2024
The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy. (Journal article)
Rashid, H. U., Ullah, S., Carr, D. F., Khattak, M. I. K., Asad, M. I., Rehman, M. U., & Tipu, M. K. (2024). The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.. Molecular biology reports, 51(1), 191. doi:10.1007/s11033-023-09061-5DOI: 10.1007/s11033-023-09061-5
2023
Nwikue, G., Olsson-Brown, A., Aboheimed, N., Yip, V., Jolly, C., Luchian, A., . . . Carr, D. F. (2023). TNF-α induced extracellular release of keratinocyte high-mobility group box 1 in Stevens-Johnson syndrome/toxic epidermal necrolysis: Biomarker and putative mechanism of pathogenesis. JOURNAL OF DERMATOLOGY, 50(9), 1129-1139. doi:10.1111/1346-8138.16847DOI: 10.1111/1346-8138.16847
Moosa, M. S., Russomanno, G., Dorfman, J. R., Gunter, H., Patel, C., Costello, E., . . . Cohen, K. (2023). Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15661DOI: 10.1111/bcp.15661
Olsson-Brown, A., Yip, V., Ogiji, E. D., Jolly, C., Ressel, L., Sharma, A., . . . Carr, D. F. (2023). TNF-α-Mediated Keratinocyte Expression and Release of Matrix Metalloproteinase 9: Putative Mechanism of Pathogenesis in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 143(6), 1023-+. doi:10.1016/j.jid.2022.11.024DOI: 10.1016/j.jid.2022.11.024
McCaddon, A., Carr, D. F., Peter, H., Moat, S. J., & Quadros, E. V. (2023). Transcobalamin receptor gene polymorphisms and mutation in an elderly population.. Clinical nutrition ESPEN, 55, 425-427. doi:10.1016/j.clnesp.2023.04.023DOI: 10.1016/j.clnesp.2023.04.023
McEvoy, L., Cliff, J., Carr, D. F., Jorgensen, A., Lord, R., & Pirmohamed, M. (2023). <i>CYP3A</i> genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study. FRONTIERS IN PHARMACOLOGY, 14. doi:10.3389/fphar.2023.1178421DOI: 10.3389/fphar.2023.1178421
Mcevoy, L., Cliff, J., Carr, D. F., Jorgensen, A., Lord, R., & Pirmohamed, M. (2023). <i>CYP3A</i> genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study (vol 14, 1178421, 2023). FRONTIERS IN PHARMACOLOGY, 14. doi:10.3389/fphar.2023.1274075DOI: 10.3389/fphar.2023.1274075
Gurjar, R., Dickinson, L., Carr, D., Stohr, W., Bonora, S., Owen, A., . . . Boffito, M. (2022). Influence of <i>UGT1A1</i> and <i>SLC22A6</i> polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study. PHARMACOGENOMICS JOURNAL. doi:10.1038/s41397-022-00293-5DOI: 10.1038/s41397-022-00293-5
Parry, C. M., Chan, L. F., Carr, D. F., & Hawcutt, D. B. (2023). Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression. PEDIATRIC RESEARCH, 93(1), 97-101. doi:10.1038/s41390-022-02094-9DOI: 10.1038/s41390-022-02094-9
2022
An in vitro model of drug-induced Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN) (Journal article)
DICKINSON, A. M., AHMED, S., Dan, C., PIRMOHAMED, M., OLSSON-BROWN, A., & Takesi, A. (2022). An in vitro model of drug-induced Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN). Unknown Journal, p-249. doi:10.14869/toxpt.49.1.0_p-249DOI: 10.14869/toxpt.49.1.0_p-249
2.15 Pharmacogenomics of Anti-Cancer Drugs (Chapter)
Carr, D. F., Turner, R. M., & Pirmohamed, M. (2022). 2.15 Pharmacogenomics of Anti-Cancer Drugs. In Comprehensive Pharmacology (pp. 311-325). Elsevier. doi:10.1016/b978-0-12-820472-6.00159-6DOI: 10.1016/b978-0-12-820472-6.00159-6
Pharmacogenomics of Anti-Cancer Drugs (Chapter)
Carr, D. F., Turner, R. M., & Pirmohamed, M. (2022). Pharmacogenomics of Anti-Cancer Drugs. In Comprehensive Pharmacology (pp. 311-325). Elsevier. doi:10.1016/b978-0-12-820472-6.00159-6DOI: 10.1016/b978-0-12-820472-6.00159-6
2021
