyses incorporating uk patient-level cost data. GUT, 57, A48. Retrieved from https://www.webofscience.com/
The pharmacokinetic profile of warfarin: a systematic review (Conference Paper)
Al-Zubiedi, S., Hughes, D., & Pirmohamed, M. (2008). The pharmacokinetic profile of warfarin: a systematic review. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1002-1003). Retrieved from https://www.webofscience.com/
Understanding medication compliance and persistence from an economics perspective (Journal article)
Elliott, R. A., Shinogle, J. A., Peele, P., Bhosle, M., & Hughes, D. A. (2008). Understanding medication compliance and persistence from an economics perspective. VALUE IN HEALTH, 11(4), 600-610. doi:10.1111/j.1524-4733.2007.00304.xDOI: 10.1111/j.1524-4733.2007.00304.x
2007
Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., . . . Russell, I. (2007). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC PSYCHIATRY, 7. doi:10.1186/1471-244X-7-65DOI: 10.1186/1471-244X-7-65
Literature review on the costs of non-compliance in osteoporosis (Conference Paper)
Cowell, W., Palmer, K., & Hughes, D. (2007). Literature review on the costs of non-compliance in osteoporosis. In VALUE IN HEALTH Vol. 10 (pp. A394-A395). doi:10.1016/S1098-3015(10)65383-1DOI: 10.1016/S1098-3015(10)65383-1
Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire (Journal article)
Hughes, D. A. (2007). Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire. QUALITY OF LIFE RESEARCH, 16(8), 1419-1423. doi:10.1007/s11136-007-9238-9DOI: 10.1007/s11136-007-9238-9
Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses? (Journal article)
Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 82(2), 123-127. doi:10.1038/sj.clpt.6100240DOI: 10.1038/sj.clpt.6100240
Current assessment of risk-benefit by regulators: is it time to introduce decision analyses? (Journal article)
Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?. Clinical pharmacology and therapeutics, 82(2), 123-127. doi:10.1038/sj.clpt.6100240DOI: 10.1038/sj.clpt.6100240
When drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices (Journal article)
Hughes, D. (2007). When drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices. PHARMACOECONOMICS, 25(8), 621-635. doi:10.2165/00019053-200725080-00001DOI: 10.2165/00019053-200725080-00001
Adverse drug reactions in economic evaluations (Conference Paper)
Hughes, D. (2007). Adverse drug reactions in economic evaluations. In VALUE IN HEALTH Vol. 10 (pp. A109-A110). doi:10.1016/S1098-3015(10)68871-7DOI: 10.1016/S1098-3015(10)68871-7
Assessing the association between compliance and therapeutic failure for antiretroviral drugs in hiv positive patients (Conference Paper)
Hughes, D. (2007). Assessing the association between compliance and therapeutic failure for antiretroviral drugs in hiv positive patients. In VALUE IN HEALTH Vol. 10 (pp. A171). doi:10.1016/S1098-3015(10)69058-4DOI: 10.1016/S1098-3015(10)69058-4
Biological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiple treatment comparison (Conference Paper)
Hughes, D., Kikuchi, T., & Bodger, K. (2007). Biological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiple treatment comparison. In VALUE IN HEALTH Vol. 10 (pp. A147). doi:10.1016/S1098-3015(10)68985-1DOI: 10.1016/S1098-3015(10)68985-1
Factors influencing user choices to visit either general practitioners or community pharmacists for minor ailments - A discrete choice experiment (Conference Paper)
Hughes, D., Myles, S., Longo, M., Lisles, C., & Hood, K. (2007). Factors influencing user choices to visit either general practitioners or community pharmacists for minor ailments - A discrete choice experiment. In VALUE IN HEALTH Vol. 10 (pp. A23). doi:10.1016/S1098-3015(10)68601-9DOI: 10.1016/S1098-3015(10)68601-9
Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire (Conference Paper)
Hughes, D. (2007). Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire. In VALUE IN HEALTH Vol. 10 (pp. A189-A190). doi:10.1016/S1098-3015(10)69119-XDOI: 10.1016/S1098-3015(10)69119-X
Parenting programme for parents of children at risk of developing conduct disorder: cost effectiveness analysis (Journal article)
Edwards, R. T., Ceilleachair, A., Bywater, T., Hughes, D. A., & Hutchings, J. (2007). Parenting programme for parents of children at risk of developing conduct disorder: cost effectiveness analysis. BRITISH MEDICAL JOURNAL, 334(7595), 682-685. doi:10.1136/bmj.39126.699421.55DOI: 10.1136/bmj.39126.699421.55
Non-compliance with antibiotic therapy for acute community infections: a global survey (Journal article)
