Photo of Dr Bettina Wilm

Dr Bettina Wilm Dr rer nat

Senior Lecturer Molecular Physiology & Cell Signalling

    Research

    Investigating the potential, safety and efficacy of mouse and human stem cells for renal replacement therapies using murine kidney injury models.

    We analyse the potential of human stem cells as regenerative medicine therapies in vitro and in vivo.
    We use multimodal preclinical imaging (optoacoustic imaging, in vivo bioluminescence imaging, MR imaging and ultrasound) to track administered cells as therapies in animals of a preclinical model of focal segmental glomerulosclerosis. We follow the cells in order to determine whether they can integrate into the damaged kidneys and contribute to the repair processes, and to assess whether the cells may cause long-term health problems due to tumour formation.
    We assess the efficacy of the administered cells by analysing kidney function; for this, we also use multimodal imaging technologies. In addition, we measure the GFR with a transcutaneous device, and we determine urinary and serum biomarkers.

    Analysing the role of mesothelial cells in tissue development, homeostasis and repair.

    We study the role of mesothelial cells by employing genetic lineage tracing methods in embryos and adult mice. Mesothelial cells have been shown to contribute to mural components of the vasculature in the heart, lungs and intestine.
    In order to analyse the molecular mechanisms of the recruitment, we use an in vitro angiogenesis system in combination with live cell imaging, RNA and protein expression analysis.

    Research Grants

    Bench Fees for Suad Hassan S Alghamdi

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    October 2018 - September 2022

    Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease RenalToolBox

    EUROPEAN COMMISSION

    November 2018 - April 2023

    Assessing the therapeutic effects of renal regenerative medicine therapies using a suite of in vitro assays

    CHILDRENS RESEARCH FUND (UK)

    February 2021 - October 2021

    Utilising point-of-care technology in cardiovascular surgery for the identification of pathologic haemolysis implicated in Acute Kidney Injury (AKI).

    KIDNEY RESEARCH UK (UK)

    October 2022 - September 2024

    Developing a human kidney cell model of vancomycin-induced kidney injury to support translational research

    KIDNEY RESEARCH NORTHWEST (UK)

    November 2021 - April 2022

    Investigating the potential of cell-based regenerative medicine therapies to ameliorate acute kidney injury and prevent progression to chronic disease

    KIDNEY RESEARCH UK (UK)

    April 2018 - July 2019

    Exploring how cell therapies ameliorate renal damage

    MERSEY KIDNEY FIRST (UK)

    October 2018 - September 2021

    Modelling cell therapies for Hirschsprung’s patients

    BOWEL AND CANCER RESEARCH (UK)

    September 2018 - March 2021

    Investigating the efficacy, safety and mechanisms of action of regenerative medicine therapies in Ischaemia Reperfusion Injury of the Mouse Kidney: KRUK Training Fellowship for Rachel Harwood

    KIDNEY RESEARCH UK (UK)

    August 2018 - January 2022

    Investigating how cell based regenerative medicine therapies modulate T-cells and macrophages to ameliorate acute kidney injury

    KIDNEY RESEARCH UK (UK)

    November 2018 - September 2021

    Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies

    EUROPEAN COMMISSION

    August 2016 - July 2018

    Modelling therapies for surgical adhesions

    MEDICAL RESEARCH COUNCIL

    August 2015 - August 2018

    Analysis of the behaviour and control of enteric nervous system progenitor cells isolated from aganglionic bowel in Hirschsprung’s disease RCS/BAPS Surgical Research Fellowship for Sumita Chhabra

    ROYAL COLLEGE OF SURGEONS OF ENGLAND(UK)

    October 2016 - September 2017

    Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology Programme

    WELLCOME TRUST (UK)

    October 2011 - March 2016

    Investigating the potential of mouse kidney-derived stem cells to integrate and improve renal function in a murine model of chronic kidney disease

    ALDER HEY CHILDREN'S KIDNEY FUND (UK)

    October 2010 - September 2012

    The efficacy and safety of stem cell therapies in mouse models of kidney disease

    DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)

    January 2015 - January 2016

    Analysis of the mesothelium as a source of adult progenitor cells for tissue homeostasis

    WELLCOME TRUST (UK)

    August 2010 - April 2015

    Regenerative Medicine Platform in Stem Cell Safety Science

    MEDICAL RESEARCH COUNCIL

    June 2013 - March 2018