Carter, B., Zenasni, Z., Moat, S. J., Hudson, P. R., Russell, I. T., & McCaddon, A. (2021). Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial. JOURNAL OF NUTRITION, 151(12), 3738-3745. doi:10.1093/jn/nxab280DOI: 10.1093/jn/nxab280
Bourgeois, S., Carr, D. F., Musumba, C. O., Penrose, A., Esume, C., Morris, A. P., . . . Pirmohamed, M. (2021). Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration. EBioMedicine, 74, 103728. doi:10.1016/j.ebiom.2021.103728DOI: 10.1016/j.ebiom.2021.103728
Development of an in vitro model of drug-induced toxic epidermal necrosis (Journal article)
DICKINSON, A. M., AHMED, S., CARR, D. F., OLSSON-BROWN, A., & PIRMOHAMED, M. (2021). Development of an in vitro model of drug-induced toxic epidermal necrosis. Unknown Journal, p-174. doi:10.14869/toxpt.48.1.0_p-174DOI: 10.14869/toxpt.48.1.0_p-174
McEvoy, L., Carr, D. F., & Pirmohamed, M. (2021). Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.684162DOI: 10.3389/fphar.2021.684162
Yip, V. L. M., Pertinez, H., Meng, X., Maggs, J. L., Carr, D. F., Park, B. K., . . . Pirmohamed, M. (2021). Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2572-2588. doi:10.1111/bcp.14667DOI: 10.1111/bcp.14667
Hammond, S., Olsson-Brown, A., Gardner, J., Thomson, P., Ali, S. -E., Jolly, C., . . . Naisbitt, D. (2021). T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5). doi:10.1136/jitc-2021-002521DOI: 10.1136/jitc-2021-002521
Nicoletti, P., Carr, D. F., Barrett, S., McEvoy, L., Friedmann, P. S., Shear, N. H., . . . Pirmohamed, M. (n.d.). Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort. Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2020.10.004DOI: 10.1016/j.jaci.2020.10.004
Carr, D. F., Turner, R. M., & Pirmohamed, M. (2021). Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(2), 237-255. doi:10.1111/bcp.14407DOI: 10.1111/bcp.14407
2020
Carr, D. F., & Pirmohamed, M. (2020). Precision medicine in drug safety. Current Opinion in Toxicology, 23-24, 87-97. doi:10.1016/j.cotox.2020.07.003DOI: 10.1016/j.cotox.2020.07.003
Turner, R. M., Fontana, V., Zhang, J. E., Carr, D., Yin, P., FitzGerald, R., . . . Pirmohamed, M. (2020). A Genome‐wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites. Clinical Pharmacology and Therapeutics, 108(2), 287-297. doi:10.1002/cpt.1820DOI: 10.1002/cpt.1820
Carr, D., Turner, R. M., & Pirmohamed, M. (n.d.). Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response. British Journal of Clinical Pharmacology. doi:10.1111/bcp.14407DOI: 10.1111/bcp.14407
Elliot, E. R., Neary, M., Else, L., Khoo, S., Moyle, G., Carr, D. F., . . . Owen, A. (2020). Genetic influence of <i>ABCG2, UGT1A1</i> and <i>NR1I2</i> on dolutegravir plasma pharmacokinetics. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 75(5), 1259-1266. doi:10.1093/jac/dkz558DOI: 10.1093/jac/dkz558
Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles (Journal article)
Ramsbottom, K. A., Carr, D. F., Rigden, D. J., & Jones, A. R. (2020). Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles. PLOS ONE, 15(2). doi:10.1371/journal.pone.0220754DOI: 10.1371/journal.pone.0220754
2019
Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink (Journal article)
Carr, D. (2019). Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557DOI: 10.1002/cpt.1557
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)
DB, H., B, F., DF, C., AL, J., P, Y., N, W., . . . M, P. (n.d.). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Yearbook of Paediatric Endocrinology. doi:10.1530/ey.16.8.11DOI: 10.1530/ey.16.8.11
Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles (Preprint)
DOI: 10.1101/713743
HMGB1 expression in SJS/TEN sera and skin (Journal article)
Carr, D. F., Wang, C., Bellón, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). HMGB1 expression in SJS/TEN sera and skin. British Journal of Dermatology, 181(1). doi:10.1111/bjd.18061DOI: 10.1111/bjd.18061
Carr, D. F., Wang, C. -W., Bellon, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. BRITISH JOURNAL OF DERMATOLOGY, 181(1), 166-174. doi:10.1111/bjd.17610DOI: 10.1111/bjd.17610
Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PLoS One, 14(6). doi:10.1371/journal.pone.0218115DOI: 10.1371/journal.pone.0218115
Hope, W., Johnstone, G., Cicconi, S., Felton, T., Goodwin, J., Whalley, S., . . . Neely, M. (2019). Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.02353-18DOI: 10.1128/aac.02353-18
Foulkes, A. C., Watson, D. S., Carr, D. F., Kenny, J. G., Slidel, T., Parslew, R., . . . Barnes, M. R. (2019). A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(1), 100-107. doi:10.1016/j.jid.2018.04.041DOI: 10.1016/j.jid.2018.04.041
2018
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)
DB, H., B, F., DF, C., AL, J., P, Y., N, W., . . . M, P. (n.d.). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Yearbook of Paediatric Endocrinology. doi:10.1530/ey.15.8.6DOI: 10.1530/ey.15.8.6
Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions (Journal article)
Ramsbottom, K. A., Carr, D. F., Jones, A. R., & Rigden, D. J. (2018). Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions. MOLECULAR IMMUNOLOGY, 101, 488-499. doi:10.1016/j.molimm.2018.08.003DOI: 10.1016/j.molimm.2018.08.003
Hawcutt, D. B., Francis, B., Carr, D., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. The Lancet Respiratory Medicine, 6(6), 442-450. doi:10.1016/S2213-2600(18)30058-4DOI: 10.1016/S2213-2600(18)30058-4
Elliot, E., Neary, M. G., Else, L., Khoo, S., Moyle, G., Carr, D., . . . Boffito, M. (n.d.). ABCG2 rs2231142 and NR1I2 rs2472677 influence dolutegravir concentrations in plasma.. In CROI. Boston, MA, USA.
Carr, D. F., & Pirmohamed, M. (2018). Biomarkers of adverse drug reactions. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(3), 291-299. doi:10.1177/1535370217733425DOI: 10.1177/1535370217733425
Urticarial Reactions to Drugs (Chapter)
Carr, D. F. (2019). Urticarial Reactions to Drugs. In Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions (pp. 123-129). Springer Singapore. doi:10.1007/978-981-13-1489-6_9DOI: 10.1007/978-981-13-1489-6_9
2017
Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467DOI: 10.1093/eurheartj/ehx467
The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis (Journal article)
Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 120, 127-140. doi:10.1016/j.critrevonc.2017.09.009DOI: 10.1016/j.critrevonc.2017.09.009
Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population (Journal article)
Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545DOI: 10.1093/jac/dkw545
Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002DOI: 10.1016/j.pharmthera.2017.01.002
Turner, R. M., Bayliss, M., Carr, D., Kitteringham, N., Henderson, C., & Pirmohamed, M. (2016, December 13). The impact of P450 oxidoreductase knock out on systemic exposure to rosuvastatin, atorvastatin and atorvastatin metabolites. In http://www.pa2online.org/abstract/abstract.jsp?abid=33238&kw=P450%20oxidoreductase&cat=-1&period=-1. London, UK.
2016
A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)
Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.