Pechere, J. -C., Hughes, D., Kardas, P., & Cornaglia, G. (2007). Non-compliance with antibiotic therapy for acute community infections: a global survey. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 29(3), 245-253. doi:10.1016/j.ijantimicag.2006.09.026DOI: 10.1016/j.ijantimicag.2006.09.026
A global survey of antibiotic leftovers in the outpatient setting (Journal article)
Kardas, P., Pechere, J. -C., Hughes, D. A., & Cornaglia, G. (2007). A global survey of antibiotic leftovers in the outpatient setting. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 30(6), 530-536. doi:10.1016/j.ijantimicag.2007.08.005DOI: 10.1016/j.ijantimicag.2007.08.005
Costs of non-compliance and non-persistence with medications for diabetes mellitus (Conference Paper)
Salas, M., Vardeva, K., Lebmeier, M., & Hughes, D. (2007). Costs of non-compliance and non-persistence with medications for diabetes mellitus. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 16 (pp. S140). Retrieved from https://www.webofscience.com/
Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations (Journal article)
Hughes, D., Cowell, W., Koncz, T., & Cramer, J. (2007). Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations. VALUE IN HEALTH, 10(6), 498-509. doi:10.1111/j.1524-4733.2007.00205.xDOI: 10.1111/j.1524-4733.2007.00205.x
The effect of compliance upon clinical effectiveness of chlorproguanil-dapsone (CD) and artemether-lumefantrine (AL) when compared to sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated falciparum malaria in Malawi - A randomised controlled trial (Conference Paper)
Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2007). The effect of compliance upon clinical effectiveness of chlorproguanil-dapsone (CD) and artemether-lumefantrine (AL) when compared to sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated falciparum malaria in Malawi - A randomised controlled trial. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 77 (pp. 287). Retrieved from https://www.webofscience.com/
Warfarin pharmacogenetics: Economic considerations (Journal article)
Hughes, D. A., & Pirmohamed, M. (2007). Warfarin pharmacogenetics: Economic considerations. PHARMACOECONOMICS, 25(11), 899-902. doi:10.2165/00019053-200725110-00001DOI: 10.2165/00019053-200725110-00001
2006
Comments on NICE do not reflect expertise available within the profession [12] (Journal article)
Hughes, D. A., Elliott, R., & Payne, K. (2006). Comments on NICE do not reflect expertise available within the profession [12]. Pharmaceutical Journal, 277(7423), 484.
Orphan drugs revisited: author's response (Journal article)
Hughes, D. (2006). Orphan drugs revisited: author's response. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 99(5), 350-351. doi:10.1093/qjmed/hcl046DOI: 10.1093/qjmed/hcl046
Rationing of drugs for rare diseases (Journal article)
Hughes, D. (2006). Rationing of drugs for rare diseases. PHARMACOECONOMICS, 24(4), 315-316. doi:10.2165/00019053-200624040-00001DOI: 10.2165/00019053-200624040-00001
Less is more: Medicines that require less frequent administration improve adherence, but are they better? (Journal article)
Hughes, D. (2006). Less is more: Medicines that require less frequent administration improve adherence, but are they better?. PHARMACOECONOMICS, 24(3), 211-213. doi:10.2165/00019053-200624030-00001DOI: 10.2165/00019053-200624030-00001
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone (Journal article)
Simpson, J. A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., . . . Ward, S. (2006). Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 61(3), 289-300. doi:10.1111/j.1365-2125.2005.02567.xDOI: 10.1111/j.1365-2125.2005.02567.x
Beyond registration - measuring the public-health potential of new treatments for malaria in Africa (Journal article)
Lang, T., Hughes, D., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., . . . Winstanley, P. (2006). Beyond registration - measuring the public-health potential of new treatments for malaria in Africa. LANCET INFECTIOUS DISEASES, 6(1), 46-52. doi:10.1016/S1473-3099(05)70326-1DOI: 10.1016/S1473-3099(05)70326-1
2005
Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease (Journal article)
Hughes, D. A., Bodger, K., Bytzer, P., de Herdt, D., & Dubois, D. (2005). Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease. PHARMACOECONOMICS, 23(10), 1031-1041. doi:10.2165/00019053-200523100-00006DOI: 10.2165/00019053-200523100-00006
Drugs for exceptionally rare diseases: do they deserve special status for funding? (Journal article)
Hughes, D. A., Tunnage, B., & Yeo, S. T. (2005). Drugs for exceptionally rare diseases: do they deserve special status for funding?. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 98(11), 829-836. doi:10.1093/qjmed/hci128DOI: 10.1093/qjmed/hci128
