Photo of Dr Dominic Williams

Dr Dominic Williams

Senior Lecturer Pharmacology & Therapeutics

    Research

    Research Grants

    Chemical stress.

    WELLCOME TRUST (UK)

    August 2004 - September 2004

    Development of an in vitro microsomal assay that can determine the rate of consumption of reduced glutathione

    WELLCOME TRUST (UK)

    July 2011 - August 2011

    Mechanistic investigation into novel rodenticides

    BASF PLC (UK)

    February 2010 - January 2013

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL

    October 2003 - October 2006

    Role of inflammation in organ-selective off target adverse drug reactions

    MINISTRY OF HIGHER EDUCATION (MALAYSIA)

    July 2012 - June 2015

    Towards NanoMedicine Interventions for HIV/AIDS

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

    May 2012 - November 2016

    In vivo physiological mechanisms underlying a1-adrenoceptor mediated protection during drug-induced hepatotoxicity in the mouse

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

    October 2007 - September 2008

    Investigation of Inflammatory Signalling during Drug-induced Hepatotoxicity Background

    BRITISH TOXICOLOGY SOCIETY (UK)

    October 2007 - September 2010

    The chemical and molecular basis of the prevention of drug-induced liver injury by Nrf2.

    WELLCOME TRUST (UK)

    January 2007 - December 2009

    Investigation into drug toxicity using high density array analysis corroborated with Northern Blot, real time PCR and RT-PCR.

    WELLCOME TRUST (UK)

    July 2001 - September 2001

    Hepatocyte protein adduct formation with paracetamol and furosemide.

    WELLCOME TRUST (UK)

    June 2005 - August 2005

    Paracetamol and PARP inhibitors

    ASTRAZENECA LIMITED (UK)

    November 2010 - February 2012

    Research Collaborations

    Gallagher / Jarvis

    Internal

    Alkaptonuria research

    Prof ANja Kipar

    Internal

    CDSS Pathology collaboration

    Integrative Toxicology Training Programme

    External: Medical Research Council

    Research & Development

    External: Sorex, BASF

    New Opportunities Group

    External: AstraZeneca Pharmceuticals

    Group

    External: AstraZeneca Pharmceuticals

    Drug-induced hepatic toxicity

    Group

    External: Pfizer Ltd

    Investigation of reactive and potentially toxic intermediates

    Transmitter Group

    External: The University of Nottingham

    Measurement of serum catecholamines

    Group

    External: AstraZeneca Pharmceuticals

    Bioactivation of drugs

    Group

    External: Pfizer Ltd

    Transcription factor activation as safety assessment