Cliff, J. R., Carr, D. F., Lord, R. H., Jorgensen, A. L., & Pirmohamed, M. (2016). A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS). In ANNALS OF ONCOLOGY Vol. 27. doi:10.1093/annonc/mdw392.54DOI: 10.1093/annonc/mdw392.54
Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative <i>in silico</i> system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473DOI: 10.1111/epi.13473
Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis (Journal article)
Nightingale, S., Chau, T. T. H., Fisher, M., Nelson, M., Winston, A., Else, L., . . . Grp, P. -V. S. (2016). Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis. Antimicrobial Agents and Chemotherapy, 60(8), 4511-4518. doi:10.1128/AAC.00280-16DOI: 10.1128/AAC.00280-16
Advances in the Pharmacogenomics of Adverse Drug Reactions (Journal article)
Collins, S. L., Carr, D. F., & Pirmohamed, M. (2016). Advances in the Pharmacogenomics of Adverse Drug Reactions. DRUG SAFETY, 39(1), 15-27. doi:10.1007/s40264-015-0367-8DOI: 10.1007/s40264-015-0367-8
2015
Mirza, N., Appleton, R., Burn, S., Carr, D. F., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. Human Molecular Genetics, 24(15), 4306-4316. doi:10.1093/hmg/ddv163DOI: 10.1093/hmg/ddv163
Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. Gastroenterology, 148(4), S-566. doi:10.1016/s0016-5085(15)31907-7DOI: 10.1016/s0016-5085(15)31907-7
Cornejo Castro, E. M., Carr, D., Jorgensen, A., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.. Pharmacogenetics and genomics, 25(04), 186-198. doi:10.1097/FPC.0000000000000124DOI: 10.1097/FPC.0000000000000124
A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)
Foulkes, A., Rattray, N. J. W., Correa, E., Trivedi, D. K., Carr, D. F., Maratou, K., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 173 (pp. 12). Retrieved from https://www.webofscience.com/
Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from https://www.webofscience.com/
2014
Carr, D. F., Chaponda, M., Cornejo Castro, E. M., Jorgensen, A. L., Khoo, S., Van Oosterhout, J. J., . . . Pirmohamed, M. (2014). CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. Journal of Antimicrobial Chemotherapy, 69(12), 3329-3334. doi:10.1093/jac/dku315DOI: 10.1093/jac/dku315
Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)
Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121DOI: 10.1038/clpt.2014.121
GATM gene variants and statin myopathy risk (Journal article)
Carr, D., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. Nature, 513(7518). doi:10.1038/nature13628DOI: 10.1038/nature13628
Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment (Journal article)
van Staa, T. P., Carr, D. F., O'Meara, H., McCann, G., & Pirmohamed, M. (2014). Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. British Journal of Clinical Pharmacology, 78(3), 649-659. doi:10.1111/bcp.12367DOI: 10.1111/bcp.12367
Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Williams, N. (2014). Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.. Health Technology Assessment, 18(48). doi:10.3310/hta18480DOI: 10.3310/hta18480
CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population (Journal article)
Carr, D., Chaponda, M., Castro, E. C., Jorgensen, A., Khoo, S., & Pirmohamed, M. (2014). CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population. Clinical and translational allergy, 4(Suppl 3), P126. doi:10.1186/2045-7022-4-s3-p126DOI: 10.1186/2045-7022-4-s3-p126
Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population (Journal article)
Carr, D., Bourgeois, S., Chaponda, M., Castro, E. C., Deloukas, P., & Pirmohamed, M. (2014). Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population. Clinical and translational allergy, 4(Suppl 3), P125. doi:10.1186/2045-7022-4-s3-p125DOI: 10.1186/2045-7022-4-s3-p125
Pharmacogenomics: Current State-of-the-Art (Journal article)
Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430DOI: 10.3390/genes5020430
Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink (Journal article)
O'Meara, H., Carr, D. F., Evely, J., Hobbs, M., McCann, G., Van Staa, T., & Pirmohamed, M. (2014). Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink. British Journal of Clinical Pharmacology, 77(5), 831-838. doi:10.1111/bcp.12269DOI: 10.1111/bcp.12269
Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi (Journal article)
Dickinson, L., Chaponda, M., Carr, D. F., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2014). Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 706-712. doi:10.1128/AAC.02069-13DOI: 10.1128/AAC.02069-13
Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4 (Conference Paper)
Thompson, B., Hawcutt, D., Carr, D., Bloch, K., Swale, A., Smyth, R., & Pirmohamed, M. (2014). Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. 115-116). Retrieved from https://www.webofscience.com/