Public funding of drugs for orphan diseases (Conference Paper)
Hughes, D. (2005). Public funding of drugs for orphan diseases. In VALUE IN HEALTH Vol. 8 (pp. A192-A193). doi:10.1016/S1098-3015(10)67739-XDOI: 10.1016/S1098-3015(10)67739-X
Trends and influences on use of antidiabetic drugs in England, 1992-2003 (Journal article)
Walley, T., Hughes, D., & Kendall, H. (2005). Trends and influences on use of antidiabetic drugs in England, 1992-2003. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 14(11), 769-773. doi:10.1002/pds.1089DOI: 10.1002/pds.1089
Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations (Journal article)
Hughes, D. A. (2005). Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations. EUROPEAN JOURNAL OF CANCER, 41(11), 1655. doi:10.1016/j.ejca.2005.02.033DOI: 10.1016/j.ejca.2005.02.033
Cost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease. (Journal article)
Hughes, D. A., Marchetti, M., & Colombo, G. (2005). Cost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease.. Expert review of pharmacoeconomics & outcomes research, 5(1), 29-38. doi:10.1586/14737167.5.1.29DOI: 10.1586/14737167.5.1.29
Trends in and influences on use of antidiabetic drugs in primary care in the United Kingdom, 1992-2003 (Conference Paper)
Walley, T., Hughes, D., & Kendall, H. (2005). Trends in and influences on use of antidiabetic drugs in primary care in the United Kingdom, 1992-2003. In EUROPEAN JOURNAL OF PUBLIC HEALTH Vol. 15 (pp. 95). Retrieved from https://www.webofscience.com/
2004
Cost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence (Journal article)
Hughes, D. A., & Dubois, D. (2004). Cost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence. PHARMACOECONOMICS, 22(16), 1047-1059. doi:10.2165/00019053-200422160-00002DOI: 10.2165/00019053-200422160-00002
Economic evaluation of on-demand maintenance therapy with proton pump inhibitors in patients with symptomatic gastroesophageal reflux disease - A Monte-Carlo analysis for Italy (Conference Paper)
Hughes, D. A., Marchetti, M., & Colombo, G. L. (2004). Economic evaluation of on-demand maintenance therapy with proton pump inhibitors in patients with symptomatic gastroesophageal reflux disease - A Monte-Carlo analysis for Italy. In VALUE IN HEALTH Vol. 7 (pp. 753-754). doi:10.1016/S1098-3015(10)66004-4DOI: 10.1016/S1098-3015(10)66004-4
HLA-B*5701 and abacavir hypersensitivity (Journal article)
Watson, M. E., Pimenta, J. M., Spreen, W. R., & Hernandez, J. E. (2004). HLA-B*5701 and abacavir hypersensitivity. PHARMACOGENETICS, 14(11), 783-784. doi:10.1097/00008571-200411000-00011DOI: 10.1097/00008571-200411000-00011
HLA-B*5701 and abacavir hypersensitivity - Reply (Journal article)
Hughes, D., Park, B. K., & Pirmohamed, M. (2004). HLA-B*5701 and abacavir hypersensitivity - Reply. PHARMACOGENETICS, 14(11), 784. doi:10.1097/00008571-200411000-00012DOI: 10.1097/00008571-200411000-00012
The difference between effectiveness and efficacy of antimalarial drugs in Kenya (Journal article)
Amin, A. A., Hughes, D. A., Marsh, V., Abuya, T. O., Kokwaro, G. O., Winstanley, P. A., . . . Snow, R. W. (2004). The difference between effectiveness and efficacy of antimalarial drugs in Kenya. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 9(9), 967-974. doi:10.1111/j.1365-3156.2004.01291.xDOI: 10.1111/j.1365-3156.2004.01291.x
Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance (Journal article)
Atuah, K. N., Hughes, D., & Pirmohamed, M. (2004). Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance. DRUG SAFETY, 27(8), 535-554. doi:10.2165/00002018-200427080-00006DOI: 10.2165/00002018-200427080-00006
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. (Journal article)
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002DOI: 10.1097/00008571-200406000-00002
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity (Journal article)
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002DOI: 10.1097/00008571-200406000-00002
2003
Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective? (Conference Paper)
Hughes, D. A., & Pirmohamed, M. (2003). Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?. In VALUE IN HEALTH Vol. 6 (pp. 749). doi:10.1016/S1098-3015(10)61908-0DOI: 10.1016/S1098-3015(10)61908-0
Cost-utility analysis of "on demand" rabeprazole and esomeprazole for symptomatic gastro oesophageal reflux disease (Conference Paper)
Hughes, D. A., & Dubois, D. (2003). Cost-utility analysis of "on demand" rabeprazole and esomeprazole for symptomatic gastro oesophageal reflux disease. In VALUE IN HEALTH Vol. 6 (pp. 613). doi:10.1016/S1098-3015(10)61575-6DOI: 10.1016/S1098-3015(10)61575-6
Predicting "real world" effectiveness by integrating adherence with pharmacodynamic modeling (Journal article)
Hughes, D. A., & Walley, T. (2003). Predicting "real world" effectiveness by integrating adherence with pharmacodynamic modeling. CLINICAL PHARMACOLOGY & THERAPEUTICS, 74(1), 1-8. doi:10.1016/S0009-9236(03)00091-2DOI: 10.1016/S0009-9236(03)00091-2
2002
Economic impact of poor compliance with pharmaceuticals. (Journal article)
Hughes, D. A. (2002). Economic impact of poor compliance with pharmaceuticals.. Expert review of pharmacoeconomics & outcomes research, 2(4), 327-335. doi:10.1586/14737167.2.4.327DOI: 10.1586/14737167.2.4.327
2001
The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature (Journal article)
Hughes, D. A., Bagust, A., Haycox, A., & Walley, T. (2001). The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature. HEALTH ECONOMICS, 10(7), 601-615. doi:10.1002/hec.609DOI: 10.1002/hec.609
Accounting for noncompliance in pharmacoeconomic evaluations (Journal article)
Hughes, D. A., Bagust, A., Haycox, A., & Walley, T. (2001). Accounting for noncompliance in pharmacoeconomic evaluations. PHARMACOECONOMICS, 19(12), 1185-1197. doi:10.2165/00019053-200119120-00001DOI: 10.2165/00019053-200119120-00001
Economic evaluations during early (phase II) drug development - A role for clinical trial simulations? (Journal article)
Hughes, D. A., & Walley, T. (2001). Economic evaluations during early (phase II) drug development - A role for clinical trial simulations?. PHARMACOECONOMICS, 19(11), 1069-1077. doi:10.2165/00019053-200119110-00001DOI: 10.2165/00019053-200119110-00001
2000
Patient compliance with drug therapy for diabetic nephropathy. (Journal article)
Hughes, D., & Manns, B. (2000). Patient compliance with drug therapy for diabetic nephropathy.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 162(11), 1553-1554.
Patient compliance with drug therapy for diabetic nephropathy (Journal article)
Hughes, D., & Manns, B. (2000). Patient compliance with drug therapy for diabetic nephropathy. CANADIAN MEDICAL ASSOCIATION JOURNAL, 162(11), 1553. Retrieved from https://www.webofscience.com/
1999
Review of therapeutically equivalent alternatives to short acting beta(2) adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers (Journal article)
Hughes, D. A., Woodcock, A., & Walley, T. (1999). Review of therapeutically equivalent alternatives to short acting beta(2) adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers. THORAX, 54(12), 1087-1092. doi:10.1136/thx.54.12.1087DOI: 10.1136/thx.54.12.1087
1998
Mechanisms contributing to the interaction of diazepam with the cascade of events following beta-adrenoceptor stimulation in isolated atria (Conference Paper)
Hughes, D. A., & Coker, S. J. (1998). Mechanisms contributing to the interaction of diazepam with the cascade of events following beta-adrenoceptor stimulation in isolated atria. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 124 (pp. U15). Retrieved from https://www.webofscience.com/
Mefloquine potentiates halofantrine-induced QTc prolongation by altering the distribution of halofantrine (Conference Paper)
Coker, S. J., Lightbown, I. D., Hughes, D. A., Lambert, J. P., & Edwards, G. (1998). Mefloquine potentiates halofantrine-induced QTc prolongation by altering the distribution of halofantrine. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 123 (pp. U63). Retrieved from https://www.webofscience.com/
1997
A microdialysis study of the effects of fluoxetine infusion on noradrenaline (NA) efflux in the frontal cortex of saline or DSP-4-treated rats (Conference Paper)
Hughes, Z. A., & Stanford, S. C. (1997). A microdialysis study of the effects of fluoxetine infusion on noradrenaline (NA) efflux in the frontal cortex of saline or DSP-4-treated rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 122 (pp. U28). Retrieved from https://www.webofscience.com/
Attenuation of the negative inotropic effects of chloroquine by combined administration of diazepam and adrenaline in anaesthetized rats (Conference Paper)
Hughes, D. A., & Coker, S. J. (1997). Attenuation of the negative inotropic effects of chloroquine by combined administration of diazepam and adrenaline in anaesthetized rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 120 (pp. P24). Retrieved from https://www.webofscience.com/
1996
Effects of diazepam on chloroquine intoxicated, anaesthetized rats (Conference Paper)
Hughes, D. A., & Coker, S. J. (1996). Effects of diazepam on chloroquine intoxicated, anaesthetized rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 119 (pp. P152). Retrieved from https://www.webofscience.com/