Johnson, G. G., Carr, D. F., Pirmohamed, M., & Pettitt, A. R. (2014). Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?. PHARMACOGENOMICS, 15(7), 897-900. doi:10.2217/pgs.14.60DOI: 10.2217/pgs.14.60
Pharmacogenomic signatures of response to etanercept therapy for psoriasis (Conference Paper)
Foulkes, A. C., Carr, D. F., Al-Sharqi, A., Parslew, R., Pirmohamed, M., Reynolds, N. J., . . . Warren, R. B. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. E114-E115). Retrieved from https://www.webofscience.com/
2013
<i>CYP2B6</i>*<i>6</i> is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)
Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). <i>CYP2B6</i>*<i>6</i> is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. BLOOD, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666DOI: 10.1182/blood-2013-07-516666
CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)
Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. Blood, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666DOI: 10.1182/blood-2013-07-516666
<i>SLCO1B1</i> Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink (Journal article)
Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). <i>SLCO1B1</i> Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161DOI: 10.1038/clpt.2013.161
Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)
Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 72(2), 359-368. doi:10.1007/s00280-013-2199-5DOI: 10.1007/s00280-013-2199-5
PP122—Regulation of human leukocyte antigen expression and nevirapine-induced adverse drug reactions in a malawian hiv-positive population (Journal article)
Cornejo Castro, E. M., Carr, D. F., Marshall, V. A., Chaponda, M., Lane, S., Alfirevic, A., . . . Pirmohamed, M. (2013). PP122—Regulation of human leukocyte antigen expression and nevirapine-induced adverse drug reactions in a malawian hiv-positive population. Clinical Therapeutics, 35(8), e53. doi:10.1016/j.clinthera.2013.07.145DOI: 10.1016/j.clinthera.2013.07.145
Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)
Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021DOI: 10.1093/cid/cit021
<i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)
Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). <i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215DOI: 10.1038/clpt.2012.215
The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)
Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73DOI: 10.2217/PGS.13.73
2012
VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN (Journal article)
Thompson, B., Hawcutt, D. B., Carr, D. F., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2012). VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN. THORAX, 67, A17. doi:10.1136/thoraxjnl-2012-202678.037DOI: 10.1136/thoraxjnl-2012-202678.037
2011
Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine. (Journal article)
Carr, D. F., & Alfirevic, A. (2011). Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.. Pharmacogenomics, 12(3), 315-317. doi:10.2217/pgs.10.217DOI: 10.2217/pgs.10.217
The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1 (Journal article)
Carrol, E. D., Payton, A., Payne, D., Miyajima, F., Chaponda, M., Mankhambo, L. A., . . . Ollier, W. E. (2011). The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1. JOURNAL OF IMMUNOLOGY, 186(4), 2329-2335. doi:10.4049/jimmunol.1002402DOI: 10.4049/jimmunol.1002402
2010
Dickinson, L., Chaponda, M., Carr, D., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2010). Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi. In Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection Vol. 13 (pp. 181). Glasgow, UK: Journal of the International AIDS Society. doi:10.1186/1758-2652-13-S4-P181DOI: 10.1186/1758-2652-13-S4-P181
Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort (Journal article)
Carr, D. F., la Porte, C. J. L., Pirmohamed, M., Owen, A., & Cortes, C. P. (2010). Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 65(9), 1889-1893. doi:10.1093/jac/dkq260DOI: 10.1093/jac/dkq260
2009
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)
Carr, D. F., Whiteley, G., Alfirevic, A., & Pirmohamed, M. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29DOI: 10.1038/tpj.2009.29
2007
Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)
Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12bDOI: 10.1097/FPC.0b013e3282f1f12b
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)
Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919DOI: 10.1097/FPC.0b013e3282f00919
2006
Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases (Journal article)
Carr, D. F., Alfirevic, A., Sherwood, J., Tugwood, J. D., Park, B. K., & Pirmohamed, M. (2006). Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases. DRUG METABOLISM REVIEWS, 38, 54. Retrieved from https://www.webofscience.com/